Nortriptyline + Pregabalin

Find more information about this combination medication at the webpages for pregabalin and nortriptyline

English

Brand Name

Pegabanyl NT Tablet 10s , Premed N 10mg/75mgTablet 10s ... show more

Approved Treatment Indication:

Postherpetic Neuralgia, Depressive Disorder ... show more

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This medicine contains a combination of 2 drugs nortriptyline and pregabalin.
nortriptyline and pregabalin are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
The combination of nortriptyline and pregabalin is classified as a controlled substance. Due to its potential for abuse and addiction, the government restricts its prescription and usage.

Summary

What conditions nortriptyline and pregabalin is used for
Nortriptyline is used to treat depression, which is a mental health condition characterized by persistent sadness and loss of interest. Pregabalin is used to treat nerve pain, which is discomfort caused by nerve damage, and to control seizures, which are sudden, uncontrolled electrical disturbances in the brain.
How nortriptyline and pregabalin works in the body
Nortriptyline works by increasing levels of certain brain chemicals, such as serotonin and norepinephrine, which help improve mood. Pregabalin works by calming overactive nerves, which helps reduce nerve pain and control seizures. Both affect the central nervous system, but in different ways.
The usual dosages and routes of administration of nortriptyline and pregabalin
Nortriptyline is usually started at 25 mg per day, taken orally, and adjusted based on response. Pregabalin typically starts at 150 mg per day, divided into two or three doses, also taken orally. Both require careful dosing adjustments by a healthcare provider.
The most commonly observed adverse effects of nortriptyline and pregabalin
Common side effects of nortriptyline include dry mouth, drowsiness, and dizziness. Pregabalin may cause dizziness, sleepiness, and weight gain. Both can lead to more serious side effects like mood changes or allergic reactions, though these are less common.
Important safety warnings and contraindications of nortriptyline and pregabalin
Nortriptyline should not be used with MAO inhibitors, which are a type of antidepressant, or in those with heart problems. Pregabalin should be used cautiously in people with a history of substance abuse, as it can be habit-forming. Both can cause drowsiness, so caution is advised when driving.

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

None

Controlled Drug Substance

YES

Summary

What conditions nortriptyline and pregabalin is used for
Nortriptyline is used to treat depression, which is a mental health condition characterized by persistent sadness and loss of interest. Pregabalin is used to treat nerve pain, which is discomfort caused by nerve damage, and to control seizures, which are sudden, uncontrolled electrical disturbances in the brain.
How nortriptyline and pregabalin works in the body
Nortriptyline works by increasing levels of certain brain chemicals, such as serotonin and norepinephrine, which help improve mood. Pregabalin works by calming overactive nerves, which helps reduce nerve pain and control seizures. Both affect the central nervous system, but in different ways.
The usual dosages and routes of administration of nortriptyline and pregabalin
Nortriptyline is usually started at 25 mg per day, taken orally, and adjusted based on response. Pregabalin typically starts at 150 mg per day, divided into two or three doses, also taken orally. Both require careful dosing adjustments by a healthcare provider.
The most commonly observed adverse effects of nortriptyline and pregabalin
Common side effects of nortriptyline include dry mouth, drowsiness, and dizziness. Pregabalin may cause dizziness, sleepiness, and weight gain. Both can lead to more serious side effects like mood changes or allergic reactions, though these are less common.
Important safety warnings and contraindications of nortriptyline and pregabalin
Nortriptyline should not be used with MAO inhibitors, which are a type of antidepressant, or in those with heart problems. Pregabalin should be used cautiously in people with a history of substance abuse, as it can be habit-forming. Both can cause drowsiness, so caution is advised when driving.

Indications and Purpose

How does combination of nortriptyline and pregabalin work?

Nortriptyline works by increasing the levels of certain chemicals in the brain, such as serotonin and norepinephrine, which help improve mood and relieve depression. Pregabalin works by calming overactive nerves, which helps reduce nerve pain and control seizures. Both medications affect the central nervous system, but they do so in different ways. Nortriptyline primarily targets mood regulation, while pregabalin focuses on nerve activity. Together, they can address both mood and nerve-related issues.

How does combination of Nortriptyline and Pregabalin work?

Pregabalin works by binding to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, which reduces the release of excitatory neurotransmitters and helps alleviate pain and seizures. Nortriptyline, a tricyclic antidepressant, works by inhibiting the reuptake of norepinephrine and serotonin, increasing their levels in the brain to improve mood and relieve pain. Both medications modulate neurotransmitter activity, but they target different pathways and receptors to achieve their therapeutic effects.

How effective is combination of nortriptyline and pregabalin?

Nortriptyline has been shown to be effective in treating depression through numerous clinical studies, which demonstrate its ability to improve mood and mental health. Pregabalin has been proven effective in reducing nerve pain and controlling seizures, with studies showing significant symptom relief. Both medicines have been tested in various clinical trials, providing evidence of their effectiveness for their respective conditions. They share a common goal of improving quality of life by alleviating symptoms, though they work in different ways within the body.

How effective is combination of Nortriptyline and Pregabalin?

Clinical trials have demonstrated the effectiveness of pregabalin in reducing neuropathic pain, controlling seizures, and improving symptoms of fibromyalgia. It has been shown to significantly decrease pain scores and improve quality of life in patients with these conditions. Nortriptyline has been proven effective in treating depression and certain types of chronic pain, with studies showing improvements in mood and pain relief. Both medications have been validated through rigorous clinical research, highlighting their efficacy in their respective indications.

Directions for Use

What is the usual dose of combination of nortriptyline and pregabalin?

The usual adult dose for nortriptyline varies, but it often starts at 25 mg per day and can be adjusted based on the patient's response and needs. Pregabalin's typical starting dose is 150 mg per day, divided into two or three doses, and may be increased as needed. Both medications require careful dosing adjustments by a healthcare provider to ensure effectiveness and minimize side effects. It's important to follow the prescribed dosage and not to adjust it without consulting a doctor.

What is the usual dose of combination of Nortriptyline and Pregabalin?

The usual adult daily dose for pregabalin varies depending on the condition being treated, typically ranging from 150 mg to 600 mg per day, divided into two or three doses. For neuropathic pain, the starting dose is often 150 mg per day, which can be increased based on response and tolerability. Nortriptyline is usually started at a lower dose, around 25 mg to 75 mg per day, and can be adjusted based on the patient's response and the condition being treated. Both medications require careful dose adjustments to balance efficacy and side effects.

How does one take combination of nortriptyline and pregabalin?

Nortriptyline can be taken with or without food, but taking it with food may help reduce stomach upset. Pregabalin can also be taken with or without food. There are no specific food restrictions for either medication, but it's important to follow the healthcare provider's instructions. Both medications should be taken as prescribed, and any changes in diet or medication should be discussed with a healthcare provider to ensure safety and effectiveness.

How does one take combination of Nortriptyline and Pregabalin?

Pregabalin can be taken with or without food, but taking it with food may help reduce stomach upset. Nortriptyline is usually taken once daily, often at bedtime, to minimize daytime drowsiness, and it can also be taken with or without food. There are no specific food restrictions for either medication, but alcohol should be avoided as it can increase the sedative effects of both drugs. Patients should follow their healthcare provider's instructions regarding dosing and any potential interactions with food or other substances.

For how long is combination of nortriptyline and pregabalin taken?

The duration of use for nortriptyline can vary depending on the condition being treated, but it is often used for several months to manage depression. Pregabalin's duration also depends on the condition, such as nerve pain or seizures, and can be long-term. Both medications require regular evaluation by a healthcare provider to determine the appropriate length of treatment. It's important to follow the prescribed treatment plan and not to stop taking the medication without consulting a doctor.

For how long is combination of Nortriptyline and Pregabalin taken?

The duration of use for pregabalin and nortriptyline depends on the condition being treated. Pregabalin is often used long-term for chronic conditions like neuropathic pain and epilepsy, with treatment duration tailored to the patient's response and needs. Nortriptyline is also used long-term, particularly for depression and chronic pain management, with the duration depending on the patient's response and the risk of relapse. Both medications require regular evaluation to determine the ongoing need and effectiveness of treatment.

How long does it take for combination of nortriptyline and pregabalin to work?

Nortriptyline, which is a type of antidepressant, may take a few weeks to show its full effects, although some people might notice improvements sooner. Pregabalin, which is used to treat nerve pain and seizures, can start working within a few days. Both medicines require some time to build up in the body to reach their full potential. It's important to be patient and continue taking the medication as prescribed by your doctor, even if you don't feel better right away.

How long does it take for combination of Nortriptyline and Pregabalin to work?

Pregabalin typically starts to work within a week, with some patients experiencing relief from symptoms as early as the first week of treatment. It is used to manage neuropathic pain and seizures. Nortriptyline, on the other hand, may take several weeks to show its full effects, especially when used for depression or chronic pain. Both medications require some time to build up in the body to exert their full therapeutic effects, but pregabalin generally acts faster in terms of pain relief.

Warnings and Precautions

Are there harms and risks from taking combination of nortriptyline and pregabalin?

Common side effects of nortriptyline include dry mouth, drowsiness, and dizziness. Pregabalin may cause dizziness, sleepiness, and weight gain. Both medicines can lead to more serious side effects like mood changes or allergic reactions, though these are less common. It's important to monitor for any unusual symptoms and report them to a healthcare provider. Both medications can cause drowsiness, so caution is advised when driving or operating machinery.

Are there harms and risks from taking combination of Nortriptyline and Pregabalin?

Common side effects of pregabalin include dizziness, somnolence, dry mouth, and weight gain. Significant adverse effects can include blurred vision, peripheral edema, and potential for respiratory depression when combined with other CNS depressants. Nortriptyline's common side effects include dry mouth, constipation, and drowsiness, with significant risks of cardiac arrhythmias and increased suicidal thoughts in young adults. Both medications can cause dizziness and drowsiness, requiring caution when performing tasks that require alertness.

Can I take combination of nortriptyline and pregabalin with other prescription drugs?

Nortriptyline can interact with other antidepressants, leading to increased side effects or serotonin syndrome. Pregabalin may interact with medications that cause drowsiness, enhancing this effect. Both medications require careful monitoring when used with other drugs that affect the central nervous system. It's important for patients to inform their healthcare provider of all medications they are taking to avoid potential interactions and ensure safe use.

Can I take combination of Nortriptyline and Pregabalin with other prescription drugs?

Pregabalin can interact with other CNS depressants, such as opioids and benzodiazepines, increasing the risk of sedation and respiratory depression. Nortriptyline can interact with MAO inhibitors, SSRIs, and other antidepressants, increasing the risk of serotonin syndrome and cardiac arrhythmias. Both medications require careful monitoring when used with other drugs that affect the central nervous system, and healthcare providers should be informed of all medications a patient is taking to avoid adverse interactions.

Can I take combination of nortriptyline and pregabalin if I am pregnant?

Nortriptyline is generally not recommended during pregnancy unless the benefits outweigh the risks, as it may affect the developing baby. Pregabalin is also advised to be used with caution during pregnancy due to potential risks to the fetus. Both medications should only be used if clearly needed and prescribed by a healthcare provider. It's important for pregnant women to discuss all medications with their doctor to ensure the safety of both mother and baby.

Can I take combination of Nortriptyline and Pregabalin if I am pregnant?

Pregabalin has been associated with potential risks to the fetus, including birth defects, and should only be used during pregnancy if the benefits outweigh the risks. Nortriptyline is also used with caution during pregnancy, as it may affect fetal development, particularly in the first trimester. Both medications require a thorough evaluation of the risks and benefits by healthcare providers, and alternative treatments may be considered to minimize potential harm to the developing fetus.

Can I take combination of nortriptyline and pregabalin while breastfeeding?

Nortriptyline is considered relatively safe during breastfeeding, as only small amounts pass into breast milk. However, infants should be monitored for any side effects. Pregabalin's safety during breastfeeding is less clear, and it may be present in breast milk. Both medications require careful consideration and consultation with a healthcare provider to weigh the benefits and risks. Monitoring the infant for any adverse effects is crucial if these medications are used during breastfeeding.

Can I take combination of Nortriptyline and Pregabalin while breastfeeding?

Pregabalin is excreted in breast milk, and its effects on nursing infants are not well-studied, so breastfeeding is generally not recommended during treatment. Nortriptyline is also present in breast milk but is considered relatively safe for use during breastfeeding, with monitoring for any adverse effects in the infant. Both medications require a careful risk-benefit assessment by healthcare providers when considering use during lactation, and alternative treatments may be considered if necessary.

Who should avoid taking combination of nortriptyline and pregabalin?

Nortriptyline should not be used in individuals with a history of heart problems or those taking MAO inhibitors, which are a type of antidepressant. Pregabalin should be used cautiously in people with a history of substance abuse, as it can be habit-forming. Both medications can cause drowsiness, so caution is advised when driving or operating machinery. It's important to follow the prescribed dosage and consult a healthcare provider if any unusual symptoms occur.

Who should avoid taking combination of Nortriptyline and Pregabalin?

Pregabalin carries warnings for potential respiratory depression, especially when used with other CNS depressants, and should be used cautiously in patients with respiratory issues. Nortriptyline has contraindications for use in patients with recent myocardial infarction and those taking MAO inhibitors. Both medications have warnings about the risk of suicidal thoughts and behaviors, particularly in young adults. Patients should be monitored for mood changes and advised to report any concerning symptoms to their healthcare provider immediately.