Pregabalin
Postherpetic Neuralgia, Seizures ... show more
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
undefined
Controlled Drug Substance
YES
Pregabalin
Learn more about this medicine -
Click HereSummary
Pregabalin is primarily used to treat conditions such as neuropathic pain, fibromyalgia, and generalized anxiety disorder.
Pregabalin works by binding to specific calcium channels in the brain and spinal cord. This action reduces the release of neurotransmitters that cause pain and anxiety, thereby providing relief from these conditions.
Pregabalin capsules are taken orally, with or without food. The starting dose is usually 150 mg per day, taken in two doses of 75 mg each. The dose may be increased to 300 mg per day after one week, taken in two doses of 150 mg each. The maximum dose is 600 mg per day.
Common side effects of Pregabalin include dizziness, drowsiness, dry mouth, weight gain, and swelling in the hands or feet. Severe adverse effects can include allergic reactions, suicidal thoughts, mood changes, and rarely, muscle problems.
Pregabalin should be used with caution in people with a history of substance abuse, as it can be habit-forming. It is contraindicated in individuals with severe kidney problems. Pregnant or breastfeeding women should consult a doctor before use.
Indications and Purpose
What is Pregabalin used for?
Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. It is also used to manage neuropathic pain associated with spinal cord injury.
How does Pregabalin work?
Pregabalin works by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. This action reduces the release of neurotransmitters involved in pain transmission and seizure activity, helping to alleviate pain and control seizures.
Is Pregabalin effective?
Pregabalin is effective in managing neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial-onset seizures. Clinical trials have shown significant pain reduction and improved seizure control in patients using Pregabalin compared to placebo. Its effectiveness is attributed to its ability to decrease pain signals from damaged nerves.
How does one know if Pregabalin is working?
The benefit of Pregabalin is evaluated by monitoring the reduction in symptoms such as pain, seizure frequency, or anxiety levels. Regular follow-up appointments with your doctor will help assess the medication's effectiveness and determine if any dosage adjustments or alternative treatments are needed.
Directions for Use
What is the usual dose of Pregabalin?
For adults, the usual daily dose of Pregabalin ranges from 150 mg to 600 mg, divided into two or three doses. For children aged 1 month and older, the dose is based on body weight and ranges from 2.5 mg/kg to 10 mg/kg per day, not exceeding 600 mg per day. Always follow your doctor's specific dosage instructions.
How do I take Pregabalin?
Pregabalin can be taken with or without food. It's important to take it at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but avoid alcohol as it can increase the risk of side effects like dizziness and drowsiness.
For how long do I take Pregabalin?
The duration of Pregabalin use varies depending on the condition being treated. It may be used for several weeks to months for conditions like neuropathic pain or fibromyalgia. Your doctor will determine the appropriate length of treatment based on your specific needs and response to the medication.
How long does it take for Pregabalin to start working?
Pregabalin may start to relieve symptoms within a week, but it can take several weeks to feel the full benefits. The time it takes to work can vary depending on the condition being treated and individual response. Consult your doctor if you have concerns about its effectiveness.
How should I store Pregabalin?
Store Pregabalin in its original container at room temperature, away from excess heat and moisture. Keep it out of reach of children and pets. Do not store it in the bathroom, and ensure the container is tightly closed to maintain the medication's effectiveness and safety.
Warnings and Precautions
Who should avoid taking Pregabalin?
Pregabalin may cause serious side effects like allergic reactions, suicidal thoughts, and respiratory depression. It should be used cautiously in patients with a history of substance abuse, and those with renal impairment may require dose adjustments. Pregabalin is contraindicated in patients with known hypersensitivity to the drug or its components.
Can I take Pregabalin with other prescription drugs?
Pregabalin can interact with central nervous system depressants like opioids, benzodiazepines, and alcohol, increasing the risk of sedation and respiratory depression. It's important to inform your doctor about all medications you're taking to avoid potential interactions and ensure safe use of Pregabalin.
Can I take Pregabalin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Pregabalin be taken safely while pregnant?
Pregabalin should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. Some studies suggest a possible risk of birth defects, but data is limited. Pregnant women should consult their doctor to weigh the risks and benefits before using Pregabalin.
Can Pregabalin be taken safely while breastfeeding?
Pregabalin is excreted in breast milk, and its effects on nursing infants are unknown. Breastfeeding is not recommended while taking Pregabalin. Consult your doctor to discuss the risks and benefits and explore alternative treatments if necessary.
Is Pregabalin safe for the elderly?
Elderly patients may be more sensitive to the side effects of Pregabalin, such as dizziness and drowsiness, which can increase the risk of falls. Dose adjustments may be necessary due to decreased renal function. It's important for elderly patients to be closely monitored by their healthcare provider while taking Pregabalin.
Is it safe to exercise while taking Pregabalin?
Pregabalin may cause dizziness, drowsiness, and coordination issues, which can affect your ability to exercise safely. If you experience these side effects, it is advisable to avoid strenuous activities until you know how the medication affects you. Consult your doctor for personalized advice on exercise while taking Pregabalin.
Is it safe to drink alcohol while taking Pregabalin?
Drinking alcohol while taking Pregabalin can increase the risk of side effects such as dizziness, drowsiness, and difficulty concentrating. It is generally advised to avoid alcohol to prevent these enhanced effects and ensure safety while on this medication.
Forms / Brands
