Nortriptyline

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Brand Name

Sensival 25mg Tablet 10s , Nortimer 25mg Tablet 10s ... show more

Approved Treatment Indication:

Depressive Disorder, Pain ... show more

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What conditions Nortriptyline is used for
Nortriptyline is primarily used to treat depression, which is a mood disorder causing persistent sadness and loss of interest. It may also be used for panic disorders, which are sudden episodes of intense fear, and chronic pain conditions like post-herpetic neuralgia, which is nerve pain following shingles.
How Nortriptyline works in the body
Nortriptyline works by increasing the levels of certain neurotransmitters, which are chemicals in the brain that help improve mood and mental balance. It belongs to a class of medications called tricyclic antidepressants, which are used to treat depression and other mood disorders.
The usual dosages and routes of administration of Nortriptyline
For adults, the usual dose of Nortriptyline is 25 mg taken three or four times daily. The total daily dose can also be given once a day, usually at night. Doses above 150 mg per day are not recommended. Nortriptyline is not recommended for children.
The most commonly observed adverse effects of Nortriptyline
Common side effects of Nortriptyline include drowsiness, which is feeling sleepy, dry mouth, which is a lack of saliva, constipation, which is difficulty in passing stools, and weight changes. Serious effects can include irregular heartbeat and severe mood changes.
Important safety warnings and contraindications of Nortriptyline
Nortriptyline should not be used with monoamine oxidase inhibitors, which are another type of antidepressant, due to the risk of serotonin syndrome, which is a potentially life-threatening condition. It is contraindicated in patients with recent heart attacks or severe liver disease.

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Tricyclic Antidepressant

Controlled Drug Substance

Summary

What conditions Nortriptyline is used for
Nortriptyline is primarily used to treat depression, which is a mood disorder causing persistent sadness and loss of interest. It may also be used for panic disorders, which are sudden episodes of intense fear, and chronic pain conditions like post-herpetic neuralgia, which is nerve pain following shingles.
How Nortriptyline works in the body
Nortriptyline works by increasing the levels of certain neurotransmitters, which are chemicals in the brain that help improve mood and mental balance. It belongs to a class of medications called tricyclic antidepressants, which are used to treat depression and other mood disorders.
The usual dosages and routes of administration of Nortriptyline
For adults, the usual dose of Nortriptyline is 25 mg taken three or four times daily. The total daily dose can also be given once a day, usually at night. Doses above 150 mg per day are not recommended. Nortriptyline is not recommended for children.
The most commonly observed adverse effects of Nortriptyline
Common side effects of Nortriptyline include drowsiness, which is feeling sleepy, dry mouth, which is a lack of saliva, constipation, which is difficulty in passing stools, and weight changes. Serious effects can include irregular heartbeat and severe mood changes.
Important safety warnings and contraindications of Nortriptyline
Nortriptyline should not be used with monoamine oxidase inhibitors, which are another type of antidepressant, due to the risk of serotonin syndrome, which is a potentially life-threatening condition. It is contraindicated in patients with recent heart attacks or severe liver disease.

Indications and Purpose

How does Nortriptyline work?

Nortriptyline works by increasing the levels of certain neurotransmitters in the brain, such as norepinephrine and serotonin, which help improve mood and mental balance. It is part of a class of medications known as tricyclic antidepressants, which are used to treat depression and other mood disorders.

Is Nortriptyline effective?

Nortriptyline is a tricyclic antidepressant that has been shown to be effective in treating depression by increasing the levels of certain natural substances in the brain that help maintain mental balance. Clinical studies have demonstrated its efficacy in alleviating symptoms of depression, particularly endogenous depression.

What is Nortriptyline?

Nortriptyline is a tricyclic antidepressant used primarily to treat depression. It works by increasing the levels of certain natural substances in the brain that help maintain mental balance. It may also be used for other conditions like panic disorders and chronic pain. Always follow your doctor's instructions when using this medication.

Directions for Use

For how long do I take Nortriptyline?

Nortriptyline is typically used for several weeks to months, depending on the condition being treated. The antidepressant effect usually sets in after 2 to 4 weeks. Treatment may continue for up to 6 months after recovery to prevent relapse. Always follow your doctor's guidance on the duration of use.

How do I take Nortriptyline?

Nortriptyline can be taken with or without food, usually one to four times a day. It is important to take it at the same time each day. There are no specific food restrictions, but it is advisable to avoid alcohol as it can increase the sedative effects of the medication.

How long does it take for Nortriptyline to start working?

Nortriptyline may take 2 to 4 weeks to start showing its antidepressant effects. It is important to continue taking the medication as prescribed, even if you do not notice immediate improvement. Regular follow-ups with your doctor will help assess its effectiveness.

How should I store Nortriptyline?

Nortriptyline should be stored in its original container, tightly closed, and kept out of reach of children. It should be stored at room temperature, away from excess heat and moisture. Unused medication should be disposed of properly, preferably through a medicine take-back program.

What is the usual dose of Nortriptyline?

For adults, the usual dose of Nortriptyline is 25 mg taken three or four times daily. The total daily dose can also be given once a day, usually at night. Doses above 150 mg per day are not recommended. Nortriptyline is not recommended for children as its safety and effectiveness have not been established for this age group.

Warnings and Precautions

Can I take Nortriptyline with other prescription drugs?

Nortriptyline can interact with several medications, including MAOIs, which can lead to serotonin syndrome. It may also interact with other antidepressants, anticholinergic drugs, and certain heart medications, potentially causing increased side effects or reduced effectiveness. Always inform your doctor of all medications you are taking.

Can Nortriptyline be taken safely while breastfeeding?

Nortriptyline is excreted in breast milk, but adverse effects in infants have not been reported. Breastfeeding can continue if the benefits to the mother outweigh the potential risks to the infant. It is important to monitor the infant for any side effects and consult your doctor for personalized advice.

Can Nortriptyline be taken safely while pregnant?

Nortriptyline should be used during pregnancy only if the potential benefits outweigh the risks. There is limited data on its safety in pregnancy, and it may cause withdrawal symptoms in newborns if used in the final weeks. Always consult your doctor before using Nortriptyline if you are pregnant or planning to become pregnant.

Is it safe to drink alcohol while taking Nortriptyline?

Drinking alcohol while taking Nortriptyline can enhance the sedative effects of the medication, leading to increased drowsiness and dizziness. This combination may also increase the risk of overdose and suicidal attempts, especially in individuals with a history of emotional disturbances. It is advisable to avoid alcohol consumption while on Nortriptyline.

Is it safe to exercise while taking Nortriptyline?

Nortriptyline may cause drowsiness, dizziness, or fatigue, which can affect your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. If you feel unwell or experience side effects that impact your ability to exercise, consult your doctor for advice.

Is Nortriptyline safe for the elderly?

Elderly patients are more susceptible to the side effects of Nortriptyline, such as confusion, agitation, and cardiovascular issues. Lower dosages are recommended for elderly patients, and they should be closely monitored for adverse effects. Regular follow-ups with a healthcare provider are important to ensure safe use.

Who should avoid taking Nortriptyline?

Nortriptyline has several important warnings and contraindications. It should not be used with monoamine oxidase inhibitors (MAOIs) due to the risk of serotonin syndrome. It is contraindicated in patients with recent myocardial infarction, heart block, or severe liver disease. Patients should be monitored for worsening depression and suicidal thoughts, especially in young adults.