Hydrochlorothiazide + Nebivolol
Find more information about this combination medication at the webpages for Nebivolol and Hydrochlorothiazide
Hypertension, Malignant Hypertension ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Nebivolol.
- Hydrochlorothiazide and Nebivolol are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Hydrochlorothiazide + Nebivolol
Summary
Nebivolol and Hydrochlorothiazide are primarily used to treat high blood pressure, also known as hypertension. In addition, Nebivolol can be used for certain types of heart failure, and Hydrochlorothiazide can be used to treat fluid buildup, or edema, associated with heart, kidney, or liver disease.
Nebivolol works by relaxing your blood vessels and slowing your heart rate. This improves blood flow and reduces blood pressure. Hydrochlorothiazide works differently. It's a diuretic, which means it helps your body get rid of excess salt and water through your urine. This reduces fluid volume in your body, which also lowers your blood pressure.
Nebivolol is usually taken at a dose of 5 mg once daily, which can be increased to 40 mg if needed. Hydrochlorothiazide is typically taken at a dose of 25 mg daily, which can be increased to 50 mg if needed. Both medications are taken orally.
Common side effects of Nebivolol include headache, tiredness, dizziness, and nausea. Hydrochlorothiazide may cause frequent urination, dizziness, and electrolyte imbalances, which means it can disrupt the balance of minerals in your body. Both medications can cause low blood pressure and dizziness, especially when standing up quickly.
Nebivolol should not be used in patients with severe slow heart rate, heart block, or severe liver impairment. Hydrochlorothiazide should not be used in patients who can't produce urine or who are allergic to sulfa drugs. Both medications require caution in patients with kidney impairment, diabetes, or electrolyte imbalances. Regular monitoring of blood pressure and electrolytes is essential.
Indications and Purpose
How does combination of Hydrochlorothiazide and Nebivolol work?
The combination of Hydrochlorothiazide and Nebivolol is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of extra salt and water by making you urinate more. This helps to lower blood pressure and reduce swelling. Nebivolol is a beta-blocker, which works by slowing down your heart rate and relaxing blood vessels, making it easier for your heart to pump blood around your body. Together, these medications help to effectively lower blood pressure and reduce the risk of heart-related complications.
How does combination of Nebivolol and Hydrochlorothiazide work?
Nebivolol works by blocking beta-adrenergic receptors, which leads to relaxation of blood vessels and a slower heart rate, improving blood flow and reducing blood pressure. Hydrochlorothiazide acts as a diuretic, promoting the excretion of excess salt and water through the kidneys, which decreases fluid volume and lowers blood pressure. Both medications aim to reduce blood pressure but do so through different mechanisms, providing a comprehensive approach to hypertension management.
How effective is combination of Hydrochlorothiazide and Nebivolol?
The combination of Hydrochlorothiazide and Nebivolol is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water, reducing blood pressure. Nebivolol is a beta-blocker that helps the heart to beat more slowly and with less force, also lowering blood pressure. Together, they can be more effective than using either drug alone, as they target different mechanisms in the body to control blood pressure. However, effectiveness can vary based on individual health conditions, and it's important to follow a healthcare provider's guidance when using these medications.
How effective is combination of Nebivolol and Hydrochlorothiazide?
Clinical trials and studies have demonstrated the effectiveness of both Nebivolol and Hydrochlorothiazide in lowering blood pressure. Nebivolol has been shown to reduce cardiovascular events by improving blood flow and decreasing heart rate. Hydrochlorothiazide effectively reduces fluid retention and lowers blood pressure by promoting diuresis. Together, they provide a synergistic effect in managing hypertension, with evidence supporting their use in reducing the risk of heart attacks and strokes.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Nebivolol?
The usual dose of the combination of Hydrochlorothiazide and Nebivolol can vary based on individual health needs and the specific condition being treated. However, a common starting dose is often 5 mg of Nebivolol combined with 12.5 mg of Hydrochlorothiazide, taken once daily. It's important to follow the dosage prescribed by a healthcare provider, as they will tailor it to your specific health requirements. Hydrochlorothiazide is a diuretic, which helps reduce fluid retention, while Nebivolol is a beta-blocker that helps lower blood pressure by slowing down the heart rate.
What is the usual dose of combination of Nebivolol and Hydrochlorothiazide?
The usual adult daily dose for Nebivolol is typically 5 mg once daily, which can be adjusted up to 40 mg depending on the patient's response and tolerance. For Hydrochlorothiazide, the usual dose for treating hypertension is 25 mg daily, which can be increased to 50 mg if needed. Both medications are taken orally and can be used alone or in combination with other antihypertensive agents. It's important to follow the prescribed dosage and not to adjust it without consulting a healthcare provider.
How does one take combination of Hydrochlorothiazide and Nebivolol?
Hydrochlorothiazide and Nebivolol are medications often used together to manage high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of excess salt and water by increasing urine production. Nebivolol is a beta-blocker that helps to slow down the heart rate and reduce blood pressure by blocking certain natural substances in the body. When taking these medications together, it is important to follow your healthcare provider's instructions carefully. Typically, they are taken once daily, with or without food. It is crucial to take them at the same time each day to maintain an even level of the medication in your body. Do not stop taking these medications suddenly without consulting your doctor, as this can lead to adverse effects. If you experience any side effects or have concerns about the medication, contact your healthcare provider for advice. For more detailed information, you can refer to trusted sources like the NHS or NLM websites.
How does one take combination of Nebivolol and Hydrochlorothiazide?
Nebivolol can be taken with or without food, and it is important to take it at the same time each day to maintain consistent blood levels. Hydrochlorothiazide should also be taken as prescribed, usually once or twice daily, and can be taken with or without food. Patients are advised to follow a low-salt diet and maintain adequate hydration. It's important to avoid alcohol, as it can enhance the blood pressure-lowering effects and increase the risk of side effects like dizziness.
For how long is combination of Hydrochlorothiazide and Nebivolol taken?
The duration for taking a combination of Hydrochlorothiazide and Nebivolol can vary based on individual health needs and the condition being treated. Typically, these medications are used for managing high blood pressure and may be taken long-term. However, the exact duration should be determined by a healthcare provider, who will consider factors like the patient's response to the medication and any side effects. Regular check-ups are important to assess the effectiveness and adjust the treatment as necessary. Always follow the guidance of a healthcare professional regarding medication use.
For how long is combination of Nebivolol and Hydrochlorothiazide taken?
Both Nebivolol and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. They do not cure hypertension but help control it, requiring continuous use to maintain their effects. Patients are advised to take these medications regularly, even if they feel well, and not to stop them abruptly without consulting their doctor. The duration of use is generally determined by the patient's response and the healthcare provider's guidance.
How long does it take for combination of Hydrochlorothiazide and Nebivolol to work?
The combination of Hydrochlorothiazide and Nebivolol typically starts to work within a few hours after taking it. Hydrochlorothiazide is a diuretic, which helps reduce fluid retention and lower blood pressure by increasing urine production. Nebivolol is a beta-blocker that helps to lower blood pressure by slowing down the heart rate and reducing the force of heart contractions. While you may notice some effects within hours, it can take several weeks to see the full benefits in terms of blood pressure control. It's important to take the medication as prescribed and consult with your healthcare provider for personalized advice.
How long does it take for combination of Nebivolol and Hydrochlorothiazide to work?
Nebivolol, a beta-blocker, typically begins to show its effects on blood pressure within 2 weeks, although it may take longer for the full benefits to be observed. Hydrochlorothiazide, a diuretic, usually starts working within 2 hours of ingestion, with its peak effect occurring around 4 hours and lasting up to 12 hours. Both medications work to lower blood pressure, but they do so through different mechanisms. Nebivolol relaxes blood vessels and slows heart rate, while Hydrochlorothiazide helps the body eliminate excess salt and water. Together, they provide a comprehensive approach to managing high blood pressure.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Nebivolol?
Yes, there can be risks and side effects when taking Hydrochlorothiazide and Nebivolol together. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of excess salt and water by making you urinate more. Nebivolol is a beta-blocker, which helps to lower blood pressure by slowing down your heart rate. When taken together, these medications can cause a significant drop in blood pressure, leading to symptoms like dizziness, lightheadedness, or fainting, especially when standing up quickly. This is known as orthostatic hypotension. Additionally, Hydrochlorothiazide can cause an imbalance in electrolytes, such as low potassium levels, which can be dangerous. Nebivolol can also affect heart rate and may not be suitable for people with certain heart conditions. It's important to take these medications under the guidance of a healthcare professional who can monitor for side effects and adjust dosages as necessary. Always inform your doctor about any other medications you are taking to avoid potential interactions.
Are there harms and risks from taking combination of Nebivolol and Hydrochlorothiazide?
Common side effects of Nebivolol include headache, tiredness, dizziness, and nausea. Hydrochlorothiazide may cause frequent urination, dizziness, and electrolyte imbalances. Both medications can lead to low blood pressure and dizziness, especially when standing up quickly. Serious adverse effects include slow heart rate, difficulty breathing, and severe allergic reactions for Nebivolol, and severe dehydration, electrolyte imbalance, and skin reactions for Hydrochlorothiazide. Patients should report any severe or persistent side effects to their healthcare provider.
Can I take combination of Hydrochlorothiazide and Nebivolol with other prescription drugs?
Hydrochlorothiazide and Nebivolol are medications used to manage high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of excess salt and water, while Nebivolol is a beta-blocker that helps slow down your heart rate and reduce blood pressure. When taking these medications, it's important to be cautious about combining them with other prescription drugs. Some drugs can interact with Hydrochlorothiazide and Nebivolol, potentially leading to increased side effects or reduced effectiveness. For example, combining them with other blood pressure medications can sometimes lower your blood pressure too much. Always consult with your healthcare provider or pharmacist before adding any new medications to your regimen. They can provide guidance based on your specific health needs and the other medications you are taking. For more detailed information, you can refer to trusted sources like the NHS, DailyMeds, or the National Library of Medicine (NLM).
Can I take combination of Nebivolol and Hydrochlorothiazide with other prescription drugs?
Nebivolol can interact with other beta-blockers, calcium channel blockers, and CYP2D6 inhibitors, potentially leading to increased effects or side effects. Hydrochlorothiazide may interact with other diuretics, corticosteroids, and non-steroidal anti-inflammatory drugs (NSAIDs), affecting its efficacy and increasing the risk of electrolyte imbalances. Both medications can interact with drugs that affect blood pressure, so it's important to inform healthcare providers of all medications being taken to avoid adverse interactions.
Can I take combination of Hydrochlorothiazide and Nebivolol if I am pregnant?
It is important to consult your healthcare provider before taking any medication during pregnancy. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of extra salt and water. Nebivolol is a beta-blocker, which helps to lower blood pressure by slowing down the heart rate. According to the NHS, some medications can be harmful to the developing baby, especially in the first trimester. The NLM advises that Hydrochlorothiazide should be used during pregnancy only if clearly needed, as it may pose risks to the fetus. Similarly, the use of Nebivolol during pregnancy is not well-studied, and its safety is not established. Always discuss with your doctor to weigh the potential benefits and risks before taking these medications while pregnant.
Can I take combination of Nebivolol and Hydrochlorothiazide if I am pregnant?
Nebivolol's safety during pregnancy is not well established, and it should be used only if clearly needed, as beta-blockers can affect fetal development. Hydrochlorothiazide crosses the placental barrier and may cause fetal or neonatal jaundice, thrombocytopenia, and other adverse effects. Both medications should be used with caution during pregnancy, and the potential risks and benefits should be carefully weighed. Alternative treatments may be considered to manage hypertension during pregnancy.
Can I take combination of Hydrochlorothiazide and Nebivolol while breastfeeding?
When considering the use of Hydrochlorothiazide and Nebivolol while breastfeeding, it's important to understand the potential effects on both the mother and the baby. Hydrochlorothiazide is a diuretic, which means it helps the body get rid of excess salt and water by increasing urine production. According to the NHS, small amounts of Hydrochlorothiazide can pass into breast milk, but it is generally considered safe for short-term use during breastfeeding. However, it may reduce milk production, especially at higher doses. Nebivolol is a beta-blocker, which is used to manage high blood pressure by slowing down the heart and reducing its workload. The NHS suggests that beta-blockers can pass into breast milk in small amounts, but they are usually considered safe for breastfeeding mothers. However, it's important to monitor the baby for any signs of side effects, such as slow heart rate or low blood pressure. Before taking these medications, it's crucial to consult with a healthcare provider to weigh the benefits and potential risks, and to ensure that the treatment plan is safe for both the mother and the baby.
Can I take combination of Nebivolol and Hydrochlorothiazide while breastfeeding?
Nebivolol is not recommended during breastfeeding due to the potential for serious adverse reactions in nursing infants, such as bradycardia. Hydrochlorothiazide is excreted in breast milk and may cause adverse effects in the infant, including electrolyte imbalances. Both medications should be used with caution, and alternative treatments should be considered. If these medications are necessary, monitoring the infant for any adverse effects is crucial, and breastfeeding may need to be discontinued.
Who should avoid taking combination of Hydrochlorothiazide and Nebivolol?
People who should avoid taking the combination of Hydrochlorothiazide and Nebivolol include those with certain medical conditions or risk factors. According to trusted sources like the NHS and NLM, individuals with severe liver or kidney problems, those with a history of severe allergic reactions to either drug, and people with certain heart conditions such as very slow heart rate or heart block should avoid this combination. Additionally, pregnant women, breastfeeding mothers, and individuals with low blood pressure or electrolyte imbalances should consult their healthcare provider before using these medications together. It's important to discuss your full medical history with a healthcare professional to determine if this combination is safe for you.
Who should avoid taking combination of Nebivolol and Hydrochlorothiazide?
Nebivolol is contraindicated in patients with severe bradycardia, heart block, or severe liver impairment. Hydrochlorothiazide should not be used in patients with anuria or hypersensitivity to sulfonamide-derived drugs. Both medications require caution in patients with renal impairment, diabetes, or electrolyte imbalances. Patients should avoid abrupt discontinuation of Nebivolol to prevent angina or heart attack. Regular monitoring of blood pressure and electrolytes is essential to manage potential side effects and interactions.
