Hydrochlorothiazide + Lisinopril

Find more information about this combination medication at the webpages for Lisinopril and Hydrochlorothiazide

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Approved Treatment Indication:

Hypertension, Left Ventricular Hypertrophy ... show more

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Advisory

This medicine contains a combination of 2 drugs Hydrochlorothiazide and Lisinopril.
Hydrochlorothiazide and Lisinopril are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Hydrochlorothiazide and Lisinopril used for?
Hydrochlorothiazide and Lisinopril are primarily used to treat high blood pressure, which is also known as hypertension. By effectively managing blood pressure, these medications help reduce the risk of serious complications such as heart attacks, strokes, and kidney problems. Lisinopril, which is an ACE inhibitor, is particularly beneficial for patients with heart failure or those who have had a heart attack. Hydrochlorothiazide, which is a diuretic, is effective in reducing fluid retention, which can also help in managing conditions like edema, which is swelling caused by excess fluid trapped in the body's tissues.
How do Hydrochlorothiazide and Lisinopril work in the body?
Lisinopril works by inhibiting the action of an enzyme called angiotensin-converting enzyme (ACE), which reduces the production of a substance called angiotensin II. Angiotensin II narrows blood vessels, so by reducing its production, Lisinopril helps relax and widen blood vessels, making it easier for the heart to pump blood. Hydrochlorothiazide, on the other hand, is a diuretic, which means it helps the kidneys remove excess salt and water from the body through urine. This reduces fluid volume and pressure on the blood vessels, helping to lower blood pressure. Together, these medications provide a comprehensive approach to managing high blood pressure by addressing both vascular resistance and fluid retention.
What are the usual dosages and routes of administration for Hydrochlorothiazide and Lisinopril?
The usual adult daily dose for Lisinopril ranges from 10 mg to 80 mg, while Hydrochlorothiazide is typically dosed between 12.5 mg and 50 mg per day. When used in combination, common dosages are 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg of Lisinopril and Hydrochlorothiazide, respectively. These medications are taken orally, which means they are swallowed in the form of a tablet. It is important to take them at the same time each day to maintain consistent blood levels. They can be taken with or without food, but patients should follow their healthcare provider's instructions regarding the timing and dosage.
What are the most commonly observed adverse effects of Hydrochlorothiazide and Lisinopril?
Common side effects of Lisinopril include dizziness, headache, and a persistent dry cough. In rare cases, it can cause angioedema, which is swelling of the deeper layers of the skin. Hydrochlorothiazide can lead to increased urination, electrolyte imbalances, and, in some cases, gout, which is a form of arthritis characterized by severe pain, redness, and tenderness in joints. Both medications can cause low blood pressure, especially when standing up quickly, leading to dizziness or fainting. Serious adverse effects, though rare, include severe allergic reactions, kidney problems, and significant changes in blood electrolytes, which are minerals in your blood that carry an electric charge.
What are the important safety warnings and contraindications of Hydrochlorothiazide and Lisinopril?
Lisinopril and Hydrochlorothiazide carry important warnings, including the risk of fetal toxicity, which means they can harm a developing fetus. They should not be used during pregnancy, especially in the second and third trimesters. Patients with a history of angioedema, which is swelling beneath the skin, or severe kidney impairment should avoid these medications. Caution is advised for those with liver disease, diabetes, or electrolyte imbalances. It's crucial to monitor for signs of low blood pressure, especially in those on diuretics or with heart conditions. Regular medical supervision is necessary to manage these risks effectively. Additionally, these medications are generally not recommended during breastfeeding due to potential adverse effects on the nursing infant.

Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

YES

Known Teratogen

Definite

Pharmaceutical Class

None

Controlled Drug Substance

NO

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Drug Ingredient

Hydrochlorothiazide + Lisinopril

Summary

What conditions are Hydrochlorothiazide and Lisinopril used for?
Hydrochlorothiazide and Lisinopril are primarily used to treat high blood pressure, which is also known as hypertension. By effectively managing blood pressure, these medications help reduce the risk of serious complications such as heart attacks, strokes, and kidney problems. Lisinopril, which is an ACE inhibitor, is particularly beneficial for patients with heart failure or those who have had a heart attack. Hydrochlorothiazide, which is a diuretic, is effective in reducing fluid retention, which can also help in managing conditions like edema, which is swelling caused by excess fluid trapped in the body's tissues.
How do Hydrochlorothiazide and Lisinopril work in the body?
Lisinopril works by inhibiting the action of an enzyme called angiotensin-converting enzyme (ACE), which reduces the production of a substance called angiotensin II. Angiotensin II narrows blood vessels, so by reducing its production, Lisinopril helps relax and widen blood vessels, making it easier for the heart to pump blood. Hydrochlorothiazide, on the other hand, is a diuretic, which means it helps the kidneys remove excess salt and water from the body through urine. This reduces fluid volume and pressure on the blood vessels, helping to lower blood pressure. Together, these medications provide a comprehensive approach to managing high blood pressure by addressing both vascular resistance and fluid retention.
What are the usual dosages and routes of administration for Hydrochlorothiazide and Lisinopril?
The usual adult daily dose for Lisinopril ranges from 10 mg to 80 mg, while Hydrochlorothiazide is typically dosed between 12.5 mg and 50 mg per day. When used in combination, common dosages are 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg of Lisinopril and Hydrochlorothiazide, respectively. These medications are taken orally, which means they are swallowed in the form of a tablet. It is important to take them at the same time each day to maintain consistent blood levels. They can be taken with or without food, but patients should follow their healthcare provider's instructions regarding the timing and dosage.
What are the most commonly observed adverse effects of Hydrochlorothiazide and Lisinopril?
Common side effects of Lisinopril include dizziness, headache, and a persistent dry cough. In rare cases, it can cause angioedema, which is swelling of the deeper layers of the skin. Hydrochlorothiazide can lead to increased urination, electrolyte imbalances, and, in some cases, gout, which is a form of arthritis characterized by severe pain, redness, and tenderness in joints. Both medications can cause low blood pressure, especially when standing up quickly, leading to dizziness or fainting. Serious adverse effects, though rare, include severe allergic reactions, kidney problems, and significant changes in blood electrolytes, which are minerals in your blood that carry an electric charge.
What are the important safety warnings and contraindications of Hydrochlorothiazide and Lisinopril?
Lisinopril and Hydrochlorothiazide carry important warnings, including the risk of fetal toxicity, which means they can harm a developing fetus. They should not be used during pregnancy, especially in the second and third trimesters. Patients with a history of angioedema, which is swelling beneath the skin, or severe kidney impairment should avoid these medications. Caution is advised for those with liver disease, diabetes, or electrolyte imbalances. It's crucial to monitor for signs of low blood pressure, especially in those on diuretics or with heart conditions. Regular medical supervision is necessary to manage these risks effectively. Additionally, these medications are generally not recommended during breastfeeding due to potential adverse effects on the nursing infant.

Indications and Purpose

How does combination of Hydrochlorothiazide and Lisinopril work?

The combination of Hydrochlorothiazide and Lisinopril is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps your body get rid of extra salt and water by increasing urine production. This helps to lower blood pressure and reduce swelling. Lisinopril is an ACE inhibitor, which stands for Angiotensin-Converting Enzyme inhibitor. It works by relaxing blood vessels, making it easier for the heart to pump blood around the body. Together, these medications help to lower blood pressure more effectively than either would alone, reducing the risk of heart attacks and strokes.

How does combination of Lisinopril and Hydrochlorothiazide work?

Lisinopril and Hydrochlorothiazide work together to lower blood pressure through complementary mechanisms. Lisinopril, an ACE inhibitor, reduces the production of angiotensin II, a substance that narrows blood vessels, thereby relaxing and widening them for smoother blood flow. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess salt and water from the body, reducing fluid volume and pressure on the blood vessels. Together, they effectively manage hypertension by addressing both vascular resistance and fluid retention.

How effective is combination of Hydrochlorothiazide and Lisinopril?

The combination of Hydrochlorothiazide and Lisinopril is effective in treating high blood pressure (hypertension). Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water by increasing urine production. This helps to lower blood pressure. Lisinopril is an ACE inhibitor, which helps relax blood vessels, making it easier for the heart to pump blood. Together, these medications work to lower blood pressure more effectively than either would alone, reducing the risk of heart attacks and strokes.

How effective is combination of Lisinopril and Hydrochlorothiazide?

Clinical studies have demonstrated that the combination of Lisinopril and Hydrochlorothiazide effectively lowers blood pressure more than either drug alone. Lisinopril, an ACE inhibitor, has been shown to reduce blood pressure by decreasing the production of angiotensin II, leading to vasodilation. Hydrochlorothiazide, a diuretic, enhances this effect by reducing fluid volume through increased urine production. Together, they provide an additive effect, improving blood pressure control and reducing the risk of cardiovascular events such as heart attacks and strokes.

Directions for Use

What is the usual dose of combination of Hydrochlorothiazide and Lisinopril?

The usual dose of the combination of Hydrochlorothiazide and Lisinopril can vary depending on the specific needs of the patient, but a common starting dose is 10 mg of Lisinopril and 12.5 mg of Hydrochlorothiazide once daily. This combination is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water, while Lisinopril is an ACE inhibitor that helps relax blood vessels. It's important to follow a healthcare provider's instructions and not adjust the dose without consulting them.

What is the usual dose of combination of Lisinopril and Hydrochlorothiazide?

The usual adult daily dose for Lisinopril ranges from 10 mg to 80 mg, while Hydrochlorothiazide is typically dosed between 12.5 mg and 50 mg per day. In combination, the common dosages are 10 mg/12.5 mg, 20 mg/12.5 mg, and 20 mg/25 mg of Lisinopril and Hydrochlorothiazide, respectively. The combination is designed to provide a synergistic effect, with Lisinopril reducing blood vessel constriction and Hydrochlorothiazide promoting fluid excretion, thereby effectively managing high blood pressure.

How does one take combination of Hydrochlorothiazide and Lisinopril?

When taking these medications, it's important to follow your doctor's instructions carefully. Typically, they are taken once a day, with or without food. It's best to take them at the same time each day to maintain an even level in your bloodstream.Make sure to drink plenty of water unless your doctor advises otherwise, as Hydrochlorothiazide can cause dehydration. Also, be aware of potential side effects like dizziness or lightheadedness, especially when you first start taking the medication or if your dose is increased.Always consult your healthcare provider for personalized advice and before making any changes to how you take your medication.

How does one take combination of Lisinopril and Hydrochlorothiazide?

Lisinopril and Hydrochlorothiazide can be taken with or without food, but it is important to take it at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium unless advised by their doctor, as these can interact with the medication. Additionally, alcohol should be consumed in moderation, as it can enhance the blood pressure-lowering effects and increase the risk of side effects like dizziness. Staying hydrated is important, especially in hot weather or during exercise.

For how long is combination of Hydrochlorothiazide and Lisinopril taken?

The combination of Hydrochlorothiazide and Lisinopril is typically taken as a long-term treatment. This means that it is usually prescribed for ongoing use to manage high blood pressure or heart failure. The exact duration will depend on the individual's health condition and how well they respond to the medication. It's important to follow the healthcare provider's instructions and not to stop taking the medication without consulting them, as stopping suddenly can lead to a return of symptoms or other health issues. Regular check-ups with a healthcare provider are necessary to monitor the effectiveness and adjust the dosage if needed.

For how long is combination of Lisinopril and Hydrochlorothiazide taken?

Lisinopril and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. While they do not cure hypertension, they help control it, and patients are usually advised to continue taking the medication even if they feel well. Regular monitoring by a healthcare provider is essential to ensure the medication remains effective and to adjust dosages if necessary. The duration of use is generally indefinite, depending on the patient's response and any side effects experienced.

How long does it take for combination of Hydrochlorothiazide and Lisinopril to work?

The combination of Hydrochlorothiazide and Lisinopril typically begins to work within a few hours after taking the medication. Hydrochlorothiazide is a diuretic, which helps your body get rid of excess salt and water, and it usually starts to work within 2 hours. Lisinopril is an ACE inhibitor that helps relax blood vessels, and it generally starts to work within 1 to 2 hours. However, it may take several weeks to see the full effect on blood pressure. It's important to take the medication as prescribed and consult with your healthcare provider for personalized advice.

How long does it take for combination of Lisinopril and Hydrochlorothiazide to work?

Lisinopril and Hydrochlorothiazide work together to lower blood pressure. Lisinopril, an ACE inhibitor, typically begins to lower blood pressure within 1 to 2 hours after ingestion, with peak effects around 6 hours. Hydrochlorothiazide, a diuretic, starts to work within 2 hours, with its peak diuretic effect occurring around 4 hours after ingestion. The combination of these two medications provides a complementary effect, with Lisinopril reducing blood vessel constriction and Hydrochlorothiazide promoting the excretion of excess fluid, leading to a more comprehensive blood pressure reduction.

Warnings and Precautions

Are there harms and risks from taking combination of Hydrochlorothiazide and Lisinopril?

Yes, there are potential harms and risks when taking a combination of Hydrochlorothiazide and Lisinopril. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water, while Lisinopril is an ACE inhibitor, which helps relax blood vessels. Together, they are often used to treat high blood pressure. However, combining these medications can lead to side effects such as dizziness, lightheadedness, or dehydration due to increased urination. More serious risks include kidney problems, high potassium levels, and allergic reactions. It's important to monitor for symptoms like swelling, difficulty breathing, or unusual tiredness, and consult a healthcare provider if they occur. Always follow the prescribed dosage and discuss any concerns with a healthcare professional to ensure safe use of these medications.

Are there harms and risks from taking combination of Lisinopril and Hydrochlorothiazide?

Common side effects of Lisinopril and Hydrochlorothiazide include dizziness, headache, cough, and fatigue. Lisinopril may cause a persistent dry cough and, in rare cases, angioedema, which is swelling of the deeper layers of the skin. Hydrochlorothiazide can lead to increased urination, electrolyte imbalances, and, in some cases, gout. Both medications can cause low blood pressure, especially when standing up quickly, leading to dizziness or fainting. Serious adverse effects, though rare, include severe allergic reactions, kidney problems, and significant changes in blood electrolytes.

Can I take combination of Hydrochlorothiazide and Lisinopril with other prescription drugs?

Hydrochlorothiazide and Lisinopril are medications often used together to treat high blood pressure. However, combining them with other prescription drugs can sometimes lead to interactions. It's important to consult with a healthcare provider before adding any new medications. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of extra salt and water. Lisinopril is an ACE inhibitor, which helps relax blood vessels. Both can interact with other medications, potentially affecting how they work or increasing side effects.You should be cautious when taking these drugs with other medications that affect blood pressure, such as other diuretics or ACE inhibitors, as this can lead to very low blood pressure. Additionally, combining them with non-steroidal anti-inflammatory drugs (NSAIDs) can reduce their effectiveness.Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.

Can I take combination of Lisinopril and Hydrochlorothiazide with other prescription drugs?

Lisinopril and Hydrochlorothiazide can interact with several prescription medications. Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce their blood pressure-lowering effects and worsen kidney function. Combining with other blood pressure medications can enhance the hypotensive effect, leading to low blood pressure. Lisinopril can increase lithium levels, leading to toxicity, while Hydrochlorothiazide can interact with antidiabetic drugs, requiring dose adjustments. It's crucial to inform healthcare providers of all medications being taken to manage potential interactions effectively.

Can I take combination of Hydrochlorothiazide and Lisinopril if I am pregnant?

It is generally not recommended to take Hydrochlorothiazide and Lisinopril during pregnancy. Lisinopril, which is an ACE inhibitor, can harm the developing baby, especially if taken during the second and third trimesters. Hydrochlorothiazide, a diuretic, may also pose risks during pregnancy. It is important to consult with a healthcare provider for safer alternatives if you are pregnant or planning to become pregnant.

Can I take combination of Lisinopril and Hydrochlorothiazide if I am pregnant?

Lisinopril and Hydrochlorothiazide are contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Lisinopril can affect fetal kidney development and lead to complications such as low amniotic fluid and skeletal deformities. Hydrochlorothiazide can cause electrolyte imbalances and jaundice in the newborn. If pregnancy is detected, the medication should be discontinued immediately, and alternative treatments should be considered to manage hypertension safely during pregnancy.

Can I take combination of Hydrochlorothiazide and Lisinopril while breastfeeding?

When considering the use of Hydrochlorothiazide and Lisinopril while breastfeeding, it's important to consult with a healthcare professional. Hydrochlorothiazide is a diuretic, which means it helps remove excess fluid from the body, and Lisinopril is an ACE inhibitor, which helps relax blood vessels. Both medications can pass into breast milk in small amounts.Hydrochlorothiazide is generally considered safe during breastfeeding, but it may reduce milk production if taken in high doses. Lisinopril is also considered to be low risk during breastfeeding, but it's crucial to monitor the baby for any signs of side effects, such as low blood pressure or changes in kidney function.Always discuss with your doctor or a healthcare provider to weigh the benefits and potential risks before taking these medications while breastfeeding.

Can I take combination of Lisinopril and Hydrochlorothiazide while breastfeeding?

Lisinopril and Hydrochlorothiazide are generally not recommended during breastfeeding due to the potential for adverse effects on the nursing infant. Lisinopril's presence in human milk is unknown, but it is found in animal milk, while Hydrochlorothiazide is known to be excreted in human milk. High doses of Hydrochlorothiazide can reduce milk production. If treatment is necessary, the benefits and risks should be carefully weighed, and alternative medications with established safety profiles during lactation should be considered.

Who should avoid taking combination of Hydrochlorothiazide and Lisinopril?

People who should avoid taking the combination of Hydrochlorothiazide and Lisinopril include those who have a history of allergic reactions to either of these medications or similar drugs. Additionally, individuals with severe kidney disease, liver disease, or those who are unable to urinate should not take this combination. Pregnant women should also avoid it, as it can harm the unborn baby. It's important for anyone considering this medication to consult with a healthcare provider, especially if they have conditions like diabetes, lupus, or gout, or if they are taking other medications that might interact with Hydrochlorothiazide and Lisinopril.

Who should avoid taking combination of Lisinopril and Hydrochlorothiazide?

Lisinopril and Hydrochlorothiazide carry important warnings, including the risk of fetal toxicity; they should not be used during pregnancy as they can harm the developing fetus. Patients with a history of angioedema or severe kidney impairment should avoid this medication. Caution is advised in those with liver disease, diabetes, or electrolyte imbalances. It's crucial to monitor for signs of low blood pressure, especially in those on diuretics or with heart conditions. Regular medical supervision is necessary to manage these risks effectively.