Lisinopril

English

Brand Name

Listril 10mg Tablet 15s , Listril 5 Tablet 15s ... show more

Approved Treatment Indication:

Hypertension, Left Ventricular Dysfunction ... show more

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Government Approvals

US(FDA), UK(BNF)

WHO Essential Medicine

YES

Known Teratogen

Definite

Pharmaceutical Class

Angiotensin Converting Enzyme Inhibitor

Controlled Drug Substance

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Summary

Indications and Purpose

How does Lisinopril work?

Lisinopril works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for converting angiotensin I to angiotensin II, a substance that narrows blood vessels. By blocking this conversion, Lisinopril relaxes blood vessels, lowers blood pressure, and reduces the heart's workload, improving blood flow and oxygen delivery.

How does one know if Lisinopril is working?

The benefit of Lisinopril is evaluated by regularly monitoring blood pressure and assessing the patient's response to the medication. Healthcare providers may also order lab tests to check kidney function and electrolyte levels to ensure the medication is working effectively and safely.

Is Lisinopril effective?

Lisinopril is an ACE inhibitor that effectively lowers blood pressure, reducing the risk of cardiovascular events like heart attacks and strokes. Clinical trials have shown its efficacy in treating hypertension, heart failure, and improving survival after a heart attack. It works by relaxing blood vessels, making it easier for the heart to pump blood.

What is Lisinopril?

Lisinopril is an ACE inhibitor used to treat high blood pressure, heart failure, and improve survival after a heart attack. It works by relaxing blood vessels, allowing blood to flow more easily, which helps lower blood pressure and reduce the heart's workload. This medication can prevent strokes, heart attacks, and kidney problems.

What is Lisinopril used for?

Lisinopril is indicated for the treatment of high blood pressure (hypertension), heart failure, and to improve survival after a heart attack. It is also used to protect the kidneys from damage due to diabetes. By lowering blood pressure, it helps prevent strokes, heart attacks, and kidney problems.

Directions for Use

For how long do I take Lisinopril?

Lisinopril is typically used as a long-term treatment for conditions like hypertension and heart failure. The duration of use depends on the individual's medical condition and response to treatment. It is important to follow the doctor's instructions and not to stop taking the medication without consulting a healthcare provider.

How do I dispose of Lisinopril?

If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.

How do I take Lisinopril?

Lisinopril can be taken with or without food, usually once a day. It is important to take it at the same time each day to maintain consistent blood levels. Avoid using salt substitutes containing potassium unless advised by a healthcare provider, as they can increase the risk of high potassium levels.

How long does it take for Lisinopril to start working?

Lisinopril begins to work within an hour of taking it, with peak effects occurring around 6 hours after administration. However, it may take several weeks to achieve the full blood pressure-lowering effect. It is important to continue taking the medication as prescribed, even if you feel well.

How should I store Lisinopril?

Lisinopril should be stored at room temperature, away from excess heat and moisture. It should be kept in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom to avoid exposure to moisture.

What is the usual dose of Lisinopril?

For adults, the usual starting dose of Lisinopril for hypertension is 10 mg once daily, with a maintenance dose typically ranging from 20 mg to 40 mg per day. For children aged 6 years and older, the starting dose is 0.07 mg per kg once daily, up to a maximum of 5 mg. The dose can be adjusted based on the child's response, up to a maximum of 0.61 mg per kg or 40 mg daily.

Warnings and Precautions

Can I take Lisinopril with other prescription drugs?

Lisinopril can interact with diuretics, increasing the risk of low blood pressure. It should not be used with aliskiren in patients with diabetes. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce its effectiveness. Combining it with potassium supplements or potassium-sparing diuretics can lead to high potassium levels.

Can I take Lisinopril with vitamins or supplements?

Lisinopril can interact with potassium supplements and salt substitutes containing potassium, increasing the risk of hyperkalemia. It is important to consult a healthcare provider before taking any new vitamins or supplements while on Lisinopril.

Can Lisinopril be taken safely while breastfeeding?

There is limited data on the use of Lisinopril while breastfeeding. Due to the potential for serious adverse reactions in the breastfed infant, it is advised to avoid breastfeeding while taking Lisinopril. Consult a healthcare provider for alternative treatments.

Can Lisinopril be taken safely while pregnant?

Lisinopril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including kidney damage and death. If pregnancy is detected, Lisinopril should be discontinued immediately, and alternative treatments should be considered.

Does Lisinopril have adverse effects?

Adverse effects are unwanted or harmful effects caused by a medicine. Lisinopril can cause dizziness, headache, fatigue, cough, and nausea. These are common but usually mild. Rarely, it can cause serious effects like swelling of the face or throat, which needs immediate medical attention. Always report new symptoms to your healthcare provider and consult them before stopping any medication.

Does Lisinopril have any safety warnings?

Lisinopril has safety warnings, including the risk of angioedema, which is severe swelling, especially of the face and throat. This can be life-threatening and requires immediate medical attention. It can also cause low blood pressure, leading to dizziness or fainting. Monitor for these symptoms and contact your doctor if they occur. Always follow your healthcare provider's advice and report any unusual symptoms.

Is it safe to drink alcohol while taking Lisinopril?

Drinking alcohol while taking Lisinopril can enhance the blood pressure-lowering effect of the medication, which may lead to increased dizziness or lightheadedness. It is advisable to limit alcohol consumption and consult with a healthcare provider for personalized advice.

Is it safe to exercise while taking Lisinopril?

Lisinopril does not typically limit the ability to exercise. However, it can cause dizziness or lightheadedness, especially when starting the medication or increasing the dose. If you experience these symptoms, it is advisable to avoid strenuous activities and consult a healthcare provider for guidance.

Is it safe to stop Lisinopril?

Lisinopril is typically used for long-term management of chronic conditions like hypertension. Stopping it suddenly can lead to a rebound effect, causing your blood pressure to rise again, which can be dangerous. There are no withdrawal symptoms, but the risk of complications from high blood pressure increases. Always consult your doctor before stopping Lisinopril to ensure it's done safely.

Is Lisinopril addictive?

Lisinopril has no known potential for dependence or addiction. It does not cause physical or psychological dependence, so there are no behaviors or warning signs to watch for in terms of addiction. You can take it as prescribed without worrying about addiction.

Is Lisinopril safe for the elderly?

Elderly patients may be more sensitive to the effects of Lisinopril, particularly the risk of renal impairment and hypotension. It is important to monitor kidney function and blood pressure closely in older adults. Dosage adjustments may be necessary based on individual response and tolerance.

What are the most common side effects of Lisinopril?

A side effect is an unwanted effect of a medicine. Common side effects of Lisinopril include dizziness, headache, fatigue, cough, and nausea. These effects are usually mild and may go away as your body adjusts. It's important to note that new symptoms can occur when starting any medicine and may not be related to the medicine itself. Always talk to your healthcare provider before stopping any medication.

Who should avoid taking Lisinopril?

Lisinopril should not be used during pregnancy as it can harm the fetus. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Caution is advised in patients with renal impairment, and it should not be combined with certain medications like sacubitril/valsartan due to the risk of angioedema.