Diltiazem + Enalapril
Find more information about this combination medication at the webpages for Enalapril and Diltiazem
Hypertension, Supraventricular Tachycardia ... show more
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Advisory
- This medicine contains a combination of 2 drugs Diltiazem and Enalapril.
- Diltiazem and Enalapril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Diltiazem is used to treat high blood pressure, which is a condition where the force of the blood against the artery walls is too high, and angina, which is chest pain caused by reduced blood flow to the heart. Enalapril is used for high blood pressure and heart failure, which is a condition where the heart cannot pump blood effectively. Both medications help improve blood flow and reduce the heart's workload, but they are not cures; they help manage symptoms and prevent complications.
Diltiazem works by blocking calcium channels, which are pathways that allow calcium to enter heart and blood vessel cells, leading to relaxation of the heart muscle and dilation of blood vessels. This helps lower blood pressure and reduce chest pain. Enalapril works by inhibiting the angiotensin-converting enzyme, which decreases the production of a substance that narrows blood vessels, helping to relax them and lower blood pressure. Both medications aim to improve blood flow and reduce cardiovascular strain, but they achieve this through different mechanisms.
Enalapril is usually taken as a tablet, starting at 5 mg once daily, with a common range of 10 mg to 40 mg per day, adjusted based on the patient's response. Diltiazem's dosage varies depending on the formulation; for extended-release tablets, it often starts at 180 mg to 240 mg once daily, with a maximum of 540 mg per day. Both medications should be taken consistently to manage conditions effectively, and dosages may be adjusted by a healthcare provider based on individual needs.
Common side effects of Enalapril include cough, dizziness, and rash. Serious side effects can include swelling of the face or throat and difficulty breathing. Diltiazem may cause dizziness, headache, and flushing, with serious side effects including a slow heartbeat and severe skin reactions. Both medications can cause lightheadedness, and patients should report any severe or persistent side effects to their healthcare provider immediately.
Enalapril is contraindicated in pregnancy due to the risk of fetal harm and should not be used in patients with a history of angioedema, which is swelling beneath the skin. Diltiazem is contraindicated in patients with certain heart conditions like sick sinus syndrome or second- or third-degree AV block without a pacemaker. Both medications require caution in patients with renal or hepatic impairment and should be used under medical supervision. Patients should be aware of potential serious side effects and interactions with other medications.
Indications and Purpose
How does combination of Diltiazem and Enalapril work?
Diltiazem and Enalapril are medications that work together to help manage high blood pressure and heart-related conditions. Diltiazem is a type of drug known as a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels, which helps to lower blood pressure and reduce the heart's workload. Enalapril is an ACE inhibitor, which stands for angiotensin-converting enzyme inhibitor. It helps to relax blood vessels by blocking a substance in the body that causes them to tighten. This also helps to lower blood pressure and makes it easier for the heart to pump blood. When used together, these medications can be more effective in controlling blood pressure than when used alone, as they target different pathways in the body to achieve a similar goal.
How does combination of Enalapril and Diltiazem work?
Enalapril works by inhibiting the angiotensin-converting enzyme (ACE), which decreases the production of angiotensin II, a substance that narrows blood vessels. This action helps relax blood vessels, lowering blood pressure and reducing the heart's workload. Diltiazem, on the other hand, blocks calcium channels in the heart and blood vessels, leading to relaxation of the heart muscle and dilation of blood vessels. Both medications ultimately aim to improve blood flow and reduce cardiovascular strain, but they achieve this through different mechanisms.
How effective is combination of Diltiazem and Enalapril?
Diltiazem and Enalapril are medications often used to manage high blood pressure and heart-related conditions. Diltiazem is a calcium channel blocker, which helps relax the heart muscles and blood vessels, making it easier for the heart to pump blood. Enalapril is an ACE inhibitor, which helps lower blood pressure by relaxing blood vessels. When used together, these medications can be more effective in controlling high blood pressure than when used alone. This combination can help reduce the risk of heart attacks and strokes by ensuring blood flows more easily through the body. However, the effectiveness can vary based on individual health conditions, and it's important to follow a healthcare provider's guidance when using these medications together. For more detailed information, you can refer to trusted sources like the NHS or NLM websites.
How effective is combination of Enalapril and Diltiazem?
Clinical trials and studies have demonstrated the effectiveness of Enalapril in reducing blood pressure and improving heart failure symptoms by inhibiting the angiotensin-converting enzyme. Diltiazem has been shown to effectively manage high blood pressure and angina by blocking calcium channels, which relaxes the heart and blood vessels. Both medications have been proven to reduce the risk of cardiovascular events like heart attacks and strokes. Their effectiveness is supported by their ability to improve blood flow and reduce the heart's workload, as evidenced by numerous clinical studies and patient outcomes.
Directions for Use
What is the usual dose of combination of Diltiazem and Enalapril?
The usual dose of a combination of Diltiazem and Enalapril can vary based on individual health needs and the specific condition being treated. Diltiazem is a medication that helps to relax the muscles of your heart and blood vessels, while Enalapril is an ACE inhibitor that helps to lower blood pressure by relaxing blood vessels. For Diltiazem, the typical starting dose for adults can range from 30 mg to 60 mg taken three to four times a day, depending on the form of the medication. For Enalapril, the usual starting dose is often 5 mg taken once daily, which can be adjusted based on the patient's response and needs. It's important to follow a healthcare provider's instructions for dosing, as they will tailor the dose to your specific health situation. Always consult with a healthcare professional before starting or adjusting any medication regimen.
What is the usual dose of combination of Enalapril and Diltiazem?
The usual adult daily dose for Enalapril typically starts at 5 mg once daily, which can be adjusted based on the patient's response, with a common range being 10 mg to 40 mg per day. Diltiazem's dosage varies depending on the formulation; for extended-release tablets, it often starts at 180 mg to 240 mg once daily, with a maximum of 540 mg per day. Both medications require careful dose adjustments based on individual patient needs and responses, and they should be taken consistently to manage conditions effectively.
How does one take combination of Diltiazem and Enalapril?
Diltiazem and Enalapril are medications used to treat high blood pressure and other heart-related conditions. When taking these medications together, it is important to follow your healthcare provider's instructions carefully. 1. **Diltiazem**: This medication is a calcium channel blocker, which helps to relax the muscles of your heart and blood vessels. It is usually taken once or twice a day, with or without food. Swallow the tablet whole with a glass of water. 2. **Enalapril**: This is an ACE inhibitor, which helps to relax blood vessels and reduce blood pressure. It is typically taken once or twice a day, with or without food. Swallow the tablet whole with a glass of water. **Important Considerations**: - Always take these medications at the same time each day to maintain an even level in your bloodstream. - Do not stop taking these medications suddenly without consulting your doctor, as this could worsen your condition. - Monitor your blood pressure regularly to ensure the medications are working effectively. - Be aware of potential side effects, such as dizziness or lightheadedness, especially when starting the medication or adjusting the dose. - Inform your healthcare provider about any other medications you are taking to avoid interactions. For more detailed information, consult resources like the [NHS](https://www.nhs.uk/), [DailyMeds](https://dailymeds.co.uk/), or [NLM](https://www.nlm.nih.gov/).
How does one take combination of Enalapril and Diltiazem?
Enalapril can be taken with or without food, but it's important to take it at the same time each day to maintain consistent blood levels. Patients should avoid salt substitutes containing potassium unless advised by a doctor. Diltiazem's instructions may vary depending on the formulation, so it's important to follow the specific guidance provided by a healthcare provider or pharmacist. Both medications require adherence to prescribed dosages and schedules, and patients should discuss any dietary restrictions or interactions with their healthcare provider.
For how long is combination of Diltiazem and Enalapril taken?
The duration for taking a combination of Diltiazem and Enalapril can vary based on individual health conditions and the specific advice of a healthcare provider. These medications are often prescribed for long-term management of conditions like high blood pressure or heart-related issues. It's important to follow the guidance of a healthcare professional, who will determine the appropriate length of treatment based on your specific needs and response to the medication. Regular check-ups are essential to monitor the effectiveness and adjust the treatment as necessary.
For how long is combination of Enalapril and Diltiazem taken?
Both Enalapril and Diltiazem are typically used as long-term treatments for managing chronic conditions like high blood pressure and heart-related issues. They are not cures but help control symptoms and prevent complications. Patients are usually advised to continue taking these medications even if they feel well, as stopping them without medical advice can lead to a return of symptoms or worsening of the condition. Regular monitoring by a healthcare provider is essential to ensure their effectiveness and adjust dosages as needed.
How long does it take for combination of Diltiazem and Enalapril to work?
The combination of Diltiazem and Enalapril can start to work within a few hours, but it may take a few weeks to see the full effect on blood pressure. Diltiazem is a calcium channel blocker that helps relax the heart muscles and blood vessels, while Enalapril is an ACE inhibitor that helps widen blood vessels. Together, they help lower blood pressure and improve heart function. It's important to follow your healthcare provider's instructions and continue taking the medication even if you don't feel immediate effects.
How long does it take for combination of Enalapril and Diltiazem to work?
Enalapril and Diltiazem both work to manage cardiovascular conditions, but they have different onset times. Enalapril, an ACE inhibitor, may take a few weeks to show its full effect in controlling blood pressure. Diltiazem, a calcium channel blocker, can start working within hours to reduce blood pressure and control angina, but it may take up to two weeks to feel the full benefit. Both medications require consistent use to maintain their effects, and neither provides immediate relief for acute symptoms.
Warnings and Precautions
Are there harms and risks from taking combination of Diltiazem and Enalapril?
Taking Diltiazem and Enalapril together can increase the risk of certain side effects. Both medications are used to treat high blood pressure and heart-related conditions, but they work in different ways. Diltiazem is a calcium channel blocker, which helps relax the heart muscles and blood vessels, while Enalapril is an ACE inhibitor, which helps widen blood vessels. When taken together, they can cause an excessive drop in blood pressure, leading to symptoms like dizziness, lightheadedness, or fainting. Additionally, there is a risk of increased potassium levels in the blood, which can be harmful if not monitored. It's important to have regular check-ups with a healthcare provider to monitor blood pressure and kidney function when using these medications together. Always consult with a healthcare professional before starting or combining medications to ensure safety and effectiveness.
Are there harms and risks from taking combination of Enalapril and Diltiazem?
Common side effects of Enalapril include cough, dizziness, and rash, while serious side effects can include swelling of the face or throat and difficulty breathing. Diltiazem may cause dizziness, headache, and flushing, with serious side effects including slow heartbeat and severe skin reactions. Both medications can cause lightheadedness and should be used with caution in patients with certain pre-existing conditions. It's important for patients to report any severe or persistent side effects to their healthcare provider immediately.
Can I take combination of Diltiazem and Enalapril with other prescription drugs?
When considering taking Diltiazem and Enalapril with other prescription drugs, it is important to be aware of potential interactions. Diltiazem is a medication used to treat high blood pressure and certain heart conditions. It works by relaxing the blood vessels so the heart does not have to pump as hard. Enalapril is also used to treat high blood pressure and heart failure, and it works by relaxing blood vessels and reducing the workload on the heart. According to the NHS, combining these medications with other drugs can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. For example, taking Diltiazem with other medications that lower blood pressure can increase the risk of your blood pressure dropping too low. Similarly, Enalapril can interact with other medications that affect blood pressure or kidney function. The NLM advises that you should always consult with a healthcare provider or pharmacist before combining these medications with others. They can provide guidance based on your specific health needs and the other medications you are taking. In summary, while it is possible to take Diltiazem and Enalapril with other prescription drugs, it should be done under the guidance of a healthcare professional to ensure safety and effectiveness.
Can I take combination of Enalapril and Diltiazem with other prescription drugs?
Enalapril can interact with medications like diuretics, NSAIDs, and other blood pressure medications, potentially leading to increased side effects or reduced effectiveness. Diltiazem may interact with beta-blockers, digoxin, and other heart medications, increasing the risk of bradycardia or heart block. Both medications require careful management when used with other drugs that affect blood pressure or heart function, and patients should always inform their healthcare provider of all medications they are taking.
Can I take combination of Diltiazem and Enalapril if I am pregnant?
It is generally not recommended to take Diltiazem and Enalapril during pregnancy. Diltiazem is a medication used to treat high blood pressure and certain heart conditions. It can affect the baby's development, especially if taken during the first trimester. Enalapril is an ACE inhibitor, which is also used to treat high blood pressure and heart failure. It is known to cause harm to the developing baby, particularly in the second and third trimesters, and can lead to serious complications. If you are pregnant or planning to become pregnant, it is important to discuss with your healthcare provider to find safer alternatives for managing your condition. Always consult your doctor before starting or stopping any medication during pregnancy.
Can I take combination of Enalapril and Diltiazem if I am pregnant?
Enalapril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including renal impairment and developmental issues. Diltiazem should be used during pregnancy only if the potential benefit justifies the risk to the fetus, as there are no well-controlled studies in pregnant women. Both medications require careful consideration and consultation with a healthcare provider to weigh the risks and benefits if used during pregnancy.
Can I take combination of Diltiazem and Enalapril while breastfeeding?
According to the NHS, both Diltiazem and Enalapril can be used while breastfeeding, but it is important to do so under the guidance of a healthcare professional. Diltiazem is a medication used to treat high blood pressure and certain heart conditions, while Enalapril is an ACE inhibitor also used for high blood pressure and heart failure. The NHS advises that small amounts of these medications can pass into breast milk, but they are not expected to cause harm to a breastfeeding infant. However, it is crucial to monitor the baby for any unusual symptoms, such as changes in feeding or sleeping patterns, and consult a doctor if any concerns arise. Always discuss with your healthcare provider before starting or continuing these medications while breastfeeding to ensure it is safe for your specific situation.
Can I take combination of Enalapril and Diltiazem while breastfeeding?
Enalapril and its active metabolite, enalaprilat, are excreted in human breast milk, and there is a potential for adverse effects in nursing infants, so a decision should be made whether to discontinue nursing or the medication. Diltiazem is also excreted in breast milk, and due to the potential for serious adverse reactions in nursing infants, breastfeeding is generally not recommended while taking Diltiazem. Both medications require careful consideration and consultation with a healthcare provider when used during lactation.
Who should avoid taking combination of Diltiazem and Enalapril?
People who should avoid taking a combination of Diltiazem and Enalapril include those with certain medical conditions or who are taking specific medications that could interact negatively. According to trusted sources like the NHS and NLM, individuals with low blood pressure, heart conditions such as heart block, or severe kidney problems should be cautious. Additionally, those who are pregnant or breastfeeding should consult their healthcare provider before using these medications together. It's important to discuss all medications and health conditions with a healthcare professional to ensure safety.
Who should avoid taking combination of Enalapril and Diltiazem?
Enalapril is contraindicated in pregnancy due to the risk of fetal harm and should not be used in patients with a history of angioedema. Diltiazem is contraindicated in patients with certain heart conditions like sick sinus syndrome or second- or third-degree AV block without a pacemaker. Both medications require caution in patients with renal or hepatic impairment and should be used under medical supervision. Patients should be aware of the potential for serious side effects and interactions with other medications.
