Diltiazem
Hypertension, Supraventricular Tachycardia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Calcium Channel Blocker
Controlled Drug Substance
NO
Diltiazem
Learn more about this medicine -
Click HereSummary
Diltiazem is used to treat high blood pressure, chest pain known as angina, and certain abnormal heart rhythms like atrial fibrillation or flutter.
Diltiazem works by blocking calcium channels in your heart and blood vessels. This relaxes and widens your blood vessels, lowers your heart rate, and reduces the workload on your heart. This improves blood flow and helps control abnormal heart rhythms.
The usual dose for adults is 30-60 mg taken 3-4 times daily, or a once-daily dose of 120-360 mg, depending on the condition being treated. Diltiazem should be taken orally, with or without food. It is typically in tablet or extended-release capsule form.
Common side effects of Diltiazem include dizziness, headache, constipation, and swelling. Some people may also experience gastrointestinal issues such as nausea or abdominal discomfort.
Diltiazem should not be taken by those with severe low blood pressure, heart block, or certain arrhythmias. Pregnant or breastfeeding women should consult their doctor before using this medication. It may cause dizziness or tiredness which could impair your ability to drive or operate machinery.
Indications and Purpose
What is Diltiazem used for?
Diltiazem is indicated for the treatment of high blood pressure (hypertension) and to control angina (chest pain). It is also sometimes used to treat certain types of arrhythmias (abnormal heart rhythms). Consult your doctor for more information on its use for your specific condition.
How does Diltiazem work?
Diltiazem works by blocking calcium channels in the heart and blood vessels, leading to relaxation of the blood vessels. This reduces the heart's workload and increases the supply of blood and oxygen to the heart, helping to lower blood pressure and control angina symptoms.
Is Diltiazem effective?
Diltiazem is proven effective in treating hypertension and angina through clinical trials. It works by relaxing blood vessels, reducing the heart's workload, and increasing blood and oxygen supply to the heart. These effects help lower blood pressure and improve exercise tolerance in angina patients.
How does one know if Diltiazem is working?
The benefit of Diltiazem is evaluated through regular monitoring of blood pressure and heart rate. Patients may also be asked to report any changes in symptoms, such as chest pain or exercise tolerance. Regular follow-ups with a healthcare provider help assess the medication's effectiveness and adjust the treatment plan if necessary.
Directions for Use
What is the usual dose of Diltiazem?
For adults, the usual dose of Diltiazem for hypertension starts at 180mg to 240mg once daily, with a maximum of 540mg daily. For angina, the starting dose is 180mg once daily, increasing to a maximum of 360mg if needed. Diltiazem is not recommended for children as safety and effectiveness have not been established.
How do I take Diltiazem?
Diltiazem can be taken with or without food, but it's important to take it at the same time each day. Swallow extended-release capsules and tablets whole without crushing or chewing. Follow any specific dietary instructions from your doctor, such as a low-salt diet, to help manage your condition effectively.
For how long do I take Diltiazem?
Diltiazem is typically used as a long-term treatment for conditions like hypertension and angina. It is important to continue taking it even if you feel well, as it helps manage these conditions over time. Always follow your doctor's instructions regarding the duration of use.
How long does it take for Diltiazem to start working?
Diltiazem may take up to 2 weeks to feel the full benefit, although some effects, like reduced blood pressure, can be noticed sooner. It's important to continue taking the medication as prescribed, even if you feel well, to maintain its benefits.
How should I store Diltiazem?
Store Diltiazem in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program to prevent accidental ingestion by children or pets.
Warnings and Precautions
Who should avoid taking Diltiazem?
Diltiazem is contraindicated in patients with sick sinus syndrome, second- or third-degree AV block without a pacemaker, hypotension, and acute myocardial infarction with pulmonary congestion. It may cause bradycardia, heart failure, and liver injury. Patients should inform their doctor of any existing health conditions before starting Diltiazem.
Can I take Diltiazem with other prescription drugs?
Diltiazem can interact with beta-blockers, digoxin, and other medications affecting heart rate and blood pressure, increasing the risk of bradycardia and heart block. It also interacts with CYP3A4 substrates, such as statins, increasing the risk of side effects. Patients should inform their doctor of all medications they are taking.
Can I take Diltiazem with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Diltiazem be taken safely while pregnant?
Diltiazem is classified as pregnancy category C, indicating that risk to the fetus cannot be ruled out. Animal studies have shown potential for fetal harm, but there are no well-controlled studies in pregnant women. It should only be used if the potential benefit justifies the risk to the fetus. Consult your doctor for personalized advice.
Can Diltiazem be taken safely while breastfeeding?
Diltiazem is excreted in human milk, and there is potential for serious adverse reactions in nursing infants. A decision should be made to either discontinue nursing or discontinue the drug, considering the importance of the medication to the mother. Consult your doctor for personalized advice.
Is Diltiazem safe for the elderly?
Elderly patients may be more sensitive to the effects of Diltiazem, particularly its impact on heart rate and blood pressure. It is recommended to start at the lower end of the dosing range and monitor for side effects. Regular check-ups with a healthcare provider are advised to ensure safe use.
Is it safe to exercise while taking Diltiazem?
Diltiazem is generally used to improve exercise tolerance in patients with chronic stable angina. However, if you experience dizziness, fatigue, or other side effects, it may temporarily affect your ability to exercise. Consult your doctor if you notice any limitations in your exercise capacity.
Is it safe to drink alcohol while taking Diltiazem?
Drinking alcohol while taking Diltiazem can increase the risk of side effects such as dizziness and lightheadedness. It may also enhance the blood pressure-lowering effects of the medication, leading to increased risk of hypotension. Therefore, it is advisable to limit alcohol consumption and consult with a healthcare provider for personalized advice.
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