Captopril + Hydrochlorothiazide
Find more information about this combination medication at the webpages for Captopril and Hydrochlorothiazide
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Advisory
- This medicine contains a combination of 2 drugs Captopril and Hydrochlorothiazide.
- Captopril and Hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Phenothiazine and Tricyclic Antidepressant
Controlled Drug Substance
NO
Captopril + Hydrochlorothiazide
Summary
Captopril and Hydrochlorothiazide are primarily used to treat hypertension, or high blood pressure. By reducing blood pressure, they help prevent serious complications like heart disease, stroke, and kidney damage.
Captopril is an ACE inhibitor that relaxes blood vessels, making it easier for blood to flow. Hydrochlorothiazide is a diuretic that helps your body get rid of excess salt and water, which reduces fluid buildup and lowers blood pressure. Together, they lower blood pressure more effectively.
The usual adult daily dose varies based on the patient's needs. Captopril typically starts at a low dose of 25 mg and can be adjusted up to 150 mg per day. Hydrochlorothiazide is usually given at doses ranging from 15 mg to 50 mg per day. The medication is taken orally.
Common side effects include cough, dizziness, taste changes, and rash. More serious side effects can include swelling of the face or throat, difficulty breathing, and signs of infection like fever or sore throat. It's important to report any severe or persistent side effects to your healthcare provider immediately.
These medications should not be used during pregnancy due to the risk of harm to the fetus. Patients with a history of angioedema related to ACE inhibitors should avoid Captopril. Those with severe kidney impairment should use these medications cautiously. Regular monitoring and consultation with a healthcare provider are essential to manage these risks.
Indications and Purpose
How does combination of Captopril and Hydrochlorothiazide work?
Captopril and hydrochlorothiazide work together to lower blood pressure through different mechanisms. Captopril, an ACE inhibitor, blocks the conversion of angiotensin I to angiotensin II, a substance that narrows blood vessels, thereby reducing vascular resistance and lowering blood pressure. Hydrochlorothiazide, a diuretic, helps the kidneys eliminate excess water and salt, reducing blood volume and pressure. Together, they provide a dual approach to managing hypertension by addressing both fluid retention and vascular constriction, leading to more effective blood pressure control.
How does combination of Hydrochlorothiazide and Captopril work?
Hydrochlorothiazide and captopril work together to lower blood pressure through different mechanisms. Captopril, an ACE inhibitor, reduces the production of angiotensin II, a substance that narrows blood vessels, thereby relaxing the vessels and lowering blood pressure. Hydrochlorothiazide, a diuretic, helps the kidneys remove excess salt and water from the body, reducing fluid volume and blood pressure. Together, they provide a complementary effect, enhancing the overall blood pressure-lowering action.
How effective is combination of Captopril and Hydrochlorothiazide?
The effectiveness of captopril and hydrochlorothiazide in treating hypertension is supported by clinical studies and their individual mechanisms of action. Captopril, as an ACE inhibitor, has been shown to lower blood pressure by reducing the production of angiotensin II, a potent vasoconstrictor. Hydrochlorothiazide, a thiazide diuretic, effectively reduces blood pressure by promoting the excretion of excess salt and water, thereby decreasing blood volume. Together, these medications provide a synergistic effect, enhancing blood pressure control more effectively than either drug alone. Regular monitoring of blood pressure and laboratory tests further confirm their efficacy in managing hypertension.
How effective is combination of Hydrochlorothiazide and Captopril?
The effectiveness of hydrochlorothiazide and captopril in treating hypertension is well-documented through clinical trials and studies. Captopril, as an ACE inhibitor, has been shown to effectively lower blood pressure by reducing angiotensin II levels, leading to vasodilation. Hydrochlorothiazide, a diuretic, complements this action by reducing fluid volume, further lowering blood pressure. Together, they provide an additive effect, enhancing blood pressure control. Clinical evidence supports their use in reducing the risk of cardiovascular events and improving outcomes in patients with hypertension.
Directions for Use
What is the usual dose of combination of Captopril and Hydrochlorothiazide?
The usual adult daily dose for the combination of captopril and hydrochlorothiazide varies depending on the specific needs of the patient. Captopril is typically started at a low dose, often 25 mg, and can be adjusted based on the patient's response, with a maximum daily dose not exceeding 150 mg. Hydrochlorothiazide is usually administered at a dose of 15 mg to 25 mg per day, with a maximum of 50 mg. The combination tablets are available in different strengths, such as 25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, and 50 mg/25 mg, allowing for flexibility in dosing. It's important to follow the doctor's prescription and not exceed the recommended doses.
What is the usual dose of combination of Hydrochlorothiazide and Captopril?
The usual adult daily dose for the combination of captopril and hydrochlorothiazide varies based on the specific needs of the patient. Captopril is typically started at a low dose, often 25 mg, and can be adjusted up to 150 mg per day. Hydrochlorothiazide is usually administered at doses ranging from 15 mg to 50 mg per day. The combination tablets are available in different strengths, such as 25 mg/15 mg, 25 mg/25 mg, 50 mg/15 mg, and 50 mg/25 mg. The dosage is individualized based on the patient's response and may be adjusted every 6 to 8 weeks.
How does one take combination of Captopril and Hydrochlorothiazide?
Captopril and hydrochlorothiazide should be taken on an empty stomach, typically one hour before meals, to ensure optimal absorption. Patients are advised to take the medication at the same time each day to maintain consistent blood levels. It's important to follow any dietary restrictions recommended by a healthcare provider, such as a low-sodium diet, to enhance the medication's effectiveness. Patients should also avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with the medication.
How does one take combination of Hydrochlorothiazide and Captopril?
Hydrochlorothiazide and captopril should be taken on an empty stomach, typically one hour before meals, to enhance absorption. Patients are advised to take the medication at the same time each day to maintain consistent blood levels. It's important to follow any dietary restrictions, such as a low-sodium diet, as advised by a healthcare provider. Patients should also avoid potassium supplements or salt substitutes containing potassium unless directed by their doctor, as these can interact with the medication.
For how long is combination of Captopril and Hydrochlorothiazide taken?
Captopril and hydrochlorothiazide are typically used for long-term management of high blood pressure. While they help control blood pressure, they do not cure hypertension, so patients are usually advised to continue taking them even if they feel well. The duration of use is often indefinite, as maintaining controlled blood pressure is crucial to preventing complications such as heart disease and stroke. Regular monitoring by a healthcare provider is essential to ensure the medication remains effective and to adjust the dosage if necessary.
For how long is combination of Hydrochlorothiazide and Captopril taken?
Hydrochlorothiazide and captopril are typically used as long-term treatments for managing high blood pressure. While they help control blood pressure, they do not cure hypertension, so patients are usually advised to continue taking them even if they feel well. The duration of use is often indefinite, as maintaining controlled blood pressure is crucial for preventing complications. Regular monitoring and adjustments by a healthcare provider ensure the treatment remains effective and safe.
How long does it take for combination of Captopril and Hydrochlorothiazide to work?
Captopril and hydrochlorothiazide work together to lower blood pressure, but they have different onset times. Captopril, an ACE inhibitor, typically starts to lower blood pressure within 60 to 90 minutes after oral administration. Hydrochlorothiazide, a diuretic, begins to work within two hours, with its peak effect occurring around four hours after ingestion. The combination of these two medications provides a more comprehensive approach to managing high blood pressure, with captopril reducing the production of angiotensin II, a chemical that narrows blood vessels, and hydrochlorothiazide helping to eliminate excess fluid and salt from the body. Together, they help to lower blood pressure more effectively than either would alone.
How long does it take for combination of Hydrochlorothiazide and Captopril to work?
Captopril and hydrochlorothiazide work together to lower blood pressure, but they have different onset times. Captopril, an ACE inhibitor, typically starts working within 60 to 90 minutes after oral administration, with its effects lasting longer than the measurable inhibition of circulating ACE. Hydrochlorothiazide, a diuretic, begins to work within two hours, with its peak effect occurring around four hours and lasting for six to twelve hours. Together, these medications help reduce blood pressure by relaxing blood vessels and removing excess fluid, but the full effect may take several weeks to be fully realized.
Warnings and Precautions
Are there harms and risks from taking combination of Captopril and Hydrochlorothiazide?
Common side effects of captopril and hydrochlorothiazide include cough, dizziness, taste changes, rash, and itching. More serious side effects can occur, such as swelling of the face or throat, difficulty breathing, yellowing of the skin or eyes, and rapid heartbeat. Captopril may cause angioedema, a potentially life-threatening condition, while hydrochlorothiazide can lead to electrolyte imbalances, such as low potassium levels. Patients should report any severe or persistent side effects to their doctor immediately. Regular monitoring by a healthcare provider is essential to manage these risks effectively.
Are there harms and risks from taking combination of Hydrochlorothiazide and Captopril?
Common side effects of hydrochlorothiazide and captopril include cough, dizziness, taste changes, and rash. More serious adverse effects can occur, such as swelling of the face or throat, difficulty breathing, and signs of infection like fever or sore throat. Hydrochlorothiazide may cause electrolyte imbalances, while captopril can lead to kidney issues or angioedema. Patients should report any severe or persistent side effects to their healthcare provider immediately. Monitoring and regular check-ups help manage these potential risks.
Can I take combination of Captopril and Hydrochlorothiazide with other prescription drugs?
Captopril and hydrochlorothiazide can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may reduce the effectiveness of captopril. Potassium-sparing diuretics and potassium supplements can increase the risk of hyperkalemia. Lithium levels may be increased, leading to toxicity. Patients taking other blood pressure medications, such as beta-blockers, should be monitored for additive effects. It's crucial to inform healthcare providers of all medications being taken to manage potential interactions effectively.
Can I take combination of Hydrochlorothiazide and Captopril with other prescription drugs?
Hydrochlorothiazide and captopril can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen may reduce their effectiveness. Combining with other blood pressure medications can enhance the blood pressure-lowering effect, potentially leading to hypotension. Captopril may increase lithium levels, leading to toxicity. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions and ensure safe use.
Can I take combination of Captopril and Hydrochlorothiazide if I am pregnant?
Captopril and hydrochlorothiazide are not recommended during pregnancy, particularly in the second and third trimesters, due to the risk of fetal harm, including injury and death. ACE inhibitors like captopril can cause fetal and neonatal morbidity and mortality, while hydrochlorothiazide can lead to fetal or neonatal jaundice and thrombocytopenia. If pregnancy is detected, the medication should be discontinued as soon as possible, and alternative treatments should be considered. Pregnant women should consult their healthcare provider to discuss safer options for managing hypertension.
Can I take combination of Hydrochlorothiazide and Captopril if I am pregnant?
Hydrochlorothiazide and captopril are not recommended during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Captopril, an ACE inhibitor, can cause injury or death to the developing fetus, including issues like low blood pressure, kidney failure, and developmental abnormalities. If pregnancy is detected, these medications should be discontinued immediately. Women of childbearing age should discuss alternative treatments with their healthcare provider to manage hypertension safely during pregnancy.
Can I take combination of Captopril and Hydrochlorothiazide while breastfeeding?
Both captopril and hydrochlorothiazide are excreted in human milk, which poses potential risks to nursing infants. Due to the possibility of serious adverse reactions in breastfed infants, a decision should be made to either discontinue nursing or discontinue the medication, considering the importance of the treatment to the mother. It's crucial for breastfeeding mothers to discuss the risks and benefits with their healthcare provider to make an informed decision.
Can I take combination of Hydrochlorothiazide and Captopril while breastfeeding?
Both hydrochlorothiazide and captopril are excreted in breast milk, which may pose risks to a nursing infant. Due to the potential for serious adverse reactions in infants, a decision should be made to either discontinue breastfeeding or discontinue the medication, considering the importance of the treatment to the mother. It's essential for breastfeeding mothers to discuss the risks and benefits with their healthcare provider to make an informed decision.
Who should avoid taking combination of Captopril and Hydrochlorothiazide?
Captopril and hydrochlorothiazide have several important warnings and contraindications. They should not be used during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Patients with a history of angioedema related to ACE inhibitors should avoid captopril. Hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs. Caution is advised in patients with renal or hepatic impairment, and those with electrolyte imbalances. Regular monitoring and consultation with a healthcare provider are essential to manage these risks.
Who should avoid taking combination of Hydrochlorothiazide and Captopril?
Hydrochlorothiazide and captopril have important warnings and contraindications. They should not be used during pregnancy due to the risk of harm to the fetus. Patients with a history of angioedema related to ACE inhibitors should avoid captopril. Those with severe kidney impairment should use these medications cautiously. It's crucial to monitor for signs of infection, as captopril can affect white blood cell counts. Patients should inform their healthcare provider of any allergies or medical conditions before starting treatment.
