Captopril
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor
Controlled Drug Substance
No
Captopril
Summary
Captopril is used to treat high blood pressure, heart failure, and certain kidney conditions. It can also be used after heart attacks to improve survival and reduce strain on the heart.
Captopril works by inhibiting an enzyme called ACE, which reduces the production of a hormone that narrows blood vessels. This helps to relax the blood vessels, lower blood pressure, and ease strain on the heart.
For adults, the typical starting dose of Captopril is 25 mg, taken two to three times daily. Doses may be adjusted up to 150 mg per day depending on the condition being treated. It's taken orally, usually on an empty stomach one hour before meals.
Common side effects of Captopril include dizziness, fatigue, and a dry cough. Some people may also experience nausea, diarrhea, or abdominal pain. Serious risks include severe low blood pressure, high potassium levels, and swelling.
Captopril is not recommended for pregnant women or those breastfeeding. It should also be avoided by people with a history of angioedema, severe kidney disease, or high potassium levels. Always inform your doctor of all medications and supplements you're taking as Captopril can interact with other drugs.
Indications and Purpose
How does Captopril work?
Captopril inhibits ACE, which reduces the production of angiotensin II, a hormone that narrows blood vessels. This relaxation of blood vessels lowers blood pressure and eases heart strain.
Is Captopril effective?
Yes, clinical studies have shown that Captopril effectively reduces blood pressure, improves heart function, and protects kidney health in certain conditions when taken as prescribed.
What is Captopril?
Captopril is an ACE (angiotensin-converting enzyme) inhibitor used to treat high blood pressure, heart failure, and certain kidney conditions. It works by relaxing blood vessels, reducing the workload on the heart, and improving blood flow.
Directions for Use
For how long do I take Captopril?
Captopril is usually taken long-term to manage chronic conditions like high blood pressure or heart failure. Follow your doctor’s advice on the duration based on your response to treatment.
How do I take Captopril?
Take Captopril on an empty stomach, one hour before meals. Swallow the tablet with water and follow the dosing schedule prescribed by your doctor. Avoid skipping doses or doubling up.
How long does it take for Captopril to start working?
Captopril begins to lower blood pressure within 15 to 60 minutes, with peak effects seen in 1 to 2 hours. Full benefits for conditions like heart failure or kidney disease may take weeks.
How should I store Captopril?
Store Captopril at room temperature (15–30°C), away from light, moisture, and heat. Keep the medication out of reach of children.
What is the usual dose of Captopril?
For adults, the typical starting dose is 25 mg taken two to three times daily. Doses may be adjusted up to 150 mg per day depending on the condition being treated. It is generally not used in children unless prescribed specifically.
Warnings and Precautions
Can Captopril be taken safely while breastfeeding?
Captopril is generally not recommended while breastfeeding, as it can pass into breast milk and may affect the baby. Discuss alternatives with your doctor.
Can Captopril be taken safely while pregnant?
Captopril is not safe during pregnancy as it can harm the developing baby. Women of childbearing age should use effective contraception and consult their doctor if they become pregnant.
Can I take Captopril with other prescription drugs?
Captopril may interact with diuretics, NSAIDs, and other blood pressure medications. These interactions can cause side effects or reduce efficacy, so always share your medication list with your doctor.
Is Captopril safe for the elderly?
The elderly are more sensitive to Captopril and may require lower doses. Monitoring for side effects, such as low blood pressure or kidney issues, is crucial in this group.
Is it safe to drink alcohol while taking Captopril?
Limit alcohol consumption, as it can increase dizziness or lower your blood pressure excessively. Speak with your doctor if you drink alcohol regularly.
Is it safe to exercise while taking Captopril?
Yes, light to moderate exercise is beneficial. However, avoid overexertion, as Captopril may cause dizziness or fatigue, especially at first. Consult your doctor about a safe activity level.
Who should avoid taking Captopril?
People with a history of angioedema, severe kidney disease, or high potassium levels should avoid Captopril. Pregnant women and those allergic to ACE inhibitors should not use it.
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