Amlodipine + Hydrochlorothiazide

Find more information about this combination medication at the webpages for amlodipine and hydrochlorothiazide

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Brand Name

Amloz H Tablet , Amlovin H 2.5mg/12.5mg Tablet ... show more

Approved Treatment Indication:

Hypertension, Variant Angina Pectoris ... show more

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This medicine contains a combination of 2 drugs amlodipine and hydrochlorothiazide.
amlodipine and hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions amlodipine and hydrochlorothiazide is used for
Amlodipine and hydrochlorothiazide are used to treat high blood pressure, which is also known as hypertension. Amlodipine is also used for angina, which refers to chest pain caused by reduced blood flow to the heart. Hydrochlorothiazide can treat fluid retention, which is also known as edema, associated with conditions like heart failure. Together, they help manage blood pressure and reduce the risk of heart-related complications.
How amlodipine and hydrochlorothiazide works in the body
Amlodipine works by blocking calcium channels in blood vessels, which helps to relax and widen them, leading to lower blood pressure. Hydrochlorothiazide acts as a diuretic, which means it helps the body get rid of excess salt and water through urine, reducing blood volume and pressure. Together, they complement each other by both relaxing blood vessels and reducing fluid retention, effectively lowering blood pressure.
The usual dosages and routes of administration of amlodipine and hydrochlorothiazide
The usual adult dose for amlodipine is 5 to 10 mg once daily, depending on the individual's response and medical condition. For hydrochlorothiazide, the typical dose is 12.5 to 25 mg once daily. Both medicines are taken orally, usually in the morning to avoid nighttime urination. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them.
The most commonly observed adverse effects of amlodipine and hydrochlorothiazide
Common side effects of amlodipine include swelling of the ankles, dizziness, and flushing, which refers to a warm, red feeling in the face. Hydrochlorothiazide may cause increased urination, dizziness, and electrolyte imbalances, which are changes in the levels of minerals in the blood. Both medicines can cause dizziness, especially when standing up quickly. It's important to monitor for these effects and consult a healthcare provider if they occur.
Important safety warnings and contraindications of amlodipine and hydrochlorothiazide
Amlodipine should be used cautiously in patients with severe heart conditions, as it can affect heart rate and blood pressure. Hydrochlorothiazide is contraindicated in individuals with severe kidney disease or an inability to urinate. Both medicines can cause low blood pressure, so patients should be cautious when standing up quickly. It's important to avoid alcohol, as it can enhance these effects. Patients should inform their healthcare provider of any existing health conditions to ensure these medications are safe for them.

Government Approvals

US(FDA)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Angiotensin 2 Receptor Blocker and Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker and Thiazide Diuretic

Controlled Drug Substance

Summary

What conditions amlodipine and hydrochlorothiazide is used for
Amlodipine and hydrochlorothiazide are used to treat high blood pressure, which is also known as hypertension. Amlodipine is also used for angina, which refers to chest pain caused by reduced blood flow to the heart. Hydrochlorothiazide can treat fluid retention, which is also known as edema, associated with conditions like heart failure. Together, they help manage blood pressure and reduce the risk of heart-related complications.
How amlodipine and hydrochlorothiazide works in the body
Amlodipine works by blocking calcium channels in blood vessels, which helps to relax and widen them, leading to lower blood pressure. Hydrochlorothiazide acts as a diuretic, which means it helps the body get rid of excess salt and water through urine, reducing blood volume and pressure. Together, they complement each other by both relaxing blood vessels and reducing fluid retention, effectively lowering blood pressure.
The usual dosages and routes of administration of amlodipine and hydrochlorothiazide
The usual adult dose for amlodipine is 5 to 10 mg once daily, depending on the individual's response and medical condition. For hydrochlorothiazide, the typical dose is 12.5 to 25 mg once daily. Both medicines are taken orally, usually in the morning to avoid nighttime urination. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them.
The most commonly observed adverse effects of amlodipine and hydrochlorothiazide
Common side effects of amlodipine include swelling of the ankles, dizziness, and flushing, which refers to a warm, red feeling in the face. Hydrochlorothiazide may cause increased urination, dizziness, and electrolyte imbalances, which are changes in the levels of minerals in the blood. Both medicines can cause dizziness, especially when standing up quickly. It's important to monitor for these effects and consult a healthcare provider if they occur.
Important safety warnings and contraindications of amlodipine and hydrochlorothiazide
Amlodipine should be used cautiously in patients with severe heart conditions, as it can affect heart rate and blood pressure. Hydrochlorothiazide is contraindicated in individuals with severe kidney disease or an inability to urinate. Both medicines can cause low blood pressure, so patients should be cautious when standing up quickly. It's important to avoid alcohol, as it can enhance these effects. Patients should inform their healthcare provider of any existing health conditions to ensure these medications are safe for them.

Indications and Purpose

How does combination of amlodipine and hydrochlorothiazide work?

Amlodipine works by blocking calcium channels in the blood vessels, which helps to relax and widen them, leading to lower blood pressure. Hydrochlorothiazide acts as a diuretic, which means it helps the body get rid of excess salt and water through urine, reducing blood volume and pressure. Together, they complement each other by both relaxing blood vessels and reducing fluid retention, effectively lowering blood pressure. This combination helps manage hypertension and reduces the risk of complications like heart attacks.

How does combination of Amlodipine and Hydrochlorothiazide work?

Amlodipine works by blocking calcium channels in the smooth muscle of blood vessels, leading to relaxation and dilation of the vessels, which lowers blood pressure. Hydrochlorothiazide acts as a diuretic, promoting the excretion of excess salt and water through the kidneys, which reduces fluid volume and blood pressure. Both medications are used to manage hypertension, but they do so through different mechanisms: Amlodipine targets vascular resistance, while Hydrochlorothiazide reduces fluid retention. Together, they provide a synergistic effect in controlling high blood pressure.

How effective is combination of amlodipine and hydrochlorothiazide?

Clinical studies have shown that amlodipine effectively lowers blood pressure by relaxing blood vessels, while hydrochlorothiazide reduces blood pressure by eliminating excess fluid through increased urination. Together, they provide a complementary effect, enhancing overall blood pressure control. Evidence from trials indicates that this combination is more effective than using either medicine alone. Patients often experience significant reductions in blood pressure, which is a key indicator of the medicine's effectiveness. The combination is well-documented in medical literature for its efficacy in managing hypertension.

How effective is combination of Amlodipine and Hydrochlorothiazide?

The effectiveness of Amlodipine and Hydrochlorothiazide in managing high blood pressure is supported by clinical trials and studies. Amlodipine has been shown to effectively lower blood pressure and reduce the risk of cardiovascular events such as stroke and heart attack by relaxing blood vessels. Hydrochlorothiazide has demonstrated efficacy in reducing blood pressure and managing edema by promoting diuresis. Both medications have been used extensively in clinical practice, with evidence supporting their role in reducing hypertension-related complications. Together, they offer a comprehensive approach to blood pressure management by addressing different physiological pathways.

Directions for Use

What is the usual dose of combination of amlodipine and hydrochlorothiazide?

The usual adult dose for amlodipine is 5 to 10 mg once daily, depending on the individual's response and medical condition. For hydrochlorothiazide, the typical dose is 12.5 to 25 mg once daily. The exact dosage may vary based on the patient's needs and the doctor's prescription. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them. Both medicines are taken orally, usually in the morning to avoid nighttime urination.

What is the usual dose of combination of Amlodipine and Hydrochlorothiazide?

The usual adult daily dose for Amlodipine is typically 5 mg to 10 mg once daily, depending on the patient's response and condition. For Hydrochlorothiazide, the usual dose ranges from 12.5 mg to 50 mg daily, either as a single dose or divided into two doses. Both medications are used to treat high blood pressure, but they work differently. Amlodipine is a calcium channel blocker that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps remove excess fluid from the body. Together, they can effectively manage hypertension by addressing different aspects of blood pressure control.

How does one take combination of amlodipine and hydrochlorothiazide?

Amlodipine and hydrochlorothiazide can be taken with or without food, but it's best to take them at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but it's advisable to limit alcohol intake, as it can enhance the blood pressure-lowering effects. Patients should also monitor their salt intake, as excessive salt can counteract the benefits of hydrochlorothiazide. It's important to follow the healthcare provider's instructions and report any unusual symptoms.

How does one take combination of Amlodipine and Hydrochlorothiazide?

Amlodipine can be taken with or without food, and it is recommended to take it at the same time each day to maintain consistent blood levels. Hydrochlorothiazide should also be taken consistently, and patients may be advised to take it in the morning to avoid nighttime urination. Patients on Hydrochlorothiazide should follow any dietary instructions provided by their doctor, such as a low-salt diet or increased potassium intake, as the medication can affect electrolyte balance. Both medications require adherence to prescribed dosages and regular monitoring of blood pressure.

For how long is combination of amlodipine and hydrochlorothiazide taken?

Amlodipine and hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. The duration of use depends on the individual's response and the healthcare provider's recommendations. These medications are often taken for many years, as they help control blood pressure and reduce the risk of heart-related complications. Regular follow-up with a healthcare provider is essential to monitor effectiveness and adjust the treatment as needed.

For how long is combination of Amlodipine and Hydrochlorothiazide taken?

Amlodipine and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. Both medications are intended for continuous use to maintain blood pressure control and prevent complications such as heart disease and stroke. While Amlodipine helps by relaxing blood vessels, Hydrochlorothiazide aids in reducing fluid retention. Patients are advised to continue taking these medications even if they feel well, as they do not cure hypertension but help manage it effectively.

How long does it take for combination of amlodipine and hydrochlorothiazide to work?

Amlodipine, which is a calcium channel blocker, usually starts working within 24 to 48 hours to lower blood pressure. Hydrochlorothiazide, which is a diuretic, can begin to reduce blood pressure within a few hours of the first dose. Together, these medicines work to lower blood pressure by relaxing blood vessels and removing excess fluid from the body. The full effect of the combination may take a few weeks to be fully realized, as the body adjusts to the medication.

How long does it take for combination of Amlodipine and Hydrochlorothiazide to work?

Amlodipine typically begins to work within 6 to 12 hours after oral administration, with peak effects observed around this time. Hydrochlorothiazide, on the other hand, starts to work within 2 hours, with its peak diuretic effect occurring around 4 hours after ingestion. Both medications are used to manage high blood pressure, but they work through different mechanisms. Amlodipine is a calcium channel blocker that relaxes blood vessels, while Hydrochlorothiazide is a diuretic that helps the body eliminate excess salt and water. Together, they provide a complementary approach to lowering blood pressure.

Warnings and Precautions

Are there harms and risks from taking combination of amlodipine and hydrochlorothiazide?

Common side effects of amlodipine include swelling of the ankles, dizziness, and flushing, which refers to a warm, red feeling in the face. Hydrochlorothiazide may cause increased urination, dizziness, and electrolyte imbalances, which are changes in the levels of minerals in the blood. Both medicines can cause dizziness, especially when standing up quickly. Significant adverse effects may include severe allergic reactions, very low blood pressure, or changes in kidney function. It's important to monitor for these effects and consult a healthcare provider if they occur.

Are there harms and risks from taking combination of Amlodipine and Hydrochlorothiazide?

Common side effects of Amlodipine include swelling of the hands, feet, ankles, or lower legs, dizziness, and flushing. Hydrochlorothiazide may cause frequent urination, dizziness, and electrolyte imbalances. Both medications can cause dizziness or lightheadedness, especially when standing up quickly. Significant adverse effects for Amlodipine include more severe chest pain and rapid heartbeat, while Hydrochlorothiazide can lead to severe dehydration and electrolyte disturbances. Patients should be monitored for these side effects, and any severe or persistent symptoms should be reported to a healthcare provider.

Can I take combination of amlodipine and hydrochlorothiazide with other prescription drugs?

Amlodipine can interact with other blood pressure medications, potentially leading to very low blood pressure. Hydrochlorothiazide may interact with medications like lithium, increasing the risk of lithium toxicity. Both medicines can interact with NSAIDs, which may reduce their effectiveness in lowering blood pressure. It's important to regularly monitor blood pressure and kidney function through blood tests. Patients should inform their healthcare provider about all prescription medications they are taking to avoid harmful interactions.

Can I take combination of Amlodipine and Hydrochlorothiazide with other prescription drugs?

Amlodipine can interact with other blood pressure medications, potentially leading to excessive lowering of blood pressure. It may also increase the effects of simvastatin, requiring dose adjustments. Hydrochlorothiazide can interact with non-steroidal anti-inflammatory drugs (NSAIDs), reducing its effectiveness, and with lithium, increasing the risk of lithium toxicity. Both medications can interact with other antihypertensive drugs, necessitating careful monitoring and possible dose adjustments to avoid adverse effects.

Can I take combination of amlodipine and hydrochlorothiazide if I am pregnant?

Amlodipine is generally considered safe during pregnancy, but it should only be used if clearly needed, as there is limited data on its effects. Hydrochlorothiazide is not typically recommended during pregnancy, especially in the first trimester, due to potential risks to the developing baby. Both medicines should be used with caution, and only under the guidance of a healthcare provider. It's important to weigh the benefits against the potential risks when considering these medications during pregnancy.

Can I take combination of Amlodipine and Hydrochlorothiazide if I am pregnant?

Amlodipine has limited data on its use during pregnancy, and while animal studies have not shown adverse developmental effects, it should only be used if clearly needed. Hydrochlorothiazide crosses the placenta and may pose risks such as fetal or neonatal jaundice and thrombocytopenia. Both medications should be used during pregnancy only if the potential benefits justify the risks to the fetus. Pregnant women should consult their healthcare provider to carefully weigh the benefits and risks of using these medications.

Can I take combination of amlodipine and hydrochlorothiazide while breastfeeding?

Amlodipine is considered to be relatively safe during breastfeeding, as only small amounts pass into breast milk. Hydrochlorothiazide is also generally considered safe, but high doses may reduce milk production. Both medicines should be used with caution, and it's important to monitor the baby for any side effects, such as unusual sleepiness or feeding difficulties. Consulting a healthcare provider is essential to ensure the safety of both the mother and the baby while using these medications during breastfeeding.

Can I take combination of Amlodipine and Hydrochlorothiazide while breastfeeding?

Amlodipine is present in human milk, but no adverse effects on breastfed infants have been observed, making it relatively safe during lactation. Hydrochlorothiazide is also excreted in breast milk, but due to the potential for serious adverse reactions in nursing infants, a decision should be made to either discontinue the drug or stop breastfeeding. Both medications require careful consideration of the benefits and risks, and healthcare providers should be consulted to make informed decisions regarding their use during lactation.

Who should avoid taking combination of amlodipine and hydrochlorothiazide?

Amlodipine should be used cautiously in patients with severe heart conditions, as it can affect heart rate and blood pressure. Hydrochlorothiazide is contraindicated in individuals with severe kidney disease or an inability to urinate. Both medicines can cause low blood pressure, so patients should be cautious when standing up quickly. It's important to avoid alcohol, as it can enhance these effects. Patients should inform their healthcare provider of any existing health conditions to ensure these medications are safe for them.

Who should avoid taking combination of Amlodipine and Hydrochlorothiazide?

Amlodipine should be used cautiously in patients with severe obstructive coronary artery disease, as it can worsen angina or cause a heart attack. Hydrochlorothiazide is contraindicated in patients with anuria and should be used with caution in those with renal impairment. Both medications can cause dizziness, especially when standing up quickly, and patients should be cautious when driving or operating machinery. Patients with a history of sulfa allergy should avoid Hydrochlorothiazide. Regular monitoring of blood pressure and kidney function is essential for both medications.