Amlodipine
Hypertension, Variant Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker
Controlled Drug Substance
NO
Amlodipine
Learn more about this medicine -
Click HereSummary
Amlodipine is primarily used to treat high blood pressure, also known as hypertension, and to prevent chest pain or angina. It may also be prescribed for other heart-related conditions.
Amlodipine is a type of medicine known as a calcium channel blocker. It works by relaxing the blood vessels, making it easier for the heart to pump blood. This helps lower blood pressure and reduce chest pain.
The recommended starting dose for adults is 5 mg once daily, with a maximum of 10 mg daily. Elderly patients or those with liver problems may start with a lower dose of 2.5 mg once daily. For children aged 6 to 17 years, the effective dose is 2.5-5 mg once daily.
Common side effects may include headache, dizziness, and swelling in the ankles. Other side effects can include drowsiness, stomach upset, and mood changes.
People with severe low blood pressure, certain heart conditions like severe aortic stenosis, or those with a history of allergic reactions to Amlodipine should avoid it. It's also important to avoid grapefruit juice while taking amlodipine, as it can affect how the medication works.
Indications and Purpose
What is Amlodipine used for?
Amlodipine is indicated for the treatment of high blood pressure (hypertension) and certain types of angina, including chronic stable angina and vasospastic angina. It is also used in patients with coronary artery disease to reduce the risk of hospitalization for angina and coronary revascularization procedures.
How does Amlodipine work?
Amlodipine works by blocking calcium channels in the smooth muscle cells of the heart and blood vessels. This action relaxes the blood vessels, reducing peripheral vascular resistance and lowering blood pressure. It also increases blood flow to the heart, helping to relieve angina.
Is Amlodipine effective?
Amlodipine has been shown in numerous clinical trials to effectively lower blood pressure and reduce the risk of cardiovascular events like stroke and heart attack. It is also effective in treating angina by improving blood flow to the heart. These benefits have been consistently observed across various studies.
How does one know if Amlodipine is working?
The benefit of Amlodipine is evaluated by regularly monitoring blood pressure and assessing the frequency and severity of angina symptoms. Regular follow-up appointments with your doctor are important to ensure the medication is working effectively and to make any necessary adjustments.
Directions for Use
What is the usual dose of Amlodipine?
For adults, the usual initial dose of Amlodipine is 5 mg once daily, which can be increased to a maximum of 10 mg once daily. For children aged 6 to 17 years, the effective dose is 2.5 mg to 5 mg once daily. Doses above 5 mg daily have not been studied in children.
How do I take Amlodipine?
Amlodipine can be taken with or without food, usually once a day. It's important to take it at the same time each day. There are no specific food restrictions, but it's advisable to follow any dietary recommendations provided by your doctor, especially regarding salt intake.
For how long do I take Amlodipine?
Amlodipine is typically used as a long-term treatment for conditions like high blood pressure and angina. It is important to continue taking it even if you feel well, as it helps manage these conditions but does not cure them. Always follow your doctor's instructions regarding the duration of use.
How long does it take for Amlodipine to start working?
Amlodipine begins to work within a few hours of taking it, but it may take several days to a week to see the full effect on blood pressure. For angina, it may take a few weeks to notice an improvement in symptoms.
How should I store Amlodipine?
Store Amlodipine tablets and oral solution at room temperature, away from light, excess heat, and moisture. The suspension should be stored in the refrigerator and protected from light. Keep all forms of Amlodipine out of reach of children and do not store in the bathroom.
Warnings and Precautions
Who should avoid taking Amlodipine?
Amlodipine is contraindicated in patients with known sensitivity to the drug. It should be used cautiously in patients with severe aortic stenosis, heart failure, or hepatic impairment. Patients should be monitored for symptoms of hypotension, especially when starting or increasing the dose.
Can I take Amlodipine with other prescription drugs?
Amlodipine can interact with CYP3A inhibitors, increasing its systemic exposure and potentially leading to hypotension. It can also increase the exposure of drugs like simvastatin, cyclosporine, and tacrolimus. Monitoring and dose adjustments may be necessary when these drugs are co-administered.
Can I take Amlodipine with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Amlodipine be taken safely while pregnant?
There is limited data on the use of Amlodipine during pregnancy, and its safety has not been established. It should only be used if the potential benefits justify the risks to the fetus. Pregnant women with hypertension should be carefully monitored and managed accordingly.
Can Amlodipine be taken safely while breastfeeding?
Amlodipine is present in human milk, but no adverse effects on breastfed infants have been observed. However, due to limited data, it's important to weigh the benefits of breastfeeding against the need for Amlodipine and any potential risks to the infant.
Is Amlodipine safe for the elderly?
Elderly patients may have decreased clearance of Amlodipine, leading to higher exposure. It's recommended to start at the lower end of the dosing range and adjust cautiously. Regular monitoring is advised to ensure safety and effectiveness.
Is it safe to exercise while taking Amlodipine?
Amlodipine does not typically limit the ability to exercise. In fact, it may help improve exercise tolerance by reducing blood pressure and relieving angina symptoms. However, if you experience dizziness or fatigue, which are side effects, it might affect your ability to exercise safely. Consult your doctor if you have concerns.
Is it safe to drink alcohol while taking Amlodipine?
Drinking alcohol while taking Amlodipine can enhance the blood pressure-lowering effects of the medication, which might lead to increased dizziness or lightheadedness. It's advisable to limit alcohol consumption and consult with a healthcare provider for personalized advice.
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