Amlodipine
Hypertension, Variant Angina Pectoris ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
No
Pharmaceutical Class
Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker
Controlled Drug Substance
No
Amlodipine
Summary
Amlodipine is primarily used to treat high blood pressure, also known as hypertension, and to prevent chest pain or angina. It may also be prescribed for other heart-related conditions.
Amlodipine is a type of medicine known as a calcium channel blocker. It works by relaxing the blood vessels, making it easier for the heart to pump blood. This helps lower blood pressure and reduce chest pain.
The recommended starting dose for adults is 5 mg once daily, with a maximum of 10 mg daily. Elderly patients or those with liver problems may start with a lower dose of 2.5 mg once daily. For children aged 6 to 17 years, the effective dose is 2.5-5 mg once daily.
Common side effects may include headache, dizziness, and swelling in the ankles. Other side effects can include drowsiness, stomach upset, and mood changes.
People with severe low blood pressure, certain heart conditions like severe aortic stenosis, or those with a history of allergic reactions to Amlodipine should avoid it. It's also important to avoid grapefruit juice while taking amlodipine, as it can affect how the medication works.
Indications and Purpose
How does Amlodipine work?
Amlodipine works by blocking calcium channels in the blood vessel walls, which relaxes and widens the vessels. This process lowers blood pressure and improves blood flow to the heart, reducing the risk of angina attacks. Think of it like opening a garden hose wider to let more water flow through. This action helps manage high blood pressure and angina effectively.
Is Amlodipine effective?
Amlodipine is effective in treating high blood pressure and angina, which is chest pain caused by reduced blood flow to the heart. It works by relaxing blood vessels, allowing blood to flow more easily. Clinical studies show Amlodipine effectively lowers blood pressure and reduces the frequency of angina attacks. It is often used as part of a comprehensive treatment plan, including lifestyle changes and other medications.
What is Amlodipine?
Amlodipine is a medication that belongs to the class of drugs called calcium channel blockers. It works by relaxing blood vessels, which allows blood to flow more easily. Amlodipine is primarily used to treat high blood pressure and angina, which is chest pain caused by reduced blood flow to the heart. It can also be used for other conditions as determined by your doctor.
Directions for Use
For how long do I take Amlodipine?
Amlodipine is usually a long-term medication for managing high blood pressure or angina. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. Always talk with your doctor before changing or stopping your Amlodipine treatment.
How do I dispose of Amlodipine?
To dispose of Amlodipine, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Amlodipine?
Amlodipine is usually taken once daily, with or without food. It's best to take it at the same time each day, either in the morning or evening. You should swallow the tablet whole and not crush or chew it. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's instructions regarding diet and fluid intake while on Amlodipine.
How long does it take for Amlodipine to start working?
Amlodipine starts working within a few hours, but it may take several days to see the full effect on blood pressure. For angina, you might notice improvement in symptoms within a week. Individual factors like age, overall health, and other medications can affect how quickly Amlodipine works. Take it exactly as prescribed for the best results and consult your doctor if you have concerns.
How should I store Amlodipine?
Store Amlodipine at room temperature, away from moisture and light. Keep it in a tightly closed container and out of reach of children. Do not store it in humid places like bathrooms. Check the expiration date regularly and properly dispose of any unused or expired medication. If you have questions about storage, ask your pharmacist for guidance.
What is the usual dose of Amlodipine?
The usual starting dose of Amlodipine for adults is 5 mg once daily. Your doctor may adjust the dose based on your response and needs, with a maximum recommended dose of 10 mg daily. For elderly patients or those with liver problems, a lower starting dose may be considered. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Amlodipine be taken safely while breastfeeding?
Amlodipine is considered safe to use while breastfeeding, as only small amounts pass into breast milk. However, it's important to monitor the breastfed infant for any unusual symptoms. Always discuss with your doctor before taking Amlodipine while breastfeeding to ensure it's the best option for you and your baby.
Can Amlodipine be taken safely while pregnant?
Amlodipine is generally not recommended during pregnancy unless absolutely necessary. Limited evidence is available on its safety during pregnancy. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your blood pressure. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Amlodipine with other prescription drugs?
Amlodipine can interact with other medications, such as certain blood pressure drugs, which may increase the risk of low blood pressure. It can also interact with medications that affect liver enzymes, altering Amlodipine's effectiveness. Always inform your doctor about all medications you take to avoid potential interactions. Your doctor can help manage any interactions and adjust your treatment as needed.
Does Amlodipine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Amlodipine include swelling of the ankles or feet, dizziness, and flushing. These effects are usually mild. Serious side effects, like severe allergic reactions or very low blood pressure, are rare but require immediate medical attention. If you experience any new or worsening symptoms, contact your doctor to discuss your treatment.
Does Amlodipine have any safety warnings?
Yes, Amlodipine has safety warnings. It can cause low blood pressure, especially when starting treatment or increasing the dose. Symptoms include dizziness or fainting. If you experience these, sit or lie down and contact your doctor. Amlodipine can also cause swelling in the ankles or feet. If you notice significant swelling, inform your healthcare provider. Always follow your doctor's advice and report any unusual symptoms.
Is Amlodipine addictive?
Amlodipine is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Amlodipine works by relaxing blood vessels to lower blood pressure, and this mechanism does not affect brain chemistry in ways that could lead to addiction. You can feel confident that Amlodipine doesn't carry a risk of addiction while managing your health condition.
Is Amlodipine safe for the elderly?
Amlodipine is generally safe for the elderly, but they may be more sensitive to its effects, such as dizziness or low blood pressure. Elderly patients should be monitored closely, and dose adjustments may be necessary. Always consult with a healthcare provider to ensure Amlodipine is appropriate for an elderly patient's health needs.
Is it safe to drink alcohol while taking Amlodipine?
It's best to limit alcohol while taking Amlodipine. Alcohol can lower blood pressure further, increasing the risk of dizziness or fainting. If you choose to drink, do so in moderation and be aware of how your body responds. Talk with your doctor about alcohol use while taking Amlodipine to get personalized advice based on your health situation.
Is it safe to exercise while taking Amlodipine?
Yes, you can exercise while taking Amlodipine. However, be aware that Amlodipine can cause dizziness, especially when starting treatment. Stay hydrated and avoid strenuous activities if you feel lightheaded. Listen to your body and rest if needed. Most people can maintain their regular exercise routine, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Amlodipine?
Amlodipine is usually used for long-term management of conditions like hypertension. Stopping it suddenly can cause your blood pressure to rise, increasing the risk of heart problems. Always talk with your doctor before stopping Amlodipine. They may suggest gradually reducing your dose or switching to another medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Amlodipine?
Side effects are unwanted reactions to a medication. Common side effects of Amlodipine include swelling of the ankles or feet, dizziness, and flushing. These occur in a small percentage of people. If you experience new symptoms after starting Amlodipine, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Amlodipine?
Amlodipine should not be used if you are allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Caution is needed for people with severe liver problems, as Amlodipine is processed by the liver. Always consult your doctor about any concerns or conditions before starting Amlodipine.
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