Alogliptin + Metformin
Find more information about this combination medication at the webpages for Alogliptin and Metformin
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Advisory
- This medicine contains a combination of 2 drugs Alogliptin and Metformin.
- Alogliptin and Metformin are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Biguanide and Dipeptidyl Peptidase 4 Inhibitor
Controlled Drug Substance
NO
Learn more about this medicine -
Click HereSummary
Alogliptin and Metformin are used to manage type 2 diabetes. They help control high blood sugar levels, reducing the risk of complications like heart disease, kidney problems, and nerve damage. It's important to note they are not suitable for type 1 diabetes or diabetic ketoacidosis.
Metformin works by decreasing glucose production in the liver and improving insulin sensitivity, which helps lower blood sugar levels. Alogliptin, on the other hand, increases insulin release by preventing the breakdown of certain hormones. Together, they provide a comprehensive approach to managing blood sugar levels in type 2 diabetes.
The usual adult daily dose for Metformin is typically 500 mg to 1000 mg, taken two or three times a day with meals. For Alogliptin, the usual dose is 25 mg once daily, which can be taken with or without food. When combined, the dosing is individualized based on the patient's current regimen and response to treatment.
Common side effects of Metformin include gastrointestinal issues such as diarrhea, nausea, and stomach discomfort. Alogliptin may cause headaches, upper respiratory tract infections, and nasopharyngitis. Both medications can lead to low blood sugar, especially when used with other diabetes medications.
Metformin carries a warning for lactic acidosis, a rare but serious condition, especially in those with kidney problems or excessive alcohol use. Alogliptin may cause pancreatitis and severe allergic reactions. Both medications should be used with caution in patients with liver disease.
Indications and Purpose
What is combination of Alogliptin and Metformin used for?
The combination of Alogliptin and Metformin is used to help control blood sugar levels in adults with type 2 diabetes. Alogliptin is a type of medication known as a DPP-4 inhibitor, which helps increase the levels of insulin produced after meals and decreases the amount of sugar made by the body. Metformin is a biguanide, which works by reducing the amount of sugar your liver releases into your blood and improving your body's response to insulin. Together, these medications help manage blood sugar levels more effectively than either would alone.
What is combination of Metformin and Alogliptin used for?
Metformin and alogliptin are indicated for the management of type 2 diabetes mellitus. They are used to help control high blood sugar levels in conjunction with diet and exercise. This combination is not suitable for type 1 diabetes or diabetic ketoacidosis. By effectively managing blood sugar levels, these medications help reduce the risk of complications associated with diabetes, such as heart disease, kidney problems, and nerve damage.
How does combination of Alogliptin and Metformin work?
The combination of Alogliptin and Metformin is used to help control blood sugar levels in people with type 2 diabetes. Alogliptin is a type of medication known as a DPP-4 inhibitor. It works by increasing the levels of certain natural substances that help to lower blood sugar levels, especially after meals. Metformin, on the other hand, is a biguanide. It helps to lower blood sugar by decreasing the amount of sugar produced by the liver and improving the body's response to insulin, which is the hormone that helps move sugar from the blood into the cells for energy. Together, these medications help to better control blood sugar levels than either would alone, which can help prevent complications associated with diabetes.
How does combination of Metformin and Alogliptin work?
Metformin works by decreasing glucose production in the liver, reducing intestinal absorption of glucose, and improving insulin sensitivity, which helps lower blood sugar levels. Alogliptin, a DPP-4 inhibitor, increases insulin release and decreases glucagon levels by preventing the breakdown of incretin hormones. Together, they provide a dual approach to managing blood sugar levels in type 2 diabetes, with metformin focusing on reducing glucose production and alogliptin enhancing insulin secretion.
How effective is combination of Alogliptin and Metformin?
The combination of Alogliptin and Metformin is effective in managing type 2 diabetes. Alogliptin is a medication that helps increase the levels of insulin produced after meals and decreases the amount of sugar made by the liver. Metformin works by improving the body's response to insulin and reducing the amount of sugar absorbed from food. Together, they help control blood sugar levels more effectively than either drug alone. According to the NHS and other trusted sources, this combination is generally well-tolerated and can be an important part of a diabetes management plan, especially when diet and exercise alone are not enough to control blood sugar levels.
How effective is combination of Metformin and Alogliptin?
Clinical trials have demonstrated the effectiveness of metformin and alogliptin in managing type 2 diabetes. Metformin has been shown to lower blood sugar levels by reducing glucose production in the liver and improving insulin sensitivity. Alogliptin, as a DPP-4 inhibitor, enhances insulin secretion and reduces glucagon levels, further aiding in blood sugar control. Together, they provide a comprehensive approach to diabetes management, with studies showing significant improvements in HbA1c levels and fasting plasma glucose. This combination therapy is effective in reducing the risk of diabetes-related complications.
How does one know if combination of Alogliptin and Metformin is working?
To determine if the combination of Alogliptin and Metformin is working, you should monitor your blood sugar levels regularly. This combination is used to help control high blood sugar in people with type 2 diabetes. If your blood sugar levels are consistently within the target range set by your healthcare provider, it indicates that the medication is effective. Additionally, you may notice improvements in symptoms of high blood sugar, such as increased energy levels and reduced thirst or urination. It's important to have regular check-ups with your healthcare provider to assess your overall health and the effectiveness of the treatment. They may also perform blood tests, such as HbA1c, which provides an average blood sugar level over the past 2-3 months, to further evaluate how well the medication is working.
How does one know if combination of Metformin and Alogliptin is working?
The benefit of metformin and alogliptin is primarily assessed through regular monitoring of blood sugar levels and glycosylated hemoglobin (HbA1c) tests. These tests help determine how well the medications are controlling blood sugar over time. Additionally, patients may monitor their blood sugar levels at home to track daily fluctuations. The goal is to maintain blood sugar levels within a target range to reduce the risk of diabetes-related complications. Regular follow-ups with healthcare providers are crucial to evaluate the effectiveness and adjust treatment as needed.
Directions for Use
What is the usual dose of combination of Alogliptin and Metformin?
The usual dose of the combination of Alogliptin and Metformin varies depending on the patient's needs and medical history. Typically, the starting dose is 12.5 mg of Alogliptin with 500 mg of Metformin taken twice daily. However, the dose can be adjusted by a healthcare provider based on the patient's response and tolerance. It's important to follow the healthcare provider's instructions and not to change the dose without consulting them. Alogliptin helps to control blood sugar levels by increasing insulin production, while Metformin decreases sugar production in the liver and improves insulin sensitivity.
What is the usual dose of combination of Metformin and Alogliptin?
The usual adult daily dose for metformin is typically 500 mg to 1000 mg taken two or three times a day with meals, with a maximum dose of 2000 mg per day. For alogliptin, the usual dose is 25 mg once daily, which can be taken with or without food. When combined, the dosing is individualized based on the patient's current regimen and response to treatment, but it generally involves taking the combination twice daily with food to minimize gastrointestinal side effects from metformin.
How does one take combination of Alogliptin and Metformin?
Alogliptin and Metformin are medications used together to help control blood sugar levels in people with type 2 diabetes. This combination is usually taken by mouth in the form of a tablet. It is important to follow your healthcare provider's instructions on how to take these medications. Typically, the tablet is taken once or twice a day with meals to help reduce the risk of stomach upset. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet, as this can affect how the medication is absorbed in your body. Your doctor will determine the right dose for you based on your medical condition and response to treatment. It is important to take the medication regularly and at the same time each day to get the most benefit. Do not change your dose or stop taking the medication without consulting your healthcare provider. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. Always consult your healthcare provider for personalized advice and read the patient information leaflet provided with the medication for more details.
How does one take combination of Metformin and Alogliptin?
Metformin should be taken with meals to reduce gastrointestinal side effects, while alogliptin can be taken with or without food. When combined, it is recommended to take the medication with food to minimize stomach upset. Patients should follow dietary recommendations provided by their healthcare provider, which typically include a balanced diet with controlled carbohydrate intake. It's important to avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis with metformin.
For how long is combination of Alogliptin and Metformin taken?
The combination of Alogliptin and Metformin is typically taken as a long-term treatment for managing type 2 diabetes. The duration of use depends on individual health needs and how well the medication helps in controlling blood sugar levels. It is important to follow the healthcare provider's instructions and have regular check-ups to assess the effectiveness and adjust the treatment as necessary. Always consult with a healthcare professional before making any changes to the medication regimen.
For how long is combination of Metformin and Alogliptin taken?
Metformin and alogliptin are typically used as long-term treatments for managing type 2 diabetes. They are not cures for diabetes but are intended to help control blood sugar levels over time. Patients are usually advised to continue taking these medications even if they feel well, as stopping them can lead to uncontrolled blood sugar levels. Regular monitoring and consultations with a healthcare provider are essential to adjust dosages and ensure effective management of diabetes.
How long does it take for combination of Alogliptin and Metformin to work?
The combination of Alogliptin and Metformin is used to help control blood sugar levels in people with type 2 diabetes. According to the NHS, Metformin usually starts to work within a few days, but it can take up to two weeks to see the full effect. Alogliptin, on the other hand, works by increasing the levels of hormones that help the body produce more insulin and reduce the amount of sugar made by the liver. The combination of these two medications can help improve blood sugar control over time, but the exact time it takes to notice a significant change can vary from person to person. It's important to follow your healthcare provider's instructions and have regular check-ups to monitor your progress.
How long does it take for combination of Metformin and Alogliptin to work?
Metformin and alogliptin work together to manage blood sugar levels in type 2 diabetes. Metformin starts working within a few days, but it may take up to two weeks to see the full effect on blood sugar levels. Alogliptin, on the other hand, begins to work within a few hours by inhibiting the DPP-4 enzyme, which increases insulin release. The combination of these two medications provides a more comprehensive approach to controlling blood sugar levels, with metformin reducing glucose production in the liver and alogliptin enhancing insulin secretion.
How does one store combination of Alogliptin and Metformin?
To store the combination of Alogliptin and Metformin, keep the medication in its original container, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom). Make sure to follow any specific storage instructions provided by your pharmacist or healthcare provider. Proper storage helps maintain the medication's effectiveness and safety.
How does one store combination of Metformin and Alogliptin?
Metformin and alogliptin do not require refrigeration. They should be stored at room temperature, away from excess heat and moisture, and kept in their original container with the lid tightly closed. It's important to keep these medications out of reach of children and pets. Proper storage ensures the effectiveness and safety of the medication over time.
Warnings and Precautions
Are there harms and risks from taking combination of Alogliptin and Metformin?
Yes, there are potential harms and risks associated with taking a combination of Alogliptin and Metformin. Alogliptin is a medication used to control blood sugar levels in people with type 2 diabetes, and Metformin is another medication that helps control blood sugar levels by improving the way the body handles insulin. Some common side effects of this combination can include: 1. **Gastrointestinal issues**: Metformin can cause stomach upset, diarrhea, and nausea. 2. **Hypoglycemia**: This is a condition where blood sugar levels drop too low, which can happen if the combination is taken with other diabetes medications or if meals are skipped. 3. **Lactic acidosis**: A rare but serious side effect of Metformin, where lactic acid builds up in the blood, leading to symptoms like muscle pain, difficulty breathing, and feeling very weak or tired. 4. **Pancreatitis**: Alogliptin has been associated with inflammation of the pancreas, which can cause severe abdominal pain. It's important to discuss with a healthcare provider before starting this combination to ensure it's safe based on individual health conditions and to understand how to manage any potential side effects.
Are there harms and risks from taking combination of Metformin and Alogliptin?
Common side effects of metformin include gastrointestinal issues such as diarrhea, nausea, and stomach discomfort. Alogliptin may cause headaches, upper respiratory tract infections, and nasopharyngitis. Significant adverse effects for metformin include the risk of lactic acidosis, a rare but serious condition. Alogliptin can cause pancreatitis and severe allergic reactions. Both medications can lead to hypoglycemia, especially when used with other diabetes medications. Patients should be aware of these potential side effects and consult their healthcare provider if they experience any severe or persistent symptoms.
Can I take combination of Alogliptin and Metformin with other prescription drugs?
When taking a combination of Alogliptin and Metformin, it's important to be cautious about interactions with other prescription drugs. According to the NHS, some medications can affect how well Alogliptin and Metformin work or increase the risk of side effects. For example, certain diuretics (water pills), corticosteroids, and other diabetes medications might interact with this combination. The NLM advises that you should always inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. They can help determine if your current medications are safe to take with Alogliptin and Metformin. DailyMeds also suggests monitoring for symptoms of low blood sugar (hypoglycemia) if you are taking other medications that can lower blood sugar levels, as this combination can increase the risk of hypoglycemia. Always consult with your healthcare provider or pharmacist before starting any new medication while on Alogliptin and Metformin.
Can I take combination of Metformin and Alogliptin with other prescription drugs?
Metformin can interact with medications that affect kidney function, such as NSAIDs, which may increase the risk of lactic acidosis. It also interacts with cationic drugs like cimetidine, which can increase metformin levels. Alogliptin has fewer drug interactions but should be used cautiously with other medications that can cause hypoglycemia, such as insulin or sulfonylureas. Both medications require careful monitoring when used with other drugs that affect blood sugar levels to avoid hypoglycemia or other adverse effects.
Can I take combination of Alogliptin and Metformin with vitamins or supplements?
According to the NHS and other trusted sources, it is generally safe to take Alogliptin and Metformin with most vitamins and supplements. However, it's important to be cautious as some supplements can interact with medications. For example, certain supplements might affect blood sugar levels, which is crucial for people taking Alogliptin and Metformin for diabetes management. Alogliptin is a medication that helps control blood sugar levels by increasing the amount of insulin your body makes after meals. Metformin works by reducing the amount of sugar your liver releases into your blood and improving your body's response to insulin. Before starting any new vitamins or supplements, it's best to consult with a healthcare professional to ensure there are no potential interactions with your current medications. They can provide personalized advice based on your health needs.
Can I take combination of Metformin and Alogliptin with vitamins or supplements?
Metformin can interfere with the absorption of vitamin B12, potentially leading to a deficiency over time. Patients taking metformin should have their vitamin B12 levels monitored regularly and may need supplementation if levels are low. There are no significant interactions between alogliptin and vitamins or supplements reported. However, patients should always inform their healthcare provider about any supplements they are taking to ensure there are no potential interactions with their diabetes medications.
Can I take combination of Alogliptin and Metformin if I am pregnant?
It is important to consult your healthcare provider before taking any medication during pregnancy, including a combination of Alogliptin and Metformin. According to the NHS, Metformin is sometimes used during pregnancy to manage diabetes, but the safety of Alogliptin during pregnancy is not well established. Your doctor will weigh the potential benefits and risks to determine the best treatment for you.
Can I take combination of Metformin and Alogliptin if I am pregnant?
Metformin is generally considered safe for use during pregnancy and is often used to manage gestational diabetes. However, there is limited data on the use of alogliptin during pregnancy, and its safety is not well established. Pregnant women should discuss the potential risks and benefits of using these medications with their healthcare provider. The goal is to maintain good blood sugar control to reduce the risk of complications for both the mother and the baby.
Can I take combination of Alogliptin and Metformin while breastfeeding?
When considering the use of Alogliptin and Metformin while breastfeeding, it's important to consult with a healthcare professional. According to the NHS, Metformin is generally considered safe to use during breastfeeding as it passes into breast milk in very low amounts and is unlikely to affect the baby. However, there is limited information available on the use of Alogliptin during breastfeeding. The NLM suggests that due to the lack of data on Alogliptin, it is best to weigh the potential benefits against any possible risks. Always discuss with your doctor to ensure the safety of both you and your baby.
Can I take combination of Metformin and Alogliptin while breastfeeding?
Metformin is known to be excreted in breast milk in small amounts, but it is generally considered safe for use during breastfeeding. There is limited information on the excretion of alogliptin in human milk, and its safety during lactation is not well established. Therefore, caution is advised when using alogliptin while breastfeeding. Mothers should discuss the potential risks and benefits with their healthcare provider to make an informed decision about using these medications during lactation.
Who should avoid taking combination of Alogliptin and Metformin?
People who should avoid taking the combination of Alogliptin and Metformin include: 1. **Individuals with Severe Kidney Problems**: Metformin can accumulate in the body if the kidneys are not functioning properly, leading to a serious condition called lactic acidosis. 2. **People with Liver Disease**: Liver problems can affect how the body processes these medications, increasing the risk of side effects. 3. **Those with a History of Lactic Acidosis**: This is a rare but serious condition that can occur with Metformin use, especially in those with kidney or liver issues. 4. **Individuals with Heart Failure**: Heart failure can increase the risk of lactic acidosis when taking Metformin. 5. **People with Allergies to Alogliptin or Metformin**: Anyone with known allergies to these medications should avoid them. 6. **Pregnant or Breastfeeding Women**: The safety of these medications during pregnancy or breastfeeding is not well established, so they should be avoided unless specifically advised by a healthcare provider. 7. **Those with Severe Dehydration**: Dehydration can increase the risk of lactic acidosis with Metformin. It is important to consult a healthcare provider before starting or stopping any medication.
Who should avoid taking combination of Metformin and Alogliptin?
Metformin carries a warning for lactic acidosis, a rare but serious condition, especially in those with kidney problems or excessive alcohol use. It is contraindicated in severe renal impairment. Alogliptin may cause pancreatitis and severe allergic reactions, and should not be used in patients with a history of these conditions. Both medications should be used with caution in patients with liver disease. Patients should be aware of these risks and report any unusual symptoms to their healthcare provider immediately.
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