Alogliptin
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dipeptidyl Peptidase 4 Inhibitor
Controlled Drug Substance
NO
Alogliptin
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Click HereSummary
Alogliptin is used to manage blood sugar levels in adults with type 2 diabetes. It is not indicated for type 1 diabetes or diabetic ketoacidosis.
Alogliptin works by inhibiting an enzyme called DPP4, which increases the levels of hormones that help increase insulin release and decrease glucagon levels. This leads to better blood sugar control in people with type 2 diabetes.
The usual daily dose of Alogliptin for adults is 25 mg taken orally once a day. It is not recommended for use in pediatric patients.
Common side effects of Alogliptin include headache, stuffy or runny nose, and sore throat. Serious adverse effects can include pancreatitis, heart failure, and severe allergic reactions.
Important warnings for Alogliptin include the risk of pancreatitis, heart failure, and severe allergic reactions. It is contraindicated in patients with a history of serious hypersensitivity to the drug. Patients should be monitored for signs of liver injury and heart failure.
Indications and Purpose
What is Alogliptin used for?
Alogliptin is indicated for the management of type 2 diabetes in adults. It is used to improve blood sugar control when diet and exercise alone are not sufficient. It is not indicated for type 1 diabetes or diabetic ketoacidosis.
How does Alogliptin work?
Alogliptin works by inhibiting the enzyme DPP-4, which increases the levels of incretin hormones. These hormones help increase insulin release and decrease glucagon levels, leading to better blood sugar control in people with type 2 diabetes.
Is Alogliptin effective?
Clinical trials have shown that Alogliptin effectively lowers blood sugar levels in adults with type 2 diabetes when used alongside diet and exercise. It works by increasing insulin production and reducing glucose production in the liver, helping to control blood sugar levels.
How does one know if Alogliptin is working?
The benefit of Alogliptin is evaluated by regularly monitoring blood sugar levels and glycosylated hemoglobin (HbA1c) to assess its effectiveness in controlling diabetes. Regular check-ups with your doctor are important to adjust treatment as needed.
Directions for Use
What is the usual dose of Alogliptin?
The usual daily dose of Alogliptin for adults is 25 mg taken orally once a day. For children, the safety and effectiveness of Alogliptin have not been established, so it is not recommended for use in pediatric patients.
How do I take Alogliptin?
Alogliptin should be taken once daily, with or without food, at the same time each day. There are no specific food restrictions, but it is important to follow a healthy diet as recommended by your doctor to manage diabetes effectively.
For how long do I take Alogliptin?
Alogliptin is typically used as a long-term treatment for managing type 2 diabetes. It should be taken continuously as prescribed by your doctor, even if you feel well, to maintain blood sugar control.
How long does it take for Alogliptin to start working?
Alogliptin begins to work shortly after ingestion, but it may take several weeks to see the full effect on blood sugar levels. Regular monitoring of blood sugar is important to assess its effectiveness.
How should I store Alogliptin?
Store Alogliptin in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and dispose of unneeded medication through a take-back program.
Warnings and Precautions
Who should avoid taking Alogliptin?
Important warnings for Alogliptin include the risk of pancreatitis, heart failure, and severe allergic reactions. It is contraindicated in patients with a history of serious hypersensitivity to the drug. Patients should be monitored for signs of liver injury and heart failure.
Can I take Alogliptin with other prescription drugs?
Alogliptin may interact with insulin and insulin secretagogues, increasing the risk of hypoglycemia. Dose adjustments of these medications may be necessary. Always inform your doctor of all medications you are taking to avoid potential interactions.
Can I take Alogliptin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Alogliptin be taken safely while pregnant?
There is limited data on the use of Alogliptin during pregnancy, and its effects on the fetus are not well established. It is important to discuss with your doctor the potential risks and benefits before using Alogliptin if you are pregnant or planning to become pregnant.
Can Alogliptin be taken safely while breastfeeding?
It is not known if Alogliptin passes into breast milk. Due to the lack of information, it is important to weigh the benefits of breastfeeding against the potential risks of Alogliptin exposure to the infant. Consult your doctor for personalized advice.
Is Alogliptin safe for the elderly?
For elderly patients, no specific dose adjustment is necessary based on age alone. However, caution is advised due to the potential for decreased renal function in this population. Regular monitoring of kidney function is recommended to ensure safe use.
Is it safe to exercise while taking Alogliptin?
Alogliptin does not typically limit the ability to exercise. In fact, exercise is an important part of managing type 2 diabetes along with medication. However, if you experience any unusual symptoms during exercise, such as shortness of breath or fatigue, consult your doctor.
Is it safe to drink alcohol while taking Alogliptin?
Drinking alcohol can affect blood sugar levels, which may interfere with the effectiveness of Alogliptin in managing type 2 diabetes. It is important to discuss alcohol consumption with your doctor to ensure it does not negatively impact your treatment plan.
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