Melatonin

Seasonal Affective Disorder, Jet Lag Syndrome

DRUG STATUS

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Approvals

US(FDA), UK(BNF)

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Essential Medicine

NO

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Teratogenicity

Unlisted

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Pharmaceutical Class

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Drug Ingredient

Melatonin

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Summary

  • Melatonin is used to manage sleep disorders like insomnia and jet lag. It's also used for delayed sleep phase disorder, sleep apnea, and to adjust sleep patterns in people who work night shifts. Other conditions include seasonal affective disorder, depression, tinnitus, migraine headaches, and fibromyalgia.

  • Melatonin is a hormone produced by the pineal gland in the brain. It regulates the body's internal clock, signaling when it's time to sleep. It promotes sleepiness and improves the quality of sleep, helping to synchronize the sleep-wake cycle.

  • The typical adult dosage of Melatonin ranges from 0.5 mg to 5 mg. It's taken orally, usually in the form of tablets or gummies, 30 minutes to an hour before bedtime. The dosage may vary based on individual needs.

  • Common side effects include daytime sleepiness, dizziness, headache, nausea, and drowsiness. Some people may also experience changes in their dreams or sleep patterns. Rare but significant effects can include feelings of depression or irritability, changes in blood pressure, and changes in blood sugar levels.

  • Melatonin should not be used by pregnant or breastfeeding women, or by people allergic to it. Those with conditions like depression, diabetes, epilepsy, kidney or liver disease, or autoimmune diseases should consult their doctor before use. It may interact with other medications, so it's important to discuss this with your doctor. Long-term use beyond 3 months should be under doctor's supervision.

Indications and Purpose

What is Melatonin used for?

Melatonin is most commonly used to help people who are having trouble sleeping, either because of a sleep disorder or jet lag. Melatonin is also sometimes used for disorders like delayed sleep phase disorder, sleep apnea, and insomnia. It is also used for other conditions like seasonal affective disorder, depression, tinnitus, migraine headaches, fibromyalgia, and to adjust sleep patterns in people who work night shifts.

How does Melatonin work?

Melatonin is a hormone that is produced by the pineal gland in the brain. It helps to regulate the body's circadian rhythm, or the natural cycle of wakefulness and sleep. When it gets dark outside, the pineal gland releases more melatonin, which makes us sleepy. Melatonin supplements help to increase the levels of melatonin in the body, which can make it easier to fall asleep. It works by sending signals to the brain that it’s time for sleep.

Is Melatonin effective?

There are many studies that show that Melatonin can be effective for some people. Studies have found that Melatonin can help with falling asleep faster, staying asleep longer, and improving overall sleep quality. It has also been found to be helpful for people with sleep disorders like delayed sleep phase disorder, jet lag, and insomnia. However, not all people respond to Melatonin in the same way, and more research is needed to better understand how and when Melatonin is most effective.

How does one know if Melatonin is working?

The benefit of Melatonin can be evaluated in several ways. First, you can monitor your sleep patterns, like how quickly you fall asleep, how long you stay asleep, and how you feel when you wake up in the morning. You can also look at how you feel during the day, like if you are less tired and have more energy. Your doctor can also check your sleep quality by using a sleep diary or sleep study. If you find that Melatonin is helping you to sleep better and feel better during the day, it might be a good treatment for you.

Directions for Use

What is the usual dose of Melatonin?

Adults can take this medicine: 10 drops, three times a day. Kids younger than 12 need a doctor to tell them how much to take.

How do I take Melatonin?

Melatonin can be taken with or without food, though taking it on an empty stomach may allow for faster absorption. There are no specific food restrictions, but it’s recommended to avoid consuming large amounts of caffeine or alcohol close to bedtime, as these can interfere with Melatonin’s effectiveness. For best results, take it about 30 minutes to an hour before bed.

For how long do I take Melatonin?

Duration depends on the condition:

  • Jet lag: Use for a few days until sleep normalizes.
  • Chronic sleep issues: Long-term use may be safe under medical supervision.

How long does it take for Melatonin to start working?

Melatonin typically begins to work within 30 to 60 minutes after taking it. The time it takes to have an effect may vary depending on the individual and the dosage. It helps signal the body to prepare for sleep, improving the ability to fall asleep and the quality of sleep, especially when taken consistently at bedtime.

How should I store Melatonin?

Melatonin should be stored in a cool, dry place, away from direct sunlight and heat. It should be kept in a tightly sealed container to prevent it from degrading over time. Melatonin should be kept out of the reach of children. Melatonin can be stored at room temperature for up to one year, but it should be discarded if it has been kept for longer than the expiration date on the bottle. It is important to follow the storage instructions on the medication label to ensure that Melatonin remains safe and effective for use.

Warnings and Precautions

Who should avoid taking Melatonin?

Melatonin should not be used by people who are pregnant or breastfeeding, or by people who are allergic to it. People with certain medical conditions, such as depression, diabetes, epilepsy, kidney or liver disease, or autoimmune diseases, should talk to their doctor before taking Melatonin. It is also important to avoid taking Melatonin if you are taking other medications, as it may interact with them. People should not use Melatonin for more than 3 months without talking to their doctor, as long-term use can cause side effects.

Can I take Melatonin with other prescription drugs?

Melatonin can interact with certain prescription drugs, including:

Sedatives: Taking Melatonin with sedatives can increase the sedative effects of these medications, which can make you feel more drowsy.

Antidepressants: Taking Melatonin with antidepressants can increase the side effects of these medications, such as sleepiness, dizziness, and confusion.

Antihistamines: Taking Melatonin with antihistamines can increase the sedative effects of these medications, which can make you feel more drowsy.

Can I take Melatonin with vitamins or supplements?

Melatonin can interact with certain vitamins and supplements, including:

Magnesium: Taking magnesium with Melatonin may increase the sedative effects of Melatonin, which can make you feel more drowsy.

Calcium: Taking calcium with Melatonin can decrease the absorption of Melatonin in the body, reducing its effectiveness.

St. John's Wort: Taking St. John's Wort with Melatonin can increase the breakdown of Melatonin in the body, reducing its effectiveness.

Can Melatonin be taken safely while pregnant?

There is limited information available on the use of Melatonin during pregnancy, but there are some potential risks to consider. Animal studies have shown that high doses of Melatonin can affect fetal growth, but it is not known if these effects occur in humans. It is important to talk to your doctor before using Melatonin if you are pregnant or planning to become pregnant. Melatonin should not be used during pregnancy without medical advice, as it may pose risks to the fetus.

Can Melatonin be taken safely while breastfeeding?

There is limited information available on the use of Melatonin during lactation and breastfeeding. While Melatonin is not known to be passed into breast milk in significant amounts, it is recommended that women who are breastfeeding avoid taking Melatonin. This is because it is not known how Melatonin might affect the developing baby. It is important to talk to your doctor before using Melatonin if you are breastfeeding or planning to breastfeed. If you choose to use Melatonin while breastfeeding, monitor your baby closely for any adverse effects.

Is Melatonin safe for the elderly?

Melatonin is often safe and effective for elderly individuals, as natural melatonin production declines with age. However, lower doses are recommended to avoid excessive drowsiness.

Is it safe to exercise while taking Melatonin?

Exercise is safe, but avoid vigorous activity close to bedtime, as it may interfere with melatonin’s ability to promote sleep.

Is it safe to drink alcohol while taking Melatonin?

Alcohol can reduce melatonin’s effectiveness and increase drowsiness. Avoid drinking alcohol when using melatonin.