Trandolapril + Verapamil
Find more information about this combination medication at the webpages for Trandolapril and Verapamil
Hypertension, Variant Angina Pectoris ... show more
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Advisory
- This medicine contains a combination of 2 drugs Trandolapril and Verapamil.
- Trandolapril and Verapamil are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker
Controlled Drug Substance
NO
Trandolapril + Verapamil
Summary
Trandolapril and Verapamil are primarily used to treat hypertension, which means high blood pressure. By lowering blood pressure, they help reduce the risk of complications such as heart attack, stroke, and kidney problems.
Trandolapril is an ACE inhibitor that works by relaxing blood vessels, making it easier for the heart to pump blood. Verapamil is a calcium channel blocker that helps to lower blood pressure by relaxing the muscles of the heart and blood vessels. Together, they provide a more effective reduction in blood pressure than either medicine alone.
The usual adult daily dose for Trandolapril ranges from 1 to 4 mg per day, which can be administered in a single dose or divided into two doses. For Verapamil, the typical daily dose ranges from 120 to 480 mg, also administered in a single dose or divided doses.
Common side effects of Trandolapril and Verapamil include dizziness, headache, constipation, and cough. These are generally mild and transient. Significant adverse effects can include hypotension (low blood pressure), bradycardia (slow heart rate), and elevated liver enzymes.
Trandolapril and Verapamil should not be used in patients with severe left ventricular dysfunction, hypotension, or a history of angioedema related to ACE inhibitors. Verapamil is contraindicated in patients with certain heart conditions such as sick sinus syndrome or second or third-degree AV block unless a pacemaker is present. Pregnant women should avoid this combination due to the risk of fetal toxicity.
Indications and Purpose
How does combination of Trandolapril and Verapamil work?
Trandolapril works by inhibiting the angiotensin-converting enzyme (ACE), which decreases the production of angiotensin II, a chemical that causes blood vessels to constrict. This leads to vasodilation, reduced blood pressure, and decreased workload on the heart. Verapamil, on the other hand, is a calcium-channel blocker that relaxes blood vessels and reduces the heart's workload by slowing electrical activity in the heart. Both medications help lower blood pressure and improve heart function, but they do so through different mechanisms, making them complementary in treating cardiovascular conditions.
How effective is combination of Trandolapril and Verapamil?
Clinical trials and studies have demonstrated the effectiveness of both Trandolapril and Verapamil in managing high blood pressure and improving cardiovascular outcomes. Trandolapril has been shown to reduce mortality and heart failure-related hospitalizations in patients with left ventricular dysfunction post-myocardial infarction. Verapamil effectively controls blood pressure, angina, and certain arrhythmias by relaxing blood vessels and reducing heart workload. Both medications have been proven to lower blood pressure, which is a key factor in reducing the risk of cardiovascular events such as heart attacks and strokes.
Directions for Use
What is the usual dose of combination of Trandolapril and Verapamil?
For Verapamil, the usual adult dose for hypertension is 80 mg to 120 mg taken three times a day, with a maximum daily dose of 480 mg. For Trandolapril, the typical starting dose is 1 mg once daily, which can be increased to 2 to 4 mg daily based on the patient's response. Both medications are used to treat high blood pressure, but they have different dosing schedules and mechanisms of action. Verapamil is a calcium-channel blocker, while Trandolapril is an ACE inhibitor. It's important to follow the prescribed dosing regimen for each medication to achieve optimal blood pressure control.
How does one take combination of Trandolapril and Verapamil?
Trandolapril can be taken with or without food, but it's important to take it at the same time each day to maintain consistent blood levels. Verapamil should also be taken at the same time daily, and certain formulations may need to be taken with food or at specific times, such as morning or bedtime, as advised by a doctor. Patients should avoid grapefruit juice while taking Verapamil, as it can increase the medication's levels in the blood. Both medications require adherence to prescribed instructions and may involve dietary considerations, such as avoiding high potassium foods or salt substitutes with Trandolapril.
For how long is combination of Trandolapril and Verapamil taken?
Both Trandolapril and Verapamil are typically used as long-term treatments for managing high blood pressure and related cardiovascular conditions. They do not cure these conditions but help control them, so they are usually taken continuously, even if the patient feels well. It's important to follow the doctor's instructions and not stop taking these medications without consulting a healthcare provider. Regular monitoring and adjustments may be necessary to maintain optimal blood pressure control.
How long does it take for combination of Trandolapril and Verapamil to work?
Verapamil typically begins to work within 1 to 2 hours after oral administration, with peak plasma concentrations reached between 1 and 2 hours. Trandolapril, on the other hand, shows its antihypertensive effect about 1 hour after administration. Both medications are used to manage high blood pressure, but they work through different mechanisms. Verapamil is a calcium-channel blocker that relaxes blood vessels and reduces heart workload, while Trandolapril is an ACE inhibitor that decreases certain chemicals that tighten blood vessels. Together, they provide a comprehensive approach to lowering blood pressure, with effects noticeable within a few hours of administration.
Warnings and Precautions
Are there harms and risks from taking combination of Trandolapril and Verapamil?
Common side effects of Trandolapril include cough, dizziness, and muscle pain, while Verapamil may cause constipation, dizziness, and headache. Both medications can cause more serious side effects, such as swelling, difficulty breathing, and slow heartbeat. Trandolapril may also lead to angioedema, a serious allergic reaction, and Verapamil can cause heart failure or liver enzyme elevations. Patients should be aware of these potential side effects and seek medical attention if they experience severe or persistent symptoms.
Can I take combination of Trandolapril and Verapamil with other prescription drugs?
Trandolapril can interact with diuretics, NSAIDs, and other medications affecting the renin-angiotensin system, potentially leading to increased risks of hypotension, hyperkalemia, and renal impairment. Verapamil interacts with beta-blockers, digoxin, and certain antiarrhythmic agents, which can enhance its effects on heart rate and conduction. Both medications require careful monitoring when used with other cardiovascular drugs to avoid adverse effects and ensure safe and effective treatment.
Can I take combination of Trandolapril and Verapamil if I am pregnant?
Trandolapril is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm, including renal impairment and developmental issues. Verapamil should be used during pregnancy only if clearly needed, as there is limited data on its safety. Both medications require careful consideration of the risks and benefits, and alternative treatments should be considered for managing hypertension during pregnancy. Pregnant women should consult their healthcare provider to discuss the safest treatment options.
Can I take combination of Trandolapril and Verapamil while breastfeeding?
Trandolapril is not recommended during breastfeeding due to the lack of information on its safety and potential effects on the nursing infant. Verapamil is excreted in human milk, and while the risk to the infant is considered low, caution is advised. Both medications should be used during lactation only if the potential benefits justify the potential risks to the infant. Mothers should discuss with their healthcare provider whether to discontinue breastfeeding or the medication, considering the importance of the drug to the mother's health.
Who should avoid taking combination of Trandolapril and Verapamil?
Trandolapril is contraindicated in pregnancy due to the risk of fetal harm and should not be used with certain medications like aliskiren in patients with diabetes. Verapamil should be used cautiously in patients with severe left ventricular dysfunction or heart block. Both medications require caution in patients with renal or hepatic impairment and may cause significant hypotension. Patients should be aware of the potential for serious allergic reactions, such as angioedema with Trandolapril, and should seek immediate medical attention if they experience symptoms like swelling or difficulty breathing.
