Indapamide + Perindopril
Find more information about this combination medication at the webpages for Indapamide and Perindopril
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs Indapamide and Perindopril.
- Indapamide and Perindopril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Thiazide-like Diuretic
Controlled Drug Substance
NO
Summary
Perindopril and Indapamide are used for treating high blood pressure, also known as hypertension. Perindopril is also used to reduce the risk of heart-related death in patients with stable heart artery disease. Indapamide is used to manage salt and fluid retention associated with heart failure.
Perindopril works by relaxing your blood vessels, making it easier for your heart to pump blood. Indapamide works by increasing urine production, which helps reduce fluid retention and lower blood pressure. Together, they help manage high blood pressure.
The usual starting dose for Perindopril is 4 mg once daily, and for Indapamide, it's 1.25 mg once daily. These medications are taken orally and the dosage can be adjusted based on your response and tolerance.
Common side effects of Perindopril include cough, dizziness, and headache. Indapamide may cause side effects such as dizziness, headache, and fatigue. Both can lead to electrolyte imbalances, like low potassium levels, and low blood pressure.
Both medications are not recommended during pregnancy and should be used carefully in patients with kidney issues. Perindopril is not recommended for patients who have had swelling under the skin due to previous ACE inhibitor treatment. Indapamide should not be used by patients with an inability to produce urine or known allergy to sulfonamide-derived drugs.
Indications and Purpose
How does combination of Indapamide and Perindopril work?
The combination of Indapamide and Perindopril is used to treat high blood pressure. Indapamide is a type of medication known as a diuretic, or 'water pill,' which helps the body get rid of excess salt and water by increasing urine production. This helps to lower blood pressure by reducing the volume of fluid in the blood vessels. Perindopril is an ACE inhibitor, which stands for angiotensin-converting enzyme inhibitor. It works by relaxing blood vessels, making it easier for the heart to pump blood through the body. By combining these two medications, the treatment effectively reduces blood pressure by both decreasing fluid volume and relaxing blood vessels, which can help prevent heart attacks and strokes.
How does combination of Perindopril and Indapamide work?
Perindopril works by inhibiting the angiotensin-converting enzyme (ACE), which leads to the relaxation of blood vessels and a reduction in blood pressure. Indapamide acts as a diuretic, increasing urine production to help reduce fluid retention and lower blood pressure. Both medications help decrease the workload on the heart and improve blood flow, but they do so through different mechanisms. Together, they provide a synergistic effect in managing hypertension.
How effective is combination of Indapamide and Perindopril?
The combination of Indapamide and Perindopril is often used to treat high blood pressure (hypertension). Indapamide is a diuretic, which means it helps the body get rid of excess salt and water by increasing urine production. This can help lower blood pressure. Perindopril is an ACE inhibitor, which helps relax blood vessels, making it easier for the heart to pump blood. Together, these medications can be more effective in lowering blood pressure than when used alone. According to the NHS, this combination is generally well-tolerated and can significantly reduce the risk of heart attacks and strokes in people with high blood pressure. However, as with any medication, effectiveness can vary from person to person, and it's important to follow a healthcare provider's guidance when using these medications.
How effective is combination of Perindopril and Indapamide?
Clinical trials have demonstrated the effectiveness of Perindopril and Indapamide in lowering blood pressure and reducing cardiovascular risks. Perindopril has been shown to significantly reduce the risk of cardiovascular mortality and nonfatal myocardial infarction in patients with stable coronary artery disease. Indapamide effectively reduces blood pressure and fluid retention, particularly in patients with hypertension and congestive heart failure. Both medications have been proven to provide significant antihypertensive effects, either alone or in combination with other treatments, offering a comprehensive approach to managing high blood pressure.
Directions for Use
What is the usual dose of combination of Indapamide and Perindopril?
The usual dose of the combination of Indapamide and Perindopril can vary based on individual health needs and the specific formulation prescribed by a healthcare provider. Typically, this combination is used to treat high blood pressure. Indapamide is a diuretic, which helps reduce excess fluid in the body, while Perindopril is an ACE inhibitor that helps relax blood vessels. It's important to follow the dosage instructions provided by your doctor or pharmacist, as they will tailor the dose to your specific condition. Always consult with a healthcare professional before starting or adjusting any medication.
What is the usual dose of combination of Perindopril and Indapamide?
For Perindopril, the usual starting dose for hypertension is 4 mg once daily, which can be adjusted up to a maximum of 16 mg per day based on the patient's response. For Indapamide, the typical starting dose for hypertension is 1.25 mg once daily, which can be increased to 2.5 mg if needed. Both medications are taken orally and are often adjusted based on the patient's blood pressure response and tolerance. It's important to follow a healthcare provider's instructions for dosing adjustments.
How does one take combination of Indapamide and Perindopril?
Indapamide and Perindopril are medications often prescribed together to manage high blood pressure. Indapamide is a diuretic, which helps reduce excess fluid in the body, while Perindopril is an ACE inhibitor that helps relax blood vessels. According to the NHS, these medications are usually taken once a day, preferably in the morning. It's important to take them at the same time each day to maintain an even level in your bloodstream. You can take them with or without food, but try to be consistent with your choice. The DailyMeds website advises that you should swallow the tablets whole with a glass of water. Do not crush or chew them, as this can affect how the medication is absorbed in your body. Always follow the dosage instructions provided by your healthcare provider, and do not stop taking the medication without consulting them, even if you feel well. Regular monitoring of your blood pressure and kidney function may be necessary while on these medications. If you experience any side effects or have concerns about taking these medications, contact your healthcare provider for advice.
How does one take combination of Perindopril and Indapamide?
Perindopril and Indapamide can be taken with or without food, but it's important to take them consistently at the same time each day. Patients should avoid high-salt diets, as salt can counteract the effects of these medications. It's also advisable to limit alcohol consumption, as it can increase the risk of side effects like dizziness. Regular monitoring of blood pressure and kidney function is recommended to ensure the medications are working effectively and safely.
For how long is combination of Indapamide and Perindopril taken?
The combination of Indapamide and Perindopril is typically taken as a long-term treatment. This combination is often prescribed to manage high blood pressure (hypertension) and may be taken indefinitely to maintain blood pressure control. However, the exact duration of treatment should be determined by a healthcare professional based on individual health needs and response to the medication. Regular check-ups are important to assess the effectiveness and adjust the treatment as necessary. Always follow the advice of your doctor regarding the duration of any medication.
For how long is combination of Perindopril and Indapamide taken?
Perindopril and Indapamide are typically used as long-term treatments for hypertension and related conditions. The duration of use is often indefinite, as these medications are intended to manage chronic conditions rather than cure them. Regular monitoring by a healthcare provider is essential to ensure the medications are effective and to adjust dosages as needed. Both medications require consistent daily use to maintain their therapeutic effects.
How long does it take for combination of Indapamide and Perindopril to work?
The combination of Indapamide and Perindopril is used to treat high blood pressure. Indapamide is a diuretic, which helps remove excess fluid from the body, and Perindopril is an ACE inhibitor, which helps relax blood vessels. According to the NHS, it may take a few weeks to see the full effect of these medications on blood pressure. However, some people may notice an improvement in their blood pressure within a few days. It's important to continue taking the medication as prescribed and consult with a healthcare provider for personalized advice.
How long does it take for combination of Perindopril and Indapamide to work?
Perindopril and Indapamide both work to lower blood pressure, but they do so in different ways. Perindopril, an ACE inhibitor, typically starts to work within a few hours, with peak effects seen after several weeks of consistent use. Indapamide, a diuretic, also begins to act within a few hours, helping to reduce fluid retention and lower blood pressure. Both medications are absorbed quickly, but their full therapeutic effects may take a few weeks to become apparent. The combination of these two medicines can provide a more comprehensive approach to managing hypertension.
Warnings and Precautions
Are there harms and risks from taking combination of Indapamide and Perindopril?
Taking Indapamide and Perindopril together can have potential risks and side effects. Indapamide is a diuretic, which means it helps your body get rid of excess salt and water by making you urinate more. Perindopril is an ACE inhibitor, which helps relax blood vessels and lower blood pressure. When used together, they can effectively lower blood pressure, but they may also increase the risk of certain side effects. These can include dizziness, especially when standing up quickly, due to a drop in blood pressure. There is also a risk of dehydration and an imbalance in electrolytes, which are minerals in your blood that are important for your body's functions. Additionally, combining these medications can sometimes lead to kidney problems, so regular monitoring by a healthcare provider is important. It's crucial to follow your doctor's instructions and report any unusual symptoms, such as severe dizziness, muscle cramps, or changes in urination, to ensure safe use of these medications. For more detailed information, you can refer to trusted sources like the NHS, DailyMeds, or the National Library of Medicine (NLM).
Are there harms and risks from taking combination of Perindopril and Indapamide?
Common side effects of Perindopril include cough, dizziness, and headache. Indapamide may cause side effects such as dizziness, headache, and fatigue. Both medications can lead to electrolyte imbalances, such as low potassium levels, and may cause hypotension, especially when starting treatment or adjusting doses. Serious adverse effects can include angioedema with Perindopril and severe hyponatremia with Indapamide. Regular monitoring of blood pressure and electrolytes is important to manage these potential side effects.
Can I take combination of Indapamide and Perindopril with other prescription drugs?
Indapamide and Perindopril are medications often used together to manage high blood pressure. However, combining them with other prescription drugs can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. According to the NHS, it's important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and supplements. This helps them assess any potential interactions. The NLM notes that Indapamide is a diuretic, which means it helps remove excess fluid from the body, while Perindopril is an ACE inhibitor, which helps relax blood vessels. Both can interact with other medications, such as other blood pressure drugs, lithium, or non-steroidal anti-inflammatory drugs (NSAIDs). DailyMeds suggests that before starting any new medication, you should consult with your healthcare provider to ensure it's safe to use with your current treatment plan. They can provide guidance tailored to your specific health needs.
Can I take combination of Perindopril and Indapamide with other prescription drugs?
Perindopril can interact with diuretics, increasing the risk of hypotension, and with lithium, potentially leading to lithium toxicity. Indapamide may interact with other antihypertensive drugs, enhancing their effects, and with lithium, increasing the risk of toxicity. Both medications can interact with non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce their effectiveness and increase the risk of kidney damage. It's important to inform healthcare providers of all medications being taken to manage these interactions effectively.
Can I take combination of Indapamide and Perindopril if I am pregnant?
It is generally not recommended to take Indapamide and Perindopril during pregnancy. According to the NHS, Perindopril, which is an ACE inhibitor, can affect the baby's development, especially if taken during the second and third trimesters. Indapamide, a diuretic, may also pose risks during pregnancy. It is crucial to consult with a healthcare provider to discuss safer alternatives for managing your condition while pregnant.
Can I take combination of Perindopril and Indapamide if I am pregnant?
Perindopril is classified as pregnancy category D, indicating potential risk to the fetus, particularly in the second and third trimesters, due to its effects on the renin-angiotensin system. Indapamide should be used during pregnancy only if clearly needed, as diuretics can cross the placental barrier and may pose risks to the fetus. Both medications are generally not recommended during pregnancy, and alternative treatments should be considered. Pregnant women should consult their healthcare provider to discuss potential risks and alternative options.
Can I take combination of Indapamide and Perindopril while breastfeeding?
According to the NHS, it is important to consult with a healthcare professional before taking any medication while breastfeeding. Indapamide and Perindopril are medications used to treat high blood pressure. Indapamide is a diuretic, which helps the body get rid of excess salt and water, while Perindopril is an ACE inhibitor, which helps relax blood vessels. The safety of these medications during breastfeeding is not well established. The NHS advises that some medications can pass into breast milk and may affect the baby. Therefore, it is crucial to discuss with your doctor or a healthcare provider to weigh the benefits and potential risks before taking these medications while breastfeeding.
Can I take combination of Perindopril and Indapamide while breastfeeding?
The safety of Perindopril and Indapamide during lactation is not well established. Perindopril is known to be excreted in animal milk, and while it's unclear if it appears in human milk, caution is advised. Indapamide's excretion in human milk is also unknown, but due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or the drug, considering the importance of the medication to the mother. Consulting a healthcare provider is essential for breastfeeding mothers.
Who should avoid taking combination of Indapamide and Perindopril?
People who should avoid taking the combination of Indapamide and Perindopril include: 1. **Pregnant Women**: This combination can harm the developing baby, especially in the second and third trimesters. 2. **Individuals with Severe Kidney Problems**: Since these drugs can affect kidney function, those with severe kidney issues should avoid them. 3. **People with Low Blood Pressure**: The combination can further lower blood pressure, which might be dangerous. 4. **Patients with Allergies to Sulfonamides**: Indapamide is a sulfonamide, and those allergic to this class of drugs should avoid it. 5. **Individuals with Angioedema**: Those who have experienced angioedema (swelling under the skin) related to previous ACE inhibitor use should not take Perindopril. 6. **People with Hyperkalemia**: This is a condition where there is too much potassium in the blood, and Perindopril can increase potassium levels. Always consult a healthcare provider before starting or stopping any medication.
Who should avoid taking combination of Perindopril and Indapamide?
Perindopril is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Indapamide is contraindicated in patients with anuria or known hypersensitivity to sulfonamide-derived drugs. Both medications should be used cautiously in patients with renal impairment, as they can affect kidney function. They are also not recommended during pregnancy due to potential harm to the fetus. Regular monitoring of blood pressure, kidney function, and electrolytes is essential to ensure safe use.
