Perindopril
Hypertension, Left Ventricular Dysfunction ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Possible
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor
Controlled Drug Substance
No
Perindopril
Summary
Perindopril is used to treat high blood pressure (hypertension) and stable coronary artery disease. It helps lower blood pressure and reduce the risk of cardiovascular events such as heart attacks.
Perindopril is an ACE inhibitor. It works by blocking the conversion of a substance called angiotensin I to angiotensin II, which narrows blood vessels. This helps relax and widen blood vessels, reducing blood pressure and making it easier for the heart to pump blood.
For adults, the usual starting dose of Perindopril for hypertension is 4 mg once daily, which may be increased to a maximum of 16 mg per day. For stable coronary artery disease, the initial dose is 4 mg once daily, increasing to 8 mg if tolerated. It should be taken once daily, preferably in the morning before a meal.
Common side effects of Perindopril include cough, headache, dizziness, and gastrointestinal issues like diarrhea and stomach pain. Serious side effects can include angioedema, which is swelling of the face, throat, or tongue and requires immediate medical attention.
Perindopril should not be used during pregnancy as it can harm the fetus. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Caution is advised in patients with renal impairment and it should not be combined with certain medications like aliskiren in diabetic patients.
Indications and Purpose
How does Perindopril work?
Perindopril is an ACE inhibitor that works by blocking the conversion of angiotensin I to angiotensin II, a substance that narrows blood vessels. By preventing this conversion, Perindopril helps relax and widen blood vessels, reducing blood pressure and making it easier for the heart to pump blood.
Is Perindopril effective?
Perindopril is an ACE inhibitor that effectively lowers blood pressure by relaxing blood vessels, making it easier for the heart to pump blood. Clinical studies have shown that it reduces the risk of cardiovascular events in patients with stable coronary artery disease. It is widely used and considered effective for managing hypertension and reducing cardiovascular risk.
What is Perindopril?
Perindopril is an ACE inhibitor used to treat high blood pressure and stable coronary artery disease. It works by relaxing blood vessels, allowing blood to flow more easily, which helps lower blood pressure and reduce the risk of cardiovascular events. It is often used in combination with other medications for optimal effect.
Directions for Use
For how long do I take Perindopril?
Perindopril is typically used as a long-term treatment for managing high blood pressure and stable coronary artery disease. It is important to continue taking it even if you feel well, as it controls but does not cure these conditions. Always follow your doctor's instructions regarding the duration of use.
How do I take Perindopril?
Perindopril should be taken once daily, preferably in the morning before a meal. It can be taken with or without food, but taking it before a meal may enhance absorption. Avoid using salt substitutes containing potassium unless advised by your doctor.
How long does it take for Perindopril to start working?
Perindopril begins to lower blood pressure within a few hours of taking the first dose, but it may take several weeks to achieve the full effect. It is important to continue taking the medication as prescribed, even if you do not feel immediate results.
How should I store Perindopril?
Store Perindopril in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program, not by flushing it down the toilet.
What is the usual dose of Perindopril?
For adults, the usual starting dose of Perindopril for hypertension is 4 mg once daily, which may be increased to a maximum of 16 mg per day. For stable coronary artery disease, the initial dose is 4 mg once daily, increasing to 8 mg if tolerated. For children, the safety and efficacy of Perindopril have not been established, and it is not recommended for use in pediatric patients.
Warnings and Precautions
Can I take Perindopril with other prescription drugs?
Perindopril can interact with potassium supplements, potassium-sparing diuretics, and NSAIDs, increasing the risk of hyperkalemia and renal impairment. It should not be used with aliskiren in diabetic patients. Always inform your doctor about all medications and supplements you are taking to avoid potential interactions.
Can Perindopril be taken safely while pregnant?
Perindopril is not recommended during pregnancy, especially in the second and third trimesters, as it can harm the fetus, leading to issues like kidney failure and even death. If pregnancy is detected, discontinue use immediately and consult your doctor for alternative treatments.
Is it safe to drink alcohol while taking Perindopril?
Drinking alcohol while taking Perindopril can enhance the blood pressure-lowering effect of the medication, which may lead to dizziness or lightheadedness. It is advisable to limit alcohol consumption and discuss with your doctor how much alcohol is safe for you to consume while on this medication.
Is it safe to exercise while taking Perindopril?
Perindopril does not typically limit the ability to exercise. However, it can cause dizziness or lightheadedness, especially when starting the medication or increasing the dose. If you experience these symptoms, it is advisable to avoid strenuous activities until you know how the medication affects you. Consult your doctor if you have concerns about exercising while taking Perindopril.
Is Perindopril safe for the elderly?
Elderly patients may be more sensitive to the effects of Perindopril, particularly the risk of dizziness and falls due to blood pressure changes. It is recommended to start at a lower dose and adjust gradually. Regular monitoring of blood pressure and kidney function is advised. Consult your doctor for personalized advice.
Who should avoid taking Perindopril?
Perindopril should not be used during pregnancy as it can harm the fetus. It is contraindicated in patients with a history of angioedema related to previous ACE inhibitor treatment. Caution is advised in patients with renal impairment, and it should not be combined with certain medications like aliskiren in diabetic patients. Always consult your doctor for personalized advice.
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