Hydrochlorothiazide + Triamterene
Find more information about this combination medication at the webpages for Hydrochlorothiazide and Triamterene
Hypertension, Edema ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Triamterene.
- Hydrochlorothiazide and Triamterene are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Potassium-sparing Diuretic and Thiazide Diuretic
Controlled Drug Substance
NO
Hydrochlorothiazide + Triamterene
Summary
Hydrochlorothiazide and Triamterene are used to treat high blood pressure, also known as hypertension, and edema, which is fluid retention in the body. These conditions can occur in patients who have low potassium levels or are at risk of developing low potassium.
Hydrochlorothiazide is a diuretic that helps the body eliminate excess salt and water, reducing fluid buildup and lowering blood pressure. Triamterene helps conserve potassium, which can be lost with diuretics, ensuring that potassium levels remain balanced. Together, they manage blood pressure and fluid retention while preventing potassium deficiency.
The usual adult daily dose for the combination of triamterene and hydrochlorothiazide is either one or two tablets of the 37.5 mg/25 mg strength, or one tablet of the 75 mg/50 mg strength. The medication is taken orally.
Common side effects include frequent urination and headaches. More serious side effects can include dehydration, electrolyte imbalances, dizziness, nausea, vomiting, muscle cramps, rash, difficulty breathing, and signs of liver issues like yellowing of the skin or eyes.
This medication should not be used in patients with high potassium levels, severe kidney impairment, or known hypersensitivity to the components. It should be used cautiously in those with diabetes, liver disease, or a history of kidney stones. The risk of high potassium levels is significant, especially in patients with kidney issues or those taking other potassium-conserving medications. Regular monitoring of blood potassium levels is essential.
Indications and Purpose
How does combination of Hydrochlorothiazide and Triamterene work?
The combination of Hydrochlorothiazide and Triamterene is used to treat high blood pressure and fluid retention (edema). Hydrochlorothiazide is a type of medication known as a diuretic, or "water pill," which helps the body get rid of excess salt and water by increasing urine production. This helps to lower blood pressure and reduce swelling. However, it can also lead to a loss of potassium, an important mineral for the body. Triamterene is also a diuretic, but it works differently by helping the body retain potassium while still removing excess fluid. By combining these two medications, the treatment helps maintain a balance of potassium in the body while effectively reducing blood pressure and fluid retention. This combination is particularly useful for people who need to manage their blood pressure without losing too much potassium.
How does combination of Triamterene and Hydrochlorothiazide work?
Triamterene and hydrochlorothiazide work together as diuretics to help the body eliminate excess water and salt, which can lower blood pressure and reduce fluid retention. Hydrochlorothiazide promotes the excretion of sodium and chloride, leading to increased urine production. Triamterene, on the other hand, helps conserve potassium by preventing its loss during the diuretic process. This combination ensures effective management of hypertension and edema while maintaining balanced potassium levels, which is crucial for overall health.
How effective is combination of Hydrochlorothiazide and Triamterene?
The combination of Hydrochlorothiazide and Triamterene is effective in treating high blood pressure and reducing fluid retention (edema). Hydrochlorothiazide is a diuretic, which means it helps the body get rid of excess salt and water by increasing urine production. Triamterene is a potassium-sparing diuretic, which helps prevent the loss of potassium that can occur with Hydrochlorothiazide. Together, they help lower blood pressure and reduce swelling by balancing fluid and electrolyte levels in the body. This combination is particularly useful for people who need to manage their blood pressure while maintaining normal potassium levels.
How effective is combination of Triamterene and Hydrochlorothiazide?
Triamterene and hydrochlorothiazide have been shown to effectively manage high blood pressure and edema through clinical studies. Hydrochlorothiazide, a well-known diuretic, has demonstrated efficacy in reducing blood pressure by promoting the excretion of sodium and water. Triamterene complements this by conserving potassium, preventing the common side effect of hypokalemia associated with diuretics. Together, they provide a balanced approach to managing hypertension and fluid retention, with the added benefit of maintaining potassium levels, which is supported by clinical experience and patient outcomes.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Triamterene?
The usual dose of the combination of Hydrochlorothiazide and Triamterene is typically one tablet taken once daily. Each tablet usually contains 25 mg of Hydrochlorothiazide and 37.5 mg of Triamterene. However, the exact dosage may vary based on individual health needs and should be determined by a healthcare provider. Hydrochlorothiazide is a diuretic, which helps remove excess fluid from the body, while Triamterene helps prevent the loss of too much potassium, a vital mineral.
What is the usual dose of combination of Triamterene and Hydrochlorothiazide?
The usual adult daily dose for the combination of triamterene and hydrochlorothiazide is either one or two tablets of the 37.5 mg/25 mg strength or one tablet of the 75 mg/50 mg strength. Triamterene is included to help conserve potassium, which can be lost with the use of hydrochlorothiazide, a diuretic. Hydrochlorothiazide helps reduce fluid retention and high blood pressure by promoting the excretion of excess salt and water. The combination ensures effective diuresis while maintaining potassium levels, which is crucial for patients at risk of hypokalemia.
How does one take combination of Hydrochlorothiazide and Triamterene?
Hydrochlorothiazide and Triamterene are medications often combined to treat high blood pressure and fluid retention. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water by increasing urine production. Triamterene is a potassium-sparing diuretic, which helps prevent the loss of too much potassium, an important mineral for heart and muscle function. When taking this combination, it is usually administered orally in tablet form. It is important to follow the dosage instructions provided by your healthcare provider, which typically involves taking the medication once daily, with or without food. It is advisable to take it at the same time each day to maintain an even level in your bloodstream. Always consult with your healthcare provider before starting or adjusting the dosage, and inform them of any other medications you are taking to avoid potential interactions. Regular monitoring of blood pressure and kidney function may be necessary while on this medication.
How does one take combination of Triamterene and Hydrochlorothiazide?
Triamterene and hydrochlorothiazide should be taken once daily, ideally at the same time each day, to maintain consistent blood levels. It can be taken with or without food, but patients should follow their doctor's dietary recommendations, which may include a low-salt diet or increased intake of potassium-rich foods like bananas and orange juice. Patients should avoid potassium supplements unless advised by their doctor, as the medication already helps conserve potassium. It's also important to stay hydrated and avoid excessive alcohol consumption, which can exacerbate side effects.
For how long is combination of Hydrochlorothiazide and Triamterene taken?
The duration for taking the combination of Hydrochlorothiazide and Triamterene depends on the individual's medical condition and response to treatment. It is typically prescribed for managing high blood pressure or fluid retention, and the length of treatment can vary. It is important to follow the doctor's instructions and not to stop taking the medication without consulting a healthcare professional. Regular check-ups are necessary to monitor the effectiveness and adjust the dosage if needed.
For how long is combination of Triamterene and Hydrochlorothiazide taken?
Triamterene and hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure and edema. While they help control these conditions, they do not cure them, so continuous use is often necessary to maintain their benefits. Patients should follow their doctor's instructions and not stop taking the medication without consulting their healthcare provider. Regular monitoring and lifestyle changes may also be recommended to support the treatment.
How long does it take for combination of Hydrochlorothiazide and Triamterene to work?
The combination of Hydrochlorothiazide and Triamterene typically starts to work within a few hours after taking it. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of extra salt and water by making you urinate more. Triamterene helps to keep your potassium levels from getting too low, which can happen with diuretics. You may notice an increase in urination within a few hours, but it may take a few days to see the full effect on your blood pressure. It's important to take the medication as prescribed and consult your healthcare provider if you have any concerns.
How long does it take for combination of Triamterene and Hydrochlorothiazide to work?
Triamterene and hydrochlorothiazide work together to help reduce high blood pressure and fluid retention. Hydrochlorothiazide, a diuretic, typically starts working within 2 hours, with its peak effect occurring around 4 hours after ingestion. Triamterene, which helps conserve potassium, also begins to work relatively quickly, although its exact onset time is not specified. Together, they help the kidneys remove excess water and salt, which can help lower blood pressure and reduce swelling. The combination of these two medicines ensures that while excess fluid is removed, potassium levels are maintained, preventing potential deficiencies.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Triamterene?
Yes, there are potential harms and risks associated with taking a combination of Hydrochlorothiazide and Triamterene. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of excess salt and water by increasing urine production. Triamterene is also a diuretic but works differently by helping to retain potassium, a vital mineral. Some common side effects of this combination can include dizziness, headache, and upset stomach. More serious risks involve electrolyte imbalances, such as high potassium levels (hyperkalemia) or low sodium levels (hyponatremia), which can affect heart and muscle function. It's important to monitor these levels through regular blood tests. People with kidney problems, liver disease, or those taking certain medications should be cautious, as these conditions can increase the risk of side effects. Always consult with a healthcare provider before starting or changing any medication regimen.
Are there harms and risks from taking combination of Triamterene and Hydrochlorothiazide?
Common side effects of triamterene and hydrochlorothiazide include frequent urination and headaches. More serious side effects can occur, such as dehydration, electrolyte imbalances, and dizziness. Patients may also experience nausea, vomiting, or muscle cramps. Significant adverse effects include rash, difficulty breathing, and signs of liver issues like yellowing of the skin or eyes. It's important to monitor for these symptoms and seek medical attention if they occur. The combination of these medications helps manage potassium levels, but patients should be aware of the potential for both hypokalemia and hyperkalemia.
Can I take combination of Hydrochlorothiazide and Triamterene with other prescription drugs?
Hydrochlorothiazide and Triamterene are diuretics, which help your body get rid of excess salt and water. When taking these medications, it's important to be cautious about interactions with other prescription drugs. According to the NHS, combining these diuretics with other medications can sometimes lead to increased side effects or reduced effectiveness. For example, taking them with other blood pressure medications can enhance the blood pressure-lowering effect, which might lead to dizziness or fainting. The NLM advises that you should inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. DailyMeds highlights that certain medications, like non-steroidal anti-inflammatory drugs (NSAIDs), can reduce the effectiveness of Hydrochlorothiazide and Triamterene. Additionally, combining them with potassium supplements or other potassium-sparing diuretics can lead to high potassium levels, which can be dangerous. Always consult with your healthcare provider before starting or stopping any medication to ensure it is safe and appropriate for your specific health needs.
Can I take combination of Triamterene and Hydrochlorothiazide with other prescription drugs?
Triamterene and hydrochlorothiazide can interact with several prescription medications. Notably, they should be used cautiously with ACE inhibitors, as both can increase potassium levels, raising the risk of hyperkalemia. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the effectiveness of diuretics. Additionally, lithium levels can be affected, increasing the risk of toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of Hydrochlorothiazide and Triamterene if I am pregnant?
It is generally not recommended to take the combination of Hydrochlorothiazide and Triamterene during pregnancy. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of extra salt and water by making you urinate more. Triamterene is also a diuretic but works differently by helping your body retain potassium, an important mineral. According to the NHS and other trusted sources, these medications can potentially affect the balance of fluids and electrolytes in your body, which is crucial during pregnancy. They may also pose risks to the developing baby. It's important to consult with your healthcare provider to discuss safer alternatives for managing your condition during pregnancy.
Can I take combination of Triamterene and Hydrochlorothiazide if I am pregnant?
Triamterene and hydrochlorothiazide should be used during pregnancy only if the potential benefits justify the risks to the fetus. Diuretics are generally not recommended during pregnancy unless necessary, as they can affect fetal development and cause complications like jaundice or thrombocytopenia. Both triamterene and hydrochlorothiazide cross the placental barrier, and their use requires careful consideration and consultation with a healthcare provider. Alternative treatments should be explored to manage hypertension or edema during pregnancy.
Can I take combination of Hydrochlorothiazide and Triamterene while breastfeeding?
According to the NHS and NLM, Hydrochlorothiazide and Triamterene are diuretics, which means they help your body get rid of extra salt and water by making you urinate more. While there is limited information on the use of these specific medications during breastfeeding, they are generally considered to be low risk. However, it's important to consult with your healthcare provider before taking these medications while breastfeeding, as they can affect milk production and may pass into breast milk in small amounts. Your doctor can help weigh the benefits and potential risks to you and your baby.
Can I take combination of Triamterene and Hydrochlorothiazide while breastfeeding?
Triamterene and hydrochlorothiazide are not recommended during breastfeeding. Thiazides, like hydrochlorothiazide, are known to be excreted in breast milk and may affect milk production or cause adverse effects in the nursing infant. Triamterene's presence in animal milk suggests it may also be excreted in human milk. If the use of this medication is deemed essential, breastfeeding should be discontinued to avoid potential risks to the infant. Mothers should discuss alternative treatments with their healthcare provider.
Who should avoid taking combination of Hydrochlorothiazide and Triamterene?
People who should avoid taking the combination of Hydrochlorothiazide and Triamterene include those with severe kidney problems, as this medication can affect kidney function. Additionally, individuals with high levels of potassium in their blood (hyperkalemia) should not take this combination, as Triamterene can increase potassium levels further. Pregnant women and those with allergies to sulfa drugs should also avoid this medication. It's important to consult a healthcare provider for personalized advice.
Who should avoid taking combination of Triamterene and Hydrochlorothiazide?
Triamterene and hydrochlorothiazide should not be used in patients with high potassium levels, severe kidney impairment, or known hypersensitivity to the components. Caution is advised for those with diabetes, liver disease, or a history of kidney stones. The risk of hyperkalemia is significant, especially in patients with renal impairment or those taking other potassium-conserving medications. Regular monitoring of blood potassium levels is essential. Patients should also be aware of potential dizziness and avoid activities requiring alertness until they know how the medication affects them.
