Hydrochlorothiazide + Telmisartan
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Hypertension, Edema ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Telmisartan.
- Hydrochlorothiazide and Telmisartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Hydrochlorothiazide + Telmisartan
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Click HereSummary
Hydrochlorothiazide and Telmisartan are primarily used to treat high blood pressure, which is also known as hypertension. High blood pressure is a condition where the force of the blood against the artery walls is too high, which can lead to health problems like heart disease. Telmisartan is also used to reduce the risk of heart attack, stroke, or death in people who are at high risk for cardiovascular disease. Hydrochlorothiazide can also be used to treat edema, which is swelling caused by excess fluid trapped in the body's tissues, often associated with heart, kidney, or liver disease.
Telmisartan works by blocking angiotensin II receptors, which are proteins that cause blood vessels to tighten. By blocking these receptors, Telmisartan helps blood vessels relax and widen, which lowers blood pressure and improves blood flow. Hydrochlorothiazide is a diuretic, which means it helps the kidneys remove excess salt and water from the body. This reduces fluid retention and lowers blood pressure. Together, these medications provide a dual mechanism to effectively manage hypertension by both reducing fluid volume and relaxing blood vessels.
The usual adult daily dose for Telmisartan is typically 40 to 80 mg taken once daily. For Hydrochlorothiazide, the usual dose is 12.5 to 25 mg taken once daily. When these medications are combined, the starting dose is often 40 mg of Telmisartan with 12.5 mg of Hydrochlorothiazide. The dose can be adjusted by a healthcare provider based on the patient's response and needs. Both medications are taken orally, which means they are swallowed by mouth, and it's important to take them at the same time each day to maintain consistent blood levels.
Common side effects of Telmisartan include dizziness, back pain, and sinus congestion. Hydrochlorothiazide may cause frequent urination, dizziness, and fatigue. Both medications can lead to upper respiratory tract infections. Significant adverse effects include electrolyte imbalances, which are disturbances in the levels of minerals in the blood, dehydration, and potential kidney issues. It's important to report any severe or persistent side effects to a healthcare provider.
Telmisartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal toxicity, which means potential harm to the developing fetus. Hydrochlorothiazide crosses the placenta and may cause fetal or neonatal jaundice, which is yellowing of the skin and eyes, and thrombocytopenia, which is a low platelet count. Both medications should be used cautiously in patients with severe kidney or liver impairment. Patients should avoid unnecessary sun exposure due to increased skin sensitivity. Regular monitoring and consultation with a healthcare provider are crucial to manage these risks.
Indications and Purpose
What is combination of Hydrochlorothiazide and Telmisartan used for?
The combination of Hydrochlorothiazide and Telmisartan is used to treat high blood pressure, also known as hypertension. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water by increasing urine production. Telmisartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels, making it easier for blood to flow. Together, they help lower blood pressure, reducing the risk of heart attacks and strokes.
What is combination of Telmisartan and Hydrochlorothiazide used for?
Telmisartan and Hydrochlorothiazide are primarily indicated for the treatment of high blood pressure (hypertension). Telmisartan is also used to reduce the risk of heart attack, stroke, or death in individuals at high risk for cardiovascular disease. Hydrochlorothiazide is additionally used to treat edema associated with heart, kidney, or liver disease. Together, they provide a comprehensive approach to managing hypertension and associated cardiovascular risks.
How does combination of Hydrochlorothiazide and Telmisartan work?
The combination of Hydrochlorothiazide and Telmisartan is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps your body get rid of extra salt and water by making you urinate more. This helps to lower blood pressure. Telmisartan is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels so that blood can flow more easily, which also helps to lower blood pressure. Together, these medications help to control blood pressure more effectively than either would alone.
How does combination of Telmisartan and Hydrochlorothiazide work?
Telmisartan works by blocking angiotensin II receptors, preventing blood vessels from constricting, which helps lower blood pressure and improve blood flow. Hydrochlorothiazide acts as a diuretic, promoting the excretion of excess salt and water through the kidneys, reducing fluid retention and blood pressure. Together, they provide a dual mechanism to effectively manage hypertension by both reducing fluid volume and relaxing blood vessels.
How effective is combination of Hydrochlorothiazide and Telmisartan?
This combination is effective in lowering blood pressure more than either drug alone. By combining these two medications, they work together to provide a more comprehensive approach to managing hypertension, which can help reduce the risk of heart attacks and strokes.The combination is generally well-tolerated, but like all medications, it may have side effects. It's important for patients to follow their healthcare provider's instructions and report any unusual symptoms.Overall, the combination of Hydrochlorothiazide and Telmisartan is considered effective for controlling high blood pressure, especially in patients who may not achieve desired results with a single medication.
How effective is combination of Telmisartan and Hydrochlorothiazide?
Clinical trials have demonstrated that Telmisartan and Hydrochlorothiazide effectively lower blood pressure, reducing the risk of cardiovascular events such as stroke and heart attack. Telmisartan's ability to block angiotensin II receptors leads to improved blood flow, while Hydrochlorothiazide's diuretic action helps reduce fluid volume. Together, they provide a synergistic effect, enhancing overall blood pressure control. The combination has been shown to be more effective than either medication alone in achieving target blood pressure levels.
How does one know if combination of Hydrochlorothiazide and Telmisartan is working?
To determine if the combination of Hydrochlorothiazide and Telmisartan is working, you should monitor your blood pressure regularly. This combination is used to lower high blood pressure, so effective treatment will result in a decrease in your blood pressure readings. You may not feel any different when your blood pressure is controlled, as high blood pressure often has no symptoms. Therefore, regular monitoring is essential. Your healthcare provider may also conduct periodic blood tests to check kidney function and electrolyte levels, as these can be affected by the medication. If you experience side effects or if your blood pressure does not improve, consult your healthcare provider for further evaluation.
How does one know if combination of Telmisartan and Hydrochlorothiazide is working?
The benefit of Telmisartan and Hydrochlorothiazide is primarily assessed by monitoring blood pressure levels. Regular blood pressure checks help determine the effectiveness of the treatment in lowering systolic and diastolic pressures. Additionally, healthcare providers may conduct blood tests to monitor kidney function and electrolyte levels, ensuring the medications are working effectively without causing adverse effects. Patient-reported outcomes, such as reduced symptoms of hypertension, also contribute to assessing the treatment's success.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Telmisartan?
The usual dose of the combination of Hydrochlorothiazide and Telmisartan can vary depending on the specific needs of the patient, but a common starting dose is 40 mg of Telmisartan and 12.5 mg of Hydrochlorothiazide taken once daily. It's important to follow a healthcare provider's instructions for the correct dosage.
What is the usual dose of combination of Telmisartan and Hydrochlorothiazide?
The usual adult daily dose for Telmisartan is typically 40 to 80 mg once daily, while Hydrochlorothiazide is usually prescribed at 12.5 to 25 mg once daily. When combined, the starting dose is often 40 mg of Telmisartan with 12.5 mg of Hydrochlorothiazide, which can be adjusted based on the patient's response and needs. Both medications are taken orally and can be adjusted by healthcare providers to achieve optimal blood pressure control.
How does one take combination of Hydrochlorothiazide and Telmisartan?
To take this combination, follow your doctor's instructions carefully. Typically, it is taken once a day, with or without food. It's important to take it at the same time each day to maintain an even level of medication in your body.Do not stop taking the medication without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Never take two doses at once.Always check with your healthcare provider or pharmacist if you have any questions or concerns about your medication.
How does one take combination of Telmisartan and Hydrochlorothiazide?
Telmisartan and Hydrochlorothiazide can be taken with or without food, but it's important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with the medication. If prescribed a low-salt diet, it's crucial to follow these dietary instructions carefully to enhance the medication's effectiveness and reduce the risk of side effects.
For how long is combination of Hydrochlorothiazide and Telmisartan taken?
The combination of Hydrochlorothiazide and Telmisartan is typically taken as a long-term treatment for managing high blood pressure. The duration of treatment can vary depending on individual health needs and how well the medication is controlling blood pressure. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as stopping suddenly can lead to a rise in blood pressure.
For how long is combination of Telmisartan and Hydrochlorothiazide taken?
Telmisartan and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. While Hydrochlorothiazide provides immediate diuretic effects, Telmisartan offers sustained blood pressure control. Patients are usually advised to continue taking these medications even if they feel well, as they manage but do not cure hypertension. Regular monitoring by a healthcare provider is essential to ensure effectiveness and adjust dosages as needed.
How long does it take for combination of Hydrochlorothiazide and Telmisartan to work?
The combination of Hydrochlorothiazide and Telmisartan typically starts to work within a few hours after taking the first dose. However, it may take several weeks to experience the full benefits in terms of blood pressure reduction.
How long does it take for combination of Telmisartan and Hydrochlorothiazide to work?
Telmisartan and Hydrochlorothiazide work together to manage high blood pressure. Telmisartan, an angiotensin II receptor antagonist, typically begins to lower blood pressure within 3 hours, with full effects seen in about 4 weeks. Hydrochlorothiazide, a diuretic, starts working within 2 hours, peaking at around 4 hours, and its effects last for 6 to 12 hours. Together, they provide a comprehensive approach to blood pressure management, with Telmisartan offering long-term control and Hydrochlorothiazide providing more immediate diuretic effects.
How does one store combination of Hydrochlorothiazide and Telmisartan?
The combination of Hydrochlorothiazide and Telmisartan should be stored at room temperature, away from excess heat and moisture. It should be kept in its original container, tightly closed, and out of reach of children. Avoid storing it in the bathroom to prevent exposure to humidity.
How does one store combination of Telmisartan and Hydrochlorothiazide?
Telmisartan and Hydrochlorothiazide do not require refrigeration. They should be stored at room temperature, away from excess heat and moisture, and kept in their original blister packaging until use to protect them from moisture. It's important to keep these medications out of reach of children and pets to prevent accidental ingestion.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Telmisartan?
Hydrochlorothiazide and Telmisartan are medications often used together to treat high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of extra salt and water, while Telmisartan is an angiotensin receptor blocker that helps relax blood vessels. Taking these medications together can be effective, but there are potential risks and side effects. Common side effects include dizziness, lightheadedness, or dehydration, especially when you first start taking them or if your dose is increased. This happens because the medications can lower your blood pressure too much or cause your body to lose too much water. More serious risks include kidney problems, as these drugs can affect how well your kidneys work. They can also cause an imbalance in electrolytes, which are minerals in your blood that are important for your body's functions. Symptoms of an electrolyte imbalance might include muscle cramps, weakness, or an irregular heartbeat. It's important to have regular check-ups with your healthcare provider to monitor your blood pressure, kidney function, and electrolyte levels while taking these medications. Always discuss any concerns or side effects with your doctor, who can adjust your treatment if necessary.
Are there harms and risks from taking combination of Telmisartan and Hydrochlorothiazide?
Common side effects of Telmisartan and Hydrochlorothiazide include dizziness, fatigue, and upper respiratory tract infections. Hydrochlorothiazide may cause frequent urination, while Telmisartan can lead to back pain and sinus congestion. Significant adverse effects include electrolyte imbalances, dehydration, and potential kidney issues. Both medications can cause allergic reactions, and Telmisartan has a specific warning for fetal toxicity if taken during pregnancy. Patients should report any severe or persistent side effects to their healthcare provider.
Can I take combination of Hydrochlorothiazide and Telmisartan with other prescription drugs?
Hydrochlorothiazide and Telmisartan are medications often used together to manage high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of excess salt and water, while Telmisartan is an angiotensin receptor blocker that helps relax blood vessels.When taking these medications, it's important to be cautious about combining them with other prescription drugs. Some medications can interact with Hydrochlorothiazide and Telmisartan, potentially leading to increased side effects or reduced effectiveness. For example, combining them with other blood pressure medications can sometimes lower your blood pressure too much.Additionally, certain non-prescription drugs, like non-steroidal anti-inflammatory drugs (NSAIDs), can affect how well these medications work. It's crucial to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.
Can I take combination of Telmisartan and Hydrochlorothiazide with other prescription drugs?
Telmisartan and Hydrochlorothiazide can interact with several prescription drugs. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce their effectiveness and increase the risk of kidney problems. Combining with other blood pressure medications can enhance hypotensive effects. Telmisartan should not be used with aliskiren in patients with diabetes due to increased risk of adverse effects. Additionally, Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions.
Can I take combination of Hydrochlorothiazide and Telmisartan with vitamins or supplements?
Hydrochlorothiazide and Telmisartan are medications used to manage high blood pressure. Generally, it is safe to take these medications with most vitamins and supplements, but there are some considerations to keep in mind.1. Potassium Levels: Hydrochlorothiazide can lower potassium levels in your body. If you are taking potassium supplements or potassium-rich foods, it is important to monitor your levels to avoid an imbalance.2. Calcium Supplements: Taking calcium supplements with Hydrochlorothiazide may increase calcium levels in your blood, so it’s advisable to monitor this if you are on calcium supplements.3. Consult Your Doctor: Always consult with your healthcare provider before starting any new vitamins or supplements to ensure they do not interact with your medications or affect your health condition.
Can I take combination of Telmisartan and Hydrochlorothiazide with vitamins or supplements?
Patients taking Telmisartan and Hydrochlorothiazide should be cautious with potassium supplements or salt substitutes containing potassium, as these can lead to hyperkalemia, a condition of elevated potassium levels in the blood. It's important to discuss any vitamin or supplement use with a healthcare provider to avoid potential interactions. Monitoring of electrolyte levels may be necessary to ensure safe use of these medications alongside supplements.
Can I take combination of Hydrochlorothiazide and Telmisartan if I am pregnant?
It is generally not recommended to take a combination of Hydrochlorothiazide and Telmisartan during pregnancy. Medications like Telmisartan, which belong to a group called angiotensin II receptor blockers (ARBs), can harm the developing baby, especially in the second and third trimesters. Hydrochlorothiazide, a diuretic, is also typically avoided during pregnancy unless absolutely necessary, as it can affect the balance of fluids and electrolytes in the body. It's important to consult with a healthcare provider for safer alternatives to manage high blood pressure during pregnancy.
Can I take combination of Telmisartan and Hydrochlorothiazide if I am pregnant?
Telmisartan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal toxicity, including potential injury or death to the developing fetus. Hydrochlorothiazide crosses the placenta and may cause fetal or neonatal jaundice and thrombocytopenia. Both medications pose significant risks during pregnancy, and women who are pregnant or planning to become pregnant should discuss alternative treatments with their healthcare provider. If pregnancy occurs while taking these medications, they should be discontinued immediately.
Can I take combination of Hydrochlorothiazide and Telmisartan while breastfeeding?
Hydrochlorothiazide is generally considered safe to use during breastfeeding in low doses, as it passes into breast milk in small amounts and is unlikely to affect the baby. However, high doses may reduce milk production.Telmisartan, on the other hand, has limited information available regarding its safety during breastfeeding. The alternative medications with more established safety profiles during breastfeeding may be preferred.It's important to consult with a healthcare provider to weigh the benefits and risks before taking these medications while breastfeeding.
Can I take combination of Telmisartan and Hydrochlorothiazide while breastfeeding?
There is limited information on the safety of Telmisartan during breastfeeding, and it is generally advised to avoid its use due to potential adverse effects on the infant. Hydrochlorothiazide is present in breast milk, but its effects on milk production and the breastfed infant are not well-documented. Due to the potential for serious adverse reactions, including hypotension and electrolyte imbalances in the infant, breastfeeding mothers are advised to either discontinue the medication or choose an alternative feeding method.
Who should avoid taking combination of Hydrochlorothiazide and Telmisartan?
People who should avoid taking the combination of Hydrochlorothiazide and Telmisartan include those who are allergic to either of these medications or any of their ingredients. Additionally, individuals with severe kidney or liver problems, or those who have difficulty urinating, should not take this combination. Pregnant women, especially in the second and third trimesters, should avoid it due to potential harm to the unborn baby. It's also not recommended for people with low blood pressure or those who have experienced angioedema, which is swelling under the skin, often around the eyes and lips. Always consult a healthcare provider before starting or stopping any medication.
Who should avoid taking combination of Telmisartan and Hydrochlorothiazide?
Important warnings for Telmisartan and Hydrochlorothiazide include the risk of fetal toxicity if taken during pregnancy, particularly in the second and third trimesters. Patients with severe kidney or liver impairment should use these medications cautiously. Hydrochlorothiazide may cause electrolyte imbalances, while Telmisartan can lead to hypotension, especially in volume-depleted patients. Both medications can cause allergic reactions, and patients should avoid unnecessary sun exposure due to increased skin sensitivity. Regular monitoring and consultation with a healthcare provider are crucial to manage these risks.
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