Hydrochlorothiazide + Quinapril
Find more information about this combination medication at the webpages for Quinapril and Hydrochlorothiazide
Hypertension, Left Ventricular Dysfunction ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Quinapril.
- Hydrochlorothiazide and Quinapril are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin Converting Enzyme Inhibitor and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Hydrochlorothiazide and Quinapril are mainly used to treat high blood pressure, also known as hypertension. Hydrochlorothiazide also helps with fluid retention (edema) related to heart, kidney, or liver disease. Quinapril is also used to manage heart failure.
Hydrochlorothiazide helps reduce fluid retention by increasing urine output. Quinapril relaxes blood vessels by blocking a hormone that narrows them. Together, they effectively lower blood pressure.
Typically, Hydrochlorothiazide is taken at 12.5 to 50 mg per day, and Quinapril at 10 to 80 mg per day. They are often combined in a single tablet, usually taken once a day.
Common side effects include frequent urination, dizziness, cough, fatigue, and electrolyte imbalances. More serious side effects can include severe allergic reactions, kidney dysfunction, and changes in blood pressure.
Quinapril should not be used during pregnancy. Both medications can cause severe allergic reactions. Patients with kidney or liver disease should use these medications with caution. Regular monitoring of blood pressure, kidney function, and electrolytes is essential.
Indications and Purpose
How does combination of Hydrochlorothiazide and Quinapril work?
Hydrochlorothiazide works by increasing the excretion of sodium and water through the kidneys, which helps reduce fluid retention and lower blood pressure. Quinapril, on the other hand, inhibits the angiotensin-converting enzyme (ACE), which decreases the production of angiotensin II, a substance that narrows blood vessels. This action helps relax and widen blood vessels, improving blood flow and reducing blood pressure. Together, these medications complement each other by addressing different mechanisms that contribute to high blood pressure, providing a more comprehensive treatment approach.
How effective is combination of Hydrochlorothiazide and Quinapril?
The effectiveness of Hydrochlorothiazide and Quinapril in treating high blood pressure is supported by clinical trials and extensive use in medical practice. Hydrochlorothiazide has been shown to effectively reduce fluid retention and lower blood pressure by promoting diuresis. Quinapril has demonstrated efficacy in lowering blood pressure and improving heart function by inhibiting the ACE enzyme, which reduces vasoconstriction. Together, they provide a synergistic effect, enhancing blood pressure control and reducing cardiovascular risks. The combination therapy is particularly beneficial for patients who require multiple mechanisms of action to achieve optimal blood pressure management.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Quinapril?
The usual adult dose for Hydrochlorothiazide when used alone is typically 12.5 to 50 mg per day, depending on the condition being treated. Quinapril is usually prescribed in doses ranging from 10 to 80 mg per day, often starting at a lower dose and gradually increasing. When combined in a single tablet, the typical doses are 10 mg of Quinapril with 12.5 mg of Hydrochlorothiazide, or 20 mg of Quinapril with 12.5 or 25 mg of Hydrochlorothiazide. The combination is designed to enhance blood pressure control by utilizing the diuretic effect of Hydrochlorothiazide and the vasodilatory effect of Quinapril.
How does one take combination of Hydrochlorothiazide and Quinapril?
Hydrochlorothiazide and Quinapril can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. Patients are advised to follow any dietary recommendations from their doctor, such as a low-salt or low-sodium diet, and to avoid potassium supplements or salt substitutes containing potassium without consulting their healthcare provider. It's also important to stay hydrated, especially in hot weather or when exercising, to prevent dehydration. Alcohol should be consumed in moderation as it can enhance side effects like dizziness.
For how long is combination of Hydrochlorothiazide and Quinapril taken?
Hydrochlorothiazide and Quinapril are typically used as long-term treatments for managing high blood pressure and heart failure. While Hydrochlorothiazide can be used on a daily basis or on specific days to manage fluid retention, Quinapril is usually taken daily to maintain consistent blood pressure control. Both medications are intended for ongoing use, even if the patient feels well, as they manage symptoms but do not cure the underlying conditions. Regular monitoring by a healthcare provider is essential to ensure effectiveness and adjust dosages as needed.
How long does it take for combination of Hydrochlorothiazide and Quinapril to work?
Hydrochlorothiazide, a diuretic, typically begins to work within 2 hours of ingestion, with its effects peaking around 4 hours and lasting up to 12 hours. Quinapril, an ACE inhibitor, starts to lower blood pressure within 1 hour, with peak effects usually occurring between 2 to 4 hours after dosing. When combined, the onset of action for the combination of Hydrochlorothiazide and Quinapril is expected to be within a similar timeframe, providing a synergistic effect in reducing blood pressure. Both medications work together to enhance the antihypertensive effect, with Hydrochlorothiazide reducing fluid retention and Quinapril relaxing blood vessels.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Quinapril?
Common side effects of Hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances such as low potassium levels. Quinapril may cause dizziness, cough, and fatigue. Both medications can lead to more serious side effects like severe allergic reactions, including angioedema, which involves swelling of the face, lips, or throat. Other significant adverse effects include kidney dysfunction and changes in blood pressure. Patients should be monitored for signs of dehydration and electrolyte disturbances, and any severe or persistent side effects should be reported to a healthcare provider immediately.
Can I take combination of Hydrochlorothiazide and Quinapril with other prescription drugs?
Hydrochlorothiazide and Quinapril can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can reduce the effectiveness of both medications. Quinapril should not be taken with other ACE inhibitors or angiotensin receptor blockers due to the risk of increased side effects. Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity. Both medications can interact with other blood pressure medications, potentially leading to excessive lowering of blood pressure. Patients should inform their healthcare provider of all medications they are taking to avoid harmful interactions.
Can I take combination of Hydrochlorothiazide and Quinapril if I am pregnant?
Hydrochlorothiazide and Quinapril are generally not recommended during pregnancy. Quinapril, an ACE inhibitor, is particularly contraindicated as it can cause injury and even death to the developing fetus, especially during the second and third trimesters. Hydrochlorothiazide may also pose risks, such as affecting fetal electrolyte balance. If a patient becomes pregnant while taking these medications, they should contact their healthcare provider immediately to discuss alternative treatments. The potential risks to the fetus must be weighed against the benefits of controlling maternal blood pressure.
Can I take combination of Hydrochlorothiazide and Quinapril while breastfeeding?
Hydrochlorothiazide and Quinapril are both excreted in human milk, and caution is advised when administering these medications to breastfeeding mothers. Hydrochlorothiazide may reduce milk production, especially at higher doses, and could potentially affect the nursing infant. Quinapril's effects on a breastfeeding infant are not well-studied, but due to the potential for serious adverse reactions, a decision should be made to either discontinue the medication or stop breastfeeding. Mothers should discuss the risks and benefits with their healthcare provider to make an informed decision.
Who should avoid taking combination of Hydrochlorothiazide and Quinapril?
Hydrochlorothiazide and Quinapril have several important warnings and contraindications. Quinapril should not be used during pregnancy due to the risk of fetal harm. Both medications can cause severe allergic reactions, including angioedema. Patients with a history of angioedema related to ACE inhibitors should avoid Quinapril. Hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs. Both medications require caution in patients with kidney or liver disease, and regular monitoring of blood pressure, kidney function, and electrolytes is essential to prevent adverse effects.
