Hydrochlorothiazide + Irbesartan
Find more information about this combination medication at the webpages for Irbesartan and Hydrochlorothiazide
Hypertension
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Advisory
- This medicine contains a combination of 2 drugs Hydrochlorothiazide and Irbesartan.
- Hydrochlorothiazide and Irbesartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Hydrochlorothiazide + Irbesartan
Summary
Hydrochlorothiazide and Irbesartan are primarily used to treat high blood pressure, which is also known as hypertension. High blood pressure is a condition where the force of the blood against the artery walls is too high, which can lead to heart disease, stroke, and kidney problems if not managed. Irbesartan is also used to treat kidney disease in patients with type 2 diabetes and high blood pressure. Hydrochlorothiazide can also help manage edema, which is fluid retention associated with heart, kidney, or liver disease. Together, these medications provide a comprehensive approach to managing hypertension and related conditions by addressing both blood vessel constriction and fluid retention.
Irbesartan works by blocking the action of angiotensin II, which is a substance that tightens blood vessels. By blocking this action, Irbesartan helps relax blood vessels, allowing blood to flow more easily and lowering blood pressure. Hydrochlorothiazide is a diuretic, which means it helps the kidneys remove excess fluid and salt from the body through urine. This reduces blood volume and pressure. Together, these medications effectively manage high blood pressure by addressing both the resistance in blood vessels and the amount of fluid in the body.
The usual adult daily dose for Irbesartan is typically between 150 mg to 300 mg, taken once daily. For Hydrochlorothiazide, the usual dose ranges from 12.5 mg to 25 mg per day. When these medications are combined, the starting dose is often 150 mg of Irbesartan and 12.5 mg of Hydrochlorothiazide, taken once daily. The dose can be adjusted based on the patient's response and needs. These medications are taken orally, which means they are swallowed as a pill. It is important to take them at the same time each day to maintain consistent blood levels.
Common side effects of taking Hydrochlorothiazide and Irbesartan include dizziness, fatigue, and nausea. Hydrochlorothiazide may cause increased urination, as it helps remove excess fluid from the body. Irbesartan can lead to diarrhea and heartburn. Some people may experience electrolyte imbalances, which means there are changes in the levels of minerals like potassium in the blood. Allergic reactions, such as swelling of the face or difficulty breathing, are rare but serious. If you experience any severe or persistent side effects, it is important to contact your healthcare provider.
Hydrochlorothiazide and Irbesartan should not be used during pregnancy, especially in the second and third trimesters, due to the risk of harm to the fetus. Patients with severe kidney impairment or anuria, which means the inability to produce urine, should avoid this medication. Caution is advised for those with electrolyte imbalances, liver disease, or a history of allergic reactions to sulfa drugs. Patients should be aware of the potential for dizziness and lightheadedness, especially when standing up quickly, and should avoid activities requiring alertness until they know how the medication affects them. It is also important to avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor, as these can interact with the medication.
Indications and Purpose
How does combination of Hydrochlorothiazide and Irbesartan work?
The combination of Hydrochlorothiazide and Irbesartan is used to treat high blood pressure. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps your body get rid of extra salt and water by increasing urine production. This helps to lower blood pressure and reduce swelling. Irbesartan is an angiotensin receptor blocker (ARB) that relaxes blood vessels by blocking the action of a natural substance that tightens them. Together, these medications help to lower blood pressure more effectively than either would alone, reducing the risk of heart attacks and strokes.
How does combination of Irbesartan and Hydrochlorothiazide work?
Irbesartan and Hydrochlorothiazide work together to lower blood pressure through complementary mechanisms. Irbesartan is an angiotensin II receptor antagonist that blocks the action of substances that tighten blood vessels, leading to relaxed blood vessels and improved blood flow. Hydrochlorothiazide is a diuretic that helps the kidneys remove excess fluid and salt from the body, reducing blood volume and pressure. Together, they effectively manage hypertension by addressing both vascular resistance and fluid retention.
How effective is combination of Hydrochlorothiazide and Irbesartan?
The combination of Hydrochlorothiazide and Irbesartan is used to treat high blood pressure (hypertension). Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water by increasing urine production. Irbesartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, making it easier for the heart to pump blood. According to the NHS, this combination is effective in lowering blood pressure, which can help prevent strokes, heart attacks, and kidney problems. The combination works better than either drug alone because it targets different mechanisms that contribute to high blood pressure. The NLM also notes that this combination is generally well-tolerated, but like all medications, it may have side effects. Common side effects include dizziness, lightheadedness, or dehydration, especially when starting the medication or increasing the dose. Overall, the combination of Hydrochlorothiazide and Irbesartan is considered effective for managing high blood pressure, but it is important to follow a healthcare provider's instructions and have regular check-ups to monitor its effectiveness and any potential side effects.
How effective is combination of Irbesartan and Hydrochlorothiazide?
Clinical trials have demonstrated that Irbesartan and Hydrochlorothiazide effectively lower blood pressure in patients with hypertension. Irbesartan, as an angiotensin II receptor antagonist, has been shown to improve blood flow by relaxing blood vessels. Hydrochlorothiazide, a diuretic, reduces fluid retention, further aiding in blood pressure reduction. Studies indicate that the combination of these two medications provides a greater antihypertensive effect than either drug alone, making it a valuable treatment option for patients requiring multiple mechanisms of action to control their blood pressure.
Directions for Use
What is the usual dose of combination of Hydrochlorothiazide and Irbesartan?
The usual dose of the combination of Hydrochlorothiazide and Irbesartan can vary depending on the specific needs of the patient, but a common starting dose is 150 mg of Irbesartan and 12.5 mg of Hydrochlorothiazide once daily. This combination is used to help lower blood pressure. Hydrochlorothiazide is a diuretic, which helps the body get rid of excess salt and water, while Irbesartan is an angiotensin receptor blocker that helps relax blood vessels. It's important to follow a healthcare provider's instructions for the correct dosage.
What is the usual dose of combination of Irbesartan and Hydrochlorothiazide?
The usual adult daily dose for Irbesartan is typically 150 mg to 300 mg, taken once daily. For Hydrochlorothiazide, the usual dose ranges from 12.5 mg to 25 mg per day. When combined, the starting dose of Irbesartan and Hydrochlorothiazide is often 150 mg/12.5 mg once daily, which can be adjusted based on the patient's response and needs. Both medications work together to effectively manage high blood pressure, with Irbesartan relaxing blood vessels and Hydrochlorothiazide reducing fluid retention.
How does one take combination of Hydrochlorothiazide and Irbesartan?
Hydrochlorothiazide and Irbesartan are medications often combined to treat high blood pressure. Hydrochlorothiazide is a diuretic, which helps your body get rid of extra salt and water, while Irbesartan is an angiotensin receptor blocker that helps relax blood vessels. To take this combination, follow your doctor's prescription carefully. Typically, it is taken once a day, with or without food. It's important to take it at the same time each day to maintain an even level in your bloodstream. Swallow the tablet whole with a glass of water. Do not stop taking the medication suddenly without consulting your doctor, as this can cause your blood pressure to rise. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Never double up to make up for a missed dose. Always consult your healthcare provider for personalized advice, especially if you have other health conditions or are taking other medications.
How does one take combination of Irbesartan and Hydrochlorothiazide?
Irbesartan and Hydrochlorothiazide can be taken with or without food, but it is important to take it at the same time each day to maintain consistent blood levels. Patients should follow any dietary recommendations provided by their healthcare provider, such as a low-salt diet, to enhance the medication's effectiveness. It is also advised to avoid potassium supplements or salt substitutes containing potassium unless directed by a doctor, as these can interact with the medication.
For how long is combination of Hydrochlorothiazide and Irbesartan taken?
The combination of Hydrochlorothiazide and Irbesartan is typically taken as a long-term treatment. This medication is used to manage high blood pressure, and it is usually taken daily. The duration of treatment can vary depending on individual health needs and how well the blood pressure is controlled. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as high blood pressure often requires ongoing management.
For how long is combination of Irbesartan and Hydrochlorothiazide taken?
Irbesartan and Hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. Both medications are intended for continuous use to maintain blood pressure control and prevent complications such as heart disease and stroke. Patients are advised to continue taking the medication even if they feel well, as it helps manage blood pressure over time. Regular monitoring by a healthcare provider is essential to ensure the treatment remains effective and to adjust dosages if necessary.
How long does it take for combination of Hydrochlorothiazide and Irbesartan to work?
The combination of Hydrochlorothiazide and Irbesartan typically starts to work within a few hours after taking the first dose. However, it may take several weeks to see the full effect on blood pressure. Hydrochlorothiazide is a diuretic, which helps reduce fluid retention, and Irbesartan is an angiotensin receptor blocker, which helps relax blood vessels. Together, they help lower blood pressure more effectively. It's important to continue taking the medication as prescribed and consult with a healthcare provider for personalized advice.
How long does it take for combination of Irbesartan and Hydrochlorothiazide to work?
Irbesartan and Hydrochlorothiazide combination medicine typically starts working within a few hours after taking the first dose. Irbesartan, an angiotensin II receptor antagonist, begins to lower blood pressure by relaxing blood vessels, allowing blood to flow more easily. Hydrochlorothiazide, a diuretic, helps reduce fluid retention by increasing urine output, which also contributes to lowering blood pressure. While the initial effects can be seen quickly, it may take up to two weeks to notice the full benefits of the medication as the body adjusts to the treatment.
Warnings and Precautions
Are there harms and risks from taking combination of Hydrochlorothiazide and Irbesartan?
Hydrochlorothiazide and Irbesartan are medications often used together to treat high blood pressure. While they can be effective, there are potential risks and side effects to be aware of. Hydrochlorothiazide is a diuretic, which means it helps your body get rid of excess salt and water by making you urinate more. This can lead to dehydration, low blood pressure, and an imbalance of electrolytes like potassium and sodium. Irbesartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, lowering blood pressure. It can cause side effects such as dizziness, fatigue, and in rare cases, kidney problems. When taken together, these medications can increase the risk of low blood pressure, especially when standing up quickly, and can affect kidney function. It's important to have regular check-ups with your healthcare provider to monitor your blood pressure, kidney function, and electrolyte levels. Always consult with a healthcare professional before starting or stopping any medication.
Are there harms and risks from taking combination of Irbesartan and Hydrochlorothiazide?
Common side effects of Irbesartan and Hydrochlorothiazide include dizziness, fatigue, and nausea. Hydrochlorothiazide may cause increased urination, while Irbesartan can lead to diarrhea and heartburn. Significant adverse effects may include electrolyte imbalances, such as low potassium levels, and allergic reactions like swelling of the face or difficulty breathing. Patients should report any severe or persistent side effects to their healthcare provider for further evaluation and management.
Can I take combination of Hydrochlorothiazide and Irbesartan with other prescription drugs?
Hydrochlorothiazide and Irbesartan are medications often used together to manage high blood pressure. However, combining them with other prescription drugs can sometimes lead to interactions. It's important to consult with a healthcare provider before adding any new medications. According to the NHS, some drugs can affect how Hydrochlorothiazide and Irbesartan work or increase the risk of side effects. For example, taking them with other blood pressure medications can lower your blood pressure too much. The NLM advises that non-steroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, can reduce the effectiveness of Hydrochlorothiazide and Irbesartan. Additionally, potassium supplements or potassium-sparing diuretics should be used cautiously, as they can increase potassium levels in the blood, which can be dangerous. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to ensure safe and effective treatment.
Can I take combination of Irbesartan and Hydrochlorothiazide with other prescription drugs?
Irbesartan and Hydrochlorothiazide can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of both medications. Combining with other blood pressure medications can increase the risk of low blood pressure. Irbesartan should not be used with aliskiren in patients with diabetes due to increased risk of kidney problems. Hydrochlorothiazide can interact with lithium, increasing the risk of lithium toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions.
Can I take combination of Hydrochlorothiazide and Irbesartan if I am pregnant?
No, you should not take a combination of Hydrochlorothiazide and Irbesartan if you are pregnant. According to the NHS and other trusted sources, Irbesartan, which is an angiotensin receptor blocker (ARB), can harm an unborn baby, especially if taken during the second and third trimesters of pregnancy. Hydrochlorothiazide, a diuretic, is also generally not recommended during pregnancy as it can affect the balance of fluids and electrolytes in your body, which is crucial during pregnancy. Always consult your healthcare provider for advice on managing your condition during pregnancy.
Can I take combination of Irbesartan and Hydrochlorothiazide if I am pregnant?
Irbesartan and Hydrochlorothiazide are not recommended during pregnancy, particularly in the second and third trimesters, due to the risk of fetal harm. Irbesartan can cause injury or death to the developing fetus by affecting kidney function and blood pressure regulation. Hydrochlorothiazide may lead to electrolyte imbalances and reduced placental blood flow. Women who are pregnant or planning to become pregnant should discuss alternative treatments with their healthcare provider to ensure the safety of both mother and child.
Can I take combination of Hydrochlorothiazide and Irbesartan while breastfeeding?
According to the NHS, Hydrochlorothiazide is generally considered safe to use while breastfeeding, as it passes into breast milk in very small amounts and is unlikely to affect the baby. However, it is always best to consult with a healthcare provider before taking any medication while breastfeeding. Irbesartan, on the other hand, is not recommended during breastfeeding. The NLM states that there is limited information on the use of Irbesartan while breastfeeding, and it may pose risks to the infant. Therefore, it is important to discuss with your doctor whether the benefits of taking Irbesartan outweigh the potential risks to your baby. In summary, while Hydrochlorothiazide might be safe, Irbesartan is generally not recommended for breastfeeding mothers. Always consult your healthcare provider for personalized advice.
Can I take combination of Irbesartan and Hydrochlorothiazide while breastfeeding?
There is limited information on the safety of Irbesartan and Hydrochlorothiazide during lactation. Hydrochlorothiazide is known to be excreted in breast milk in small amounts, and high doses can reduce milk production. The effects of Irbesartan on breastfed infants are not well-studied, so caution is advised. It is generally recommended to avoid this combination during breastfeeding or to use it only if the potential benefits outweigh the risks. Alternative medications with established safety profiles during lactation may be preferred.
Who should avoid taking combination of Hydrochlorothiazide and Irbesartan?
People who should avoid taking the combination of Hydrochlorothiazide and Irbesartan include those who are allergic to either of these medications or any of their ingredients. Additionally, individuals with severe kidney or liver problems, those who are pregnant or planning to become pregnant, and people with low blood pressure should avoid this combination. It's also important for individuals with diabetes who are taking aliskiren, a medication used to treat high blood pressure, to avoid this combination. Always consult a healthcare professional before starting or stopping any medication.
Who should avoid taking combination of Irbesartan and Hydrochlorothiazide?
Irbesartan and Hydrochlorothiazide should not be used during pregnancy, especially in the second and third trimesters, due to the risk of harm to the fetus. Patients with severe kidney impairment or anuria should avoid this medication. Caution is advised for those with electrolyte imbalances, liver disease, or a history of allergic reactions to sulfa drugs. Patients should be aware of the potential for dizziness and lightheadedness, especially when standing up quickly, and should avoid activities requiring alertness until they know how the medication affects them.
