Hydralazine + Hydrochlorothiazide
Find more information about this combination medication at the webpages for Hydralazine and Hydrochlorothiazide
Hypertension, Pulmonary Hypertension ... show more
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Advisory
- This medicine contains a combination of 2 drugs Hydralazine and Hydrochlorothiazide.
- Hydralazine and Hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Arteriolar Vasodilator and Thiazide Diuretic
Controlled Drug Substance
NO
Hydralazine + Hydrochlorothiazide
Summary
Hydralazine and Hydrochlorothiazide are primarily used for treating high blood pressure, also known as hypertension. Hydralazine is also used in managing heart failure and after heart valve replacement. Hydrochlorothiazide is used to treat fluid build-up, or edema, associated with heart, kidney, and liver diseases, as well as edema caused by certain medications.
Hydralazine works by relaxing the smooth muscles of blood vessels, leading to easier blood flow. Hydrochlorothiazide is a diuretic, meaning it helps the body eliminate excess salt and water through urine. Together, they lower blood pressure by reducing resistance in blood vessels and reducing fluid volume.
The usual adult dose for Hydralazine starts at 10 mg four times daily, which can be increased based on response. For Hydrochlorothiazide, the typical adult dose for hypertension is 25 mg daily, which can be increased if needed. Both medications are taken orally.
Common side effects of Hydralazine include flushing, headache, upset stomach, and vomiting. Hydrochlorothiazide may cause frequent urination, diarrhea, and headache. Both medications can cause dizziness and lightheadedness. Serious side effects include rapid heartbeat, chest pain, and severe allergic reactions.
Hydralazine is not recommended for patients with coronary artery disease and mitral valvular rheumatic heart disease. Hydrochlorothiazide is not recommended for patients with anuria and hypersensitivity to sulfonamides. Both medications require caution in patients with kidney or liver impairment.
Indications and Purpose
How does combination of Hydralazine and Hydrochlorothiazide work?
Hydralazine works by directly relaxing the smooth muscles of blood vessels, leading to vasodilation and reduced blood pressure. It primarily affects arterioles, which helps decrease peripheral resistance and increase cardiac output. Hydrochlorothiazide acts as a diuretic, promoting the excretion of sodium and water through the kidneys, which reduces blood volume and pressure. Together, they provide a dual approach to managing hypertension by addressing both vascular resistance and fluid retention.
How effective is combination of Hydralazine and Hydrochlorothiazide?
Hydralazine's effectiveness is supported by its ability to lower blood pressure through vasodilation, as evidenced by its rapid absorption and action on vascular smooth muscle. Hydrochlorothiazide's efficacy is demonstrated by its diuretic action, reducing fluid volume and blood pressure. Clinical studies and long-term use have shown that both medications effectively manage hypertension, either alone or in combination. Their complementary mechanisms provide a comprehensive approach to blood pressure control, reducing the risk of cardiovascular complications.
Directions for Use
What is the usual dose of combination of Hydralazine and Hydrochlorothiazide?
For hydralazine, the usual adult dose starts at 10 mg four times daily, which can be increased to 25 mg four times daily, and further adjusted to 50 mg four times daily based on response. For hydrochlorothiazide, the typical adult dose for hypertension is 25 mg daily, which can be increased to 50 mg daily if needed. Both medications are adjusted based on individual response and are often used in combination to enhance blood pressure control. It's important to follow the prescribed dosage and consult a healthcare provider for any adjustments.
How does one take combination of Hydralazine and Hydrochlorothiazide?
Hydralazine should be taken with meals or a snack to enhance absorption and reduce stomach upset. Hydrochlorothiazide can be taken with or without food, but taking it with food may help reduce stomach irritation. Patients are often advised to follow a low-salt diet to enhance the effectiveness of both medications. It's important to take these medications at the same time each day and not to skip doses. Alcohol should be used in moderation as it can exacerbate side effects.
For how long is combination of Hydralazine and Hydrochlorothiazide taken?
Hydralazine and hydrochlorothiazide are typically used as long-term treatments for managing high blood pressure. They do not cure hypertension but help control it, requiring continuous use even if symptoms improve. The duration of use is determined by a healthcare provider based on individual patient needs and response to treatment. Regular monitoring and adjustments may be necessary to maintain optimal blood pressure levels.
How long does it take for combination of Hydralazine and Hydrochlorothiazide to work?
Hydralazine typically starts working within 1 to 2 hours after oral administration, with peak plasma levels reached during this time. Hydrochlorothiazide begins its diuretic effect within 2 hours, peaks around 4 hours, and lasts about 6 to 12 hours. Both medications work relatively quickly to manage high blood pressure, with hydralazine focusing on vasodilation and hydrochlorothiazide on diuresis. The combination of these two drugs can provide a comprehensive approach to lowering blood pressure by both relaxing blood vessels and reducing fluid volume.
Warnings and Precautions
Are there harms and risks from taking combination of Hydralazine and Hydrochlorothiazide?
Common side effects of hydralazine include flushing, headache, upset stomach, and vomiting. Hydrochlorothiazide may cause frequent urination, diarrhea, and headache. Both medications can lead to dizziness and lightheadedness, especially when standing up quickly. Serious side effects include rapid heartbeat, chest pain, and severe allergic reactions. It's important to report any persistent or severe side effects to a healthcare provider. Monitoring for side effects is crucial to ensure safe and effective use of these medications.
Can I take combination of Hydralazine and Hydrochlorothiazide with other prescription drugs?
Hydralazine can interact with other antihypertensive drugs, potentially leading to an excessive drop in blood pressure. It should be used cautiously with MAO inhibitors. Hydrochlorothiazide may interact with non-steroidal anti-inflammatory drugs (NSAIDs), reducing its effectiveness. It can also increase the risk of lithium toxicity. Both medications require careful monitoring when used with other drugs to avoid adverse interactions and ensure effective blood pressure management.
Can I take combination of Hydralazine and Hydrochlorothiazide if I am pregnant?
Hydralazine should be used during pregnancy only if the benefits outweigh the risks, as animal studies have shown potential teratogenic effects at high doses. Hydrochlorothiazide crosses the placenta and may cause fetal or neonatal jaundice and other adverse effects. Both medications should be used with caution during pregnancy, and only if clearly needed. It's important to discuss potential risks and benefits with a healthcare provider to ensure the safety of both mother and child.
Can I take combination of Hydralazine and Hydrochlorothiazide while breastfeeding?
Hydralazine is excreted in breast milk, and its effects on nursing infants are not well-studied, so caution is advised. Hydrochlorothiazide is also excreted in breast milk and may cause adverse effects in nursing infants, such as electrolyte imbalances. The decision to use these medications during breastfeeding should consider the benefits to the mother and potential risks to the infant. Consulting a healthcare provider is crucial to determine the best course of action.
Who should avoid taking combination of Hydralazine and Hydrochlorothiazide?
Hydralazine is contraindicated in patients with coronary artery disease and mitral valvular rheumatic heart disease. It may cause a lupus-like syndrome in some patients. Hydrochlorothiazide is contraindicated in anuria and hypersensitivity to sulfonamides. Both medications require caution in patients with renal or hepatic impairment. Patients should be aware of potential side effects like dizziness and should avoid activities requiring alertness until they know how the medications affect them. Regular monitoring and communication with healthcare providers are essential.
