Fexofenadine + Montelukast

Find more information about this combination medication at the webpages for montelukast and fexofenadine

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Brand Name

Fixar 10mg/120mg Tablet 10s , Fexonix-M Tablet 10s ... show more

Approved Treatment Indication:

Perennial Allergic Rhinitis, Asthma ... show more

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This medicine contains a combination of 2 drugs fexofenadine and montelukast.
fexofenadine and montelukast are both used to treat the same disease or symptom but work in different ways in the body.
Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.

Summary

What conditions are Fexofenadine and Montelukast used for?
Fexofenadine is used to relieve symptoms of seasonal allergic rhinitis, which is a type of allergy that causes symptoms like a runny nose and itchy eyes, and chronic idiopathic urticaria, which means long-term hives with no known cause. Montelukast is used for the prevention and long-term treatment of asthma, which is a condition that causes wheezing and difficulty breathing, and for the relief of symptoms of seasonal and perennial allergic rhinitis, which are allergies that occur at certain times of the year or all year round.
How do Fexofenadine and Montelukast work in the body?
Fexofenadine works as an antihistamine, which means it blocks histamine receptors in the body. Histamines are chemicals that cause allergy symptoms like sneezing and itching. By blocking these receptors, fexofenadine helps reduce these symptoms. Montelukast works by blocking leukotriene receptors, which are involved in the inflammatory process of asthma and allergic rhinitis. Leukotrienes are substances in the body that cause allergy symptoms, so by blocking them, montelukast helps reduce symptoms like wheezing and nasal congestion.
What are the usual dosages and routes of administration for Fexofenadine and Montelukast?
Fexofenadine is usually taken orally, which means by mouth, with a common adult dose of 180 mg once daily or 60 mg twice daily, depending on the severity of symptoms. Montelukast is also taken orally, with the usual adult daily dose being 10 mg, typically taken in the evening. Both medications should be taken at the same time each day to maintain consistent levels in the body, and fexofenadine should be taken with water, not fruit juices, to ensure proper absorption.
What are the most commonly observed adverse effects of Fexofenadine and Montelukast?
Common side effects of fexofenadine include headache, dizziness, and nausea. Montelukast may cause headache, stomach pain, and tiredness. Both medications share some common side effects like headache and dizziness. However, montelukast has unique warnings related to mental health changes, such as agitation and depression, which are serious side effects that should be reported to a healthcare provider.
What are the important safety warnings and contraindications of Fexofenadine and Montelukast?
Montelukast carries a warning for serious neuropsychiatric events, which means mental health changes like agitation and depression, and should be used with caution in patients with a history of mental health issues. Fexofenadine should not be used by individuals with known hypersensitivity, which means an allergic reaction, to the drug or its components. Both medications should be used cautiously in patients with liver or kidney impairment, and patients should discuss any concerns with their healthcare provider to ensure safe use.

Government Approvals

None

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Histamine-1 Receptor Antagonist and Leukotriene Receptor Antagonist

Controlled Drug Substance

Summary

What conditions are Fexofenadine and Montelukast used for?
Fexofenadine is used to relieve symptoms of seasonal allergic rhinitis, which is a type of allergy that causes symptoms like a runny nose and itchy eyes, and chronic idiopathic urticaria, which means long-term hives with no known cause. Montelukast is used for the prevention and long-term treatment of asthma, which is a condition that causes wheezing and difficulty breathing, and for the relief of symptoms of seasonal and perennial allergic rhinitis, which are allergies that occur at certain times of the year or all year round.
How do Fexofenadine and Montelukast work in the body?
Fexofenadine works as an antihistamine, which means it blocks histamine receptors in the body. Histamines are chemicals that cause allergy symptoms like sneezing and itching. By blocking these receptors, fexofenadine helps reduce these symptoms. Montelukast works by blocking leukotriene receptors, which are involved in the inflammatory process of asthma and allergic rhinitis. Leukotrienes are substances in the body that cause allergy symptoms, so by blocking them, montelukast helps reduce symptoms like wheezing and nasal congestion.
What are the usual dosages and routes of administration for Fexofenadine and Montelukast?
Fexofenadine is usually taken orally, which means by mouth, with a common adult dose of 180 mg once daily or 60 mg twice daily, depending on the severity of symptoms. Montelukast is also taken orally, with the usual adult daily dose being 10 mg, typically taken in the evening. Both medications should be taken at the same time each day to maintain consistent levels in the body, and fexofenadine should be taken with water, not fruit juices, to ensure proper absorption.
What are the most commonly observed adverse effects of Fexofenadine and Montelukast?
Common side effects of fexofenadine include headache, dizziness, and nausea. Montelukast may cause headache, stomach pain, and tiredness. Both medications share some common side effects like headache and dizziness. However, montelukast has unique warnings related to mental health changes, such as agitation and depression, which are serious side effects that should be reported to a healthcare provider.
What are the important safety warnings and contraindications of Fexofenadine and Montelukast?
Montelukast carries a warning for serious neuropsychiatric events, which means mental health changes like agitation and depression, and should be used with caution in patients with a history of mental health issues. Fexofenadine should not be used by individuals with known hypersensitivity, which means an allergic reaction, to the drug or its components. Both medications should be used cautiously in patients with liver or kidney impairment, and patients should discuss any concerns with their healthcare provider to ensure safe use.

Indications and Purpose

How does combination of Fexofenadine and Montelukast work?

The combination of Fexofenadine and Montelukast works by addressing different aspects of allergic reactions and asthma. Fexofenadine is an antihistamine, which means it helps reduce the effects of histamine, a substance in the body that causes allergy symptoms like sneezing, itching, and runny nose. By blocking histamine, Fexofenadine helps alleviate these symptoms. Montelukast, on the other hand, is a leukotriene receptor antagonist. Leukotrienes are chemicals in the body that contribute to inflammation, especially in the airways, leading to asthma symptoms. Montelukast helps prevent asthma attacks and also reduces symptoms of allergic rhinitis by blocking the action of leukotrienes. Together, these medications provide a more comprehensive approach to managing symptoms of allergies and asthma by targeting both histamine and leukotrienes.

How does combination of Montelukast and Fexofenadine work?

Montelukast works by blocking leukotriene receptors, which are involved in the inflammatory process of asthma and allergic rhinitis, thereby reducing symptoms like wheezing and nasal congestion. Fexofenadine acts as an antihistamine, blocking histamine receptors to alleviate symptoms such as sneezing, itching, and runny nose. Both medications target different pathways in the allergic response, providing a comprehensive approach to managing allergy symptoms. They do not cure the conditions but help control and reduce symptoms.

How effective is combination of Fexofenadine and Montelukast?

The combination of Fexofenadine and Montelukast is often used to manage symptoms of allergic rhinitis and asthma. Fexofenadine is an antihistamine that helps reduce allergy symptoms like sneezing, runny nose, and itching by blocking histamine, a substance in the body that causes allergic symptoms. Montelukast is a leukotriene receptor antagonist that helps prevent wheezing, difficulty breathing, and chest tightness by blocking leukotrienes, chemicals in the body that cause asthma and allergy symptoms. According to the NHS, combining these two medications can be more effective than using either one alone for some individuals, particularly those with both allergic rhinitis and asthma. However, the effectiveness can vary from person to person, and it's important to follow a healthcare provider's advice on using these medications together. For more detailed information, you can visit trusted sources like the NHS or NLM websites.

How effective is combination of Montelukast and Fexofenadine?

Clinical trials have demonstrated that montelukast effectively reduces asthma symptoms and improves lung function by blocking leukotriene receptors. Fexofenadine has been shown to significantly alleviate symptoms of allergic rhinitis and urticaria by blocking histamine receptors. Both medications have been proven to improve quality of life for patients with allergic conditions. Their effectiveness is supported by their ability to target specific pathways involved in allergic reactions, providing relief from symptoms and reducing the frequency of attacks.

Directions for Use

What is the usual dose of combination of Fexofenadine and Montelukast?

The usual dose for adults taking a combination of Fexofenadine and Montelukast is typically one tablet containing 180 mg of Fexofenadine and 10 mg of Montelukast once daily. This combination is often used to manage symptoms of allergic rhinitis and asthma. However, it's important to follow the specific dosing instructions provided by a healthcare professional or the medication's packaging, as individual needs may vary. Always consult with a healthcare provider before starting any new medication.

What is the usual dose of combination of Montelukast and Fexofenadine?

The usual adult daily dose for montelukast is 10 mg, typically taken in the evening. For fexofenadine, the common adult dose is 180 mg once daily or 60 mg twice daily, depending on the severity of symptoms. Montelukast is often used for chronic management of asthma and allergies, while fexofenadine is used for immediate relief of allergy symptoms. Both medications are taken orally and can be part of a daily regimen to manage allergic conditions.

How does one take combination of Fexofenadine and Montelukast?

Fexofenadine and Montelukast can be taken together to help manage symptoms of allergies and asthma. Fexofenadine is an antihistamine that helps reduce allergy symptoms like sneezing, runny nose, and itchy eyes. Montelukast is a leukotriene receptor antagonist that helps prevent wheezing, difficulty breathing, and chest tightness caused by asthma. When taking these medications together, it is important to follow the dosage instructions provided by your healthcare provider or as indicated on the medication packaging. Typically, Fexofenadine is taken once or twice a day, while Montelukast is usually taken once daily in the evening. Always take these medications with water and avoid taking them with fruit juices, as they can interfere with the absorption of Fexofenadine. If you have any questions or experience side effects, consult your healthcare provider for advice.

How does one take combination of Montelukast and Fexofenadine?

Montelukast can be taken with or without food, but it is recommended to take it in the evening for asthma management. Fexofenadine should be taken with water and not with fruit juices like orange, grapefruit, or apple juice, as these can affect its absorption. Both medications should be taken at the same time each day to maintain consistent levels in the body. Patients should follow their healthcare provider's instructions regarding food and drink restrictions to ensure optimal effectiveness.

For how long is combination of Fexofenadine and Montelukast taken?

The combination of Fexofenadine and Montelukast is typically taken for as long as symptoms persist or as directed by a healthcare provider. Fexofenadine is an antihistamine used to relieve allergy symptoms, while Montelukast is a leukotriene receptor antagonist that helps reduce inflammation and treat asthma or allergies. The duration of use can vary based on individual needs and the specific condition being treated. It's important to follow the guidance of a healthcare professional for the appropriate duration of use.

For how long is combination of Montelukast and Fexofenadine taken?

Montelukast is typically used as a long-term treatment for asthma and allergic rhinitis, and patients are advised to continue its use even when symptoms are controlled. Fexofenadine is used for the relief of allergy symptoms and can be taken as needed, but it is often used daily during allergy seasons or as prescribed by a doctor. Both medications can be part of a long-term management plan for allergies, but montelukast is more focused on chronic management, while fexofenadine provides immediate symptom relief.

How long does it take for combination of Fexofenadine and Montelukast to work?

Fexofenadine is an antihistamine that typically starts to work within one hour of taking it, helping to relieve allergy symptoms like sneezing and runny nose. Montelukast is a leukotriene receptor antagonist, which means it blocks substances in the body that cause allergy and asthma symptoms. It may take a few days to see the full effects of Montelukast, especially for asthma control. When taken together, you might start to feel some relief from allergy symptoms within a few hours, but it could take a few days to experience the full benefits, especially for asthma-related symptoms. Always follow your healthcare provider's instructions for the best results.

How long does it take for combination of Montelukast and Fexofenadine to work?

Montelukast typically starts working within a day, as it is used for long-term management of asthma and allergies. It is not intended for immediate relief of symptoms. Fexofenadine, on the other hand, begins to relieve allergy symptoms within an hour of ingestion, providing quick relief from symptoms like runny nose and itchy eyes. Both medications work by targeting different pathways involved in allergic reactions, with montelukast blocking leukotrienes and fexofenadine blocking histamines.

Warnings and Precautions

Are there harms and risks from taking combination of Fexofenadine and Montelukast?

Fexofenadine is an antihistamine used to relieve allergy symptoms, while Montelukast is a medication that helps prevent asthma attacks and treats allergies. According to the NHS and other trusted sources, there are no known harmful interactions between Fexofenadine and Montelukast when taken together. However, as with any medication, it's important to follow your healthcare provider's instructions and report any unusual symptoms or side effects. Always consult with a healthcare professional before starting or combining medications.

Are there harms and risks from taking combination of Montelukast and Fexofenadine?

Common side effects of montelukast include headache, stomach pain, and tiredness, while serious side effects can include neuropsychiatric events like agitation and depression. Fexofenadine may cause headache, dizziness, and nausea, with serious side effects including allergic reactions like hives and difficulty breathing. Both medications share common side effects like headache and dizziness, but montelukast has unique warnings related to mental health changes. Patients should report any severe or unusual symptoms to their healthcare provider.

Can I take combination of Fexofenadine and Montelukast with other prescription drugs?

Fexofenadine is an antihistamine used to relieve allergy symptoms, and Montelukast is a medication that helps prevent asthma attacks and manage allergies. When considering taking these medications with other prescription drugs, it's important to be aware of potential interactions. According to the NHS, Fexofenadine generally has a low risk of interacting with other medications, but it's always best to check with a healthcare provider. Montelukast also has a low potential for interactions, but certain medications might affect how it works. The NLM advises that you should inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to avoid any harmful interactions. In summary, while Fexofenadine and Montelukast can often be taken with other medications, it's crucial to consult with a healthcare professional to ensure safety and effectiveness.

Can I take combination of Montelukast and Fexofenadine with other prescription drugs?

Montelukast may interact with medications like phenobarbital and rifampin, which can affect its metabolism. Fexofenadine can interact with erythromycin and ketoconazole, increasing its plasma levels. Both medications should be used cautiously with other drugs that affect liver enzymes. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions. Monitoring by a healthcare provider can help manage any interactions and ensure the safe use of these medications.

Can I take combination of Fexofenadine and Montelukast if I am pregnant?

If you are pregnant, it is important to consult your healthcare provider before taking any medication, including Fexofenadine and Montelukast. Fexofenadine is an antihistamine used to relieve allergy symptoms. According to the NHS, it is generally advised to avoid taking antihistamines during pregnancy unless prescribed by a doctor. Montelukast is a medication used to prevent asthma symptoms and treat allergies. The NHS advises that Montelukast should only be used during pregnancy if the potential benefits justify the potential risks to the fetus. Always discuss with your healthcare provider to understand the risks and benefits of taking these medications during pregnancy.

Can I take combination of Montelukast and Fexofenadine if I am pregnant?

Montelukast has not been associated with an increased risk of birth defects in available studies, but it should be used during pregnancy only if clearly needed. Fexofenadine lacks sufficient data to determine its safety during pregnancy, and it should be used only if the potential benefits justify the potential risks. Both medications should be used under the supervision of a healthcare provider during pregnancy, and patients should discuss any concerns with their doctor to ensure the safety of both mother and child.

Can I take combination of Fexofenadine and Montelukast while breastfeeding?

Fexofenadine is an antihistamine used to relieve allergy symptoms, and Montelukast is a medication that helps prevent asthma symptoms and allergic reactions. According to the NHS, Fexofenadine is generally considered safe to use while breastfeeding, as only small amounts pass into breast milk and are unlikely to harm the baby. However, there is limited information on the use of Montelukast during breastfeeding. The NLM suggests that Montelukast is also likely safe, but it is always best to consult with a healthcare provider to weigh the benefits and any potential risks before taking these medications together while breastfeeding.

Can I take combination of Montelukast and Fexofenadine while breastfeeding?

Montelukast is considered safe for use during breastfeeding, as studies have not shown significant risk to infants. Fexofenadine's safety during lactation is less clear, as it is known to pass into breast milk, and caution is advised. Both medications should be used under the guidance of a healthcare provider during breastfeeding. Mothers should discuss the potential risks and benefits with their healthcare provider to make an informed decision about using these medications while nursing.

Who should avoid taking combination of Fexofenadine and Montelukast?

People who should avoid taking the combination of Fexofenadine and Montelukast include those who have had allergic reactions to either of these medications in the past. Additionally, individuals with certain medical conditions, such as severe liver problems, should consult their healthcare provider before using this combination. Pregnant or breastfeeding women should also seek medical advice to ensure safety. It's important to discuss all current medications with a healthcare provider to avoid potential interactions.

Who should avoid taking combination of Montelukast and Fexofenadine?

Montelukast carries a warning for serious neuropsychiatric events, including agitation and depression, and should be used with caution in patients with a history of mental health issues. Fexofenadine should not be used by individuals with known hypersensitivity to the drug or its components. Both medications should be used cautiously in patients with liver or kidney impairment. Patients should be aware of these warnings and discuss any concerns with their healthcare provider to ensure safe use of these medications.