Domperidone + Ranitidine
Find more information about this combination medication at the webpages for domperidone
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Domperidone is used to relieve nausea and vomiting, which are symptoms of stomach upset. It also helps with gastroparesis, which is a condition where the stomach doesn't empty properly. Ranitidine is used to reduce stomach acid, providing relief from heartburn, indigestion, and ulcers, which are sores in the stomach lining.
Domperidone works by enhancing stomach motility, which means it helps the stomach and intestines move food along. Ranitidine works by blocking histamine, which is a substance that stimulates acid production in the stomach, thereby reducing acid levels and easing discomfort.
The usual adult dose for domperidone is 10 mg taken up to three times a day before meals. Ranitidine is typically taken as 150 mg twice a day or 300 mg once at bedtime. Both medicines are taken orally, which means by mouth, and should be used as prescribed by a healthcare provider.
Common side effects of domperidone include dry mouth, headache, and dizziness. Ranitidine may cause headaches, constipation, or diarrhea. Both medicines can cause allergic reactions, which are rare but serious. Monitoring for side effects is important to ensure safe use.
Domperidone should not be used in people with heart conditions or those taking medications that affect heart rhythm, due to the risk of heart problems. Ranitidine is contraindicated in individuals with a history of acute porphyria, which is a rare blood disorder. Both should be used cautiously in people with liver or kidney issues.
Indications and Purpose
How does combination of Domperidone and Ranitidine work?
Domperidone works by blocking dopamine receptors, which are proteins in the brain that help transmit signals. This action helps to increase the movement of the stomach and intestines, allowing food to move more easily through the digestive system. It is often used to relieve symptoms of nausea and vomiting. Ranitidine, on the other hand, works by reducing the amount of acid produced in the stomach. It does this by blocking histamine receptors, which are proteins that signal the stomach to produce acid. This helps to treat and prevent ulcers and gastroesophageal reflux disease, which is a condition where stomach acid frequently flows back into the tube connecting your mouth and stomach. Both medicines help with digestive issues, but they do so in different ways. Domperidone focuses on improving gut movement, while Ranitidine reduces stomach acid production.
How effective is combination of Domperidone and Ranitidine?
Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by blocking dopamine receptors, which are parts of the brain that can trigger these symptoms. Ranitidine, on the other hand, is used to reduce stomach acid, which can help with conditions like heartburn and ulcers, which are sores in the stomach lining. It works by blocking histamine receptors, which are parts of the stomach that signal acid production. Both Domperidone and Ranitidine are effective in their roles, but they work in different ways. Domperidone is more focused on the digestive tract's movement, while Ranitidine targets acid production. However, they share the common goal of improving digestive health and comfort. Both medications are generally well-tolerated, but they should be used under medical supervision to ensure safety and effectiveness.
Directions for Use
What is the usual dose of combination of Domperidone and Ranitidine?
The usual adult daily dose for Domperidone, which is a medicine used to relieve nausea and vomiting, is typically 10 mg taken up to three times a day. On the other hand, Ranitidine, which is used to reduce stomach acid and treat conditions like heartburn, is usually taken at a dose of 150 mg twice a day or 300 mg once a day. Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food. Ranitidine works by blocking histamine receptors, which are proteins that respond to histamine, in the stomach to reduce acid production. Both medicines are used to treat digestive issues, but they work in different ways. They share the common goal of providing relief from discomfort related to the digestive system.
How does one take combination of Domperidone and Ranitidine?
Domperidone, which is used to relieve nausea and vomiting, should be taken before meals. This is because it works by speeding up the movement of the stomach and intestines, helping food pass more quickly. There are no specific food restrictions when taking Domperidone, but it is important to follow your doctor's instructions. Ranitidine, which is used to reduce stomach acid and treat conditions like heartburn, can be taken with or without food. However, it is often recommended to take it after meals or before bedtime to manage symptoms effectively. There are no strict food restrictions, but avoiding foods that trigger heartburn, such as spicy or fatty foods, can be helpful. Both medicines aim to improve digestive issues, but they work differently. Domperidone focuses on movement in the digestive tract, while Ranitidine reduces acid production. Always follow your healthcare provider's advice when using these medications.
For how long is combination of Domperidone and Ranitidine taken?
Domperidone is typically used for short-term relief, often for a few weeks, to treat nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by speeding up the movement of the stomach and intestines, helping food pass more quickly. Ranitidine, on the other hand, is used to treat conditions like heartburn and ulcers, which are sores in the stomach lining, and can be used for longer periods, sometimes several months, depending on the condition being treated. It works by reducing the amount of acid the stomach produces. Both medicines are used to treat digestive issues, but they work in different ways and for different symptoms. They share the common goal of providing relief from discomfort related to the digestive system.
How long does it take for combination of Domperidone and Ranitidine to work?
The combination medicine you're asking about includes two active ingredients: ibuprofen and pseudoephedrine. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID), typically starts working within 20 to 30 minutes to relieve pain and reduce inflammation. Pseudoephedrine, which is a decongestant used to relieve nasal congestion, usually begins to work within 30 minutes to an hour. Both medicines are absorbed quickly into the bloodstream, which means they start working relatively fast. However, the exact time can vary depending on individual factors like metabolism and whether the medicine is taken with food. Together, this combination medicine can help relieve symptoms like pain, inflammation, and congestion within about 30 minutes to an hour. It's important to follow the dosage instructions to ensure the medicine works effectively and safely.
Warnings and Precautions
Are there harms and risks from taking combination of Domperidone and Ranitidine?
Domperidone, which is used to relieve nausea and vomiting, can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an increased risk of heart rhythm problems, especially in older adults or those taking high doses. Ranitidine, which reduces stomach acid, may cause headaches, constipation, or diarrhea. A significant concern with ranitidine is its potential link to cancer due to impurities found in some formulations. Both medications can cause headaches and dizziness, which are common side effects. However, they have unique attributes: domperidone is more associated with heart-related issues, while ranitidine has concerns about impurities. It's important to consult a healthcare provider for personalized advice, especially if you have underlying health conditions or are taking other medications.
Can I take combination of Domperidone and Ranitidine with other prescription drugs?
Domperidone, which is used to relieve nausea and vomiting, can interact with certain medications that affect heart rhythm, such as some antibiotics and antifungals. This interaction can increase the risk of an irregular heartbeat. Ranitidine, which reduces stomach acid, can interact with drugs that require a certain stomach acidity to be absorbed properly, like some antifungal medications. Both Domperidone and Ranitidine can interact with medications that affect the liver's ability to process drugs, potentially leading to increased side effects. A unique attribute of Domperidone is its effect on the digestive tract to speed up the movement of food, while Ranitidine specifically targets stomach acid production. A shared attribute is that both can affect how other drugs are absorbed or metabolized in the body, so it's important to consult a healthcare provider before combining them with other medications.
Can I take combination of Domperidone and Ranitidine if I am pregnant?
Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. During pregnancy, the safety of Domperidone is not well established, and it is generally advised to use it only if the benefits outweigh the risks. It is important to consult a healthcare provider before using it. Ranitidine is used to reduce stomach acid and treat conditions like heartburn, which is a burning feeling in the chest. It was considered safe during pregnancy, but recent concerns about impurities have led to its recall in many places. Pregnant women should discuss alternatives with their doctor. Both Domperidone and Ranitidine are used to treat digestive issues, but they work differently. Domperidone helps with nausea, while Ranitidine reduces stomach acid. Both should be used cautiously during pregnancy, and medical advice is essential to ensure safety for both the mother and the baby.
Can I take combination of Domperidone and Ranitidine while breastfeeding?
Domperidone, which is a medication used to relieve nausea and vomiting, is sometimes used to increase milk production in breastfeeding mothers. However, it can pass into breast milk in small amounts. The safety of Domperidone during breastfeeding is not fully established, and it should be used with caution, especially in mothers with heart conditions. Ranitidine, which is used to reduce stomach acid and treat conditions like heartburn, also passes into breast milk in small amounts. It is generally considered safe during breastfeeding, but it is always best to consult a healthcare provider. Both Domperidone and Ranitidine share the common attribute of passing into breast milk in small amounts. However, their safety profiles differ, with Ranitidine being generally considered safer during breastfeeding. Always consult a healthcare provider before using these medications while breastfeeding.
Who should avoid taking combination of Domperidone and Ranitidine?
Domperidone, which is used to relieve nausea and vomiting, should not be used by people with heart conditions, as it can cause serious heart rhythm problems. It is also not recommended for those with liver problems. Ranitidine, which is used to reduce stomach acid, should be avoided by people with a history of acute porphyria, which is a rare blood disorder. Both medicines should be used with caution in people with kidney problems. Common warnings for both include the potential for allergic reactions, which can cause symptoms like rash or difficulty breathing. It's important to consult a healthcare provider before using these medications, especially if you are pregnant or breastfeeding. Always follow the prescribed dosage and inform your doctor of any other medications you are taking to avoid harmful interactions.
