Domperidone
Nausea, Vomiting ... show more
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dopamine-2 Receptor Antagonist
Controlled Drug Substance
NO
Domperidone
Summary
Domperidone is primarily used to relieve nausea and vomiting. It's effective in controlling these symptoms.
Domperidone works by blocking dopamine receptors in the brain, preventing nausea signals from being transmitted. It's most effective about an hour after you take it by mouth.
Domperidone comes in 10mg tablets. You can take one tablet up to three times a day, but no more than 30mg total in a 24-hour period. It should be taken 15-30 minutes before eating. It's not meant for long-term use; don't take it for more than a week.
The most common side effect of Domperidone is a dry mouth. Other less common side effects include headache, diarrhea, rash, and itching. Serious but rare side effects can affect the heart's rhythm, especially in older people or those taking high doses.
Domperidone shouldn't be taken by people with heart problems, severe liver problems, or certain types of sugar intolerance. It can interact badly with some other medications, particularly those that affect heart rhythm. Alcohol may enhance side effects like drowsiness, so limit or avoid alcohol during treatment.
Indications and Purpose
How does Domperidone work?
Domperidone works by blocking dopamine receptors in the gut, which helps to speed up the movement of food through the stomach. This action helps relieve symptoms like nausea and vomiting by promoting normal digestion.
How does one know if Domperidone is working?
Domperidone is used to treat nausea and vomiting. You will know it's working if you experience relief from these symptoms. Monitor your symptoms and consult your healthcare provider if you do not notice improvement.
Is Domperidone effective?
Domperidone is primarily used to treat nausea and vomiting. It works by blocking dopamine receptors in the gut, which helps to speed up the movement of food through the stomach. Clinical trials have shown it to be effective in relieving these symptoms.
What is Domperidone?
Domperidone is a medication used primarily to treat nausea and vomiting. It works by blocking dopamine receptors in the gut, which helps speed up the movement of food through the stomach. It may also be used for other conditions as determined by a healthcare provider.
What is Domperidone used for?
Domperidone is used to treat nausea and vomiting. It helps by speeding up the movement of food through the stomach, which can relieve these symptoms. It may also be used for other conditions as determined by a healthcare provider.
Directions for Use
For how long do I take Domperidone?
Domperidone is typically used for short-term treatment of symptoms like nausea and vomiting. The usual duration is a few days to a week, but it can vary based on individual needs. Always follow your healthcare provider's instructions regarding the duration of use.
How do I dispose of Domperidone?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Domperidone?
Take Domperidone 15 to 30 minutes before meals, usually three times a day. It can be taken with or without food. Follow your healthcare provider's instructions regarding timing and frequency.
How long does it take for Domperidone to start working?
Domperidone usually starts working within 30 to 60 minutes after taking it. The full therapeutic effect may take a few days to be noticeable. Individual factors like metabolism can affect how quickly it works. Always follow your healthcare provider's instructions.
How should I store Domperidone?
Store Domperidone at room temperature, away from moisture and light. Keep it out of reach of children. Avoid storing it in the bathroom or near a sink to prevent exposure to moisture.
What is the usual dose of Domperidone?
The usual starting dose of Domperidone for adults is 10 mg taken three times a day. The dose may be adjusted based on individual needs, but the maximum recommended dose is 30 mg per day. For children or the elderly, dosing may differ, so it's crucial to follow a healthcare provider's instructions.
Warnings and Precautions
Can Domperidone be taken safely while breastfeeding?
Domperidone is excreted into breast milk in small amounts. There is limited information on its effects on breastfed infants, but no significant adverse effects have been reported. Domperidone is sometimes used to increase milk supply, but its safety for this purpose is not well-established. Due to insufficient evidence, it's important to consult a healthcare provider before using Domperidone while breastfeeding to weigh potential benefits and risks.
Can Domperidone be taken safely while pregnant?
The safety of Domperidone during pregnancy is not well-established, and it is generally not recommended unless the benefits outweigh the risks. There is limited data from human studies, and potential risks to the fetus are not fully understood. No specific trimester-related risks have been identified. Due to insufficient evidence, it's crucial to consult a healthcare provider before using Domperidone during pregnancy to carefully consider potential benefits and risks.
Can I take Domperidone with other prescription drugs?
Domperidone can interact with medications that affect heart rhythm, such as certain antibiotics and antifungals. These interactions can increase the risk of heart-related side effects. Always inform your healthcare provider about all medications you are taking.
Can I take Domperidone with vitamins or supplements?
There are no confirmed interactions between Domperidone and vitamins or supplements. However, it's important to inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.
Does Domperidone have adverse effects?
Adverse effects are harmful or unintended reactions to a medication. Domperidone can cause adverse effects like irregular heartbeat, severe dizziness, or allergic reactions, though these are rare. If you experience any severe symptoms, seek medical attention immediately. Always report new symptoms to your healthcare provider before stopping the medication.
Does Domperidone have any safety warnings?
Domperidone has safety warnings related to its potential to cause heart-related side effects, especially in high doses or in people with existing heart conditions. It's important to monitor for symptoms like irregular heartbeat and consult a healthcare provider if they occur.
Is Domperidone addictive?
Domperidone has no known potential for dependence or addiction. It is not considered habit-forming.
Is Domperidone safe for the elderly?
Elderly individuals may be more susceptible to the side effects of Domperidone, particularly heart-related issues. It's important for them to use this medication under close supervision of a healthcare provider.
Is it safe to drink alcohol while taking Domperidone?
Occasional or moderate alcohol consumption is generally not advisable while taking Domperidone. Alcohol can interfere with the medicine's effectiveness and may increase the risk of side effects like dizziness or drowsiness. If you choose to drink, limit your intake and monitor how you feel. Always consult your healthcare provider for personalized advice.
Is it safe to exercise while taking Domperidone?
Most people tolerate Domperidone well, and it should not limit your ability to exercise. If you experience any unusual symptoms during physical activity, consult your healthcare provider.
Is it safe to stop Domperidone?
Domperidone is generally used for symptomatic relief of temporary conditions. Stopping it abruptly may lead to a return of symptoms. There are no known withdrawal symptoms, but it's always best to consult a healthcare provider before stopping any medication to avoid complications.
What are the most common side effects of Domperidone?
A side effect is an unwanted symptom caused by medical treatment. Common side effects of Domperidone include dry mouth, headache, dizziness, and stomach cramps. These occur in a small percentage of users. It's important to note that new symptoms can appear when starting any medication, which may be unrelated or temporary. Always consult a healthcare provider before stopping any medication.
Who should avoid taking Domperidone?
Domperidone should not be used in individuals with known allergies to it, those with severe liver impairment, or those with heart conditions like prolonged QT interval. It should be used with caution in people taking other medications that affect heart rhythm.
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