Domperidone + Rabeprazole

Find more information about this combination medication at the webpages for Domperidone and Rabeprazole

English

Brand Name

R Fast D 30mg/20mg Capsule SR 10s , Orcirab-Dsr 30mg/20mg Capsule ... show more

Approved Treatment Indication:

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इस दवा में 2 दवाओं Domperidone और Rabeprazole का संयोजन है।
इनमें से प्रत्येक दवा एक अलग बीमारी या लक्षण का इलाज करती है।
विभिन्न बीमारियों का अलग-अलग दवाओं से इलाज करने से डॉक्टरों को प्रत्येक दवा की खुराक को अलग-अलग समायोजित करने की सुविधा मिलती है। इससे ओवरमेडिकेशन या अंडरमेडिकेशन से बचा जा सकता है।
अधिकांश डॉक्टर संयोजन फॉर्म का उपयोग करने से पहले यह सुनिश्चित करने की सलाह देते हैं कि प्रत्येक व्यक्तिगत दवा सुरक्षित और प्रभावी है।

Summary

What conditions Domperidone and Rabeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. Rabeprazole is used to treat acid reflux, which is when stomach acid flows back into the esophagus causing heartburn, and ulcers, which are sores on the stomach lining.
How Domperidone and Rabeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain and gut, to increase stomach and intestine movement. Rabeprazole reduces stomach acid by blocking the proton pump, which is an enzyme in the stomach lining that produces acid.
The usual dosages and routes of administration of Domperidone and Rabeprazole
The usual adult dose for Domperidone is 10 milligrams taken up to three times a day before meals. Rabeprazole is typically taken as a 20 milligram dose once daily, often before meals, to reduce stomach acid.
The most commonly observed adverse effects of Domperidone and Rabeprazole
Domperidone can cause dry mouth, headache, and dizziness, with a risk of heart rhythm problems. Rabeprazole may cause headache, diarrhea, and abdominal pain, with a risk of low magnesium levels, which can lead to muscle spasms.
Important safety warnings and contraindications of Domperidone and Rabeprazole
Domperidone should not be used by people with heart conditions due to the risk of heart rhythm problems. Rabeprazole should be used cautiously in people with liver disease and may increase fracture risk if used long-term. Both should be avoided during pregnancy unless advised by a doctor.

Government Approvals

UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

None

Controlled Drug Substance

Summary

What conditions Domperidone and Rabeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. Rabeprazole is used to treat acid reflux, which is when stomach acid flows back into the esophagus causing heartburn, and ulcers, which are sores on the stomach lining.
How Domperidone and Rabeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain and gut, to increase stomach and intestine movement. Rabeprazole reduces stomach acid by blocking the proton pump, which is an enzyme in the stomach lining that produces acid.
The usual dosages and routes of administration of Domperidone and Rabeprazole
The usual adult dose for Domperidone is 10 milligrams taken up to three times a day before meals. Rabeprazole is typically taken as a 20 milligram dose once daily, often before meals, to reduce stomach acid.
The most commonly observed adverse effects of Domperidone and Rabeprazole
Domperidone can cause dry mouth, headache, and dizziness, with a risk of heart rhythm problems. Rabeprazole may cause headache, diarrhea, and abdominal pain, with a risk of low magnesium levels, which can lead to muscle spasms.
Important safety warnings and contraindications of Domperidone and Rabeprazole
Domperidone should not be used by people with heart conditions due to the risk of heart rhythm problems. Rabeprazole should be used cautiously in people with liver disease and may increase fracture risk if used long-term. Both should be avoided during pregnancy unless advised by a doctor.

Indications and Purpose

How does combination of Domperidone and Rabeprazole work?

Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain and gut. This action helps to increase the movement of the stomach and intestines, allowing food to move more easily through the digestive system. It is often used to relieve symptoms of nausea and vomiting. Rabeprazole, on the other hand, is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. It does this by blocking the enzyme in the stomach wall that produces acid. This helps to treat conditions like acid reflux and stomach ulcers. Both Domperidone and Rabeprazole help with digestive issues, but they work in different ways. Domperidone focuses on improving gut movement, while Rabeprazole reduces stomach acid production. Together, they can help manage symptoms related to digestion and stomach discomfort.

How effective is combination of Domperidone and Rabeprazole?

Domperidone is a medication that helps with nausea and vomiting, which are symptoms of feeling sick and the act of throwing up. It works by blocking dopamine receptors, which are parts of the brain that can trigger these symptoms. Rabeprazole, on the other hand, is used to treat conditions like acid reflux, which is when stomach acid flows back into the food pipe, causing heartburn. It works by reducing the amount of acid the stomach makes. Both Domperidone and Rabeprazole are used to treat digestive issues, which are problems related to the stomach and intestines. They are often prescribed together to help manage symptoms more effectively. While Domperidone focuses on reducing nausea, Rabeprazole helps in controlling stomach acid. Together, they provide a comprehensive approach to managing digestive discomfort.

Directions for Use

What is the usual dose of combination of Domperidone and Rabeprazole?

The usual adult daily dose for Domperidone, which is a medicine used to relieve nausea and vomiting, is typically 10 milligrams taken up to three times a day. Rabeprazole, which is a proton pump inhibitor used to reduce stomach acid, is usually taken as a 20 milligram dose once daily. Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food through the stomach. Rabeprazole, on the other hand, works by blocking the proton pump, which is an enzyme in the stomach lining that produces acid, to reduce acid production. Both medicines are used to treat conditions related to the stomach and digestive system. They are often prescribed together to manage symptoms like nausea and acid reflux, which is a condition where stomach acid flows back into the esophagus.

How does one take combination of Domperidone and Rabeprazole?

Domperidone, which is used to relieve nausea and vomiting, should be taken before meals. This is because it works best when taken on an empty stomach. Rabeprazole, which is used to reduce stomach acid, can be taken with or without food, but it is often recommended to take it before meals for optimal effect. Both medicines do not have specific food restrictions, but it is generally advised to avoid alcohol as it can irritate the stomach lining. Domperidone and Rabeprazole share the common goal of improving digestive comfort, but they work in different ways. Domperidone helps with movement in the digestive tract, while Rabeprazole reduces acid production. Always follow your healthcare provider's instructions when taking these medications.

For how long is combination of Domperidone and Rabeprazole taken?

Domperidone is typically used for short-term relief of nausea and vomiting, which are symptoms of feeling sick and throwing up. It is usually prescribed for a duration of up to one week. Rabeprazole, on the other hand, is used to treat conditions like gastroesophageal reflux disease (GERD), which is a long-term condition where stomach acid comes up into the esophagus. It is often used for longer periods, sometimes several weeks or months, depending on the condition being treated. Both medicines are used to address issues related to the digestive system. However, Domperidone works by speeding up the movement of the stomach and intestines, while Rabeprazole reduces the amount of acid produced in the stomach. They both aim to relieve discomfort but do so through different mechanisms and are used for different durations based on the condition being treated.

How long does it take for combination of Domperidone and Rabeprazole to work?

The time it takes for a combination medicine to start working depends on the individual medicines involved. For example, if the combination includes ibuprofen, which is a pain reliever and anti-inflammatory drug, it typically starts working within 20 to 30 minutes. On the other hand, if the combination includes acetaminophen, which is another pain reliever, it usually begins to work within 30 to 60 minutes. Both medicines are used to relieve pain and reduce fever, which means they share these common attributes. However, ibuprofen also reduces inflammation, which is swelling and redness, while acetaminophen does not. When combined, these medicines can provide a broader range of pain relief and fever reduction, often starting to work within 30 to 60 minutes, depending on the specific combination and individual response.

Warnings and Precautions

Are there harms and risks from taking combination of Domperidone and Rabeprazole?

Domperidone, which is used to relieve nausea and vomiting, can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an increased risk of heart rhythm problems, which refers to irregular heartbeats. Rabeprazole, which is used to treat acid reflux and stomach ulcers, may cause side effects such as headache, diarrhea, and abdominal pain. A significant adverse effect is the potential for low magnesium levels, which can lead to muscle spasms or irregular heartbeats. Both medications can cause headaches as a common side effect. However, they have unique attributes: Domperidone is more associated with heart rhythm issues, while Rabeprazole can affect magnesium levels. It's important to consult a healthcare provider if you experience any severe or persistent side effects from either medication.

Can I take combination of Domperidone and Rabeprazole with other prescription drugs?

Domperidone, which is used to relieve nausea and vomiting, can interact with certain medications that affect heart rhythm, such as ketoconazole, which is an antifungal medication. This interaction can increase the risk of serious heart problems. Rabeprazole, which is used to reduce stomach acid, can interact with drugs like methotrexate, which is used to treat cancer and autoimmune diseases, potentially increasing methotrexate levels in the body. Both Domperidone and Rabeprazole can interact with medications that affect liver enzymes, which are proteins that help break down drugs in the body. This can alter the effectiveness of either drug. It's important to consult a healthcare provider before combining these medications with others. While Domperidone primarily affects the digestive system, Rabeprazole focuses on reducing stomach acid, but both require careful monitoring when used with other drugs.

Can I take combination of Domperidone and Rabeprazole if I am pregnant?

Domperidone, which is used to relieve nausea and vomiting, is not recommended during pregnancy unless the benefits outweigh the risks. This is because there is limited information on its safety for pregnant women. Rabeprazole, which is used to treat acid reflux and heartburn, also lacks sufficient data on its safety during pregnancy. It is generally advised to use it only if necessary and under medical supervision. Both medications share the common concern of insufficient data regarding their safety in pregnancy, meaning they should be used cautiously. However, they are used for different conditions: Domperidone for nausea and vomiting, and Rabeprazole for acid-related issues. It is crucial for pregnant women to consult their healthcare provider before using either medication to ensure the safety of both the mother and the unborn child.

Can I take combination of Domperidone and Rabeprazole while breastfeeding?

Domperidone, which is a medication used to relieve nausea and vomiting, is generally considered safe during breastfeeding. It is known to pass into breast milk in small amounts, but it is unlikely to harm a nursing infant. However, it should be used under medical supervision, especially if the mother or baby has any health issues. Rabeprazole, which is a medication used to reduce stomach acid, is less commonly studied in breastfeeding women. It is believed to pass into breast milk in small amounts, but there is limited data on its effects on a nursing infant. Therefore, it is recommended to use it only if clearly needed and under medical advice. Both medications share the common attribute of being used to treat digestive issues, and both pass into breast milk in small amounts. However, Domperidone is more commonly considered safe for breastfeeding, while Rabeprazole requires more caution and medical guidance.

Who should avoid taking combination of Domperidone and Rabeprazole?

Domperidone, which is used to relieve nausea and vomiting, should not be used by people with heart conditions, as it can cause serious heart rhythm problems. It is also not recommended for those with liver problems. Rabeprazole, which reduces stomach acid, should be used cautiously by people with liver disease and may increase the risk of bone fractures if used long-term. Both medicines should be avoided during pregnancy and breastfeeding unless advised by a doctor. They share a common warning of potential interactions with other medications, so it is important to inform your healthcare provider about all medicines you are taking. Additionally, both should be used with caution in older adults due to increased sensitivity to side effects. Always follow your healthcare provider's instructions when using these medications.