Domperidone + Omeprazole

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Brand Name

Pilodom 10mg/20mg Capsule , Omeeforce D 10mg/20mg Capsule ... show more

Approved Treatment Indication:

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What conditions Domperidone and Omeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of an upset stomach. It can also help with stomach discomfort by speeding up the movement of food through the stomach. Omeprazole is used to treat acid reflux, which is when stomach acid flows back into the esophagus causing heartburn, and stomach ulcers, which are sores in the stomach lining. Both medicines aim to relieve discomfort in the digestive system, but they target different causes of that discomfort.
How Domperidone and Omeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins in the brain that can trigger nausea, in the gut to increase the movement of the stomach and intestines. Omeprazole is a proton pump inhibitor, which is a type of drug that reduces the amount of acid produced in the stomach by blocking the enzyme in the stomach wall that produces acid. Both medicines help with digestive issues, but they do so in different ways.
The usual dosages and routes of administration of Domperidone and Omeprazole
The usual adult daily dose for Domperidone is typically 10 mg taken up to three times a day, and it should be taken before meals for best results. Omeprazole is usually taken as 20 mg once a day and can be taken with or without food, but it is often recommended to take it before a meal for optimal effect. Both medicines are taken orally, which means by mouth.
The most commonly observed adverse effects of Domperidone and Omeprazole
Domperidone can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Omeprazole may cause headaches, stomach pain, and nausea. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use. Both medications can cause headaches and dizziness, which refer to a feeling of lightheadedness.
Important safety warnings and contraindications of Domperidone and Omeprazole
Domperidone should not be used by people with heart conditions, as it can cause serious heart rhythm problems, and it is also not recommended for those with liver problems. Omeprazole should be used cautiously by people with liver disease and may cause kidney issues. Both medications can interact with other drugs, so it's important to inform your doctor about all medications you are taking. They share the common attribute of potentially causing allergic reactions, which can include symptoms like rash, itching, or swelling.

Government Approvals

UK(BNF)

WHO Essential Medicine

YES

Known Teratogen

Pharmaceutical Class

None

Controlled Drug Substance

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Summary

What conditions Domperidone and Omeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of an upset stomach. It can also help with stomach discomfort by speeding up the movement of food through the stomach. Omeprazole is used to treat acid reflux, which is when stomach acid flows back into the esophagus causing heartburn, and stomach ulcers, which are sores in the stomach lining. Both medicines aim to relieve discomfort in the digestive system, but they target different causes of that discomfort.
How Domperidone and Omeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins in the brain that can trigger nausea, in the gut to increase the movement of the stomach and intestines. Omeprazole is a proton pump inhibitor, which is a type of drug that reduces the amount of acid produced in the stomach by blocking the enzyme in the stomach wall that produces acid. Both medicines help with digestive issues, but they do so in different ways.
The usual dosages and routes of administration of Domperidone and Omeprazole
The usual adult daily dose for Domperidone is typically 10 mg taken up to three times a day, and it should be taken before meals for best results. Omeprazole is usually taken as 20 mg once a day and can be taken with or without food, but it is often recommended to take it before a meal for optimal effect. Both medicines are taken orally, which means by mouth.
The most commonly observed adverse effects of Domperidone and Omeprazole
Domperidone can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Omeprazole may cause headaches, stomach pain, and nausea. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use. Both medications can cause headaches and dizziness, which refer to a feeling of lightheadedness.
Important safety warnings and contraindications of Domperidone and Omeprazole
Domperidone should not be used by people with heart conditions, as it can cause serious heart rhythm problems, and it is also not recommended for those with liver problems. Omeprazole should be used cautiously by people with liver disease and may cause kidney issues. Both medications can interact with other drugs, so it's important to inform your doctor about all medications you are taking. They share the common attribute of potentially causing allergic reactions, which can include symptoms like rash, itching, or swelling.

Indications and Purpose

What is combination of Domperidone and Omeprazole used for?

Domperidone is used to treat nausea and vomiting, which are feelings of sickness and the act of throwing up. It also helps with stomach discomfort by speeding up the movement of food through the stomach. Omeprazole is used to treat conditions like acid reflux, which is when stomach acid flows back into the food pipe, and stomach ulcers, which are sores in the stomach lining. Both medicines help with stomach-related issues, but they work differently. Domperidone helps with the movement of food, while Omeprazole reduces stomach acid production. They both aim to relieve discomfort in the digestive system, but they target different causes of that discomfort.

How does combination of Domperidone and Omeprazole work?

Domperidone works by blocking dopamine receptors, which are proteins that respond to the chemical dopamine, in the gut and brain. This action helps to increase the movement of the stomach and intestines, allowing food to move more easily through the digestive system. It is often used to relieve symptoms of nausea and vomiting. Omeprazole, on the other hand, is a proton pump inhibitor, which is a type of drug that reduces the amount of acid produced in the stomach. It works by blocking the enzyme in the stomach wall that produces acid, providing relief from conditions like acid reflux and ulcers. Both Domperidone and Omeprazole help with digestive issues, but they do so in different ways. Domperidone enhances gut movement, while Omeprazole reduces stomach acid production. They are often used together to manage symptoms of gastrointestinal discomfort.

How effective is combination of Domperidone and Omeprazole?

Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of an upset stomach. It works by blocking dopamine receptors, which are proteins in the brain that can trigger nausea. Omeprazole, on the other hand, is used to treat acid reflux, which is a condition where stomach acid flows back into the esophagus causing heartburn. It works by reducing the amount of acid the stomach makes. Both Domperidone and Omeprazole are effective in treating digestive issues, but they do so in different ways. Domperidone helps with symptoms related to nausea, while Omeprazole addresses issues related to excess stomach acid. They share the common goal of improving digestive health and comfort. However, they are used for different specific conditions and work through different mechanisms in the body.

How does one know if combination of Domperidone and Omeprazole is working?

The benefits of Domperidone and Omeprazole are measured by their ability to relieve symptoms and improve quality of life. Domperidone is used to treat nausea and vomiting, which are feelings of sickness and the act of throwing up, by increasing the movement of the stomach and intestines. Omeprazole is used to reduce stomach acid, which helps treat conditions like heartburn and acid reflux, which is when stomach acid flows back into the food pipe causing discomfort. Both medicines aim to relieve discomfort and improve digestion. They share the common goal of improving gastrointestinal health, which refers to the health of the stomach and intestines. However, they work in different ways: Domperidone enhances stomach movement, while Omeprazole reduces acid production. Their effectiveness is assessed by the reduction of symptoms and improvement in the patient's daily activities.

Directions for Use

What is the usual dose of combination of Domperidone and Omeprazole?

The usual adult daily dose for Domperidone, which is a medicine used to relieve nausea and vomiting, is typically 10 mg taken up to three times a day. On the other hand, Omeprazole, which is a medicine used to reduce stomach acid, is usually taken as 20 mg once a day. Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food. Omeprazole works by blocking the proton pump, which is a protein in the stomach lining that produces acid, to reduce acid production. Both medicines are used to treat digestive issues, but they work in different ways. They are both taken orally, which means by mouth, and are generally well-tolerated by most people.

How does one take combination of Domperidone and Omeprazole?

Domperidone, which is used to relieve nausea and vomiting, should be taken before meals. This is because it works best when taken on an empty stomach. Omeprazole, which is used to reduce stomach acid, can be taken with or without food, but it is often recommended to take it before a meal for optimal effect. Both medicines do not have specific food restrictions, but it's important to follow any dietary advice given by your healthcare provider. Domperidone and Omeprazole share the common attribute of being used to treat digestive issues, but they work in different ways. Domperidone helps with movement in the digestive tract, while Omeprazole reduces acid production. Always follow the dosage instructions provided by your doctor or pharmacist for both medications.

For how long is combination of Domperidone and Omeprazole taken?

Domperidone is typically used for short-term relief, often for a few weeks, to treat nausea and vomiting. It works by speeding up the movement of the stomach and intestines, which helps to move food through the stomach more quickly. Omeprazole, on the other hand, is often used for longer periods, sometimes several weeks to months, to treat conditions like acid reflux and stomach ulcers. It works by reducing the amount of acid the stomach makes. Both medicines are used to treat digestive issues, but they work in different ways. Domperidone helps with the movement of food, while Omeprazole reduces stomach acid. They are both taken orally and can be used to improve symptoms related to the digestive system. However, the duration of use and specific conditions they treat differ.

How long does it take for combination of Domperidone and Omeprazole to work?

The time it takes for a combination medicine to start working depends on the individual medicines involved. For example, if the combination includes ibuprofen, which is a pain reliever and anti-inflammatory drug, it typically starts working within 20 to 30 minutes. If the combination includes paracetamol, which is another pain reliever, it usually begins to work within 30 to 60 minutes. Both medicines are used to relieve pain and reduce fever, which means they share these common attributes. However, ibuprofen also reduces inflammation, which is swelling and redness, while paracetamol does not. When combined, these medicines can provide a broader range of relief, but the onset of action will generally be within the first hour after taking them.

How does one store combination of Domperidone and Omeprazole?

Domperidone and Omeprazole do not require refrigeration. Both medications should be stored at room temperature, which means keeping them in a place that is not too hot or too cold, typically between 68°F and 77°F (20°C and 25°C). They should be kept away from direct sunlight and moisture, so avoid storing them in the bathroom. Domperidone, which is used to relieve nausea and vomiting, should be kept in its original packaging to protect it from light. Omeprazole, which is used to reduce stomach acid and treat conditions like acid reflux, should also be kept in its original container to maintain its effectiveness. Both medications share the common attribute of needing to be stored in a dry place, away from children and pets, to ensure safety and effectiveness.

Warnings and Precautions

Are there harms and risks from taking combination of Domperidone and Omeprazole?

Domperidone, which is used to relieve nausea and vomiting, can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Omeprazole, which reduces stomach acid, may cause headaches, stomach pain, and nausea. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use. Both medications can cause headaches and dizziness, which refer to a feeling of lightheadedness. However, they have unique attributes: Domperidone affects heart rhythm, while Omeprazole can impact bone health. It's important to use these medications under medical supervision to manage these risks effectively.

Can I take combination of Domperidone and Omeprazole with other prescription drugs?

Domperidone, which is used to relieve nausea and vomiting, can interact with certain medications that affect heart rhythm, such as ketoconazole, which is an antifungal medication. This interaction can increase the risk of serious heart problems. Omeprazole, which is used to reduce stomach acid, can interact with drugs like clopidogrel, which is a blood thinner, potentially reducing its effectiveness. Both Domperidone and Omeprazole can interact with medications that affect liver enzymes, which are proteins that help break down drugs in the body. This can alter the levels of these drugs in the blood, leading to increased side effects or reduced effectiveness. It's important to consult a healthcare provider before combining these medications with others to avoid harmful interactions.

Can I take combination of Domperidone and Omeprazole with vitamins or supplements?

Domperidone, which is used to relieve nausea and vomiting, does not have significant interactions with vitamins or supplements. However, it is important to note that Domperidone can affect the absorption of other medications, so it is best to take it before meals. Omeprazole, which is used to reduce stomach acid, can affect the absorption of certain vitamins and minerals, particularly vitamin B12, which is important for nerve function and the production of red blood cells. Long-term use of Omeprazole may lead to a deficiency in vitamin B12. Both Domperidone and Omeprazole are used to treat digestive issues, but they work in different ways. While Domperidone helps with nausea, Omeprazole reduces stomach acid. It is always important to consult with a healthcare provider before combining these medications with any vitamins or supplements.

Can I take combination of Domperidone and Omeprazole if I am pregnant?

Domperidone, which is used to relieve nausea and vomiting, is not recommended during pregnancy unless the benefits outweigh the risks. It can pass into breast milk, so caution is advised for breastfeeding mothers. Omeprazole, which reduces stomach acid, is generally considered safe during pregnancy, but it should only be used if necessary. Both medicines should be taken under medical supervision during pregnancy. Domperidone and Omeprazole share the common attribute of being used to treat stomach-related issues, but they work differently. Domperidone helps with nausea, while Omeprazole reduces acid production. Both medicines should be used with caution during pregnancy, and a healthcare provider should be consulted to weigh the benefits and risks. It is important to follow medical advice to ensure the safety of both the mother and the baby.

Can I take combination of Domperidone and Omeprazole while breastfeeding?

Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of feeling sick and throwing up. It is sometimes used to increase milk production in breastfeeding mothers. However, it is important to note that Domperidone can pass into breast milk in small amounts. The safety of Domperidone during breastfeeding is not fully established, and it should be used with caution and under medical supervision. Omeprazole is a medication used to treat acid reflux, which is a condition where stomach acid flows back into the food pipe, causing heartburn. It is considered safe for use during breastfeeding as it passes into breast milk in very low amounts and is unlikely to harm a nursing infant. Both Domperidone and Omeprazole share the common attribute of being medications that can pass into breast milk. However, Omeprazole is generally considered safer for breastfeeding mothers compared to Domperidone, which requires more caution.

Who should avoid taking combination of Domperidone and Omeprazole?

Domperidone, which is used to relieve nausea and vomiting, should not be used by people with heart conditions, as it can cause serious heart rhythm problems. It is also not recommended for those with liver problems. Omeprazole, which reduces stomach acid, should be used cautiously by people with liver disease and may cause kidney issues. Both medications can interact with other drugs, so it's important to inform your doctor about all medications you are taking. They share the common attribute of potentially causing allergic reactions, which can include symptoms like rash, itching, or swelling. It's crucial to follow the prescribed dosage and consult a healthcare provider if you experience any unusual symptoms.