Domperidone + Esomeprazole

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Brand Name

Stomatix-DSR 30mg/40mg Tablet , Ignis 30 mg/20 mg Capsule ... show more

Approved Treatment Indication:

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What conditions Domperidone and Esomeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of an upset stomach. Esomeprazole is used to treat acid reflux, which is a condition where stomach acid flows back into the esophagus causing heartburn. Both medicines aim to improve digestive comfort but target different symptoms.
How Domperidone and Esomeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food. Esomeprazole is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. Both medicines help with digestive issues but in different ways.
The usual dosages and routes of administration of Domperidone and Esomeprazole
The usual adult daily dose for Domperidone is typically 10 mg taken up to three times a day before meals. Esomeprazole is usually taken as a 20 mg or 40 mg dose once daily, at least one hour before meals. Both medicines should be taken with a glass of water to ensure proper absorption.
The most commonly observed adverse effects of Domperidone and Esomeprazole
Domperidone can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Esomeprazole may cause headache, diarrhea, and stomach pain. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use.
Important safety warnings and contraindications of Domperidone and Esomeprazole
Domperidone should not be used by people with heart problems, as it can cause serious heart rhythm issues. Esomeprazole should be used cautiously by people with severe liver disease and may increase the risk of bone fractures if used long-term. Both medicines require careful monitoring when taken with other drugs to avoid potential interactions.

Government Approvals

UK(BNF)

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

None

Controlled Drug Substance

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Summary

What conditions Domperidone and Esomeprazole is used for
Domperidone is used to relieve nausea and vomiting, which are symptoms of an upset stomach. Esomeprazole is used to treat acid reflux, which is a condition where stomach acid flows back into the esophagus causing heartburn. Both medicines aim to improve digestive comfort but target different symptoms.
How Domperidone and Esomeprazole works in the body
Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food. Esomeprazole is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. Both medicines help with digestive issues but in different ways.
The usual dosages and routes of administration of Domperidone and Esomeprazole
The usual adult daily dose for Domperidone is typically 10 mg taken up to three times a day before meals. Esomeprazole is usually taken as a 20 mg or 40 mg dose once daily, at least one hour before meals. Both medicines should be taken with a glass of water to ensure proper absorption.
The most commonly observed adverse effects of Domperidone and Esomeprazole
Domperidone can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Esomeprazole may cause headache, diarrhea, and stomach pain. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use.
Important safety warnings and contraindications of Domperidone and Esomeprazole
Domperidone should not be used by people with heart problems, as it can cause serious heart rhythm issues. Esomeprazole should be used cautiously by people with severe liver disease and may increase the risk of bone fractures if used long-term. Both medicines require careful monitoring when taken with other drugs to avoid potential interactions.

Indications and Purpose

What is combination of Domperidone and Esomeprazole used for?

Domperidone is used to treat nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by helping the stomach move food more easily into the intestines. Esomeprazole is used to treat conditions like gastroesophageal reflux disease (GERD), which is a long-term condition where stomach acid comes up into the esophagus causing heartburn. It reduces the amount of acid the stomach makes. Both medicines help with digestive issues, but they work in different ways. Domperidone helps with the movement of food, while Esomeprazole reduces stomach acid. They both aim to relieve discomfort in the stomach area, but Domperidone is more focused on nausea and vomiting, whereas Esomeprazole is more focused on acid-related issues.

How does combination of Domperidone and Esomeprazole work?

Domperidone works by blocking dopamine receptors, which are proteins in the brain that help transmit signals. This action helps to increase the movement of the stomach and intestines, allowing food to move more easily through the digestive system. It is often used to relieve symptoms of nausea and vomiting. Esomeprazole, on the other hand, is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. It is commonly used to treat conditions like acid reflux and stomach ulcers. Both Domperidone and Esomeprazole help with digestive issues, but they do so in different ways. Domperidone enhances the movement of the digestive tract, while Esomeprazole reduces stomach acid production. Together, they can help manage symptoms related to digestion and stomach discomfort.

How effective is combination of Domperidone and Esomeprazole?

Domperidone is a medication used to relieve nausea and vomiting, which are symptoms of an upset stomach. It works by blocking dopamine receptors, which are parts of the brain that trigger nausea. Esomeprazole, on the other hand, is a proton pump inhibitor, which is a type of drug that reduces stomach acid production. It is used to treat conditions like acid reflux, which is when stomach acid flows back into the esophagus causing heartburn. Both Domperidone and Esomeprazole are effective in their respective roles. Domperidone is particularly useful for gastrointestinal motility disorders, which are conditions that affect the movement of the digestive system. Esomeprazole is effective in healing erosive esophagitis, which is damage to the esophagus from stomach acid. Common attributes include their use in treating digestive issues and their ability to improve patient comfort by addressing symptoms related to the stomach and esophagus.

How does one know if combination of Domperidone and Esomeprazole is working?

The benefit of Domperidone, which is a medicine used to relieve nausea and vomiting, is measured by its ability to reduce these symptoms. It works by increasing the movement of the stomach and intestines, which helps move food through the stomach more quickly. On the other hand, Esomeprazole, which is a medicine used to reduce stomach acid, is assessed by its effectiveness in relieving symptoms of acid reflux, such as heartburn. It works by blocking the proton pumps in the stomach lining, which reduces acid production. Both medicines share the common goal of improving digestive health, but they do so in different ways. Domperidone focuses on enhancing stomach movement, while Esomeprazole reduces acid production. Their benefits are assessed by the relief of symptoms they are intended to treat, such as nausea for Domperidone and heartburn for Esomeprazole.

Directions for Use

What is the usual dose of combination of Domperidone and Esomeprazole?

The usual adult daily dose for Domperidone, which is a medicine used to relieve nausea and vomiting, is typically 10 mg taken up to three times a day. Esomeprazole, which is a medicine used to reduce stomach acid, is usually taken as a 20 mg or 40 mg dose once daily. Domperidone works by blocking dopamine receptors, which are proteins that help transmit signals in the brain, in the gut to speed up the movement of food. Esomeprazole, on the other hand, is a proton pump inhibitor, which means it reduces the amount of acid produced in the stomach. Both medicines are used to treat digestive issues, but they work in different ways. Domperidone helps with nausea and vomiting, while Esomeprazole helps with acid-related problems like heartburn. They both aim to improve comfort and digestion.

How does one take combination of Domperidone and Esomeprazole?

Domperidone, which is used to relieve nausea and vomiting, should be taken before meals. This is because it works best when taken on an empty stomach. Esomeprazole, which is used to reduce stomach acid, should be taken at least one hour before meals. This helps the medicine work more effectively. Both medicines should be taken with a glass of water. It's important to follow the specific timing instructions for each medicine to ensure they work properly. There are no specific food restrictions for either medicine, but it's always a good idea to avoid foods that can irritate your stomach, like spicy or fatty foods, when taking these medications. In summary, while both medicines should be taken before meals, Domperidone is taken on an empty stomach, and Esomeprazole is taken at least an hour before eating.

For how long is combination of Domperidone and Esomeprazole taken?

Domperidone is typically used for short-term relief, often for a few weeks, to treat nausea and vomiting, which are symptoms of feeling sick and throwing up. It works by speeding up the movement of the stomach and intestines, helping food pass more quickly. Esomeprazole, on the other hand, is often used for a longer duration, sometimes several weeks to months, to treat conditions like acid reflux, which is when stomach acid flows back into the food pipe, causing heartburn. It works by reducing the amount of acid the stomach makes. Both medicines are used to treat digestive issues, but they work in different ways and for different symptoms. While Domperidone focuses on improving stomach movement, Esomeprazole focuses on reducing stomach acid.

How long does it take for combination of Domperidone and Esomeprazole to work?

The time it takes for a combination medicine to start working depends on the individual medicines it contains. For example, if the combination includes ibuprofen, which is a pain reliever and anti-inflammatory drug, it typically starts working within 20 to 30 minutes. If it includes paracetamol, which is another pain reliever, it usually begins to work within 30 to 60 minutes. Both medicines are used to relieve pain and reduce fever, which means they share these common attributes. However, ibuprofen also reduces inflammation, which is swelling and redness, while paracetamol does not. When combined, these medicines can provide a broader range of relief, addressing both pain and inflammation more effectively. Always follow the dosage instructions provided by a healthcare professional.

How does one store combination of Domperidone and Esomeprazole?

Domperidone, which is used to relieve nausea and vomiting, does not require refrigeration. It should be stored at room temperature, away from moisture and heat. Esomeprazole, which is used to reduce stomach acid, also does not need refrigeration. It should be kept at room temperature, away from light and moisture. Both medicines share the common attribute of being stored at room temperature, which means they should be kept in a cool, dry place. However, they have unique uses: Domperidone is primarily for nausea, while Esomeprazole is for acid reduction. It's important to follow the storage instructions on the packaging to ensure the effectiveness of both medications.

Warnings and Precautions

Are there harms and risks from taking combination of Domperidone and Esomeprazole?

Domperidone, which is used to relieve nausea and vomiting, can cause side effects like dry mouth, headache, and dizziness. A significant adverse effect is an irregular heartbeat, which refers to an abnormal heart rhythm. Esomeprazole, which reduces stomach acid, may cause headache, diarrhea, and stomach pain. A serious adverse effect is a risk of bone fractures, which means broken bones, especially with long-term use. Both medications can cause headaches as a common side effect. However, they have unique attributes: Domperidone is primarily used for nausea, while Esomeprazole is used for acid-related issues. Domperidone's significant risk is related to heart rhythm, whereas Esomeprazole's risk involves bone health. It's important to use these medications under medical supervision to manage these risks effectively.

Can I take combination of Domperidone and Esomeprazole with other prescription drugs?

Domperidone, which is used to relieve nausea and vomiting, can interact with certain medications that affect heart rhythm, such as ketoconazole, which is an antifungal medication. This interaction can increase the risk of serious heart problems. Esomeprazole, which is used to reduce stomach acid, can interact with drugs like clopidogrel, which is a blood thinner, reducing its effectiveness. Both Domperidone and Esomeprazole can interact with medications that affect liver enzymes, which are proteins that help break down drugs in the body. This can alter the levels of these drugs in the blood, leading to increased side effects or reduced effectiveness. While Domperidone primarily affects the digestive system, Esomeprazole focuses on reducing stomach acid. However, both medications require careful monitoring when taken with other drugs to avoid potential interactions.

Can I take combination of Domperidone and Esomeprazole with vitamins or supplements?

Domperidone, which is used to relieve nausea and vomiting, does not have significant interactions with most vitamins or supplements. However, it is important to be cautious with supplements that affect heart rhythm, as Domperidone can cause changes in heart rhythm. Esomeprazole, which reduces stomach acid, may affect the absorption of certain vitamins and minerals. It can reduce the absorption of vitamin B12, which is important for nerve function and blood cell production, and magnesium, which is essential for muscle and nerve function. Both Domperidone and Esomeprazole should be used with caution when taking supplements that affect heart rhythm. While Domperidone primarily affects heart rhythm, Esomeprazole affects nutrient absorption. It is important to consult a healthcare provider before combining these medications with any supplements.

Can I take combination of Domperidone and Esomeprazole if I am pregnant?

Domperidone, which is used to relieve nausea and vomiting, has limited data on its safety during pregnancy. It is generally advised to use it only if the benefits outweigh the risks. Esomeprazole, which reduces stomach acid and treats conditions like acid reflux, also has limited information on its safety for pregnant women. It is recommended to use it only when necessary. Both medicines should be used with caution during pregnancy, and a healthcare provider should be consulted. Domperidone and Esomeprazole share the common attribute of having limited safety data for pregnant women, and both should be used only when clearly needed. However, they are used for different conditions: Domperidone for nausea and vomiting, and Esomeprazole for acid-related issues. Both medicines require careful consideration of the potential benefits and risks during pregnancy.

Can I take combination of Domperidone and Esomeprazole while breastfeeding?

Domperidone, which is used to treat nausea and vomiting, is generally considered safe during breastfeeding. It passes into breast milk in small amounts, but no harmful effects on the baby have been reported. However, it should be used under medical supervision, especially in mothers with heart conditions. Esomeprazole, which is used to reduce stomach acid, is also considered safe during breastfeeding. It passes into breast milk in low levels and is unlikely to harm the baby. Like Domperidone, it should be used under medical guidance. Both medications share the common attribute of being safe for breastfeeding mothers when used appropriately. They both pass into breast milk in small amounts and have not shown harmful effects on infants. However, they should be used with caution and under the advice of a healthcare provider to ensure the safety of both mother and child.

Who should avoid taking combination of Domperidone and Esomeprazole?

Domperidone, which is used to relieve nausea and vomiting, should not be used by people with heart problems, as it can cause serious heart rhythm issues. It is also not recommended for those with liver problems. Esomeprazole, which reduces stomach acid, should be used cautiously by people with severe liver disease and may increase the risk of bone fractures if used long-term. Both medicines can interact with other drugs, so it's important to inform your doctor about all medications you are taking. They share a common warning for people with liver issues, as both can affect liver function. Additionally, both should be used with caution in pregnant or breastfeeding women, as their safety in these conditions is not fully established. Always consult a healthcare professional before starting or stopping these medications.