Desloratadine + Montelukast
Find more information about this combination medication at the webpages for Montelukast and Desloratadine
Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis ... show more
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Advisory
- This medicine contains a combination of 2 drugs Desloratadine and Montelukast.
- Desloratadine and Montelukast are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Histamine-1 Receptor Antagonist and Leukotriene Receptor Antagonist
Controlled Drug Substance
NO
Desloratadine + Montelukast
Summary
Desloratadine is used to relieve symptoms of allergic rhinitis, which includes sneezing and a runny nose, and to treat chronic idiopathic urticaria, which involves hives and itching. Montelukast is used for the prevention and chronic treatment of asthma, which is a condition that causes breathing difficulties, and for the relief of symptoms of seasonal and perennial allergic rhinitis. It is also used to prevent exercise-induced bronchoconstriction, which is a narrowing of the airways that occurs during physical activity.
Desloratadine works as an antihistamine, which means it blocks histamine receptors to prevent the action of histamine, a substance in the body that causes allergy symptoms like sneezing and itching. Montelukast works by blocking leukotriene receptors, which are involved in the inflammatory process that leads to asthma and allergy symptoms. By inhibiting these receptors, Montelukast helps prevent bronchoconstriction and reduces inflammation in the airways.
The usual adult daily dose for Desloratadine is 5 mg, which can be taken once daily with or without food. Montelukast is typically taken as a 10 mg dose once daily, usually in the evening, to manage asthma and allergic rhinitis. Both medications are taken orally, meaning they are swallowed in pill form.
Common side effects of Desloratadine include headache, dry mouth, and fatigue. Montelukast may cause headache, stomach pain, and tiredness. While both medications can cause headaches and fatigue, Montelukast has a unique risk of neuropsychiatric events, which are changes in mental health such as agitation and depression, whereas Desloratadine may cause allergic reactions like rash and swelling.
Montelukast carries a warning for potential neuropsychiatric events, such as agitation, depression, and suicidal thoughts, and should be used with caution in patients with a history of mental health issues. Desloratadine is contraindicated, meaning it should not be used, in individuals with known hypersensitivity to the drug or its ingredients. Both medications should be used cautiously in patients with liver impairment, and patients should be aware of potential allergic reactions. It is important for patients to discuss their full medical history with their healthcare provider before starting these medications to ensure safe use.
Indications and Purpose
How does combination of Desloratadine and Montelukast work?
The combination of Desloratadine and Montelukast works by addressing symptoms related to allergies and asthma. Desloratadine is an antihistamine, which means it helps reduce allergy symptoms like sneezing, runny nose, and itching by blocking the action of histamine, a substance in the body that causes allergic symptoms. Montelukast, on the other hand, is a leukotriene receptor antagonist. It works by blocking leukotrienes, which are chemicals in the body that contribute to inflammation, swelling, and constriction of airways in the lungs. Together, these medications help manage and relieve symptoms of allergic rhinitis and asthma, providing a more comprehensive treatment approach.
How does combination of Montelukast and Desloratadine work?
Montelukast works by blocking leukotriene receptors, which are involved in the inflammatory process that leads to asthma and allergy symptoms. By inhibiting these receptors, Montelukast helps prevent bronchoconstriction and reduces inflammation in the airways. Desloratadine, on the other hand, is an antihistamine that blocks histamine receptors, preventing the action of histamine, which causes allergy symptoms like sneezing and itching. Both medications work by blocking specific receptors to prevent the body's allergic response, but they target different pathways: Montelukast targets leukotrienes, while Desloratadine targets histamine.
How effective is combination of Desloratadine and Montelukast?
The combination of Desloratadine and Montelukast is often used to manage symptoms of allergic rhinitis and asthma. Desloratadine is an antihistamine that helps reduce allergy symptoms like sneezing, runny nose, and itching by blocking histamine, a substance in the body that causes allergic symptoms. Montelukast is a leukotriene receptor antagonist that helps prevent wheezing, difficulty breathing, and chest tightness by blocking leukotrienes, substances in the body that cause asthma and allergy symptoms. According to the NHS, combining these two medications can be more effective than using either one alone for some patients, particularly those with both allergic rhinitis and asthma. This combination can help improve overall symptom control and quality of life. However, the effectiveness can vary from person to person, and it's important to follow a healthcare provider's advice on using these medications together. For more detailed information, you can visit trusted sources like the NHS or NLM websites.
How effective is combination of Montelukast and Desloratadine?
Clinical trials have demonstrated the effectiveness of Montelukast in reducing asthma symptoms and preventing exercise-induced bronchoconstriction, as well as alleviating symptoms of allergic rhinitis. Desloratadine has been shown to effectively relieve symptoms of allergic rhinitis and chronic idiopathic urticaria, such as sneezing, runny nose, and itching. Both medications have been proven to improve quality of life for patients with allergies, but Montelukast is particularly noted for its role in asthma management, while Desloratadine is effective in treating urticaria. The evidence for both medications is supported by patient-reported outcomes and clinical studies.
Directions for Use
What is the usual dose of combination of Desloratadine and Montelukast?
The usual dose for the combination of Desloratadine and Montelukast is typically one tablet taken once daily. This combination is often used to help manage symptoms of allergies and asthma. Desloratadine is an antihistamine that helps reduce allergy symptoms like sneezing and runny nose, while Montelukast is a leukotriene receptor antagonist that helps prevent asthma symptoms and allergic reactions. It's important to follow the specific dosing instructions provided by a healthcare professional or the medication's packaging.
What is the usual dose of combination of Montelukast and Desloratadine?
The usual adult daily dose for Montelukast is 10 mg, typically taken in the evening. This dosage is used for managing asthma and allergic rhinitis. For Desloratadine, the standard adult dose is 5 mg once daily, which can be taken with or without food. Both medications are taken once daily, but Montelukast is often taken in the evening to align with its role in managing asthma symptoms, while Desloratadine can be taken at any time of day to relieve allergy symptoms.
How does one take combination of Desloratadine and Montelukast?
Desloratadine and Montelukast are often prescribed together to help manage symptoms of allergies and asthma. Desloratadine is an antihistamine that helps reduce allergy symptoms like sneezing, runny nose, and itching. Montelukast is a leukotriene receptor antagonist that helps prevent wheezing, difficulty breathing, and chest tightness caused by asthma. When taking these medications together, it is important to follow your healthcare provider's instructions. Typically, Desloratadine is taken once daily, with or without food. Montelukast is also usually taken once daily, often in the evening, with or without food. Always take the medications at the same time each day to maintain an even level in your bloodstream. If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double up on doses to make up for a missed one. Consult your healthcare provider for personalized advice, especially if you have other health conditions or are taking other medications.
How does one take combination of Montelukast and Desloratadine?
Montelukast can be taken with or without food, but it is recommended to take it in the evening when used for asthma management. Desloratadine can also be taken with or without food, and there are no specific food restrictions associated with its use. Both medications offer flexibility in terms of food intake, allowing patients to incorporate them into their daily routines without dietary adjustments. However, Montelukast's timing is more specific to align with its role in preventing nighttime asthma symptoms.
For how long is combination of Desloratadine and Montelukast taken?
The combination of Desloratadine and Montelukast is typically taken once daily. The duration of treatment can vary depending on the individual's condition and the advice of a healthcare professional. It is often used for managing symptoms of allergies and asthma, and the length of use should be determined by a doctor based on the patient's specific needs and response to the medication. Always follow the prescribed duration and consult with a healthcare provider for personalized advice.
For how long is combination of Montelukast and Desloratadine taken?
Montelukast is typically used as a long-term treatment for asthma and allergic rhinitis, with patients often taking it daily for extended periods to manage symptoms effectively. Desloratadine is also used for long-term management of allergy symptoms, such as those associated with seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria. Both medications are intended for continuous use to maintain symptom control, but Montelukast is particularly noted for its role in preventing asthma symptoms, while Desloratadine is focused on immediate relief of allergy symptoms.
How long does it take for combination of Desloratadine and Montelukast to work?
Desloratadine and Montelukast are medications often used together to help manage symptoms of allergies and asthma. Desloratadine is an antihistamine that helps reduce allergy symptoms like sneezing and runny nose, while Montelukast is a leukotriene receptor antagonist that helps prevent asthma symptoms and allergic reactions. According to the NHS, Desloratadine typically starts to work within an hour of taking it, providing relief from allergy symptoms. Montelukast, on the other hand, may take a bit longer to show its full effects, often requiring a few days of consistent use to help manage asthma symptoms effectively. When used together, you might start to notice some relief from allergy symptoms within a few hours, but it may take a few days to experience the full benefits, especially for asthma control. It's important to take these medications as prescribed by your healthcare provider for the best results.
How long does it take for combination of Montelukast and Desloratadine to work?
Montelukast typically begins to work within a few hours after taking a dose, with its effects lasting for 24 hours. It is often used for long-term management of asthma and allergies, so its full benefits may be observed over time with regular use. Desloratadine, on the other hand, starts working within 1 hour of ingestion, providing relief from allergy symptoms such as sneezing and runny nose. Both medications are used to manage symptoms of allergies, but Montelukast is more focused on preventing asthma symptoms, while Desloratadine is an antihistamine that directly blocks histamine to relieve allergy symptoms.
Warnings and Precautions
Are there harms and risks from taking combination of Desloratadine and Montelukast?
Desloratadine and Montelukast are often prescribed together to manage symptoms of allergies and asthma. According to the NHS, this combination is generally considered safe for most people when taken as directed by a healthcare provider. However, as with any medication, there can be potential side effects. Desloratadine is an antihistamine, which helps reduce allergy symptoms like sneezing and runny nose. Montelukast is a leukotriene receptor antagonist, which helps prevent asthma attacks and also treats allergies. Possible side effects of Desloratadine include headache, dry mouth, and fatigue. Montelukast may cause side effects such as headache, stomach pain, and in rare cases, mood changes or allergic reactions. It's important to follow your healthcare provider's instructions and report any unusual symptoms. Always consult with a healthcare professional before starting or combining medications to ensure they are appropriate for your specific health needs.
Are there harms and risks from taking combination of Montelukast and Desloratadine?
Common side effects of Montelukast include headache, stomach pain, and tiredness, while serious side effects can include mental health changes such as agitation and depression. Desloratadine may cause headache, dry mouth, and fatigue, with serious side effects including allergic reactions like rash and swelling. Both medications can cause headaches and fatigue, but Montelukast has a unique risk of neuropsychiatric events, whereas Desloratadine may cause allergic reactions. Patients should be aware of these potential side effects and consult their doctor if they experience any severe or unusual symptoms.
Can I take combination of Desloratadine and Montelukast with other prescription drugs?
Desloratadine and Montelukast are medications often used to treat allergies and asthma. Desloratadine is an antihistamine that helps reduce allergy symptoms, while Montelukast is a leukotriene receptor antagonist that helps prevent asthma attacks and allergic reactions. According to the NHS and other trusted sources, it is generally safe to take Desloratadine and Montelukast with other prescription drugs, but there are some important considerations: 1. **Consult Your Doctor:** Always consult with your healthcare provider before combining these medications with other prescription drugs. They can provide personalized advice based on your health history and current medications. 2. **Drug Interactions:** While Desloratadine and Montelukast are known to have a low potential for interactions, they can still interact with other medications. Your doctor can check for any potential interactions with your current prescriptions. 3. **Side Effects:** Be aware of the side effects of each medication. Combining drugs can sometimes increase the risk of side effects, so monitoring your health and reporting any unusual symptoms to your doctor is important. 4. **Follow Prescribed Dosages:** Ensure you follow the prescribed dosages and instructions for all medications you are taking to avoid any adverse effects. For more detailed information, you can visit trusted medical websites like the NHS or consult with a healthcare professional.
Can I take combination of Montelukast and Desloratadine with other prescription drugs?
Montelukast does not have significant interactions with most common prescription drugs, but caution is advised when used with phenobarbital and rifampin, which can reduce its effectiveness. Desloratadine may interact with drugs like ketoconazole and erythromycin, which can increase its concentration in the blood. Both medications should be used with caution when taken with other drugs that affect liver enzymes, and patients should always inform their healthcare provider about all medications they are taking to avoid potential interactions.
Can I take combination of Desloratadine and Montelukast if I am pregnant?
If you are pregnant, it is important to consult with your healthcare provider before taking any medication, including Desloratadine and Montelukast. According to the NHS, some medications may not be safe during pregnancy, and your doctor can help determine the best treatment for your condition. Desloratadine is an antihistamine used to relieve allergy symptoms, while Montelukast is used to prevent asthma symptoms and treat allergies. Your healthcare provider will weigh the benefits and potential risks to you and your baby before recommending these medications.
Can I take combination of Montelukast and Desloratadine if I am pregnant?
Montelukast is generally considered safe for use during pregnancy, as studies have not shown an increased risk of birth defects. Desloratadine is also considered safe, with no evidence of harm to the fetus in animal studies, although human data is limited. Both medications should be used during pregnancy only if clearly needed and if the benefits outweigh the risks. Pregnant women should consult their healthcare provider to discuss the safety of these medications and to determine the best treatment options for managing their symptoms.
Can I take combination of Desloratadine and Montelukast while breastfeeding?
Desloratadine and Montelukast are medications used to treat allergies and asthma. Desloratadine is an antihistamine, which helps reduce allergy symptoms like sneezing and runny nose. Montelukast is a leukotriene receptor antagonist, which helps prevent asthma symptoms and allergic reactions. According to the NHS, it is generally advised to consult with a healthcare professional before taking any medication while breastfeeding. This is because some medications can pass into breast milk and may affect the baby. The NLM states that Desloratadine is considered to have low risk for breastfeeding mothers, as it is unlikely to affect the breastfed infant. However, there is limited information on the use of Montelukast during breastfeeding, so it is important to discuss with a healthcare provider to weigh the potential benefits and risks. In summary, while Desloratadine is generally considered safe, the safety of Montelukast is less clear, and a healthcare provider should be consulted to ensure the safety of both the mother and the baby.
Can I take combination of Montelukast and Desloratadine while breastfeeding?
Montelukast is generally considered safe during breastfeeding, as it is not known to pass into breast milk in significant amounts. Desloratadine does pass into breast milk, and while there is no evidence of harm to nursing infants, caution is advised. Both medications should be used during lactation only if the potential benefits outweigh the risks. Nursing mothers should consult their healthcare provider to discuss the safety of these medications while breastfeeding and to explore alternative treatments if necessary.
Who should avoid taking combination of Desloratadine and Montelukast?
According to trusted sources like the NHS and NLM, individuals who should avoid taking the combination of Desloratadine and Montelukast include: 1. **People with Allergies to the Drugs**: Anyone who has had an allergic reaction to Desloratadine, Montelukast, or any of their ingredients should not take this combination. 2. **Pregnant or Breastfeeding Women**: It is important for pregnant or breastfeeding women to consult their healthcare provider before taking these medications, as the effects on the baby are not fully known. 3. **Individuals with Liver Problems**: Since Montelukast is processed by the liver, those with liver issues should use caution and consult a healthcare provider. 4. **Children**: The safety and effectiveness of this combination in children may not be well established, so a healthcare provider should be consulted. Always consult a healthcare professional before starting or stopping any medication.
Who should avoid taking combination of Montelukast and Desloratadine?
Montelukast carries a warning for potential neuropsychiatric events, such as agitation, depression, and suicidal thoughts, and should be used with caution in patients with a history of mental health issues. Desloratadine is contraindicated in individuals with known hypersensitivity to the drug or its ingredients. Both medications should be used cautiously in patients with liver impairment, and patients should be aware of potential allergic reactions. It is important for patients to discuss their full medical history with their healthcare provider before starting these medications to ensure safe use.
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