Cefixime + Ofloxacin

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Brand Name

Jenfix-O 200mg/200mg Capsule , cafidol Of ... show more

Approved Treatment Indication:

Escherichia coli Infections, Bacterial Skin Diseases ... show more

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This medicine contains a combination of 2 active drug ingredients Cefixime and Ofloxacin.
Both drugs treat the same disease or symptom and work in similar ways.
Taking two drugs that work in the same way usually has no advantage over one of the drugs at the right dose.
Most doctors do not prescribe multiple drugs that work in the same ways.

Summary

What conditions are Cefixime and Ofloxacin used for?
Cefixime and Ofloxacin are used for treating various bacterial infections. Common conditions include respiratory tract infections like bronchitis and pneumonia, urinary tract infections, skin infections, and certain sexually transmitted infections like gonorrhea. Cefixime is effective against infections caused by gram-positive bacteria, while Ofloxacin is used for infections caused by gram-negative bacteria. They can also be used together to treat mixed bacterial infections where multiple types of bacteria are present.
How do Cefixime and Ofloxacin work in the body?
Cefixime and Ofloxacin work by killing bacteria in different ways. Cefixime, a cephalosporin antibiotic, inhibits the synthesis of the bacterial cell wall, causing the bacterial cell to die. On the other hand, Ofloxacin, a fluoroquinolone antibiotic, disrupts bacterial DNA replication by inhibiting enzymes necessary for DNA synthesis, preventing the bacteria from multiplying.
What are the usual dosages and routes of administration of Cefixime and Ofloxacin?
The usual adult dose for Cefixime is typically 400 mg per day, taken as a single dose or divided into two doses. For Ofloxacin, the usual adult dose ranges from 200 mg to 400 mg taken twice daily. The exact dosage may vary based on the type and severity of the infection being treated. Both medications should be taken as prescribed by a healthcare provider.
What are the most commonly observed adverse effects of Cefixime and Ofloxacin?
Common side effects of Cefixime include diarrhea, nausea, and abdominal pain. Ofloxacin may cause dizziness, headache, and gastrointestinal disturbances. Both medications can cause allergic reactions, though these are rare. Ofloxacin may cause tendonitis and tendon rupture, particularly in older adults, and may also cause changes in mood or behavior. Cefixime can occasionally lead to severe intestinal conditions like Clostridium difficile-associated diarrhea.
What are the important safety warnings and contraindications of Cefixime and Ofloxacin?
Cefixime should be used with caution in patients with a history of gastrointestinal disease, particularly colitis. Ofloxacin is contraindicated in patients with a history of tendon disorders related to fluoroquinolone use and should be used cautiously in those with a history of seizures. Both medications should be used with caution in patients with renal impairment and dosage adjustments may be necessary.

Government Approvals

None

WHO Essential Medicine

Known Teratogen

Pharmaceutical Class

Cephalosporin Antibacterial and Quinolone Antimicrobial

Controlled Drug Substance

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Summary

What conditions are Cefixime and Ofloxacin used for?
Cefixime and Ofloxacin are used for treating various bacterial infections. Common conditions include respiratory tract infections like bronchitis and pneumonia, urinary tract infections, skin infections, and certain sexually transmitted infections like gonorrhea. Cefixime is effective against infections caused by gram-positive bacteria, while Ofloxacin is used for infections caused by gram-negative bacteria. They can also be used together to treat mixed bacterial infections where multiple types of bacteria are present.
How do Cefixime and Ofloxacin work in the body?
Cefixime and Ofloxacin work by killing bacteria in different ways. Cefixime, a cephalosporin antibiotic, inhibits the synthesis of the bacterial cell wall, causing the bacterial cell to die. On the other hand, Ofloxacin, a fluoroquinolone antibiotic, disrupts bacterial DNA replication by inhibiting enzymes necessary for DNA synthesis, preventing the bacteria from multiplying.
What are the usual dosages and routes of administration of Cefixime and Ofloxacin?
The usual adult dose for Cefixime is typically 400 mg per day, taken as a single dose or divided into two doses. For Ofloxacin, the usual adult dose ranges from 200 mg to 400 mg taken twice daily. The exact dosage may vary based on the type and severity of the infection being treated. Both medications should be taken as prescribed by a healthcare provider.
What are the most commonly observed adverse effects of Cefixime and Ofloxacin?
Common side effects of Cefixime include diarrhea, nausea, and abdominal pain. Ofloxacin may cause dizziness, headache, and gastrointestinal disturbances. Both medications can cause allergic reactions, though these are rare. Ofloxacin may cause tendonitis and tendon rupture, particularly in older adults, and may also cause changes in mood or behavior. Cefixime can occasionally lead to severe intestinal conditions like Clostridium difficile-associated diarrhea.
What are the important safety warnings and contraindications of Cefixime and Ofloxacin?
Cefixime should be used with caution in patients with a history of gastrointestinal disease, particularly colitis. Ofloxacin is contraindicated in patients with a history of tendon disorders related to fluoroquinolone use and should be used cautiously in those with a history of seizures. Both medications should be used with caution in patients with renal impairment and dosage adjustments may be necessary.

Indications and Purpose

What is combination of Cefixime and Ofloxacin used for?

Cefixime and Ofloxacin are indicated for treating a variety of bacterial infections. Common conditions include respiratory tract infections, such as bronchitis and pneumonia, urinary tract infections, skin infections, and certain sexually transmitted infections like gonorrhea. Cefixime is particularly effective against infections caused by gram-positive bacteria, while Ofloxacin is often used for infections caused by gram-negative bacteria. Their combined use provides a broad-spectrum approach, making them suitable for treating mixed bacterial infections where multiple types of bacteria are present.

How does combination of Cefixime and Ofloxacin work?

Cefixime and Ofloxacin work by targeting and killing bacteria, but they do so in different ways. Cefixime, a cephalosporin antibiotic, inhibits the synthesis of the bacterial cell wall, leading to cell lysis and death. Ofloxacin, a fluoroquinolone antibiotic, disrupts bacterial DNA replication by inhibiting enzymes necessary for DNA synthesis, preventing the bacteria from multiplying. Both antibiotics are effective against a broad range of bacteria, making them useful for treating various infections. Their combined action helps ensure a more comprehensive approach to eliminating bacterial infections.

How effective is combination of Cefixime and Ofloxacin?

The effectiveness of Cefixime and Ofloxacin is supported by clinical studies and widespread clinical use. Cefixime has been shown to be effective in treating infections caused by susceptible strains of bacteria, particularly in respiratory and urinary tract infections. Ofloxacin has demonstrated efficacy in treating a wide range of infections, including those caused by gram-negative bacteria. Both antibiotics have been proven to reduce symptoms and clear infections in a significant number of patients. Their combined use is often recommended for mixed infections, providing a broad-spectrum approach that targets multiple types of bacteria, enhancing treatment outcomes.

How does one know if combination of Cefixime and Ofloxacin is working?

The benefit of Cefixime and Ofloxacin is assessed by the resolution of symptoms and the eradication of the bacterial infection. Improvement in symptoms such as reduced fever, pain, and inflammation indicates the effectiveness of the treatment. Laboratory tests, such as cultures, may be used to confirm the elimination of the bacteria. Both medications are evaluated based on their ability to clear the infection and improve the patient's condition, with follow-up appointments often scheduled to ensure the infection has been fully resolved.

Directions for Use

What is the usual dose of combination of Cefixime and Ofloxacin?

The usual adult dose for Cefixime is typically 400 mg per day, which can be taken as a single dose or divided into two doses. For Ofloxacin, the usual adult dose ranges from 200 mg to 400 mg, taken twice daily. The exact dosage may vary based on the type and severity of the infection being treated. Both medications should be taken as prescribed by a healthcare provider, and it's important not to exceed the recommended dose to avoid potential side effects.

How does one take combination of Cefixime and Ofloxacin?

Cefixime can be taken with or without food, but taking it with food may help reduce stomach upset. Ofloxacin should be taken on an empty stomach, either 1 hour before or 2 hours after meals, to ensure optimal absorption. It's important to avoid taking Ofloxacin with dairy products or calcium-fortified juices, as these can interfere with its absorption. Both medications should be taken with a full glass of water, and it's crucial to follow the prescribed schedule without missing doses to ensure the best outcome.

For how long is combination of Cefixime and Ofloxacin taken?

The typical duration of use for Cefixime and Ofloxacin varies depending on the type and severity of the infection. Generally, treatment lasts from 5 to 14 days. Cefixime is often prescribed for shorter durations, such as 5 to 7 days, while Ofloxacin may be used for up to 14 days, especially for more severe infections. It's crucial to follow the healthcare provider's instructions and complete the full course of antibiotics to ensure the infection is fully treated and to prevent antibiotic resistance.

How long does it take for combination of Cefixime and Ofloxacin to work?

Cefixime and Ofloxacin are antibiotics that start working soon after you take them, but it may take a few days to feel better. Cefixime, a cephalosporin antibiotic, works by stopping the growth of bacteria, while Ofloxacin, a fluoroquinolone antibiotic, kills bacteria by interfering with their DNA replication. Both medicines are effective against a wide range of bacteria, but the exact time to feel relief can vary depending on the infection's severity and location. It's important to complete the full course of treatment even if you start feeling better.

How does one store combination of Cefixime and Ofloxacin?

Cefixime and Ofloxacin do not require refrigeration. They should be stored at room temperature, away from direct sunlight and moisture, to maintain their effectiveness. It's important to keep them in their original packaging and out of reach of children. Both medications should be stored in a cool, dry place, and any unused or expired medication should be disposed of properly, following local guidelines for medication disposal.

Warnings and Precautions

Are there harms and risks from taking combination of Cefixime and Ofloxacin?

Common side effects of Cefixime include diarrhea, nausea, and abdominal pain, while Ofloxacin may cause dizziness, headache, and gastrointestinal disturbances. Both medications can cause allergic reactions, though these are rare. Significant adverse effects of Ofloxacin include tendonitis and tendon rupture, particularly in older adults, and it may also cause changes in mood or behavior. Cefixime can occasionally lead to severe intestinal conditions like Clostridium difficile-associated diarrhea. It's important to report any unusual or severe symptoms to a healthcare provider promptly.

Can I take combination of Cefixime and Ofloxacin with other prescription drugs?

Cefixime may interact with anticoagulants like warfarin, potentially increasing the risk of bleeding. Ofloxacin can interact with drugs that affect heart rhythm, such as certain antiarrhythmics, leading to an increased risk of QT prolongation, a condition that affects heart rhythm. Both medications can interact with other antibiotics, potentially altering their effectiveness. It's important to inform healthcare providers of all medications being taken to avoid potential interactions and ensure safe and effective treatment.

Can I take combination of Cefixime and Ofloxacin with vitamins or supplements?

Cefixime generally has fewer interactions with vitamins and supplements, but it's always best to consult a healthcare provider before combining it with other substances. Ofloxacin, however, can interact with multivitamins or supplements containing calcium, magnesium, aluminum, or iron, as these can reduce its absorption and effectiveness. It's recommended to take Ofloxacin at least 2 hours before or 4 hours after taking such supplements. Both medications should be used with caution when combined with other substances, and any potential interactions should be discussed with a healthcare provider.

Can I take combination of Cefixime and Ofloxacin if I am pregnant?

Cefixime is generally considered safe for use during pregnancy, as studies have not shown significant risks to the fetus. Ofloxacin, on the other hand, is usually avoided during pregnancy due to potential risks to the developing fetus, particularly concerning joint and cartilage development. Both medications should only be used during pregnancy if the potential benefits justify the potential risks. Pregnant women should consult their healthcare provider to discuss the safest treatment options for bacterial infections.

Can I take combination of Cefixime and Ofloxacin while breastfeeding?

Cefixime is generally considered safe during breastfeeding, as only small amounts are excreted in breast milk and are unlikely to harm a nursing infant. Ofloxacin, however, is excreted in breast milk in higher amounts and may pose a risk to the infant, particularly affecting the development of joints and cartilage. Therefore, Ofloxacin is usually not recommended during breastfeeding unless absolutely necessary. It's important for nursing mothers to consult their healthcare provider before using these medications to weigh the potential risks and benefits.

Who should avoid taking combination of Cefixime and Ofloxacin?

Cefixime and Ofloxacin have important warnings and contraindications. Cefixime should be used with caution in patients with a history of gastrointestinal disease, particularly colitis. Ofloxacin is contraindicated in patients with a history of tendon disorders related to fluoroquinolone use and should be used cautiously in those with a history of seizures. Both medications should be used with caution in patients with renal impairment, and dosage adjustments may be necessary. It's important to inform healthcare providers of any medical history or current conditions to ensure safe use of these antibiotics.