Cefixime
Escherichia coli Infections, Bacterial Skin Diseases ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Cephalosporin Antibacterial
Controlled Drug Substance
NO
Cefixime
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Click HereSummary
Cefixime is an antibiotic used to treat various bacterial infections. This includes ear infections, respiratory tract infections, urinary tract infections, and certain types of gastrointestinal infections like dysentery. It is also used for upper respiratory tract infections such as sinusitis, pharyngitis, tonsillitis, and lower respiratory tract infections like bronchitis and pneumonia.
Cefixime works by inhibiting the synthesis of bacterial cell walls. It binds to specific enzymes in bacteria, preventing them from forming a strong cell wall, which is essential for their survival and replication. This weakens the bacteria, and they are destroyed by the body's immune system, reducing the number of harmful bacteria in the body.
The usual adult dose of Cefixime for most infections is 400 mg per day. This can be divided into two doses of 200 mg each or taken as a single dose. It can be taken with or without food. The dose may vary depending on the type and severity of the infection. It's important to complete the full course of antibiotics as prescribed, even if symptoms improve, to prevent antibiotic resistance.
Common side effects of Cefixime include diarrhea, nausea, abdominal pain, and headache. Some people may also experience a rash, dizziness, or mild allergic reactions. Severe adverse effects, though rare, include severe allergic reactions, liver problems, or severe gastrointestinal issues like colitis. If any serious side effects occur, medical attention should be sought immediately.
Cefixime is contraindicated in people with a known allergy to cephalosporins or penicillins. Caution is advised for those with kidney disease, gastrointestinal conditions like colitis, or a history of severe allergic reactions. Prolonged use may lead to antibiotic resistance or secondary infections. Always consult a doctor before use, especially during pregnancy or breastfeeding.
Indications and Purpose
What is Cefixime used for?
Cefixime is indicated for treating bacterial infections such as bronchitis, gonorrhea, and infections of the ears, throat, tonsils, and urinary tract. It is also used for sinus infections in penicillin-allergic patients, pneumonia, shigella, salmonella, and typhoid fever. It is important to use Cefixime only for infections caused by susceptible bacteria.
How does Cefixime work?
Cefixime works by inhibiting the synthesis of the bacterial cell wall, which is essential for bacterial growth and survival. By disrupting this process, Cefixime causes the bacteria to die, effectively treating the infection. It is effective against a range of bacteria but not against viruses.
Is Cefixime effective?
Cefixime is a cephalosporin antibiotic that works by inhibiting bacterial cell wall synthesis, leading to the death of the bacteria. It is effective against a range of bacterial infections, including those affecting the respiratory tract, urinary tract, and gonorrhea. Clinical trials and post-marketing studies have demonstrated its efficacy in treating these infections.
How does one know if Cefixime is working?
The benefit of Cefixime is evaluated through clinical improvement in symptoms of the infection being treated. Laboratory tests may also be conducted to confirm the eradication of the bacteria. If symptoms do not improve or worsen, it is important to consult a doctor for further evaluation and possible adjustment of treatment.
Directions for Use
What is the usual dose of Cefixime?
For adults, the recommended dose of Cefixime is 400 mg daily, which can be taken as a single dose or split into two doses of 200 mg each. For children aged 6 months and older, the dose is typically 8 mg/kg/day, which can be given as a single daily dose or divided into two doses. It's important to follow the doctor's prescription for the exact dosage.
How do I take Cefixime?
Cefixime can be taken with or without food. It is important to take it at the same time each day to maintain consistent levels in the body. There are no specific food restrictions while taking Cefixime, but it is important to follow the doctor's instructions and complete the full course of the medication.
For how long do I take Cefixime?
The typical duration of Cefixime treatment is usually 7 to 14 days, depending on the type and severity of the infection. It's important to complete the full course of antibiotics as prescribed by your doctor, even if you start feeling better before finishing the medication.
How long does it take for Cefixime to start working?
Cefixime typically begins to work within a few days of starting treatment. Patients should start to feel better during the first few days, but it is important to complete the full course of antibiotics as prescribed to ensure the infection is fully treated and to prevent antibiotic resistance.
How should I store Cefixime?
Cefixime tablets, capsules, and chewable tablets should be stored at room temperature, away from excess heat and moisture. Liquid forms should be kept at room temperature or refrigerated and used within 14 days. Always keep medications out of reach of children and dispose of any unused medication properly.
Warnings and Precautions
Who should avoid taking Cefixime?
Cefixime is contraindicated in individuals with known allergies to cephalosporins. Caution is advised for those with a history of penicillin allergy due to possible cross-reactivity. It may cause Clostridium difficile-associated diarrhea, so any severe diarrhea should be reported to a doctor. Dose adjustments are necessary for patients with renal impairment.
Can I take Cefixime with other prescription drugs?
Cefixime may interact with carbamazepine, leading to elevated levels of the latter. It can also increase prothrombin time when taken with anticoagulants like warfarin, potentially increasing bleeding risk. Patients should inform their doctor of all medications they are taking to manage potential interactions effectively.
Can I take Cefixime with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Cefixime be taken safely while pregnant?
Cefixime is categorized as Pregnancy Category B, indicating that animal studies have not shown harm to the fetus, but there are no well-controlled studies in pregnant women. It should be used during pregnancy only if clearly needed, and the potential benefits justify the potential risks to the fetus.
Can Cefixime be taken safely while breastfeeding?
It is not known whether Cefixime is excreted in human milk. Therefore, caution is advised when administering Cefixime to breastfeeding mothers. The decision to continue or discontinue breastfeeding should consider the importance of the drug to the mother and any potential risks to the infant.
Is Cefixime safe for the elderly?
Elderly patients can generally use Cefixime at the same dosage as younger adults. However, they should be monitored for any side effects, as they may be more susceptible to adverse reactions. It's important to assess renal function in elderly patients, as dose adjustments may be necessary for those with impaired kidney function.
Is it safe to exercise while taking Cefixime?
Cefixime does not typically limit the ability to exercise. However, if you experience any side effects such as dizziness or fatigue, it may be wise to avoid strenuous activities until you feel better. Always listen to your body and consult your doctor if you have concerns about exercising while on this medication.
Is it safe to drink alcohol while taking Cefixime?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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