Candesartan + Hydrochlorothiazide
Find more information about this combination medication at the webpages for Candesartan and Hydrochlorothiazide
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Advisory
- This medicine contains a combination of 2 drugs Candesartan and Hydrochlorothiazide.
- Candesartan and Hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Thiazide Diuretic
Controlled Drug Substance
NO
Summary
Candesartan and Hydrochlorothiazide are primarily used to treat high blood pressure, also known as hypertension. Candesartan is also used to treat heart failure, while Hydrochlorothiazide can be used to manage edema, which is swelling caused by excess fluid in the body, associated with heart, kidney or liver disease.
Candesartan works by blocking substances that tighten blood vessels, thereby improving blood flow and reducing blood pressure. Hydrochlorothiazide works by helping the kidneys remove excess salt and water from the body, which reduces fluid retention and lowers blood pressure. Together, they provide a complementary approach to managing hypertension by addressing different pathways in the body.
The usual adult daily dose for Candesartan when used alone is typically 16 mg once daily, which can be adjusted up to 32 mg based on the patient's response. Hydrochlorothiazide is usually prescribed at a dose of 12.5 to 50 mg once daily. When combined, the doses are adjusted to provide effective blood pressure control while minimizing side effects.
Common side effects of Hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances such as low potassium levels. Candesartan may cause dizziness, back pain, and sore throat. Both medications can lead to more serious side effects such as severe allergic reactions, kidney problems, and significant changes in blood pressure.
Candesartan and Hydrochlorothiazide should not be used during pregnancy due to the risk of harm to the fetus. They are also contraindicated in patients with severe kidney impairment, an inability to produce urine, or hypersensitivity to the drugs. Caution is advised in patients with electrolyte imbalances, liver disease, or those taking medications that affect potassium levels.
Indications and Purpose
How does combination of Candesartan and Hydrochlorothiazide work?
Candesartan and Hydrochlorothiazide work together to lower high blood pressure. Candesartan is a type of medication called an angiotensin receptor blocker (ARB). It helps relax blood vessels by blocking a substance in the body that causes them to tighten. This makes it easier for the heart to pump blood around the body. Hydrochlorothiazide is a diuretic, often called a 'water pill,' which helps the body get rid of extra salt and water by increasing urine production. This reduces the volume of fluid in the blood vessels, further helping to lower blood pressure. Together, these medications help prevent strokes, heart attacks, and kidney problems by keeping blood pressure under control.
How does combination of Hydrochlorothiazide and Candesartan work?
Hydrochlorothiazide works by increasing the excretion of sodium and water from the kidneys, which helps reduce blood volume and lower blood pressure. Candesartan blocks the action of angiotensin II, a substance that narrows blood vessels, thereby relaxing the vessels and improving blood flow. Together, these medications complement each other by addressing different mechanisms that contribute to high blood pressure, resulting in a more effective reduction in blood pressure levels.
How effective is combination of Candesartan and Hydrochlorothiazide?
The combination of Candesartan and Hydrochlorothiazide is effective in treating high blood pressure. Candesartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, making it easier for the heart to pump blood. Hydrochlorothiazide is a diuretic, often called a 'water pill,' that helps reduce excess fluid in the body by increasing urine production. Together, they work to lower blood pressure more effectively than either drug alone. According to the NHS and other trusted sources, this combination is generally well-tolerated and can significantly reduce the risk of heart attacks and strokes by managing high blood pressure.
How effective is combination of Hydrochlorothiazide and Candesartan?
Clinical trials have demonstrated that both hydrochlorothiazide and candesartan effectively lower blood pressure, reducing the risk of cardiovascular events such as heart attacks and strokes. Hydrochlorothiazide's diuretic action helps decrease fluid retention, while candesartan's ability to block angiotensin II leads to vasodilation. When used together, they provide a synergistic effect, enhancing blood pressure control. Long-term studies have shown that this combination maintains its efficacy over time, contributing to improved cardiovascular outcomes and reduced mortality in patients with hypertension.
Directions for Use
What is the usual dose of combination of Candesartan and Hydrochlorothiazide?
The usual dose of the combination of Candesartan and Hydrochlorothiazide can vary depending on the specific needs of the patient, but a common starting dose is 16 mg of Candesartan with 12.5 mg of Hydrochlorothiazide once daily. This combination is used to help lower blood pressure. Candesartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps the body get rid of excess salt and water. It's important to follow a healthcare provider's instructions for dosing.
What is the usual dose of combination of Hydrochlorothiazide and Candesartan?
The usual adult daily dose for candesartan when used alone is typically 16 mg once daily, which can be adjusted up to 32 mg based on the patient's response. Hydrochlorothiazide is usually prescribed at a dose of 12.5 to 50 mg once daily. When combined, the doses are adjusted to provide effective blood pressure control while minimizing side effects. The combination tablets are available in strengths such as 16 mg/12.5 mg, 32 mg/12.5 mg, and 32 mg/25 mg of candesartan and hydrochlorothiazide, respectively. Both medications are used to manage high blood pressure, but they work through different mechanisms.
How does one take combination of Candesartan and Hydrochlorothiazide?
Candesartan and Hydrochlorothiazide are taken together as a single tablet, usually once a day. It's important to follow your doctor's instructions on the exact dosage and timing. This combination is used to lower high blood pressure, which helps prevent strokes and heart attacks. Candesartan is an angiotensin receptor blocker that relaxes blood vessels, while Hydrochlorothiazide is a diuretic that helps remove excess salt and water from the body. Always take the medication with a glass of water, and you can take it with or without food. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Do not double up to make up for a missed dose. Regular monitoring of blood pressure and kidney function may be necessary while on this medication.
How does one take combination of Hydrochlorothiazide and Candesartan?
Hydrochlorothiazide and candesartan can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. Patients should avoid using salt substitutes containing potassium without consulting their doctor, as these can interact with the medications. Additionally, if a low-salt or low-sodium diet is prescribed, it should be followed carefully. Staying hydrated is important, but excessive fluid intake should be avoided to prevent electrolyte imbalances.
For how long is combination of Candesartan and Hydrochlorothiazide taken?
The combination of Candesartan and Hydrochlorothiazide is typically taken as a long-term treatment for high blood pressure. The duration of treatment can vary depending on individual health needs and how well the medication is controlling blood pressure. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as high blood pressure often requires ongoing management. Regular check-ups will help determine the appropriate length of treatment.
For how long is combination of Hydrochlorothiazide and Candesartan taken?
Hydrochlorothiazide and candesartan are typically used as long-term treatments for managing high blood pressure. Both medications are intended for continuous use to maintain blood pressure control and prevent complications such as heart disease and stroke. While they do not cure hypertension, they help manage the condition effectively. Patients are advised to continue taking these medications even if they feel well, as stopping them without medical advice can lead to a return of high blood pressure.
How long does it take for combination of Candesartan and Hydrochlorothiazide to work?
The combination of Candesartan and Hydrochlorothiazide typically starts to work within a few hours after taking the first dose. However, it may take several weeks to experience the full blood pressure-lowering effects. Candesartan is an angiotensin receptor blocker that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce fluid retention. Together, they help lower blood pressure more effectively. It's important to continue taking the medication as prescribed by your healthcare provider to achieve the best results.
How long does it take for combination of Hydrochlorothiazide and Candesartan to work?
Candesartan typically begins to lower blood pressure within the first two weeks of treatment, with the full effect observed in 4 to 6 weeks. Hydrochlorothiazide, on the other hand, starts working within 2 hours, with its peak effect occurring around 4 hours after ingestion. When combined, the initial effects of blood pressure reduction can be seen relatively quickly, but the full benefits may take several weeks to manifest. Both medicines work to lower blood pressure, but they do so through different mechanisms, which can complement each other for a more effective treatment.
Warnings and Precautions
Are there harms and risks from taking combination of Candesartan and Hydrochlorothiazide?
Candesartan and Hydrochlorothiazide are medications often used together to treat high blood pressure. While they can be effective, there are potential risks and side effects to be aware of. 1. **Low Blood Pressure**: This combination can lower blood pressure too much, leading to dizziness or fainting, especially when standing up quickly. 2. **Electrolyte Imbalance**: Hydrochlorothiazide can cause imbalances in electrolytes like potassium and sodium, which are essential for body functions. Symptoms might include muscle cramps, weakness, or irregular heartbeats. 3. **Kidney Function**: Both drugs can affect kidney function, so regular monitoring by a healthcare provider is important. 4. **Allergic Reactions**: Some people may experience allergic reactions, which could include rash, itching, or swelling. 5. **Dehydration**: Hydrochlorothiazide is a diuretic, meaning it helps the body get rid of excess fluid, which can lead to dehydration if not enough fluids are consumed. It's important to follow your healthcare provider's instructions and report any unusual symptoms. Regular check-ups can help manage these risks effectively.
Are there harms and risks from taking combination of Hydrochlorothiazide and Candesartan?
Common side effects of hydrochlorothiazide include frequent urination, dizziness, and electrolyte imbalances, such as low potassium levels. Candesartan may cause dizziness, back pain, and sore throat. Both medications can lead to more serious side effects, such as severe allergic reactions, kidney problems, and significant changes in blood pressure. Patients should be monitored for signs of dehydration, electrolyte disturbances, and any unusual symptoms, and should report these to their healthcare provider promptly.
Can I take combination of Candesartan and Hydrochlorothiazide with other prescription drugs?
Candesartan and Hydrochlorothiazide are medications often used together to manage high blood pressure. Candesartan is an angiotensin receptor blocker (ARB) that helps relax blood vessels, while Hydrochlorothiazide is a diuretic that helps reduce fluid retention. When taking these medications, it's important to be cautious about interactions with other prescription drugs. According to the NHS, combining these with other medications that affect blood pressure, such as other antihypertensives, can lead to excessively low blood pressure. Additionally, combining with non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of Candesartan. The NLM advises that you should inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions. They can provide guidance on safe combinations and adjust dosages if necessary. Always consult your doctor or pharmacist before starting any new medication to ensure it is safe to take with your current prescriptions.
Can I take combination of Hydrochlorothiazide and Candesartan with other prescription drugs?
Hydrochlorothiazide and candesartan can interact with several prescription medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce their effectiveness in lowering blood pressure. Combining these medications with other antihypertensives can enhance blood pressure-lowering effects, potentially leading to hypotension. Caution is advised when used with lithium, as it can increase lithium levels and toxicity. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of Candesartan and Hydrochlorothiazide if I am pregnant?
No, you should not take Candesartan and Hydrochlorothiazide if you are pregnant. According to the NHS, Candesartan is not recommended during pregnancy as it can affect the baby's development, especially in the second and third trimesters. Hydrochlorothiazide, a diuretic, is also generally avoided during pregnancy unless absolutely necessary, as it can lead to complications. It's important to consult your healthcare provider for safer alternatives to manage your condition during pregnancy.
Can I take combination of Hydrochlorothiazide and Candesartan if I am pregnant?
Hydrochlorothiazide and candesartan are not recommended during pregnancy, particularly in the second and third trimesters, due to the risk of fetal harm. Candesartan can cause injury or death to the developing fetus by affecting kidney function and blood pressure. Hydrochlorothiazide may lead to electrolyte imbalances and reduced placental blood flow. If pregnancy is detected, these medications should be discontinued immediately, and alternative treatments should be considered to manage hypertension safely during pregnancy.
Can I take combination of Candesartan and Hydrochlorothiazide while breastfeeding?
According to the NHS, it is important to consult with a healthcare professional before taking Candesartan and Hydrochlorothiazide while breastfeeding. Candesartan is a medication used to treat high blood pressure, and Hydrochlorothiazide is a diuretic that helps reduce fluid retention. Both medications can pass into breast milk, and their effects on a breastfeeding infant are not well-studied. Therefore, a doctor can help weigh the benefits and potential risks to determine the best course of action for you and your baby.
Can I take combination of Hydrochlorothiazide and Candesartan while breastfeeding?
Hydrochlorothiazide is known to be excreted in breast milk and may reduce milk production, especially at high doses. Candesartan's excretion in human milk is not well-documented, but it is present in animal milk. Due to potential adverse effects on the nursing infant, the use of these medications during breastfeeding is generally not recommended. If treatment is necessary, the benefits and risks should be carefully weighed, and alternative medications with a better-established safety profile during lactation should be considered.
Who should avoid taking combination of Candesartan and Hydrochlorothiazide?
People who should avoid taking the combination of Candesartan and Hydrochlorothiazide include those who are allergic to either of these medications or any of their ingredients. Additionally, individuals with severe kidney or liver problems, those who are pregnant or planning to become pregnant, and people with low blood pressure should avoid this combination. It's also important for individuals with diabetes who are taking aliskiren, a medication used to treat high blood pressure, to avoid this combination. Always consult a healthcare professional before starting or stopping any medication.
Who should avoid taking combination of Hydrochlorothiazide and Candesartan?
Hydrochlorothiazide and candesartan are contraindicated in patients with severe renal impairment, anuria, or hypersensitivity to the drugs. They should not be used during pregnancy due to the risk of fetal harm. Caution is advised in patients with electrolyte imbalances, liver disease, or those taking medications that affect potassium levels. Patients should be monitored for signs of hypotension, especially if they are volume-depleted. It's important to follow medical advice closely and report any adverse effects immediately.
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