Azilsartan + Chlorthalidone
Find more information about this combination medication at the webpages for Azilsartan and Chlorthalidone
Hypertension, Renal Insufficiency ... show more
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Advisory
- This medicine contains a combination of 2 drugs Azilsartan and Chlorthalidone.
- Azilsartan and Chlorthalidone are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Thiazide-like Diuretic
Controlled Drug Substance
NO
Learn more about this medicine -
Click HereSummary
Azilsartan and Chlorthalidone are used to treat high blood pressure, also known as hypertension. In addition, Chlorthalidone can be used to treat fluid retention, also known as edema, associated with heart disease.
Azilsartan works by blocking substances that tighten blood vessels, which helps to relax them and improve blood flow. Chlorthalidone is a diuretic, meaning it helps the kidneys to remove excess salt and water from the body, reducing fluid retention and lowering blood pressure.
The usual adult dose for Azilsartan is typically 40 mg once daily. For Chlorthalidone, the usual dose is 25 mg once daily. These medications are taken orally.
Common side effects of Azilsartan include dizziness and diarrhea, while Chlorthalidone may cause frequent urination, muscle weakness, and dizziness. Both medications can lead to low blood pressure and may cause lightheadedness or fainting.
Azilsartan should not be used during pregnancy due to the risk of harm to the unborn baby. Both medications can cause low blood pressure and affect kidney function. Patients with severe kidney impairment or those who produce little to no urine should not use these medications.
Indications and Purpose
What is combination of Azilsartan and Chlorthalidone used for?
The combination of Azilsartan and Chlorthalidone is used to treat high blood pressure, also known as hypertension. Azilsartan is a medication that helps relax blood vessels, making it easier for blood to flow through them, while Chlorthalidone is a diuretic that helps the body get rid of excess salt and water, which can also help lower blood pressure. Together, they work to reduce the risk of heart attacks, strokes, and kidney problems by keeping blood pressure under control.
What is combination of Chlorthalidone and Azilsartan used for?
Chlorthalidone and azilsartan are primarily indicated for the treatment of high blood pressure (hypertension). By effectively managing blood pressure, these medications help reduce the risk of complications such as heart disease, stroke, and kidney failure. Chlorthalidone may also be used to treat fluid retention (edema) associated with heart disease, while azilsartan is specifically used to block substances that tighten blood vessels. Together, they provide a comprehensive approach to managing hypertension and its associated risks.
How does combination of Azilsartan and Chlorthalidone work?
Azilsartan and Chlorthalidone work together to lower high blood pressure. Azilsartan is a type of medication called an angiotensin II receptor blocker (ARB). It helps relax blood vessels by blocking a substance in the body that causes them to tighten. This makes it easier for the heart to pump blood. Chlorthalidone is a diuretic, often called a 'water pill,' which helps the body get rid of extra salt and water by increasing urine production. This reduces the volume of fluid in the blood vessels, further helping to lower blood pressure.
How does combination of Chlorthalidone and Azilsartan work?
Azilsartan works by blocking the action of angiotensin II, a natural substance that causes blood vessels to tighten. By preventing this action, azilsartan helps relax and widen blood vessels, improving blood flow and reducing blood pressure. Chlorthalidone, a diuretic, helps the kidneys remove excess salt and water from the body, which decreases fluid retention and lowers blood pressure. Together, these medications provide a dual approach to managing hypertension by addressing both vessel constriction and fluid overload.
How effective is combination of Azilsartan and Chlorthalidone?
The combination of Azilsartan and Chlorthalidone is used to treat high blood pressure. Azilsartan is a medication that helps relax blood vessels, making it easier for the heart to pump blood. Chlorthalidone is a diuretic, often called a 'water pill,' which helps the body get rid of excess salt and water through urine. Together, these medications work effectively to lower blood pressure more than when each is used alone. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. According to trusted sources like the NHS and NLM, this combination is generally effective and well-tolerated, but it is important to follow a healthcare provider's guidance for the best results.
How effective is combination of Chlorthalidone and Azilsartan?
Clinical trials have demonstrated that both chlorthalidone and azilsartan effectively lower blood pressure. Chlorthalidone, a thiazide-like diuretic, has been shown to reduce cardiovascular events by managing fluid retention and lowering blood pressure. Azilsartan, an angiotensin II receptor blocker, has been proven to improve blood flow by relaxing blood vessels. When used together, they provide a synergistic effect, enhancing blood pressure control and reducing the risk of heart attack and stroke. The combination has been evaluated in studies showing significant reductions in both systolic and diastolic blood pressure.
How does one know if combination of Azilsartan and Chlorthalidone is working?
To determine if the combination of Azilsartan and Chlorthalidone is working, you should monitor your blood pressure regularly. This combination is used to lower high blood pressure, which can help prevent strokes, heart attacks, and kidney problems. You should notice a decrease in your blood pressure readings over time. It's important to follow your doctor's instructions and attend regular check-ups to assess the effectiveness of the treatment. If you experience any side effects or if your blood pressure does not improve, consult your healthcare provider for further advice.
How does one know if combination of Chlorthalidone and Azilsartan is working?
The benefit of chlorthalidone and azilsartan is primarily assessed by measuring reductions in blood pressure. Regular blood pressure checks are essential to determine how well the medications are controlling hypertension. Additionally, healthcare providers may monitor for improvements in symptoms related to high blood pressure, such as headaches or dizziness. For chlorthalidone, the reduction in fluid retention can also be observed through decreased swelling or edema. Both medications aim to reduce the risk of complications like heart attack and stroke by effectively managing blood pressure levels.
Directions for Use
What is the usual dose of combination of Azilsartan and Chlorthalidone?
The usual dose of the combination of Azilsartan and Chlorthalidone is typically one tablet taken once daily. The specific strength of the tablet can vary, but a common combination is 40 mg of Azilsartan with 12.5 mg of Chlorthalidone. It's important to follow the dosage prescribed by a healthcare provider, as they will tailor it to your individual needs and health condition. Azilsartan is a medication that helps relax blood vessels, making it easier for the heart to pump blood, while Chlorthalidone is a diuretic that helps reduce excess fluid in the body.
What is the usual dose of combination of Chlorthalidone and Azilsartan?
The usual adult dose for azilsartan is typically 40 mg once daily, which can be adjusted based on the patient's response and needs. For chlorthalidone, the usual dose is 25 mg once daily, often taken in the morning to avoid nighttime urination. When combined in a single medication, the starting dose is often 40 mg of azilsartan with 12.5 mg of chlorthalidone, which can be increased to 40 mg/25 mg if needed. Both medications are used to manage high blood pressure, but they work through different mechanisms: azilsartan blocks substances that tighten blood vessels, while chlorthalidone helps remove excess fluid from the body.
How does one take combination of Azilsartan and Chlorthalidone?
Azilsartan and Chlorthalidone are medications used together to manage high blood pressure. Azilsartan is an angiotensin II receptor blocker (ARB) that helps relax blood vessels, while Chlorthalidone is a diuretic that helps remove excess fluid from the body. When taking this combination, it is important to follow your healthcare provider's instructions. Typically, the medication is taken once daily, with or without food. It's crucial to take it at the same time each day to maintain consistent blood levels. Do not stop taking the medication without consulting your doctor, even if you feel well, as high blood pressure often has no symptoms. Regular monitoring of blood pressure and kidney function may be necessary while on this medication. If you experience any side effects or have concerns, contact your healthcare provider for advice.
How does one take combination of Chlorthalidone and Azilsartan?
Chlorthalidone and azilsartan can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. Patients should follow any dietary recommendations provided by their healthcare provider, such as a low-salt diet, to enhance the effectiveness of the medications. It's also advised to avoid salt substitutes containing potassium without consulting a doctor, as these can interact with the medications. Staying hydrated is important, but excessive fluid intake should be avoided to prevent overloading the kidneys.
For how long is combination of Azilsartan and Chlorthalidone taken?
The duration for taking a combination of Azilsartan and Chlorthalidone can vary depending on the individual's health condition and response to treatment. Typically, these medications are prescribed for long-term use to manage high blood pressure. It's important to follow your healthcare provider's instructions and not to stop taking the medication without consulting them, as this could affect your blood pressure control. Regular check-ups with your healthcare provider will help determine the appropriate duration for your specific situation.
For how long is combination of Chlorthalidone and Azilsartan taken?
Both chlorthalidone and azilsartan are typically used as long-term treatments for managing high blood pressure. They are not cures for hypertension but are used to control blood pressure levels over time. Patients are usually advised to continue taking these medications even if they feel well, as stopping them can lead to a return of high blood pressure. Regular monitoring by a healthcare provider is essential to ensure the medications are working effectively and to adjust dosages if necessary.
How long does it take for combination of Azilsartan and Chlorthalidone to work?
The combination of Azilsartan and Chlorthalidone typically begins to lower blood pressure within a few hours of taking the medication. However, it may take several weeks to see the full effect on blood pressure levels. Azilsartan is a medication that helps relax blood vessels, making it easier for the heart to pump blood, while Chlorthalidone is a diuretic that helps remove excess fluid from the body, reducing blood pressure. It's important to continue taking the medication as prescribed by your healthcare provider to achieve the best results.
How long does it take for combination of Chlorthalidone and Azilsartan to work?
Azilsartan, when used alone, typically takes about 2 weeks to show its full effect in lowering blood pressure. Chlorthalidone, on the other hand, starts working more quickly, often within a few hours, as it is a diuretic that helps remove excess fluid from the body. When combined, the effects of azilsartan and chlorthalidone can complement each other, with chlorthalidone providing a more immediate reduction in blood pressure through fluid removal, while azilsartan contributes to a longer-term stabilization of blood pressure by blocking substances that tighten blood vessels. Together, they provide a comprehensive approach to managing high blood pressure.
How does one store combination of Azilsartan and Chlorthalidone?
To store a combination of Azilsartan and Chlorthalidone, keep the medication in its original container, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom). This helps maintain the medication's effectiveness and safety. Always check the packaging for specific storage instructions and consult a pharmacist if you have any questions.
How does one store combination of Chlorthalidone and Azilsartan?
Chlorthalidone and azilsartan do not require refrigeration. They should be stored at room temperature, away from excess heat and moisture, and kept in their original container to protect them from light. It's important to keep these medications out of reach of children, as many containers are not child-resistant. Proper storage ensures the medications remain effective and safe to use.
Warnings and Precautions
Are there harms and risks from taking combination of Azilsartan and Chlorthalidone?
Yes, there are potential harms and risks when taking a combination of Azilsartan and Chlorthalidone. Azilsartan is a medication used to lower blood pressure by relaxing blood vessels, while Chlorthalidone is a diuretic that helps remove excess fluid from the body. Possible side effects of this combination can include: 1. **Low Blood Pressure (Hypotension):** This can cause dizziness or fainting, especially when standing up quickly. 2. **Electrolyte Imbalance:** Chlorthalidone can lead to low levels of potassium, sodium, or magnesium in the blood, which can cause muscle cramps, weakness, or irregular heartbeats. 3. **Kidney Function Changes:** Both medications can affect kidney function, so regular monitoring by a healthcare provider is important. 4. **Dehydration:** Due to the diuretic effect of Chlorthalidone, there is a risk of dehydration, which can lead to further complications. 5. **Increased Blood Sugar Levels:** Chlorthalidone may raise blood sugar levels, which is a concern for people with diabetes. It's important to follow your healthcare provider's instructions and report any unusual symptoms. Regular check-ups and blood tests may be necessary to monitor your health while on these medications.
Are there harms and risks from taking combination of Chlorthalidone and Azilsartan?
Common side effects of azilsartan include dizziness and diarrhea, while chlorthalidone may cause frequent urination, muscle weakness, and dizziness. Both medications can lead to low blood pressure, especially when standing up quickly, and may cause lightheadedness or fainting. Serious side effects include kidney problems, electrolyte imbalances, and, in rare cases, severe skin reactions. Patients should report any unusual symptoms to their doctor, as adjustments to the medication or additional monitoring may be necessary.
Can I take combination of Azilsartan and Chlorthalidone with other prescription drugs?
Azilsartan is a medication used to lower blood pressure by relaxing blood vessels, while Chlorthalidone is a diuretic that helps remove excess fluid from the body. When taking these medications together, it's important to be cautious about interactions with other prescription drugs. 1. **Consult Your Doctor**: Always talk to your healthcare provider before combining these medications with others. They can assess your specific health needs and potential interactions. 2. **Potential Interactions**: Azilsartan and Chlorthalidone can interact with other blood pressure medications, increasing the risk of low blood pressure. They may also interact with medications that affect kidney function or electrolyte levels. 3. **Monitoring**: Your doctor may recommend regular monitoring of your blood pressure, kidney function, and electrolyte levels if you are taking these medications with others. 4. **Inform Your Doctor**: Make sure your doctor knows all the medications you are taking, including over-the-counter drugs and supplements, to avoid harmful interactions. For more detailed information, you can refer to trusted sources like the [NHS](https://www.nhs.uk/), [DailyMeds](https://dailymeds.co.uk/), or [NLM](https://www.nlm.nih.gov/).
Can I take combination of Chlorthalidone and Azilsartan with other prescription drugs?
Chlorthalidone and azilsartan can interact with nonsteroidal anti-inflammatory drugs (NSAIDs), which may reduce their effectiveness and increase the risk of kidney problems. Combining these medications with other blood pressure drugs can enhance the risk of low blood pressure. Additionally, azilsartan should not be used with aliskiren in patients with diabetes due to increased risks of adverse effects. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of Azilsartan and Chlorthalidone with vitamins or supplements?
Azilsartan is a medication used to treat high blood pressure, and Chlorthalidone is a diuretic that helps remove excess fluid from the body. When taking these medications, it's important to be cautious with vitamins and supplements, especially those containing potassium, as Azilsartan can increase potassium levels in the blood. High potassium levels can be dangerous. Before adding any vitamins or supplements to your routine, it's best to consult with a healthcare professional. They can provide guidance based on your specific health needs and ensure there are no interactions that could affect your treatment.
Can I take combination of Chlorthalidone and Azilsartan with vitamins or supplements?
Patients taking chlorthalidone and azilsartan should be cautious with potassium supplements or salt substitutes containing potassium, as these can lead to elevated potassium levels in the blood. It's important to discuss any vitamins or supplements with a healthcare provider to avoid potential interactions. Both medications can affect electrolyte balance, so monitoring and adjustments may be needed to maintain safe levels of essential minerals in the body.
Can I take combination of Azilsartan and Chlorthalidone if I am pregnant?
It is generally not recommended to take Azilsartan and Chlorthalidone during pregnancy. Azilsartan is a type of medication known as an angiotensin II receptor blocker (ARB), which can affect the development of the baby's kidneys and lead to other complications if taken during pregnancy, especially in the second and third trimesters. Chlorthalidone is a diuretic, which can also pose risks during pregnancy, such as affecting the balance of fluids and electrolytes in the body. It is important to consult with a healthcare provider for safer alternatives if you are pregnant or planning to become pregnant.
Can I take combination of Chlorthalidone and Azilsartan if I am pregnant?
Azilsartan is contraindicated during pregnancy due to the risk of fetal harm, particularly in the second and third trimesters, as it can affect fetal kidney function and lead to serious complications. Chlorthalidone crosses the placenta and may cause fetal or neonatal jaundice and other adverse effects. Pregnant women should discontinue these medications as soon as pregnancy is detected and consult their healthcare provider for alternative treatments to manage high blood pressure safely during pregnancy.
Can I take combination of Azilsartan and Chlorthalidone while breastfeeding?
When considering the use of Azilsartan and Chlorthalidone while breastfeeding, it's important to consult with a healthcare professional. According to the NHS, some medications can pass into breast milk and may affect the baby. Azilsartan is a medication used to treat high blood pressure, and Chlorthalidone is a diuretic that helps reduce fluid retention. The National Library of Medicine (NLM) suggests that while some blood pressure medications are considered safer during breastfeeding, each case is unique. The healthcare provider will weigh the benefits of controlling blood pressure against any potential risks to the breastfeeding infant. Always discuss with your doctor or a healthcare provider to ensure the safety of both you and your baby when taking any medication while breastfeeding.
Can I take combination of Chlorthalidone and Azilsartan while breastfeeding?
There is limited information on the safety of azilsartan during breastfeeding, but it is known to be present in rat milk. Chlorthalidone is excreted in human milk and may affect the nursing infant. Due to the potential for adverse effects on the infant, breastfeeding is generally not recommended while taking these medications. Mothers should discuss with their healthcare provider to weigh the benefits and risks and consider alternative treatments or feeding options.
Who should avoid taking combination of Azilsartan and Chlorthalidone?
People who should avoid taking the combination of Azilsartan and Chlorthalidone include those with severe kidney or liver problems, as these conditions can be worsened by the medication. Additionally, individuals who are allergic to either of these drugs or have a history of allergic reactions to similar medications should not take them. Pregnant women should also avoid this combination, as it can harm the developing fetus. It's important for anyone considering this medication to consult with a healthcare provider to ensure it's safe for their specific health conditions.
Who should avoid taking combination of Chlorthalidone and Azilsartan?
A critical warning for azilsartan is its potential to cause harm to an unborn baby, so it should not be used during pregnancy. Both medications can cause low blood pressure, especially in patients who are dehydrated or on high doses of diuretics. Chlorthalidone may lead to electrolyte imbalances, and both drugs can affect kidney function. Patients with severe kidney impairment or those who produce little to no urine should not use these medications. Regular monitoring and communication with a healthcare provider are essential to manage these risks.