Amlodipine + Telmisartan
Find more information about this combination medication at the webpages for Amlodipine and Telmisartan
Hypertension, Variant Angina Pectoris ... show more
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Advisory
- This medicine contains a combination of 2 drugs Amlodipine and Telmisartan.
- Amlodipine and Telmisartan are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Angiotensin 2 Receptor Blocker and Calcium Channel Blocker and Dihydropyridine Calcium Channel Blocker
Controlled Drug Substance
NO
Amlodipine + Telmisartan
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Click HereSummary
Amlodipine and Telmisartan are primarily used to treat high blood pressure, also known as hypertension. Amlodipine is also used to treat certain types of chest pain known as angina and coronary artery disease. Telmisartan is used to reduce the risk of heart attack, stroke, or death in people at high risk for cardiovascular disease.
Amlodipine works by blocking calcium channels in the blood vessels, leading to relaxation and dilation, which reduces blood pressure. Telmisartan blocks the action of a substance called angiotensin II that causes blood vessels to tighten, allowing blood to flow more smoothly and reducing blood pressure. They work through different mechanisms but together they help manage high blood pressure effectively.
The usual adult daily dose for Amlodipine is between 5 mg to 10 mg, and for Telmisartan, it ranges from 20 mg to 80 mg per day. When combined, the starting dose is often 40 mg of Telmisartan with 5 mg of Amlodipine. Both medications are taken orally, once daily.
Common side effects of Amlodipine include swelling of the hands, feet or ankles, dizziness, and flushing. Telmisartan may cause back pain, sinus pain, and diarrhea. Both medications can lead to dizziness or lightheadedness, especially when starting treatment. Serious but rare side effects include severe allergic reactions, rapid heartbeat, and significant drops in blood pressure.
Amlodipine and Telmisartan should not be used during pregnancy due to the risk of harm to the fetus. They are also not recommended for patients with severe liver or kidney impairment. Both drugs can cause dizziness, so it's advised to avoid driving or operating heavy machinery until you know how the medication affects you. Always inform your healthcare provider about all medications you are taking to avoid adverse interactions.
Indications and Purpose
What is combination of Amlodipine and Telmisartan used for?
Amlodipine and Telmisartan are primarily indicated for the treatment of high blood pressure (hypertension). Amlodipine is also used to treat certain types of angina (chest pain) and coronary artery disease. Telmisartan is additionally used to reduce the risk of heart attack, stroke, or death in people at high risk for cardiovascular disease. Both medications help manage hypertension, but they also have unique benefits for specific cardiovascular conditions.
How does combination of Amlodipine and Telmisartan work?
Amlodipine works by blocking calcium channels in the blood vessels, leading to relaxation and dilation, which reduces blood pressure. Telmisartan blocks the action of angiotensin II, a substance that causes blood vessels to tighten, thereby allowing blood to flow more smoothly and reducing blood pressure. Both medications aim to lower blood pressure but do so through different mechanisms, providing a complementary effect that enhances overall cardiovascular protection.
How effective is combination of Amlodipine and Telmisartan?
Clinical trials have demonstrated that Amlodipine and Telmisartan effectively lower blood pressure and reduce the risk of cardiovascular events. Amlodipine has been shown to improve blood flow and reduce angina symptoms, while Telmisartan has been proven to decrease the likelihood of heart attacks and strokes in high-risk patients. Both medications have been tested in various populations and have consistently shown to be effective in managing hypertension, providing a comprehensive approach to cardiovascular health.
How does one know if combination of Amlodipine and Telmisartan is working?
The benefit of Amlodipine and Telmisartan is primarily assessed by monitoring blood pressure levels. Regular blood pressure checks help determine the effectiveness of the treatment in lowering systolic and diastolic pressures. Additionally, the reduction in symptoms associated with high blood pressure, such as headaches or dizziness, can also indicate the medication's effectiveness. Both medications aim to reduce the risk of cardiovascular events, and their success can be measured by a decrease in such incidents over time.
Directions for Use
What is the usual dose of combination of Amlodipine and Telmisartan?
The usual dose of the combination of Amlodipine and Telmisartan can vary based on individual health needs, but a common starting dose is 5 mg of Amlodipine and 40 mg of Telmisartan once daily. The dose may be adjusted by a healthcare provider depending on the patient's response and blood pressure goals. It's important to follow the specific dosing instructions provided by a healthcare professional.
How does one take combination of Amlodipine and Telmisartan?
Amlodipine and Telmisartan can be taken with or without food, making them convenient for daily use. It is important to take them at the same time each day to maintain consistent blood levels. Patients should follow any specific dietary instructions provided by their doctor, such as a low-salt diet, to enhance the effectiveness of the medication. There are no specific food restrictions, but patients should avoid using potassium supplements or salt substitutes containing potassium without consulting their doctor.
For how long is combination of Amlodipine and Telmisartan taken?
Amlodipine and Telmisartan are typically used as long-term treatments for managing high blood pressure. Both medications are intended for continuous use to maintain blood pressure control and prevent complications such as heart disease and stroke. While they do not cure hypertension, they help manage the condition effectively when taken regularly. Patients are advised to continue taking these medications even if they feel well, as stopping them can lead to a return of high blood pressure.
How long does it take for combination of Amlodipine and Telmisartan to work?
Amlodipine and Telmisartan, when used together, typically start to show effects within a few hours. Amlodipine, a calcium channel blocker, begins to work by relaxing blood vessels, which can lead to a reduction in blood pressure within 6 to 12 hours. Telmisartan, an angiotensin II receptor blocker, also starts to lower blood pressure within 3 hours after the first dose. Both medications work to reduce blood pressure, but they do so through different mechanisms, which can complement each other and provide a more comprehensive approach to managing hypertension.
How does one store combination of Amlodipine and Telmisartan?
Amlodipine and Telmisartan do not require refrigeration. They should be stored at room temperature, away from excess heat and moisture, and protected from light. It is important to keep them in their original packaging until use to maintain their effectiveness. Both medications should be kept out of reach of children to prevent accidental ingestion.
Warnings and Precautions
Are there harms and risks from taking combination of Amlodipine and Telmisartan?
Common side effects of Amlodipine include swelling of the hands, feet, or ankles, dizziness, and flushing. Telmisartan may cause back pain, sinus pain, and diarrhea. Both medications can lead to dizziness or lightheadedness, especially when starting treatment. Serious adverse effects, though rare, include severe allergic reactions, rapid heartbeat, and significant drops in blood pressure. Patients should report any severe or persistent side effects to their healthcare provider.
Can I take combination of Amlodipine and Telmisartan with other prescription drugs?
Amlodipine can interact with other blood pressure medications, increasing the risk of low blood pressure. Telmisartan should not be used with aliskiren in patients with diabetes due to the risk of kidney problems. Both medications can interact with NSAIDs, potentially reducing their effectiveness and affecting kidney function. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions.
Can I take combination of Amlodipine and Telmisartan with vitamins or supplements?
Patients taking Amlodipine and Telmisartan should be cautious with potassium supplements or salt substitutes containing potassium, as these can increase the risk of hyperkalemia (high potassium levels). There are no specific interactions with vitamins, but patients should always inform their healthcare provider about all supplements they are taking. Monitoring potassium levels may be necessary to prevent potential complications.
Can I take combination of Amlodipine and Telmisartan if I am pregnant?
Amlodipine and Telmisartan are not recommended during pregnancy, especially in the second and third trimesters, due to the risk of fetal harm. Telmisartan can cause injury or death to the developing fetus by affecting kidney function and blood pressure regulation. Amlodipine's safety in pregnancy is not well established, and it should only be used if no safer alternatives are available. Pregnant women should discuss their treatment options with their healthcare provider to ensure the safety of both mother and child.
Can I take combination of Amlodipine and Telmisartan while breastfeeding?
The safety of Amlodipine and Telmisartan during lactation is not well established. Amlodipine is known to be excreted in human milk, but the effects on the nursing infant are unknown. It is not clear if Telmisartan is excreted in human milk, but it is present in the milk of lactating animals. Due to potential risks, breastfeeding mothers should consult their healthcare provider to weigh the benefits and risks of continuing these medications while nursing.
Who should avoid taking combination of Amlodipine and Telmisartan?
Amlodipine and Telmisartan should not be used during pregnancy due to the risk of harm to the fetus. Patients with severe liver or kidney impairment should use these medications with caution. Both drugs can cause dizziness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them. It's important to monitor for signs of low blood pressure, especially when starting treatment or adjusting doses.
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