Acebutolol + Hydrochlorothiazide
Find more information about this combination medication at the webpages for Acebutolol and Hydrochlorothiazide
Hypertension, Ventricular Tachycardia ... show more
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Advisory
- This medicine contains a combination of 2 drugs Acebutolol and Hydrochlorothiazide.
- Acebutolol and Hydrochlorothiazide are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
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Click HereSummary
Acebutolol is primarily used to treat high blood pressure, which is a condition where the force of the blood against the artery walls is too high, and certain irregular heart rhythms, which are abnormal heartbeats. Hydrochlorothiazide is also used to manage high blood pressure and is effective in treating edema, which is swelling caused by excess fluid trapped in the body's tissues, often associated with heart, kidney, or liver disease. Both medications help in controlling hypertension, which is another term for high blood pressure, but they also have unique uses: Acebutolol for heart rhythm disorders and Hydrochlorothiazide for fluid retention.
Acebutolol works by blocking beta-adrenergic receptors, which are parts of the body that respond to adrenaline, slowing the heart rate and relaxing blood vessels. This action improves blood flow and reduces blood pressure. Hydrochlorothiazide acts as a diuretic, which is a type of medication that helps the kidneys remove excess water and salt from the body, reducing fluid retention and lowering blood pressure. Together, they provide a comprehensive approach to managing hypertension by addressing both heart rate and fluid balance.
For Acebutolol, the usual adult daily dose for treating hypertension is typically 400 mg, which can be taken as a single dose or divided into two doses. In more severe cases, the dose may be increased up to 1200 mg per day. Hydrochlorothiazide is usually prescribed at a dose of 25 to 100 mg daily, either as a single dose or divided into two doses. Both medications are taken orally, which means they are swallowed by mouth, and should be taken consistently at the same time each day to maintain stable blood levels.
Common side effects of Acebutolol include dizziness, which is a feeling of being lightheaded or unsteady, lightheadedness, and fatigue, which means feeling very tired. Hydrochlorothiazide may cause frequent urination, headache, and loss of appetite. Both medications can lead to more serious side effects such as electrolyte imbalances, which are disturbances in the levels of minerals in the blood, causing symptoms like muscle cramps and weakness. Acebutolol may also cause a slow heart rate and shortness of breath, while Hydrochlorothiazide can lead to skin sensitivity to sunlight.
Acebutolol should not be used in patients with severe bradycardia, which is an abnormally slow heart rate, heart block, or overt cardiac failure, which is a condition where the heart cannot pump enough blood. Hydrochlorothiazide is contraindicated in patients with anuria, which is the absence of urine production, or hypersensitivity to sulfonamide-derived drugs, which are a group of antibiotics. Both medications require caution in patients with renal or hepatic impairment, which are conditions affecting the kidneys or liver. Regular monitoring of blood pressure and electrolytes is essential to prevent adverse effects.
Indications and Purpose
What is combination of Acebutolol and Hydrochlorothiazide used for?
Acebutolol is indicated for the treatment of high blood pressure and certain irregular heart rhythms, while Hydrochlorothiazide is used to treat high blood pressure and edema associated with various conditions like heart, kidney, and liver disease. Both medications are commonly prescribed for managing hypertension, but they also have unique uses: Acebutolol for heart rhythm disorders and Hydrochlorothiazide for fluid retention. Together, they offer a comprehensive treatment approach for patients with hypertension and related conditions.
What is combination of Hydrochlorothiazide and Acebutolol used for?
Hydrochlorothiazide is indicated for the treatment of hypertension and edema associated with conditions like congestive heart failure, hepatic cirrhosis, and renal dysfunction. Acebutolol is used to manage hypertension and certain types of arrhythmias, such as ventricular premature beats. Both medications are commonly prescribed for hypertension, but Hydrochlorothiazide is more focused on fluid retention issues, while Acebutolol addresses heart rate and rhythm abnormalities.
How does combination of Acebutolol and Hydrochlorothiazide work?
Acebutolol works by blocking beta-adrenergic receptors, which slows the heart rate and relaxes blood vessels, leading to improved blood flow and reduced blood pressure. Hydrochlorothiazide acts as a diuretic, promoting the excretion of excess water and salt through the kidneys, which decreases fluid retention and lowers blood pressure. Both medications are used to manage hypertension, but they achieve this through different mechanisms: Acebutolol affects heart function, while Hydrochlorothiazide targets fluid balance. Together, they provide a comprehensive approach to controlling high blood pressure.
How does combination of Hydrochlorothiazide and Acebutolol work?
Hydrochlorothiazide works by inhibiting sodium reabsorption in the distal renal tubules, leading to increased excretion of sodium and water, which reduces blood volume and pressure. Acebutolol acts as a beta-blocker, selectively blocking beta-1 adrenergic receptors in the heart, which decreases heart rate and cardiac output, leading to lower blood pressure. Both medications are used to manage hypertension, but they achieve this through different mechanisms: Hydrochlorothiazide reduces fluid retention, while Acebutolol decreases heart rate and vascular resistance.
How effective is combination of Acebutolol and Hydrochlorothiazide?
Clinical studies have demonstrated the effectiveness of Acebutolol in reducing heart rate, blood pressure, and managing irregular heart rhythms. It has shown significant β1-blocking activity, which contributes to its therapeutic effects. Hydrochlorothiazide has been proven effective in reducing blood pressure and managing edema by promoting diuresis. Both medications have been compared to placebos and other treatments, showing superior results in managing hypertension. Together, they provide a comprehensive approach to controlling high blood pressure, with Acebutolol addressing heart function and Hydrochlorothiazide managing fluid balance.
How effective is combination of Hydrochlorothiazide and Acebutolol?
Hydrochlorothiazide's effectiveness is supported by its ability to reduce blood pressure and manage edema through increased sodium and water excretion. Clinical studies have shown its efficacy in improving symptoms of fluid retention and lowering blood pressure. Acebutolol has been proven effective in reducing heart rate and blood pressure, as well as managing arrhythmias, through its selective beta-1 blocking action. Both medications have been shown in clinical trials to be effective in managing hypertension, with Hydrochlorothiazide focusing on fluid balance and Acebutolol on heart rate and rhythm control.
How does one know if combination of Acebutolol and Hydrochlorothiazide is working?
The benefit of Acebutolol and Hydrochlorothiazide is primarily assessed through regular monitoring of blood pressure levels. For Acebutolol, additional assessments may include heart rate monitoring and observing any improvements in symptoms of irregular heart rhythms. Hydrochlorothiazide's effectiveness is also evaluated by checking for reductions in fluid retention and edema. Both medications require periodic blood tests to monitor for potential side effects, such as electrolyte imbalances, and to ensure that the treatment is effectively managing hypertension.
How does one know if combination of Hydrochlorothiazide and Acebutolol is working?
The benefit of Hydrochlorothiazide is assessed by monitoring reductions in blood pressure and improvements in edema symptoms, such as decreased swelling. For Acebutolol, the benefit is measured by observing reductions in heart rate and blood pressure, as well as improvements in heart rhythm for those with arrhythmias. Both medications require regular blood pressure monitoring to ensure they are effectively managing hypertension. Additionally, electrolyte levels should be checked periodically, especially with Hydrochlorothiazide, to prevent imbalances.
Directions for Use
What is the usual dose of combination of Acebutolol and Hydrochlorothiazide?
The usual adult daily dose for Acebutolol in treating hypertension is typically 400 mg, which can be taken as a single dose or divided into two doses. For more severe cases, the dose may be increased up to 1200 mg per day. Hydrochlorothiazide is usually prescribed at a dose of 25 to 100 mg daily, either as a single dose or divided into two doses. Both medications are used to manage high blood pressure, but they work differently: Acebutolol is a beta-blocker that reduces heart rate and relaxes blood vessels, while Hydrochlorothiazide is a diuretic that helps eliminate excess fluid from the body. Together, they offer a synergistic effect in controlling blood pressure.
What is the usual dose of combination of Hydrochlorothiazide and Acebutolol?
For Hydrochlorothiazide, the usual adult dosage for edema is 25 to 100 mg daily, either as a single dose or divided doses. For hypertension, the initial dose is typically 25 mg daily, which may be increased to 50 mg if needed. Acebutolol is usually prescribed at an initial dose of 400 mg daily for hypertension, which can be given as a single dose or divided into two doses. For ventricular arrhythmias, the dose ranges from 400 to 1200 mg daily. Both medications are used to manage hypertension, but Hydrochlorothiazide is a diuretic, while Acebutolol is a beta-blocker, each contributing to blood pressure control through different mechanisms.
How does one take combination of Acebutolol and Hydrochlorothiazide?
Acebutolol can be taken with or without food, but it should be taken at the same time each day to maintain consistent blood levels. Hydrochlorothiazide should also be taken consistently, and patients may be advised to take it with food to reduce stomach upset. Patients on Hydrochlorothiazide should follow any dietary instructions from their doctor, such as a low-salt diet or increasing potassium-rich foods, to counteract potential electrolyte imbalances. Both medications require patients to avoid alcohol and excessive sunlight exposure, as these can exacerbate side effects.
How does one take combination of Hydrochlorothiazide and Acebutolol?
Hydrochlorothiazide can be taken with or without food, but it is important to maintain adequate hydration and monitor electrolyte levels. Acebutolol should be taken consistently, either with or without food, to maintain stable blood levels. Patients should avoid alcohol and be cautious with other medications that may interact with these drugs. It's important to follow a healthcare provider's instructions regarding diet, especially for those with conditions like diabetes or kidney disease, as these medications can affect blood sugar and electrolyte balance.
For how long is combination of Acebutolol and Hydrochlorothiazide taken?
Acebutolol and Hydrochlorothiazide are typically used for long-term management of high blood pressure. Acebutolol is often continued even if the patient feels well, as it controls but does not cure hypertension. Similarly, Hydrochlorothiazide is used continuously to manage blood pressure and fluid retention. Both medications require regular monitoring by a healthcare provider to ensure effectiveness and adjust dosages as needed. Discontinuation should only occur under medical supervision to avoid adverse effects.
For how long is combination of Hydrochlorothiazide and Acebutolol taken?
Hydrochlorothiazide and Acebutolol are typically used for long-term management of hypertension and related conditions. The duration of use depends on the individual's response to treatment and the specific condition being treated. Both medications are often part of a lifelong treatment plan for managing high blood pressure, as they help prevent complications such as heart disease and stroke. Regular monitoring by a healthcare provider is essential to adjust dosages and ensure effectiveness.
How long does it take for combination of Acebutolol and Hydrochlorothiazide to work?
Acebutolol and Hydrochlorothiazide both start working relatively quickly after administration. Acebutolol, a beta-blocker, begins to show effects on heart rate and blood pressure within 1.5 hours, with peak effects occurring between 3 to 8 hours. Hydrochlorothiazide, a diuretic, starts to increase urine production within 2 hours, peaks around 4 hours, and lasts about 6 to 12 hours. Both medications are used to manage high blood pressure, but they work through different mechanisms: Acebutolol by slowing the heart rate and relaxing blood vessels, and Hydrochlorothiazide by removing excess fluid from the body. Together, they provide a comprehensive approach to controlling hypertension.
How long does it take for combination of Hydrochlorothiazide and Acebutolol to work?
Hydrochlorothiazide typically begins to work within 2 hours after oral administration, with its diuretic effect peaking around 4 hours and lasting for about 6 to 12 hours. Acebutolol, on the other hand, shows significant reductions in heart rate and blood pressure within 1.5 hours after administration, with peak effects occurring between 3 and 8 hours post-dosing. Both medications are used to manage hypertension, but they work through different mechanisms: Hydrochlorothiazide is a diuretic that helps reduce fluid retention, while Acebutolol is a beta-blocker that reduces heart rate and blood pressure. Together, they provide a comprehensive approach to managing high blood pressure.
How does one store combination of Acebutolol and Hydrochlorothiazide?
Both Acebutolol and Hydrochlorothiazide should be stored at room temperature, away from excess heat and moisture. They do not require refrigeration. It is important to keep these medications in their original containers, tightly closed, and out of reach of children. Proper storage ensures the medications maintain their effectiveness and safety. Additionally, they should be disposed of properly, preferably through a medicine take-back program, to prevent accidental ingestion by children or pets.
How does one store combination of Hydrochlorothiazide and Acebutolol?
Both Hydrochlorothiazide and Acebutolol should be stored at room temperature, between 20° to 25°C (68° to 77°F), and protected from light, moisture, and freezing. They do not require refrigeration. It is important to keep the medications in their original containers, tightly closed, and out of reach of children to ensure their effectiveness and safety.
Warnings and Precautions
Are there harms and risks from taking combination of Acebutolol and Hydrochlorothiazide?
Common side effects of Acebutolol include dizziness, lightheadedness, and fatigue, while Hydrochlorothiazide may cause frequent urination, headache, and loss of appetite. Both medications can lead to more serious side effects such as electrolyte imbalances, which can cause symptoms like muscle cramps and weakness. Acebutolol may also cause slow heart rate and shortness of breath, while Hydrochlorothiazide can lead to skin sensitivity to sunlight and increased risk of skin cancer. Patients should report any severe or persistent side effects to their healthcare provider.
Are there harms and risks from taking combination of Hydrochlorothiazide and Acebutolol?
Common side effects of Hydrochlorothiazide include electrolyte imbalances, such as low potassium levels, and dehydration. It may also cause dizziness, headache, and gastrointestinal disturbances. Acebutolol can cause fatigue, dizziness, and gastrointestinal issues like nausea and diarrhea. Both medications may lead to hypotension (low blood pressure) and should be used with caution in patients with certain pre-existing conditions. Serious adverse effects can include severe electrolyte imbalances with Hydrochlorothiazide and bradycardia (slow heart rate) with Acebutolol.
Can I take combination of Acebutolol and Hydrochlorothiazide with other prescription drugs?
Acebutolol can interact with other heart medications, such as digoxin, leading to increased risk of bradycardia. It may also interact with nasal decongestants, causing increased blood pressure. Hydrochlorothiazide can interact with nonsteroidal anti-inflammatory drugs (NSAIDs), reducing its effectiveness. Both medications can interact with other antihypertensive drugs, potentially leading to excessive lowering of blood pressure. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions and ensure safe and effective treatment.
Can I take combination of Hydrochlorothiazide and Acebutolol with other prescription drugs?
Hydrochlorothiazide can interact with other antihypertensive drugs, enhancing their effects, and with non-steroidal anti-inflammatory drugs (NSAIDs), which may reduce its effectiveness. It can also interact with lithium, increasing the risk of lithium toxicity. Acebutolol may interact with other beta-blockers, leading to an increased risk of bradycardia, and with drugs that affect heart rhythm. Both medications require careful monitoring when used with other drugs that affect blood pressure or heart rate to avoid adverse effects.
Can I take combination of Acebutolol and Hydrochlorothiazide with vitamins or supplements?
Patients taking Acebutolol and Hydrochlorothiazide should be cautious with supplements that affect blood pressure or electrolyte balance. Hydrochlorothiazide can lead to potassium loss, so potassium supplements or potassium-rich foods may be recommended. However, patients should consult their doctor before starting any supplements, as excessive potassium can be harmful, especially when taking Acebutolol. Additionally, supplements like calcium or magnesium should be monitored, as they can interact with the diuretic effects of Hydrochlorothiazide. Always inform your healthcare provider about any supplements you are taking.
Can I take combination of Hydrochlorothiazide and Acebutolol with vitamins or supplements?
Hydrochlorothiazide can lead to potassium depletion, so patients may need to take potassium supplements or consume potassium-rich foods. Acebutolol does not have significant interactions with vitamins or supplements, but patients should inform their healthcare provider about all supplements they are taking. Both medications require monitoring of electrolyte levels, especially potassium, to prevent imbalances. Patients should consult their healthcare provider before starting any new supplements to avoid potential interactions.
Can I take combination of Acebutolol and Hydrochlorothiazide if I am pregnant?
Acebutolol is categorized as Pregnancy Category B, indicating no proven risk in humans, but it should only be used if clearly needed. Hydrochlorothiazide crosses the placenta and may cause fetal or neonatal jaundice, thrombocytopenia, and other adverse effects. It is generally advised to avoid diuretics during pregnancy unless necessary. Both medications should be used during pregnancy only if the potential benefits justify the risks to the fetus. Pregnant women should consult their healthcare provider to carefully consider the use of these medications.
Can I take combination of Hydrochlorothiazide and Acebutolol if I am pregnant?
Hydrochlorothiazide is generally not recommended during pregnancy as it can cross the placental barrier and may cause fetal or neonatal jaundice and other adverse effects. Acebutolol is categorized as Pregnancy Category B, indicating no evidence of harm in animal studies, but should only be used if clearly needed due to potential risks. Both medications should be used with caution during pregnancy, and only if the potential benefits justify the risks to the fetus. Close monitoring by a healthcare provider is essential.
Can I take combination of Acebutolol and Hydrochlorothiazide while breastfeeding?
Acebutolol and Hydrochlorothiazide both pass into breast milk. Acebutolol is not recommended during breastfeeding due to potential adverse effects on the infant, such as reduced heart rate and blood pressure. Hydrochlorothiazide is also excreted in breast milk and may cause serious adverse reactions in nursing infants. Therefore, a decision should be made to either discontinue breastfeeding or discontinue the medication, considering the importance of the drug to the mother. It's crucial to consult a healthcare provider to weigh the benefits and risks before using these medications while breastfeeding.
Can I take combination of Hydrochlorothiazide and Acebutolol while breastfeeding?
Hydrochlorothiazide is excreted in breast milk and may pose a risk of adverse reactions in nursing infants, so a decision should be made to either discontinue the drug or stop breastfeeding. Acebutolol also appears in breast milk and is not recommended for use during breastfeeding due to potential adverse effects on the infant. Both medications require careful consideration of the benefits to the mother versus the potential risks to the infant, and alternative treatments should be considered if possible.
Who should avoid taking combination of Acebutolol and Hydrochlorothiazide?
Acebutolol should not be used in patients with severe bradycardia, heart block, or overt cardiac failure. Hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs. Both medications require caution in patients with renal or hepatic impairment. They can cause dizziness and hypotension, so patients should avoid activities requiring alertness until they know how the drugs affect them. Both drugs can interact with other medications, so it's important to inform healthcare providers of all drugs being taken. Regular monitoring of blood pressure and electrolytes is essential to prevent adverse effects.
Who should avoid taking combination of Hydrochlorothiazide and Acebutolol?
Hydrochlorothiazide is contraindicated in patients with anuria and those with hypersensitivity to sulfonamide-derived drugs. It should be used cautiously in patients with severe renal or hepatic disease. Acebutolol is contraindicated in patients with severe bradycardia, heart block, or overt cardiac failure. Both medications should be used with caution in patients with diabetes, as they can mask symptoms of hypoglycemia. Patients should be monitored for signs of electrolyte imbalance with Hydrochlorothiazide and for heart rate changes with Acebutolol.