evergraf (EVEROLIMUS)

What is Evergraf?

Evergraf is a type of cancer and immunosuppressant drug used to treat certain types of cancers (like kidney, breast, and pancreatic cancers) and to prevent organ rejection after a kidney or liver transplant. It works by blocking a protein called mTOR, which helps cancer cells grow and divide. By inhibiting mTOR, Evergraf slows down tumor growth and suppresses the immune system to prevent organ rejection.

What is the usual dose of Evergraf?

The dose varies based on the condition being treated.

• For cancer treatment: Typically, 10 mg once daily.
• For transplant patients: Usually, 0.75 mg twice daily with other immunosuppressants.
  Doses may change based on response, blood tests, and side effects. Always follow the doctor’s prescription carefully.

How do I take Evergraf?

Take Evergraf once daily at the same time each day, with or without food. Swallow the tablet whole with water, without crushing or chewing it. Avoid grapefruit and grapefruit juice, as they can affect how the medicine works in the body.

For how long do I take Evergraf?

The duration depends on the condition:

• For cancer: As long as it remains effective and tolerated.
• For transplant patients: It is a long-term medication to prevent organ rejection.
  Your doctor will decide the treatment duration based on your health condition and response.

What is Evergraf used for?

Evergraf is used for:

• Treating kidney, breast, and pancreatic cancers.
• Preventing organ rejection in kidney and liver transplant patients.
• Treating certain types of brain tumors and lung diseases linked to genetic disorders.

How long does it take for Evergraf to start working?

It starts working within weeks, but noticeable improvements depend on the condition. Cancer patients may take a few months to see tumor shrinkage, while transplant patients need regular monitoring to ensure the organ is not being rejected.

Is Evergraf effective?

Yes, Evergraf is effective in slowing cancer growth and preventing organ rejection when taken correctly. However, it does not cure cancer but helps manage it. In transplant patients, it significantly reduces rejection risks when used with other immunosuppressants.

How does one know if Evergraf is working?

For cancer treatment, doctors check tumor size through scans and blood tests. For transplant patients, doctors monitor organ function tests and blood levels to ensure the immune system is controlled properly.

How does Evergraf work?

Evergraf blocks the mTOR pathway, stopping cancer cells from growing and slowing tumor spread. In transplant patients, it reduces immune system activity to prevent the body from attacking the new organ.

Who should avoid taking Evergraf?

People with severe liver disease, active infections, uncontrolled diabetes, or a history of severe allergic reactions to Evergraf should avoid it. Pregnant women should not use it unless absolutely necessary.

Can I take Evergraf with vitamins or supplements?

Some supplements, like St. John’s Wort, certain herbal teas, and high doses of vitamin C, may interact with Evergraf. Always consult your doctor before taking any supplements.

Can I take Evergraf with other prescription drugs?

Evergraf interacts with many drugs, including antibiotics, antifungals, seizure medicines, and blood pressure medications. Always inform your doctor about all the medicines you are taking.

Can Evergraf be taken safely while pregnant?

Evergraf is not recommended during pregnancy, as it may harm the baby. Women of childbearing age should use effective birth control during treatment and for at least 8 weeks after stopping it.

Can Evergraf be taken safely while breastfeeding?

No, Evergraf passes into breast milk and may harm the baby. Women should avoid breastfeeding while taking this medication.

Is Evergraf safe for the elderly?

Yes, but elderly patients may have a higher risk of side effects like infections, kidney problems, and lung inflammation. Doctors may monitor them closely and adjust doses if needed.

How should I store Evergraf?

Store Evergraf at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep it out of reach of children.

Does Evergraf make people tired or drowsy?

Yes, Evergraf can cause fatigue and drowsiness in some individuals. It may make you feel weak, reduce energy levels, or make daily activities harder. If you experience extreme tiredness, try getting enough rest and avoid strenuous activities. If the fatigue is persistent or severe, consult your doctor for possible dose adjustments or supportive treatments.

Does Evergraf cause stomach upset?

Yes, stomach-related side effects like nausea, vomiting, diarrhea, and loss of appetite can occur with Evergraf. Taking it with food and plenty of water may help reduce stomach discomfort. If these issues persist or become severe, your doctor may recommend dietary changes, anti-nausea medications, or adjusting the dose to minimize digestive side effects.

Does Evergraf affect sleep?

Evergraf may cause insomnia or sleep disturbances in some people. You might find it difficult to fall asleep or wake up frequently at night. Avoiding caffeine in the evening, maintaining a regular sleep schedule, and practicing relaxation techniques may help. If sleep problems continue for a long time, talk to your doctor about possible solutions.

Does Evergraf make it hard to think or concentrate?

Yes, some people taking Evergraf report brain fog, memory issues, or trouble concentrating. This can make tasks requiring focus, such as reading or driving, more difficult. Staying hydrated, getting enough rest, and managing stress may help. If the problem persists or worsens, consult your doctor to determine if the medication is the cause.

Does Evergraf affect mood?

Evergraf may cause mood swings, anxiety, or depression in some individuals. You might feel emotionally unstable, irritated, or unusually sad. If these changes become severe or impact your daily life, discuss them with your doctor. They may suggest therapy, stress management techniques, or adjusting your medication to help manage emotional side effects.

Does Evergraf interfere with sexual function?

Yes, Evergraf can lead to low libido, erectile dysfunction in men, or irregular menstrual cycles in women. It may also reduce testosterone or estrogen levels, affecting sexual health. If these issues become bothersome, speak to your doctor, as they might adjust your treatment plan or suggest strategies to improve sexual well-being.

Does Evergraf affect appetite?

Many people taking Evergraf experience loss of appetite, changes in taste, or early fullness. This may lead to weight loss if it continues for a long time. Eating small, frequent meals and including protein-rich foods can help maintain nutrition. If appetite loss is severe, your doctor may recommend dietary supplements or medications to stimulate hunger.

Does Evergraf cause weight gain?

Evergraf does not typically cause weight gain, but some patients may experience fluid retention, bloating, or metabolic changes that make them feel heavier. Maintaining a balanced diet and regular physical activity can help manage body weight. If you notice unexplained weight gain, discuss it with your doctor, as it could indicate an underlying issue.

Does Evergraf cause headaches?

Yes, headaches are a common side effect of Evergraf. They may be mild or severe, sometimes accompanied by dizziness or nausea. Drinking enough water, getting enough rest, and avoiding bright screens can help reduce headache intensity. If headaches are persistent or interfere with daily life, your doctor may suggest pain relievers or adjust your medication.

Does Evergraf limit driving?

Evergraf may cause dizziness, fatigue, or difficulty concentrating, which can make driving unsafe. If you experience these effects, avoid operating vehicles or heavy machinery. Wait until you feel alert before driving again. If drowsiness or dizziness persists, consult your doctor, as they may adjust your dosage or recommend strategies to manage side effects.

Is it safe to drink alcohol while taking Evergraf?

Drinking alcohol while on Evergraf is not recommended, as it may increase the risk of liver damage, dizziness, and drowsiness. Alcohol can also worsen dehydration and weaken the immune system, making you more prone to infections. If you drink alcohol regularly, speak to your doctor about safe consumption limits or possible risks.

Is it safe to drink coffee or tea while taking Evergraf?

Yes, moderate consumption of coffee or tea is generally safe, but excessive caffeine may worsen nervousness, insomnia, or stomach irritation, which are possible side effects of Evergraf. If you experience jitters, anxiety, or trouble sleeping, consider reducing your caffeine intake or switching to decaffeinated options. Always stay hydrated and monitor how your body reacts.

Is it safe to exercise while taking Evergraf?

Yes, but moderate exercise is recommended. Strenuous activity may worsen fatigue, dizziness, or muscle weakness, which can be side effects of Evergraf. Light activities like walking, yoga, or stretching can help maintain fitness. Listen to your body, and if you feel excessively tired, dizzy, or short of breath, stop exercising and consult your doctor.

What are Evergraf possible harms and risks?

Evergraf can cause mouth sores, fatigue, infections, nausea, high blood sugar, kidney problems, and lung issues. It may weaken the immune system, increasing the risk of infections. Serious side effects include lung inflammation and liver problems. Always inform your doctor about unusual symptoms.