sprycel (DASATINIB)

What is Sprycel?

Sprycel is a medicine that treats two types of blood cancer: chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). CML and ALL are cancers affecting the blood-forming cells in bone marrow. Sprycel works by stopping a faulty protein that tells cancer cells to multiply. This helps slow down or stop the cancer's growth. It's taken as a pill once a day, exactly as prescribed by a doctor. Kinase inhibitor means it blocks the action of specific enzymes (kinases) involved in cell growth and division. Pregnant women should be careful when handling this medicine as it should not be crushed. Always follow your doctor's instructions on how to take this medication.

What is the usual dose of Sprycel?

The usual dose for adults with chronic phase CML is 100 mg once daily, while those with advanced CML or Ph+ ALL take 140 mg once daily. In children (1+ years), the dose depends on body weight, ranging from 40 mg to 100 mg daily. Sprycel must be taken at the same time every day for consistency. Tablets should be swallowed whole, not crushed or split​

How do I take Sprycel?

Sprycel should be taken once a day, either in the morning or evening, with or without food. It's crucial to swallow the tablet whole – do not break, crush, or chew it. Avoid eating grapefruit or drinking grapefruit juice while taking this medication. There are no medical or scientific terms in the provided instructions requiring explanation. The instructions are straightforward and intended for a non-medical audience.

For how long do I take Sprycel?

• Take continuously as long as it remains effective and is tolerated.
• In children with Ph+ ALL, treatment typically lasts up to 2 years.
• Stopping the medication may lead to cancer progression.
• Your doctor will decide if and when treatment can be stopped

What disease or symptom is Sprycel used for?

Sprycel is a medication used to treat certain types of leukemia (a blood cancer). Specifically, it helps adults and children with a type of leukemia called chronic myeloid leukemia (CML), which is identified by a genetic abnormality called the Philadelphia chromosome (Ph+). It's used for people whose CML is in the chronic phase (meaning it's not yet progressed to a more serious stage) and also for those whose CML hasn't responded well to other treatments. Sprycel also treats a different type of leukemia, acute lymphoblastic leukemia (ALL), also with the Ph+ abnormality. Again, it's used for adults and children whose ALL hasn't responded to other treatments. In children, it's often given with chemotherapy (other cancer drugs). In short, Sprycel is a targeted treatment for specific types of leukemia that haven't responded to other therapies.

How long does it take for Sprycel to start working?

• It starts working at the cellular level immediately.
• A reduction in leukemia cells may take weeks to months.
• Blood tests will show a drop in cancer markers over time.
• Some symptoms, like fatigue or pain, may improve earlier

Is Sprycel effective?

Studies have shown that Sprycel is highly effective in reducing leukemia cell counts. It is often more effective than imatinib in certain cases of leukemia. Patients taking Sprycel have higher response rates and longer survival times. However, its effectiveness varies from person to person, and regular monitoring is essential

How do I know if Sprycel is working?

Sprycel's effectiveness is tracked using lab tests that measure how your body reacts to the drug. These tests are done before and during treatment. Doctors also use blood tests to check for Tumor Lysis Syndrome (TLS), a potentially dangerous condition where cancer cells break down too quickly, releasing harmful substances into the blood. Finally, liver function is monitored regularly to make sure the drug isn't harming the liver. **Tumor Lysis Syndrome (TLS):** A serious condition that can occur when cancer treatment causes cancer cells to die rapidly. This rapid cell death releases substances into the bloodstream that can damage kidneys and other organs. **Liver function:** A measure of how well your liver is working. The liver plays many important roles in the body, including filtering toxins. Tests can reveal if the liver is damaged or not functioning properly.

How does Sprycel work?

Sprycel is a medicine that stops cancer cells from multiplying. It does this by blocking abnormal proteins that tell cancer cells to grow. These proteins are called kinases, and Sprycel is a type of kinase inhibitor. This means it prevents the kinases from sending their growth signals. Sprycel is used to treat two types of blood cancer: chronic myeloid leukemia (CML), a slow-growing cancer, and acute lymphoblastic leukemia (ALL), a faster-growing cancer. It's used in both adults and children. Sometimes, doctors give children Sprycel along with chemotherapy, another cancer treatment that uses strong drugs to kill cancer cells.

Who should avoid taking Sprycel?

People with severe heart, lung, or liver disease should avoid Sprycel. It should not be used by patients with low potassium or magnesium levels or those taking certain medications like rifampin or St. John’s Wort. Pregnant or breastfeeding women should not use it, as it may cause fetal harm. Always inform your doctor about any pre-existing medical conditions before starting treatment

Can I take Sprycel with other prescription drugs?

Sprycel's effects are influenced by other medications. Avoid drugs that strongly inhibit CYP3A4 (an enzyme that breaks down Sprycel in the body), as this increases Sprycel levels, potentially causing harmful side effects. Similarly, avoid drugs that strongly induce (increase the activity of) CYP3A4, as this lowers Sprycel levels, making it less effective. Don't take Sprycel with drugs that reduce stomach acid (H2 blockers or proton pump inhibitors). Antacids are okay, but take them at least two hours before or after Sprycel. Essentially, other medications can significantly affect how well Sprycel works and how safe it is. Always talk to your doctor or pharmacist about all medications you are taking to avoid dangerous interactions.

Can Sprycel be taken safely while pregnant?

Sprycel use during pregnancy is dangerous for the unborn baby. Studies in both humans and animals show serious risks. In humans, Sprycel has been linked to hydrops fetalis (severe fluid buildup in the fetus), fetal leukopenia (low white blood cell count), and fetal thrombocytopenia (low platelet count). These conditions can harm the baby or cause death. Therefore, pregnant women should not take Sprycel unless absolutely necessary and after carefully weighing the risks with their doctor. The potential harm to the developing baby is significant.

 

Can Sprycel be taken safely while breastfeeding?

Breastfeeding isn't advised while taking Sprycel, or for two weeks after stopping treatment. We don't know if Sprycel passes into human breast milk, but it does show up in rat milk. This raises concerns about potential serious harm to a nursing baby. Because of this uncertainty and the risk to the infant, it's safest to avoid breastfeeding during this time. Sprycel is a medication.

Is Sprycel safe for the elderly?

Elderly patients are at higher risk of fluid retention, heart issues, and infections while taking Sprycel. They may also experience fatigue, diarrhea, and appetite loss more frequently. Close monitoring and possible dose adjustments may be needed. Regular medical check-ups help ensure safety in older patients

How should I store Sprycel?

Sprycel should be stored at room temperature, in a tightly closed container, away from moisture and heat. Avoid storing it in the bathroom. Keep the medication out of reach of children and pets. Proper storage ensures the medicine remains effective

Does Sprycel make people tired or drowsy?

Fatigue is a common side effect of Sprycel, but severe drowsiness is rare. Some patients may feel weak, tired, or experience a lack of energy while on this medication. If fatigue becomes severe, avoid activities that require alertness, such as driving. Rest, hydration, and balanced nutrition may help manage tiredness

Does Sprycel cause stomach upset?

Nausea, vomiting, and diarrhea are common side effects of Sprycel. Taking the medication with food may help reduce stomach discomfort. If symptoms persist or worsen, your doctor may recommend anti-nausea medication or dietary adjustments. Staying hydrated and eating light meals can also help manage these side effects

Does Sprycel affect sleep?

Sleep disturbances are not common with Sprycel, but some patients report difficulty sleeping or unusual dreams. If insomnia becomes a problem, maintaining a consistent sleep schedule and avoiding caffeine before bedtime may help. If sleep issues persist, consult your doctor for further advice. Stress management techniques, such as relaxation exercises, may also be beneficial

Does Sprycel make it hard to think or concentrate?

Some patients experience dizziness, confusion, or memory issues while taking Sprycel. These cognitive effects are usually mild but can affect daily activities. If you notice difficulty concentrating, avoid tasks that require mental sharpness, such as driving or operating heavy machinery. If the symptoms persist or worsen, consult your healthcare provider

Does Sprycel affect mood?

Sprycel is not known to cause major mood changes, but some patients may experience mild anxiety or irritability. Emotional well-being may also be affected by the stress of managing a chronic illness. If you notice severe mood swings, depression, or anxiety, seek medical advice. A support group or counseling may help in coping with emotional side effects

Does Sprycel interfere with sexual function?

There are no major reports of Sprycel causing sexual dysfunction, but some patients may experience fatigue or reduced libido. This could be due to the underlying disease rather than the medication itself. If you notice persistent sexual side effects, discuss them with your doctor. Open communication with your partner and lifestyle adjustments may help manage these concerns

Does Sprycel affect appetite?

Some patients may experience a loss of appetite, leading to unintentional weight loss. If you find yourself eating less, try consuming small, frequent meals and focus on high-calorie, nutritious foods. If appetite loss persists, your doctor may recommend dietary supplements. Staying hydrated and maintaining a healthy diet are essential during treatment

Does Sprycel cause weight gain?

Weight gain is not a common side effect, but fluid retention may cause some people to gain weight temporarily. Swelling in the hands, feet, or abdomen could indicate fluid buildup. If you notice sudden or excessive weight gain, inform your doctor. Managing salt intake and staying active may help prevent fluid retention

Does Sprycel cause headaches?

Sprycel can cause headaches. If you get a headache while taking Sprycel and it's bad or doesn't get better, tell your doctor. A headache is pain in your head. "Severe" means the pain is intense and bothersome. Your doctor can help figure out what's causing the headache and how to treat it. It's important to report any side effects you experience to your doctor, even if they seem minor. This helps ensure your safety while on the medication.

Does Sprycel limit driving?

Sprycel can cause headaches and weakness. These side effects could make it unsafe to drive. If you're taking Sprycel, talk to your doctor about whether it's okay for you to drive. They can assess your individual situation and advise you on the risks. Headaches are pain in the head, and weakness means feeling less strong or having less physical ability than normal. Your doctor will be able to determine if your symptoms are severe enough to impact your driving safely.

Is it safe to drink alcohol while taking Sprycel?

Drinking alcohol in moderation may be safe, but excessive alcohol can increase the risk of liver damage, dizziness, and bleeding problems. Alcohol may also worsen side effects like nausea and fatigue. If you choose to drink, limit your intake and monitor how your body reacts. It’s best to consult your doctor before consuming alcohol while on Sprycel

Is it safe to drink coffee or tea while taking Sprycel?

There is no direct interaction between Sprycel and caffeinated beverages like coffee or tea. However, excessive caffeine intake may worsen heart palpitations, anxiety, or stomach discomfort in some patients. If you notice any side effects after consuming caffeine, try reducing your intake. Otherwise, moderate coffee or tea consumption is generally safe

Is it safe to exercise while taking Sprycel?

Moderate exercise is safe and beneficial, but strenuous activity should be approached with caution, especially if experiencing fatigue or dizziness. Low-impact exercises like walking, yoga, or stretching can help maintain strength and energy levels. If you feel overly weak or experience shortness of breath, take breaks and adjust your activity level accordingly. Always consult your doctor before starting a new exercise routine

What are Sprycel possible harms and risks?

This document describes common side effects of a drug. The most frequent problems are diarrhea (31%), nausea (24%), vomiting (16%), fluid buildup around the lungs (pleural effusion, 24%), and swelling (superficial edema, 19%). Serious side effects include fever (pyrexia), low white blood cell count with fever (febrile neutropenia), mouth sores (mucositis), severe infection (sepsis), low blood pressure (hypotension), kidney problems (renal insufficiency), and pain. In children, 4% of serious side effects were fatal due to infections. * **Diarrhea:** Loose, watery stools. * **Nausea:** Feeling sick to your stomach. * **Vomiting:** Throwing up. * **Pleural effusion:** Fluid buildup in the space between the lungs and the chest wall. * **Superficial edema:** Swelling near the skin's surface. * **Pyrexia:** Fever. * **Febrile neutropenia:** Low white blood cell count causing fever, increasing infection risk. * **Mucositis:** Inflammation and sores in the lining of the mouth and digestive tract. * **Sepsis:** Life-threatening infection. * **Hypotension:** Low blood pressure. * **Renal insufficiency:** Kidneys not working properly.