Dasatinib

How does Dasatinib work?

Dasatinib is a medicine that stops cancer cells from multiplying. It does this by blocking abnormal proteins that tell cancer cells to grow. These proteins are called kinases, and Dasatinib is a type of kinase inhibitor. This means it prevents the kinases from sending their growth signals. Dasatinib is used to treat two types of blood cancer: chronic myeloid leukemia (CML), a slow-growing cancer, and acute lymphoblastic leukemia (ALL), a faster-growing cancer. It's used in both adults and children. Sometimes, doctors give children Dasatinib along with chemotherapy, another cancer treatment that uses strong drugs to kill cancer cells.

Is Dasatinib effective?

Studies have shown that dasatinib is highly effective in reducing leukemia cell counts. It is often more effective than imatinib in certain cases of leukemia. Patients taking dasatinib have higher response rates and longer survival times. However, its effectiveness varies from person to person, and regular monitoring is essential

What is Dasatinib?

Dasatinib is a medicine that treats two types of blood cancer: chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). CML and ALL are cancers affecting the blood-forming cells in bone marrow. Dasatinib works by stopping a faulty protein that tells cancer cells to multiply. This helps slow down or stop the cancer's growth. It's taken as a pill once a day, exactly as prescribed by a doctor. Kinase inhibitor means it blocks the action of specific enzymes (kinases) involved in cell growth and division. Pregnant women should be careful when handling this medicine as it should not be crushed. Always follow your doctor's instructions on how to take this medication.

For how long do I take Dasatinib?

• Take continuously as long as it remains effective and is tolerated.
• In children with Ph+ ALL, treatment typically lasts up to 2 years.
• Stopping the medication may lead to cancer progression.
• Your doctor will decide if and when treatment can be stopped

How do I take Dasatinib?

Dasatinib should be taken once a day, either in the morning or evening, with or without food. It's crucial to swallow the tablet whole – do not break, crush, or chew it. Avoid eating grapefruit or drinking grapefruit juice while taking this medication. There are no medical or scientific terms in the provided instructions requiring explanation. The instructions are straightforward and intended for a non-medical audience.

How long does it take for Dasatinib to start working?

• It starts working at the cellular level immediately.
• A reduction in leukemia cells may take weeks to months.
• Blood tests will show a drop in cancer markers over time.
• Some symptoms, like fatigue or pain, may improve earlier

How should I store Dasatinib?

Dasatinib should be stored at room temperature, in a tightly closed container, away from moisture and heat. Avoid storing it in the bathroom. Keep the medication out of reach of children and pets. Proper storage ensures the medicine remains effective

What is the usual dose of Dasatinib?

The usual dose for adults with chronic phase CML is 100 mg once daily, while those with advanced CML or Ph+ ALL take 140 mg once daily. In children (1+ years), the dose depends on body weight, ranging from 40 mg to 100 mg daily. Dasatinib must be taken at the same time every day for consistency. Tablets should be swallowed whole, not crushed or split​

Can Dasatinib be taken safely while breastfeeding?

Breastfeeding isn't advised while taking dasatinib, or for two weeks after stopping treatment. We don't know if dasatinib passes into human breast milk, but it does show up in rat milk. This raises concerns about potential serious harm to a nursing baby. Because of this uncertainty and the risk to the infant, it's safest to avoid breastfeeding during this time. Dasatinib is a medication.

Can Dasatinib be taken safely while pregnant?

Dasatinib use during pregnancy is dangerous for the unborn baby. Studies in both humans and animals show serious risks. In humans, dasatinib has been linked to hydrops fetalis (severe fluid buildup in the fetus), fetal leukopenia (low white blood cell count), and fetal thrombocytopenia (low platelet count). These conditions can harm the baby or cause death. Therefore, pregnant women should not take dasatinib unless absolutely necessary and after carefully weighing the risks with their doctor. The potential harm to the developing baby is significant. 

Can I take Dasatinib with other prescription drugs?

Dasatinib's effects are influenced by other medications. Avoid drugs that strongly inhibit CYP3A4 (an enzyme that breaks down dasatinib in the body), as this increases dasatinib levels, potentially causing harmful side effects. Similarly, avoid drugs that strongly induce (increase the activity of) CYP3A4, as this lowers dasatinib levels, making it less effective. Don't take dasatinib with drugs that reduce stomach acid (H2 blockers or proton pump inhibitors). Antacids are okay, but take them at least two hours before or after dasatinib. Essentially, other medications can significantly affect how well dasatinib works and how safe it is. Always talk to your doctor or pharmacist about all medications you are taking to avoid dangerous interactions.

Is Dasatinib safe for the elderly?

Elderly patients are at higher risk of fluid retention, heart issues, and infections while taking dasatinib. They may also experience fatigue, diarrhea, and appetite loss more frequently. Close monitoring and possible dose adjustments may be needed. Regular medical check-ups help ensure safety in older patients

Is it safe to drink alcohol while taking Dasatinib?

Drinking alcohol in moderation may be safe, but excessive alcohol can increase the risk of liver damage, dizziness, and bleeding problems. Alcohol may also worsen side effects like nausea and fatigue. If you choose to drink, limit your intake and monitor how your body reacts. It’s best to consult your doctor before consuming alcohol while on dasatinib

Is it safe to exercise while taking Dasatinib?

Moderate exercise is safe and beneficial, but strenuous activity should be approached with caution, especially if experiencing fatigue or dizziness. Low-impact exercises like walking, yoga, or stretching can help maintain strength and energy levels. If you feel overly weak or experience shortness of breath, take breaks and adjust your activity level accordingly. Always consult your doctor before starting a new exercise routine

Who should avoid taking Dasatinib?

People with severe heart, lung, or liver disease should avoid dasatinib. It should not be used by patients with low potassium or magnesium levels or those taking certain medications like rifampin or St. John’s Wort. Pregnant or breastfeeding women should not use it, as it may cause fetal harm. Always inform your doctor about any pre-existing medical conditions before starting treatment