Primidone
Tonic-Clonic Epilepsy, Partial Epilepsies ... show more
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Anti-epileptic Agent
Controlled Drug Substance
NO
Primidone
Learn more about this medicine -
Click HereSummary
Primidone is used to treat conditions such as seizures related to epilepsy and essential tremors, which cause involuntary shaking.
Primidone works by stabilizing the electrical activity in the brain. This helps prevent the abnormal signals that lead to seizures or tremors.
The typical starting dose for adults is 100-125 mg once or twice daily. This is gradually increased to a maintenance dose of 250-500 mg three to four times daily. For children, the dose depends on weight and doctor's recommendations. It's usually taken orally.
Common side effects of Primidone include dizziness, drowsiness, nausea, loss of coordination, and fatigue. Rare but severe effects may include mood changes, skin rashes, or liver issues.
Primidone should be avoided by those with a history of porphyria, severe liver issues, or an allergy to Primidone. It should be used with caution if you're pregnant, breastfeeding, or elderly. It can interact with other medications, so inform your doctor of all other prescriptions you're taking.
Indications and Purpose
What is Primidone used for?
Primidone is used to control epilepsy-related seizures and to manage essential tremors, helping improve motor control and reduce muscle shaking.
How does Primidone work?
Primidone is converted in the body into active compounds that help calm overactive electrical signals in the brain, preventing seizures and reducing tremors.
Is Primidone effective?
Yes, studies show that Primidone is effective in reducing the frequency of seizures and the severity of essential tremors when taken as prescribed.
How does one know if Primidone is working?
Fewer seizures, reduced tremor intensity, and improved quality of life indicate the medication’s effectiveness. Your doctor may monitor progress using symptoms or tests.
Directions for Use
What is the usual dose of Primidone?
The typical starting dose for adults is 100-125 mg once or twice daily, gradually increased. Maintenance doses usually range from 250-500 mg three to four times daily. Children’s doses depend on weight and doctor recommendations.
How do I take Primidone?
Take Primidone with or without food as prescribed by your doctor, at the same time each day. Swallow tablets whole with water, and do not stop treatment abruptly without consulting your doctor.
For how long do I take Primidone?
Primidone is usually taken long-term to manage seizures or tremors. Continue using it as directed by your doctor, who may periodically adjust your dose.
How long does it take for Primidone to start working?
Primidone may take several days or even weeks to show noticeable effects as your body adjusts to the medication.
How should I store Primidone?
Store at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.
Warnings and Precautions
Who should avoid taking Primidone?
Avoid if you have a history of porphyria, severe liver issues, or an allergy to Primidone. Use caution if pregnant, breastfeeding, or elderly, and inform your doctor of all health conditions.
Can I take Primidone with other prescription drugs?
Primidone may interact with medications like anticoagulants, other anticonvulsants, or sedatives. Inform your doctor of all other prescriptions you’re taking to avoid interactions.
Can I take Primidone with vitamins or supplements?
Consult your doctor about combining Primidone with vitamins or supplements. Calcium, vitamin D, or folic acid may be needed as Primidone can sometimes reduce nutrient levels in the body.
Can Primidone be taken safely while pregnant?
Primidone may pose risks during pregnancy, such as congenital issues. It’s essential to discuss with your doctor to weigh risks versus benefits before continuing treatment.
Can Primidone be taken safely while breastfeeding?
Primidone passes into breast milk and may affect a nursing baby. Breastfeeding while taking it should only be done under close medical supervision.
Is Primidone safe for the elderly?
Primidone is generally safe for elderly patients but may require lower doses due to increased sensitivity to side effects like dizziness or drowsiness.
Is it safe to exercise while taking Primidone?
Exercise is generally safe, but dizziness or drowsiness from the medication might require caution. Ensure hydration and avoid high-risk activities until your body adjusts.
Is it safe to drink alcohol while taking Primidone?
Alcohol should be avoided as it can worsen dizziness, drowsiness, and other side effects, increasing the risk of accidents.
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