Piroxicam
Rheumatoid Arthritis, Ankylosing Spondylitis ... show more
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Possible
Pharmaceutical Class
Nonsteroidal Anti-inflammatory Drug

Piroxicam
Know More About This Medicine -
Click HereSummary
Piroxicam is a medication used to treat pain and inflammation caused by conditions like osteoarthritis and rheumatoid arthritis. These conditions cause pain, swelling, and stiffness in the joints.
Piroxicam works by blocking the production of certain chemicals in the body that cause inflammation and pain. It reduces pain and swelling in conditions like arthritis.
The usual dosage of Piroxicam is 20mg once daily, taken by mouth. It's recommended to take it at the same time each day. The medication may take up to 12 days to work effectively.
Common side effects of Piroxicam include swelling, stomach pain, constipation, dizziness, and rash. Serious side effects can include increased risk of heart attack, stroke, liver failure, kidney failure, and life-threatening allergic reactions.
Piroxicam can increase your risk of heart attack and stroke, especially if taken for a long time or at high doses. It can also cause ulcers and bleeding in your stomach or intestines. Do not take Piroxicam before or after heart surgery, or for conditions it's not prescribed for.
Indications and Purpose
What is Piroxicam used for?
Piroxicam is a medication used to treat pain and inflammation caused by osteoarthritis and rheumatoid arthritis. Osteoarthritis is a condition that causes the cartilage in the joints to break down, leading to pain and stiffness. Rheumatoid arthritis is an autoimmune disease that causes the immune system to attack the joints, leading to pain, swelling, and stiffness. Piroxicam works by reducing inflammation and pain in the joints.
How does Piroxicam work?
Piroxicam reduces pain by blocking the production of prostaglandins, which are chemicals that make pain worse. Prostaglandins also cause inflammation, so piroxicam's pain-relieving effects may also be due to its ability to reduce inflammation.
Is Piroxicam effective?
Piroxicam has been shown to be effective in reducing pain and inflammation in conditions like osteoarthritis, rheumatoid arthritis, and acute musculoskeletal disorders. Clinical trials have demonstrated that Piroxicam effectively alleviates pain, decreases swelling, and improves joint function. Its long duration of action helps provide sustained symptom relief, making it useful for chronic inflammatory conditions.
How does one know if Piroxicam is working?
Piroxicam is a medicine that stays in your body for a long time. It can take up to two weeks for the medicine to reach its full effect. This means that you shouldn't judge how well the medicine is working for at least two weeks.
Directions for Use
What is the usual dose of Piroxicam?
For adults with rheumatoid or osteoarthritis, the typical daily dose of Piroxicam is 20 mg, taken by mouth. You may take the dose all at once or divide it into smaller doses throughout the day. It takes about 7-12 days for Piroxicam to reach its full effect in your body, so you may not notice the full benefits right away. Piroxicam has not been studied in children, so it is not recommended for use in this population.
How do I take Piroxicam?
Piroxicam is typically taken once daily, with or without food. However, it is recommended to take it with food or milk to reduce the risk of stomach irritation or ulcers. People taking Piroxicam should avoid alcohol, as it may increase the risk of gastrointestinal bleeding. It's also important to follow dosing instructions provided by your doctor and not exceed the prescribed dose.
For how long do I take Piroxicam?
For best results, use the lowest dose of NSAIDs that works for you and only for as long as needed. If you're taking piroxicam and are more than 20 weeks pregnant, your doctor may want to check your baby's amniotic fluid levels with an ultrasound after 48 hours. If the fluid levels are low (oligohydramnios), stop taking piroxicam.
How long does it take for Piroxicam to start working?
Piroxicam is a medication that takes time to work fully. While you may notice some improvement early on, it can take up to two weeks for the full effects to be felt. This is why it's important to avoid making any judgments about the medication's effectiveness before that two-week mark.
How should I store Piroxicam?
Piroxicam should be stored at room temperature, away from moisture and heat. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom, as humidity can affect the medication's effectiveness. Always check the expiration date and properly dispose of any expired or unused medicine.
Warnings and Precautions
Who should avoid taking Piroxicam?
**Important Warnings:** * **Heart Risks:** NSAIDs can increase your risk of heart attack and stroke, especially if you take them for a long time or at high doses. * **Bleeding Risks:** NSAIDs can cause ulcers and bleeding in your stomach or intestines. This can be dangerous and can even lead to death. **Contraindications:** * Don't take NSAIDs before or after heart surgery (CABG). * Don't take NSAIDs for conditions they're not prescribed for. * Don't share NSAIDs with others, even if they have the same symptoms.
Can I take Piroxicam with other prescription drugs?
Piroxicam can interact with several medications, increasing the risk of side effects. Key interactions include:
- Anticoagulants (e.g., warfarin): Increased bleeding risk.
- Other NSAIDs: Risk of gastrointestinal bleeding or ulceration.
- Antihypertensives (e.g., ACE inhibitors, diuretics): Reduced effectiveness of blood pressure medications.
- Corticosteroids: Increased risk of gastrointestinal issues. Always consult a healthcare provider before using Piroxicam with other medications.
Can I take Piroxicam with vitamins or supplements?
Piroxicam may interact with supplements like vitamin E, omega-3 fatty acids, and certain herbal remedies (e.g., ginkgo biloba, garlic) that can increase the risk of bleeding. High doses of vitamin C may also interact by affecting absorption or increasing gastric irritation. Always consult with a healthcare provider before combining Piroxicam with vitamins or supplements.
Can Piroxicam be taken safely while pregnant?
Piroxicam is classified as a Category D drug during pregnancy, indicating potential risks to the fetus. It can cause premature closure of the ductus arteriosus, a critical blood vessel in the fetus, and may lead to renal impairment or pulmonary hypertension in the newborn. It is generally advised to avoid using Piroxicam, especially in the third trimester, unless absolutely necessary. Always consult a healthcare provider before use during pregnancy.
Can Piroxicam be taken safely while breastfeeding?
Piroxicam is excreted in breast milk in small amounts. While there are no conclusive studies on its effects in nursing infants, it is recommended to avoid using Piroxicam during breastfeeding, especially in newborns or premature infants, due to potential risks like gastrointestinal bleeding or renal impairment. It's advisable to consult a healthcare provider for alternatives if breastfeeding.
Is Piroxicam safe for the elderly?
Older people are more likely to have serious health problems, like heart, stomach, or kidney problems, when they take NSAIDs. These medicines are often used to relieve pain and inflammation. The benefits of taking these medicines should be considered carefully against the risks.
Is it safe to exercise while taking Piroxicam?
Yes, unless you experience severe side effects like dizziness or joint pain. Adjust activity levels based on symptoms and consult your doctor.
Is it safe to drink alcohol while taking Piroxicam?
Drinking alcohol while taking these medicines can make stomach problems worse. It is unknown if drinking in moderation affects how well this medicine works.