Mirtazapine
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Mirtazapine
Learn more about this medicine -
Click HereSummary
Mirtazapine is primarily used to treat major depressive disorder. It can also be used for anxiety disorders, sleep problems, and in some cases, to stimulate appetite.
Mirtazapine works by increasing the levels of serotonin and norepinephrine in the brain. These are chemicals that affect mood and help to relieve depression.
The initial dose of Mirtazapine is usually 15 mg taken once daily at bedtime. The maintenance dose can range from 15 to 45 mg daily. The dose can be adjusted by your doctor based on your response.
Common side effects of Mirtazapine include drowsiness or sedation, weight gain and increased appetite, dry mouth, dizziness, and low blood pressure. There is also an increased risk of suicidal thoughts, especially in younger people.
Mirtazapine should not be used by people who are allergic to it, or by those with severe liver disease or certain heart conditions. It should be used with caution in the elderly due to increased sensitivity to side effects like sedation and weight gain.
Indications and Purpose
What is Mirtazapine used for?
- Major depressive disorder
- Sometimes used for anxiety, sleep disorders, and appetite stimulation in some cases.
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How does Mirtazapine work?
It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood and relieve depression.
Is Mirtazapine effective?
Yes, it is effective for many people, especially for treating depression and improving sleep.
How does one know if Mirtazapine is working?
You should feel a reduction in depressive symptoms, such as improved mood, increased energy, and better sleep.
Directions for Use
What is the usual dose of Mirtazapine?
- Initial dose: 15 mg once daily, usually at bedtime.
- Maintenance dose: 15–45 mg daily.The dose can be adjusted by your doctor based on your response.
How do I take Mirtazapine?
Take it once a day at night (before sleep), with or without food.
For how long do I take Mirtazapine?
It depends on your condition, but typically for several months to long-term treatment. Your doctor will guide you on how to stop it gradually if needed.
How long does it take for Mirtazapine to start working?
It may take 1–2 weeks for initial improvements and 4–6 weeks for full effects.
How should I store Mirtazapine?
Keep your mirtazapine pills in a cool, dry place, away from sunlight, at a normal room temperature.
Warnings and Precautions
Who should avoid taking Mirtazapine?
- Those with allergy to mirtazapine.
- People with severe liver disease or certain heart conditions.
Can I take Mirtazapine with other prescription drugs?
Consult your doctor, especially if taking other antidepressants, antipsychotics, benzodiazepines, or medications for heart conditions.
Can I take Mirtazapine with vitamins or supplements?
Yes, but avoid supplements that affect serotonin, such as St. John’s Wort, unless your doctor approves.
Can Mirtazapine be taken safely while pregnant?
Mirtazapine should be used during pregnancy only if necessary and prescribed by a doctor after weighing the risks and benefits.
Can Mirtazapine be taken safely while breastfeeding?
It is generally not recommended for breastfeeding, as it can pass into breast milk.
Is Mirtazapine safe for the elderly?
It is generally safe, but the elderly may be more sensitive to side effects like sedation and weight gain.
Is it safe to exercise while taking Mirtazapine?
Yes, but take care if you feel dizzy or sedated from the medication.
Is it safe to drink alcohol while taking Mirtazapine?
Mirtazapine is a medicine. Drinking alcohol while taking it doesn't significantly change how much of the medicine is in your blood. However, alcohol and mirtazapine together make it harder to think clearly and do things that require coordination, like driving. It's best to avoid alcohol while you're on this medication.
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