Metoclopramide
Gastroesophageal Reflux, Postoperative Nausea and Vomiting ... show more
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
Dopamine-2 Receptor Antagonist
Metoclopramide
Know More About This Medicine -
Click HereSummary
Metoclopramide is primarily used to treat nausea, vomiting, and gastric problems such as gastroesophageal reflux disease (GERD) and delayed stomach emptying. It can also be used to manage symptoms from chemotherapy or after surgery.
Metoclopramide works by increasing the movement of the stomach and intestines, helping food pass through the digestive system more easily. It also strengthens the muscles at the bottom of your esophagus to prevent stomach acid from flowing back.
Typically, adults take 5 to 10 mg of Metoclopramide 3 to 4 times per day, usually before meals and at bedtime. For children, the dose is determined based on their weight and specific condition. It is usually taken orally in tablet form or as a liquid.
Common side effects of Metoclopramide include drowsiness, fatigue, and diarrhea. Some people may also experience headaches, stomach upset, and mood changes. Serious side effects could include uncontrollable muscle movements, especially with long-term use.
Metoclopramide can cause serious side effects like Neuroleptic Malignant Syndrome, a life-threatening condition with symptoms like high fever and stiff muscles. It's important to avoid alcohol, driving, or operating machinery while taking this medication. Long-term use is not recommended, and it should not be used by individuals with certain medical conditions or taking certain other medications.
Indications and Purpose
What is Metoclopramide used for?
Metoclopramide is used to treat nausea and vomiting from various causes (such as chemotherapy or post-surgery), help with stomach emptying disorders like gastroparesis, and treat GERD.
How does Metoclopramide work?
Metoclopramide helps your stomach and intestines work better. It makes your stomach muscles contract more, which helps food move through your stomach and intestines faster. It also relaxes the muscles at the bottom of your stomach, which makes it easier for food to move into your intestines. Metoclopramide also strengthens the muscles at the bottom of your esophagus, which helps prevent stomach acid from flowing back into your esophagus.
Is Metoclopramide effective?
Yes, metoclopramide is effective at treating nausea, vomiting, and some gastrointestinal conditions by helping to accelerate stomach emptying and reduce reflux symptoms. Its effectiveness is generally well-established when used short-term.
How does one know if Metoclopramide is working?
You can tell if metoclopramide is working when symptoms like nausea, vomiting, or stomach bloating are reduced. The medication may also help you feel less uncomfortable after meals.
Directions for Use
What is the usual dose of Metoclopramide?
The usual dose of metoclopramide for adults is 5 to 10 mg taken 3 to 4 times per day, typically before meals and at bedtime. For children, the dose is determined based on their weight and specific condition.
How do I take Metoclopramide?
Metoclopramide is usually taken orally in tablet form or as a liquid, 30 minutes before meals, and at bedtime. It is important to follow the prescribed dosage and take it on a regular schedule for best results.
For how long do I take Metoclopramide?
Metoclopramide is generally used for short-term relief of symptoms like nausea. The duration depends on the condition being treated, but prolonged use may lead to side effects. Always follow your doctor’s instructions.
How long does it take for Metoclopramide to start working?
Metoclopramide works quickly, often within 30 minutes to an hour, to relieve symptoms like nausea or vomiting. The full effects may take a bit longer, depending on the condition.
How should I store Metoclopramide?
Store metoclopramide at room temperature, away from moisture and heat, and out of the reach of children. Keep the medication in its original container, tightly closed.
Warnings and Precautions
Who should avoid taking Metoclopramide?
Metoclopramide can cause serious side effects, including uncontrollable muscle movements, mostly facial, which may not go away. It can also cause a life-threatening condition called Neuroleptic Malignant Syndrome, which has symptoms like high fever and stiff muscles. Avoid alcohol, as it can make you more drowsy. Don't drive or operate machinery until you know how Metoclopramide affects you. Tell your doctor about all other medications you take, especially those for Parkinson's disease, depression, or high blood pressure. Do not use Metoclopramide for more than 12 weeks.
Can I take Metoclopramide with other prescription drugs?
Metoclopramide can interact with other medications, so it's important to tell your doctor about all the medicines you're taking, including those for Parkinson's, blood pressure, depression (especially MAOIs), antipsychotics, insulin, or sleep.
Can I take Metoclopramide with vitamins or supplements?
Metoclopramide may interact with certain supplements like iron or magnesium. It’s best to avoid taking them simultaneously. Always discuss supplements with your doctor to avoid interactions.
Can Metoclopramide be taken safely while pregnant?
Metoclopramide, a medication used to treat nausea and vomiting, does not increase the risk of pregnancy complications. However, it crosses the placenta and can cause muscle problems and a rare blood condition in newborns if taken during delivery. Doctors monitor newborns for these issues. The chances of a baby being born with a serious birth defect or miscarriage are 2-4% and 15-20%, respectively, in the United States.
Can Metoclopramide be taken safely while breastfeeding?
Metoclopramide can get into breast milk and could be harmful to a baby. It's important to talk to your doctor to decide if you should take Metoclopramide or breastfeed. Babies who breastfeed while their mother is taking Metoclopramide may have tummy troubles, such as discomfort or gas. Watch the baby for any unusual movements or bluish color around the lips or fingernails, as these could be signs of a serious condition.
Is Metoclopramide safe for the elderly?
For older people, start with a smaller dose of 5 mg of metoclopramide four times a day. If needed, you can gradually increase the dose to 10-15 mg four times a day, but only if the medicine is helping and you're not having side effects. Older people may be more sensitive to the effects of metoclopramide.
Is it safe to exercise while taking Metoclopramide?
Moderate exercise is generally safe while taking metoclopramide. However, if you feel fatigued or dizzy due to the medication, be cautious and consult your doctor before engaging in physical activity.
Is it safe to drink alcohol while taking Metoclopramide?
Alcohol should be avoided while taking metoclopramide, as it can increase the risk of side effects like drowsiness and dizziness. Limit alcohol and consult your doctor if you have concerns.
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