Methylergometrine
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
NA
Methylergometrine
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Click HereSummary
Methylergometrine is used to prevent or control bleeding from the uterus after childbirth or an abortion. It is also used to manage uterine atony and subinvolution of the uterus following delivery of the placenta.
Methylergometrine works by acting directly on the smooth muscle of the uterus, increasing the tone, rate and amplitude of contractions. This helps control postpartum hemorrhage and reduces blood loss.
Methylergometrine is typically taken orally as a tablet, three or four times a day. The usual dose for adults is one tablet (0.2 mg) each time. Always follow your doctor's instructions regarding dosage.
Common side effects of Methylergometrine include upset stomach, vomiting, diarrhea, headache and a bad taste in the mouth. Serious side effects can include seizures, chest pain, fast heartbeat, difficulty breathing, dizziness, ringing in the ears, leg cramps and skin rash.
Methylergometrine should not be used during pregnancy or by individuals with hypertension, toxemia, or hypersensitivity to the drug. It should not be administered intravenously due to the risk of sudden hypertensive and cerebrovascular accidents. Caution is advised in patients with impaired hepatic or renal function.
Indications and Purpose
What is Methylergometrine used for?
Methylergometrine is indicated for the prevention and control of postpartum hemorrhage, management of uterine atony, and subinvolution of the uterus following delivery of the placenta. It is also used to control uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.
How does Methylergometrine work?
Methylergometrine acts directly on the smooth muscle of the uterus, increasing the tone, rate, and amplitude of rhythmic contractions. This action induces a rapid and sustained uterotonic effect, which helps in shortening the third stage of labor and reducing blood loss.
Is Methylergometrine effective?
Methylergometrine is effective in preventing and controlling postpartum hemorrhage by acting directly on the smooth muscle of the uterus, increasing the tone, rate, and amplitude of contractions. This rapid and sustained uterotonic effect shortens the third stage of labor and reduces blood loss.
How does one know if Methylergometrine is working?
The benefit of Methylergometrine is evaluated by its effectiveness in controlling postpartum hemorrhage and uterine atony. Regular follow-up appointments with a healthcare provider can help assess the medication's effectiveness and monitor for any side effects.
Directions for Use
What is the usual dose of Methylergometrine?
For adults, Methylergometrine is typically taken as one tablet (0.2 mg) three or four times daily. The use in children is not established, and the safety and effectiveness in pediatric patients have not been determined. Always follow the doctor's prescription for the correct dosage.
How do I take Methylergometrine?
Methylergometrine is taken orally as a tablet three or four times a day. The content does not specify whether it should be taken with or without food, so it is best to follow your doctor's instructions. There are no specific food restrictions mentioned, but always consult your healthcare provider for personalized advice.
For how long do I take Methylergometrine?
Methylergometrine is usually prescribed for a maximum of one week during the puerperium period to manage uterine atony and hemorrhage after childbirth. The exact duration should be determined by a healthcare provider based on individual needs.
How long does it take for Methylergometrine to start working?
Methylergometrine starts working within 5-10 minutes after oral administration. Its rapid action helps in controlling postpartum hemorrhage effectively by inducing uterine contractions.
How should I store Methylergometrine?
Methylergometrine should be stored in its original container, tightly closed, at room temperature, away from light, excess heat, and moisture. It should be kept out of reach of children and not stored in the bathroom. Unneeded medication should be disposed of through a take-back program.
Warnings and Precautions
Who should avoid taking Methylergometrine?
Methylergometrine should not be used in individuals with hypertension, toxemia, pregnancy, or hypersensitivity to the drug. It should not be administered intravenously routinely due to the risk of sudden hypertensive and cerebrovascular accidents. Caution is advised in patients with impaired hepatic or renal function.
Can I take Methylergometrine with other prescription drugs?
Methylergometrine should not be coadministered with potent CYP 3A4 inhibitors, as this can lead to serious adverse events like vasospasm and ischemia. Caution is advised when used with beta-blockers, anesthetics, and other vasoconstrictors, as these can enhance Methylergometrine's effects.
Can I take Methylergometrine with vitamins or supplements?
The content does not specify interactions with vitamins or supplements. However, it is important to inform your doctor about all medications, vitamins, and supplements you are taking to avoid potential interactions.
Can Methylergometrine be taken safely while pregnant?
Methylergometrine is contraindicated during pregnancy due to its uterotonic effects, which can harm the fetus. It should only be used after delivery to manage uterine atony and hemorrhage. There is no specific evidence from human studies provided, but the contraindication is based on its pharmacological action.
Can Methylergometrine be taken safely while breastfeeding?
Mothers should not breastfeed during treatment with Methylergometrine and should wait at least 12 hours after the last dose before resuming breastfeeding. Milk secreted during this period should be discarded, as Methylergometrine can produce adverse effects in the breastfeeding infant and reduce milk yield.
Is Methylergometrine safe for the elderly?
The content does not provide specific recommendations for the elderly. However, it is generally advised to start at the low end of the dosing range due to the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in older adults.
Is it safe to exercise while taking Methylergometrine?
The content does not specifically address whether Methylergometrine affects the ability to exercise. However, if you experience side effects like dizziness or leg cramps, it may be advisable to avoid strenuous activities and consult your doctor.
Is it safe to drink alcohol while taking Methylergometrine?
The provided content does not mention the effects of alcohol on Methylergometrine. However, it is generally advisable to avoid alcohol while taking medications unless specified by a healthcare provider, as alcohol can potentially interact with medications and affect their effectiveness or increase side effects.
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