Linagliptin
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DRUG STATUS
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dipeptidyl Peptidase 4 Inhibitor
Controlled Drug Substance
NO
Linagliptin
Learn more about this medicine -
Click HereSummary
Linagliptin is primarily used for treating type 2 diabetes. It helps to control blood sugar levels in combination with a healthy diet and regular exercise. It can be used alone or with other diabetes medications like metformin or insulin.
Linagliptin works by blocking an enzyme called DPP-4. This enzyme breaks down hormones that help control blood sugar levels. By inhibiting this enzyme, Linagliptin increases the levels of these hormones, which helps to lower blood sugar levels.
The usual daily dosage of Linagliptin for adults is 5 mg taken once a day. It can be taken with or without food. Always follow your doctor's instructions for proper dosage.
Common side effects of Linagliptin include stuffy or runny nose, sore throat, and headache. More serious side effects can include inflammation of the pancreas, allergic reactions, severe joint pain, and kidney problems. Always report any unusual symptoms to your doctor.
Linagliptin should be used with caution in people with a history of pancreatitis. It's also not recommended for individuals with known hypersensitivity to Linagliptin. People with severe kidney impairment should be monitored closely. Always consult a healthcare provider before starting treatment.
Indications and Purpose
What is Linagliptin used for?
Linagliptin is indicated for the treatment of type 2 diabetes mellitus in adults. It is used to improve glycemic control in conjunction with diet and exercise. Linagliptin is not recommended for type 1 diabetes or diabetic ketoacidosis.
How does Linagliptin work?
Linagliptin works by inhibiting the enzyme DPP-4, which breaks down incretin hormones. By preventing this breakdown, Linagliptin increases the levels of active incretin hormones, which stimulate insulin release and decrease glucagon levels in a glucose-dependent manner. This helps to improve blood sugar control in people with type 2 diabetes.
Is Linagliptin effective?
Linagliptin has been shown to effectively lower blood sugar levels in adults with type 2 diabetes when used alongside diet and exercise. Clinical trials have demonstrated significant improvements in hemoglobin A1c (HbA1c) levels, fasting plasma glucose, and post-prandial glucose compared to placebo. It is effective as monotherapy or in combination with other diabetes medications.
How does one know if Linagliptin is working?
The benefit of Linagliptin is evaluated by regularly monitoring blood sugar levels and glycosylated hemoglobin (HbA1c) to assess its effectiveness in controlling diabetes. Patients should have regular check-ups with their healthcare provider to adjust the treatment plan as needed and ensure optimal diabetes management.
Directions for Use
What is the usual dose of Linagliptin?
The usual daily dose of Linagliptin for adults is 5 mg taken orally once a day, with or without food. The safety and effectiveness of Linagliptin in children have not been established, so it is not recommended for pediatric use.
How do I take Linagliptin?
Linagliptin should be taken once daily, with or without food, at the same time each day. There are no specific food restrictions while taking Linagliptin, but it is important to follow a healthy diet and exercise plan as recommended by your healthcare provider to effectively manage diabetes.
For how long do I take Linagliptin?
Linagliptin is typically used as a long-term treatment for managing type 2 diabetes. It should be taken continuously as prescribed by a healthcare provider, even if you feel well, to maintain blood sugar control.
How long does it take for Linagliptin to start working?
Linagliptin begins to work shortly after ingestion, with peak plasma concentrations occurring about 1.5 hours after a dose. However, it may take several weeks to see the full effect on blood sugar levels. Regular monitoring and follow-up with a healthcare provider are important to assess its effectiveness.
How should I store Linagliptin?
Store Linagliptin in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children. Do not store it in the bathroom. Dispose of unneeded medication through a take-back program or as advised by a pharmacist.
Warnings and Precautions
Who should avoid taking Linagliptin?
Important warnings for Linagliptin include the risk of acute pancreatitis, severe allergic reactions, and hypoglycemia when used with insulin or sulfonylureas. It is contraindicated in patients with a history of hypersensitivity to Linagliptin or its ingredients. Patients should be aware of symptoms like severe abdominal pain, rash, or difficulty breathing and seek medical attention if they occur.
Can I take Linagliptin with other prescription drugs?
Linagliptin may interact with insulin and insulin secretagogues, increasing the risk of hypoglycemia. It can also interact with strong inducers of P-glycoprotein or CYP3A4 enzymes, such as rifampin, which may reduce its effectiveness. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Can I take Linagliptin with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Linagliptin be taken safely while pregnant?
There is limited data on the use of Linagliptin during pregnancy, and its effects on fetal harm are not well established. It is generally recommended to avoid using Linagliptin during pregnancy unless the potential benefits outweigh the risks. Pregnant women should consult their healthcare provider to discuss the best treatment options for managing diabetes.
Can Linagliptin be taken safely while breastfeeding?
There is no information on the presence of Linagliptin in human milk or its effects on the breastfed infant. It is present in rat milk, so caution is advised. Breastfeeding mothers should weigh the benefits of breastfeeding against the need for Linagliptin and any potential risks to the infant. Consulting a healthcare provider is recommended.
Is Linagliptin safe for the elderly?
Linagliptin is generally safe for use in the elderly without the need for dosage adjustment based on age. However, elderly patients should be monitored for any side effects, especially if they have other health conditions or are taking multiple medications. Regular check-ups with a healthcare provider are recommended to ensure safe and effective use.
Is it safe to exercise while taking Linagliptin?
Linagliptin does not typically limit the ability to exercise. However, managing blood sugar levels is important during physical activity. If you experience symptoms like dizziness or fatigue while exercising, consult your healthcare provider to ensure your diabetes management plan is appropriate.
Is it safe to drink alcohol while taking Linagliptin?
Drinking alcohol can affect blood sugar levels, which may interfere with the effectiveness of Linagliptin in managing type 2 diabetes. It is important to discuss alcohol consumption with your healthcare provider to ensure safe use of Linagliptin.
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