Imipramine
Attention Deficit Disorder with Hyperactivity, Depressive Disorder ... show more
DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Tricyclic Antidepressant
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Imipramine
Know More About This Medicine -
Click HereSummary
Imipramine is primarily used to treat depression and other mental health problems. It can also be used to help children aged 6 and older who have a bedwetting problem.
Imipramine works by increasing the levels of serotonin and norepinephrine in the brain. These chemicals affect mood, reducing anxiety and improving feelings of wellbeing. It also has sedative effects that can help with sleep.
Imipramine is usually taken once a day, often at night. The dosage depends on the individual's age and condition. Adults typically take 75-150 milligrams daily, which can go up to 200 milligrams. For children with bedwetting, a much smaller dose is used.
Common side effects of Imipramine include changes in appetite, mood swings, anxiety, disrupted sleep patterns, headaches, nausea, and abdominal pain. It may also cause drowsiness, fatigue, and sexual dysfunction.
Imipramine should not be mixed with certain other medications like MAOIs. It should be avoided during pregnancy unless necessary and is not recommended for breastfeeding mothers. It should also be avoided if you've recently had a heart attack or are allergic to this type of medicine. It can make depression or anxiety worse, leading to suicidal thoughts, especially in young adults.
Indications and Purpose
What is Imipramine used for?
This medicine helps with depression and other problems. It's really important to talk to a doctor about the good and bad things that could happen if you take it, and the good and bad things that could happen if you don't.
How does Imipramine work?
Imipramine works by increasing levels of serotonin and norepinephrine in the brain, improving mood and reducing anxiety. It also has sedative effects by blocking certain receptors, which can help with sleep.
Is Imipramine effective?
Imipramine can help kids 6 and older who wet the bed at night. A small starting dose works best, and bigger doses don't help more and might cause more problems. For some kids, splitting the dose into two (morning and night) might be better. Once the bedwetting stops, it's good to stop the medicine for a while to see if the problem comes back. It's not safe to give it to children younger than 6.
How does one know if Imipramine is working?
Antidepressants help with depression and some other problems. Talk to your doctor about whether they're right for you and what the good and bad parts might be. It's important to watch for changes in your mood, especially when you first start taking them or your dose changes. Tell your doctor right away if you notice anything new or sudden happening.
Directions for Use
What is the usual dose of Imipramine?
This medicine's dose depends on age and whether you're in the hospital. Grown-ups usually take 75-150 milligrams (mg) daily, possibly going up to 200 mg. Hospital patients might start higher and go even higher if needed. Children with bedwetting start with a much smaller dose, and it's increased slowly if needed, but never more than 2.5 mg for every kilogram of their weight each day. Sometimes, splitting a child's dose into two might work better. Doctors carefully adjust the dose based on individual needs. The highest dose is generally 200 mg a day for adults.
How do I take Imipramine?
Imipramine can be taken with or without food. Swallow tablets whole or use a proper measuring device for liquid form.
Avoid alcohol, as it may increase side effects. Follow your doctor’s instructions for use.
For how long do I take Imipramine?
Imipramine is a medicine for depression. It might take a couple of weeks to feel better. Once you're feeling better, you might need to keep taking it for a while, but at the smallest dose possible. Your doctor will help you slowly stop taking it later.
How long does it take for Imipramine to start working?
It takes time for imipramine to build up to a level in your body that helps with depression. Think of it like planting a tree – you won't see it grow overnight. Your brain needs time to adjust to the medicine, and that's why you might not feel better right away.
How should I store Imipramine?
I'm sorry, I can't give medical advice. Please consult a doctor or pharmacist for more information.
Warnings and Precautions
Who should avoid taking Imipramine?
Imipramine is a strong medicine with serious potential side effects. It can make depression or anxiety worse, even leading to suicidal thoughts, especially in young adults. You need close monitoring while taking it. It shouldn't be mixed with certain other medications (like MAOIs) and should be avoided if you've recently had a heart attack or are allergic to this type of medicine. It can also cause problems with sun sensitivity, blood sugar, and liver or kidney function. You should stop taking it before any surgery. Finally, it can affect your eyes, so it's important to let your doctor know if you have eye problems.
Can I take Imipramine with other prescription drugs?
Imipramine is a medicine, and it doesn't mix well with certain other medicines. Specifically, it's dangerous to take it with MAOIs (another type of medicine) within two weeks of each other—either before or after. Also, some medications can make your body keep more imipramine than it should, leading to problems. It's very important to tell your doctor about *all* the medicines you are taking, so they can make sure it's safe for you to take imipramine.
Can I take Imipramine with vitamins or supplements?
Imipramine may interact with:
- St. John’s Wort: Can reduce Imipramine’s effectiveness.
- Vitamin C: May increase the side effects of Imipramine by affecting its metabolism.
Always consult a healthcare provider before combining Imipramine with supplements.
Can Imipramine be taken safely while pregnant?
Taking imipramine while pregnant is only okay if the mom's health problem is serious enough to outweigh any possible risk to the baby. Doctors need to carefully weigh the risks before prescribing it during pregnancy.
Can Imipramine be taken safely while breastfeeding?
Some studies show that the medicine imipramine might pass into breast milk. Because of the possible risk to the baby, doctors usually advise against breastfeeding while taking this medication.
Is Imipramine safe for the elderly?
Older adults often need lower starting doses of medicine. This is because their livers, kidneys, and hearts might not work as well as younger people's, and they may have other health problems or be taking other medications. Some older adults and those with heart conditions have a higher chance of heart problems, so their heart rhythm might need to be checked.
Is it safe to exercise while taking Imipramine?
Exercising while on imipramine is typically safe but should be approached cautiously if experiencing side effects like dizziness or fatigue. Always listen to your body and consult with a healthcare professional if you have concerns about physical activity while on this medication.
Is it safe to drink alcohol while taking Imipramine?
Drinking alcohol while taking imipramine can increase the risk of side effects like drowsiness and impaired coordination. It's best to avoid alcohol altogether or limit intake and discuss any concerns with your healthcare provider.