Haloperidol

Schizophrenia, Psychotic Disorders ... show more

DRUG STATUS

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Approvals

US(FDA), UK(BNF)

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Essential Medicine

YES

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Teratogenicity

Unlisted

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Pharmaceutical Class

Typical Antipsychotic

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Drug Ingredient

Haloperidol

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Summary

  • Haloperidol is used to treat mental health conditions like psychosis, Tourettes syndrome, and severe behavioral problems in children. It helps control symptoms like being overly active, impulsive, or aggressive.

  • Haloperidol works by affecting certain chemicals in the brain, particularly dopamine. However, the exact way it does this is still being studied by scientists.

  • Haloperidol can be taken orally, starting from 0.5 to 2 mg a few times a day for mild symptoms in adults, and up to 3 to 5 mg for severe cases. For children aged 3 to 12, a smaller amount is gradually increased as needed.

  • Common side effects of Haloperidol include movement problems, sleepiness, confusion, and changes in appetite or libido. Serious but rare side effects include heart problems, high fever, stiff muscles, and unstable blood pressure.

  • Haloperidol should not be used if you are allergic to it, very sleepy or unconscious, or have Parkinson's disease. It is especially dangerous for older people with dementia as it can increase their risk of death. It can also cause heart problems, including a dangerous heart rhythm and sudden death.

Indications and Purpose

What is Haloperidol used for?

Haloperidol is a medicine that helps control problems caused by mental illnesses like psychosis. It can also help with tics and uncontrolled movements in Tourette's Syndrome, and severe behavioral issues in children, such as extreme anger or aggression. Doctors might use it for a short time to help very hyperactive children with behavior problems only if other treatments haven't worked.

How does Haloperidol work?

Haloperidol is a medicine that helps with mental health issues like psychosis. We know it works by affecting certain chemicals in the brain, particularly dopamine, but the exact way it does this is still being figured out by scientists. It's like knowing a key opens a lock, but not knowing exactly how the teeth on the key interact with the tumblers inside.

Is Haloperidol effective?

Haloperidol helps some people, but we don't know exactly how much is best. Most people don't get better taking more than 6mg a day. For someone really upset, a shot of 2-5mg can help, maybe every hour at first, but later, every 4-8 hours might be enough. Once someone is better, the goal is to give the smallest amount that still works.

How does one know if Haloperidol is working?

Haloperidol is a medicine used to help people with mental health issues like psychosis (seeing or hearing things that aren't there), Tourette's syndrome (tics and involuntary movements), and serious behavioral problems in kids. Doctors check how well it works by seeing if it reduces symptoms like being overly active, impulsive, or aggressive. While it can sometimes raise prolactin levels (a hormone), doctors aren't always sure what that means for most people.

Directions for Use

What is the usual dose of Haloperidol?

This medicine, haloperidol, comes in different strengths depending on age and how sick someone is. Adults with mild symptoms might take a small amount (0.5 to 2 mg) a few times a day. Those who are very sick might need a larger amount (3 to 5 mg) a few times a day. In rare cases, much higher doses are used. For children ages 3 to 12, doctors start with a very small amount and gradually increase it as needed, but it's never given to children under 3.

How do I take Haloperidol?

Haloperidol can be taken with or without food. Swallow tablets whole or use a proper dose-measuring device for liquid form.

Avoid excessive alcohol to reduce side effects. Follow your doctor's instructions for personalized use.

For how long do I take Haloperidol?

The typical duration of use for Haloperidol depends on the condition being treated:

  • For acute conditions (e.g., severe agitation or psychosis), it may be used for short-term management until symptoms stabilize, typically a few days to weeks.
  • For chronic conditions (e.g., schizophrenia or long-term psychosis management), Haloperidol may be used long-term, often months or years, with ongoing monitoring by a healthcare provider.

The duration should always be determined by a doctor based on the individual’s response and condition.

How long does it take for Haloperidol to start working?

Haloperidol typically starts working within 30 to 60 minutes after oral administration, with the full therapeutic effects taking a few days to weeks to be fully noticeable, especially for long-term symptom management. For injectable forms, effects may be seen more rapidly, often within a few hours. The time for full effect can vary depending on the condition being treated.

How should I store Haloperidol?

Keep the medicine haloperidol at room temperature, between 68 and 77 degrees Fahrenheit. Don't let it freeze or get direct sunlight. The pharmacy will give it to you in a special container that protects it from light.

Warnings and Precautions

Who should avoid taking Haloperidol?

Haloperidol is a strong medicine with risks. It shouldn't be used if someone is already very sleepy or unconscious, allergic to it, or has Parkinson's disease. It's especially dangerous for older people with dementia; it can increase their risk of death. Also, there's a risk of heart problems, including a dangerous heart rhythm and even sudden death.

Can I take Haloperidol with other prescription drugs?

Haloperidol's effectiveness can change if you take other medicines at the same time. Some medicines, like rifampin, can make haloperidol less effective. Others, like pain killers (opiates), sleeping pills, or alcohol, can make you much sleepier than usual when taken with haloperidol. Stopping haloperidol and Parkinson's medicine at the same time can cause serious side effects involving movement. Finally, some medicines used to treat Parkinson's disease can raise eye pressure if you're also on haloperidol. It's crucial to tell your doctor about all the medicines you take, including over-the-counter ones, to avoid problems.

Can I take Haloperidol with vitamins or supplements?

Haloperidol may interact with:

  1. Vitamin E: Can increase the sedative effects of Haloperidol.
  2. Calcium and Magnesium supplements: May affect Haloperidol absorption, reducing its effectiveness.

Always consult a doctor before using supplements with Haloperidol.

Can Haloperidol be taken safely while pregnant?

Using haloperidol during pregnancy is risky. While there's no proof it directly harms the baby, the possibility exists. Some reports show birth defects when it's used with other risky medications early in pregnancy, but it's unclear if haloperidol was the cause. Doctors should only prescribe it if the benefit to the mother is much greater than any potential risk to the baby. Also, you shouldn't breastfeed while taking haloperidol.

Can Haloperidol be taken safely while breastfeeding?

Haloperidol is a strong medicine. Some of it can pass into breast milk. For babies, even a small amount can be harmful. To keep the baby safe, mothers taking haloperidol shouldn't breastfeed. They should talk to their doctor about other ways to feed their baby.

Is Haloperidol safe for the elderly?

Older people with dementia who also have mental problems like seeing things that aren't there are more likely to die if they take strong antipsychotic medicines. One specific medicine, haloperidol, isn't even meant for this. Older adults need lower doses of these drugs because their bodies process them differently. Also, a serious side effect called tardive dyskinesia (uncontrollable movements) is more common in older people, especially women, who take these medicines.

Is it safe to exercise while taking Haloperidol?

Exercise is generally safe while taking haloperidol. However, if you experience side effects like dizziness or muscle rigidity, adjust your activity level and consult your doctor for further guidance

Is it safe to drink alcohol while taking Haloperidol?

This medicine and alcohol don't mix well. Drinking alcohol while taking this medicine can make the medicine's effects stronger than they should be (additive effects), and it could also make your blood pressure drop dangerously low (hypotension). It's best to avoid alcohol completely while you're on this medication.