Domperidone
Nausea, Vomiting ... show more
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DRUG STATUS
Approvals
UK(BNF)
Essential Medicine
NO
Teratogenicity
Unlisted
Pharmaceutical Class
Dopamine-2 Receptor Antagonist
Domperidone
Know More About This Medicine -
Click HereSummary
Domperidone is primarily used to relieve nausea and vomiting. It's effective in controlling these symptoms.
Domperidone works by blocking dopamine receptors in the brain, preventing nausea signals from being transmitted. It's most effective about an hour after you take it by mouth.
Domperidone comes in 10mg tablets. You can take one tablet up to three times a day, but no more than 30mg total in a 24-hour period. It should be taken 15-30 minutes before eating. It's not meant for long-term use; don't take it for more than a week.
The most common side effect of Domperidone is a dry mouth. Other less common side effects include headache, diarrhea, rash, and itching. Serious but rare side effects can affect the heart's rhythm, especially in older people or those taking high doses.
Domperidone shouldn't be taken by people with heart problems, severe liver problems, or certain types of sugar intolerance. It can interact badly with some other medications, particularly those that affect heart rhythm. Alcohol may enhance side effects like drowsiness, so limit or avoid alcohol during treatment.
Indications and Purpose
What is Domperidone used for?
Domperidone tablets help stop nausea and vomiting.
How does Domperidone work?
Domperidone, a medication, is mostly broken down in the liver. This breakdown involves two main processes. Most of the drug leaves the body through urine and stool. A small amount leaves unchanged. It typically stays in the body for about 7-9 hours, but this time can be longer if someone has serious kidney problems.
Is Domperidone effective?
Clinical studies and post-marketing data have shown Domperidone to be effective in controlling nausea and vomiting. However, it should be used at the lowest effective dose for the shortest duration to minimize side effects.
How does one know if Domperidone is working?
A reduction in nausea and vomiting typically indicates effectiveness. Persistent symptoms should prompt consultation with a healthcare provider.
Directions for Use
What is the usual dose of Domperidone?
This medicine is for adults and teens weighing at least 35 kilograms (about 77 pounds). You can take one 10mg tablet up to three times a day, but no more than 30mg total in a 24-hour period. It's not been tested on younger children, so it shouldn't be given to them. Don't take it for longer than a week.
How do I take Domperidone?
To get the most out of Domperidone, take it 15–30 minutes before you eat. If you take it after a meal, it won't work as well. There's no need to avoid any particular foods.
For how long do I take Domperidone?
The medicine or treatment should only last for a maximum of seven days.
How long does it take for Domperidone to start working?
Domperidone, a medicine, works best in your body about an hour after you take it by mouth. But, it's only meant for short-term use; you shouldn't take it for more than a week.
How should I store Domperidone?
Store below 30°C in the original packaging to protect from light and moisture.
Warnings and Precautions
Who should avoid taking Domperidone?
Domperidone is a medicine that shouldn't be taken by people with heart problems, especially those with irregular heartbeats or low potassium, magnesium, or high potassium levels. It's also not safe for people with severe liver problems or certain types of sugar intolerance. If you have mild liver or kidney problems, your doctor might give you a lower dose. Adults and older kids should not take more than 30mg a day, and treatment shouldn't last longer than a week. It's important to tell your doctor about all other medicines you're taking, as some can interact badly with Domperidone.
Can I take Domperidone with other prescription drugs?
Domperidone is a medicine, but it's risky to take it with certain other drugs. Some medications, like erythromycin and ketoconazole, can make your body keep more domperidone than it should, leading to a dangerous heart rhythm problem. Problems with your body's salt levels (like too little potassium or magnesium) or a slow heart rate also increase this risk. If you're taking domperidone and another medicine that could affect your heart, talk to your doctor.
Can I take Domperidone with vitamins or supplements?
Some supplements may interact, especially those altering electrolytes (e.g., potassium or magnesium), which could exacerbate cardiac risks. Consult your doctor.
Can Domperidone be taken safely while pregnant?
Pregnant women should only take domperidone if the doctor thinks it's absolutely necessary and the medicine's benefits are greater than any potential harm to the baby.
Can Domperidone be taken safely while breastfeeding?
Use only if benefits outweigh risks. Domperidone passes into breast milk in minimal amounts but may affect the baby.
Is Domperidone safe for the elderly?
For older adults (60 and up), start with the smallest amount of this medicine that works. Taking more than 30mg a day greatly increases the risk of dangerous heart problems. Don't take this medicine with other drugs that affect heart rhythm or certain other medications (your doctor will know which ones).
Is it safe to exercise while taking Domperidone?
Exercise is generally safe unless side effects like dizziness or fatigue occur. Avoid strenuous activity if symptoms are present.
Is it safe to drink alcohol while taking Domperidone?
Alcohol may enhance side effects like drowsiness. Limit or avoid alcohol during treatment.
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