Chlorambucil
Non-Hodgkin Lymphoma, B-Cell Chronic Lymphocytic Leukemia ... show more
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DRUG STATUS
Approvals
US(FDA), UK(BNF)
Essential Medicine
YES
Teratogenicity
Unlisted
Pharmaceutical Class
Alkylating Drug
Chlorambucil
Know More About This Medicine -
Click HereSummary
Chlorambucil is a chemotherapy medication used to treat certain cancers, including leukemia and lymphoma. It is also used for chronic lymphocytic leukemia (CLL), Hodgkin's and non-Hodgkin's lymphoma, and other rare blood or bone marrow disorders.
Chlorambucil is an alkylating agent. It works by binding to the DNA in cancer cells, preventing them from dividing. This slows their growth and eventually leads to their death.
Chlorambucil is typically taken orally, once daily on an empty stomach. The usual dose for adults varies depending on the type of cancer, typically 0.1 to 0.2 mg per kilogram of body weight daily. However, the dosage is highly individualized and determined by a healthcare professional.
Common side effects of Chlorambucil include nausea, vomiting, fatigue, and hair thinning. Serious risks include bone marrow suppression, infections, and secondary cancers. It can also cause mood changes, sleep disturbances, and 'chemo brain', which is difficulty with concentration and memory.
Chlorambucil is not safe for pregnant or breastfeeding women as it can harm the baby. It's also unsuitable for people allergic to it or those with severe bone marrow suppression. Alcohol should be limited or avoided during treatment. It's important to consult your doctor about all other medications, vitamins, or supplements you're taking as they may interact with Chlorambucil.
Indications and Purpose
What is Chlorambucil used for?
Chlorambucil treats chronic lymphocytic leukemia (CLL), Hodgkin's and non-Hodgkin's lymphoma, and other rare blood or bone marrow disorders.
How does Chlorambucil work?
Chlorambucil is an alkylating agent that binds to DNA, preventing cells from dividing and leading to cancer cell death while also affecting normal rapidly dividing cells.
Is Chlorambucil effective?
Yes, studies and clinical use have demonstrated Chlorambucil's effectiveness in managing specific cancers. It can help achieve remission or reduce symptoms in many cases when used properly.
How does one know if Chlorambucil is working?
Improvement in symptoms, reduced cancer cell counts, or scans showing decreased tumor size indicate effectiveness. Regular blood tests and follow-ups with your doctor are essential to monitor progress.
Directions for Use
What is the usual dose of Chlorambucil?
The usual dose for adults varies depending on the type of cancer, typically 0.1 to 0.2 mg per kilogram of body weight daily. Dosing is highly individualized and determined by a healthcare professional. It's rarely used in children.
How do I take Chlorambucil?
Take Chlorambucil orally as prescribed, usually once daily on an empty stomach. Swallow the tablets whole with water. Avoid breaking or chewing them and follow safety precautions for handling.
For how long do I take Chlorambucil?
The treatment duration depends on the specific condition and response to therapy. It may be given in cycles with rest periods between doses as determined by your doctor.
How long does it take for Chlorambucil to start working?
It may take several weeks to see the effects of Chlorambucil, as its impact builds over time by reducing cancerous cell growth and improving symptoms.
How should I store Chlorambucil?
Store Chlorambucil in a cool, dry place below 25°C, away from light and moisture. Keep it out of reach of children and handle with care.
Warnings and Precautions
Who should avoid taking Chlorambucil?
It’s unsuitable for people allergic to it or those with severe bone marrow suppression. Pregnant and breastfeeding women should avoid it due to potential harm to the baby.
Can I take Chlorambucil with other prescription drugs?
Some medications, including those affecting the immune system or bone marrow, may interact with Chlorambucil. Inform your doctor of all other drugs you're taking.
Can I take Chlorambucil with vitamins or supplements?
Consult your doctor before taking any vitamins or supplements, as some may interact with Chlorambucil or increase the risk of side effects.
Can Chlorambucil be taken safely while pregnant?
No, Chlorambucil is not safe during pregnancy. It can cause significant harm to the developing fetus. Women should use effective contraception and avoid pregnancy while on treatment.
Can Chlorambucil be taken safely while breastfeeding?
No, Chlorambucil is not recommended while breastfeeding. It can pass into breast milk and harm the baby. Alternative feeding methods should be considered.
Is Chlorambucil safe for the elderly?
Elderly patients may tolerate Chlorambucil differently and may need careful dose adjustments. Close monitoring is essential to avoid severe side effects.
Is it safe to exercise while taking Chlorambucil?
Light to moderate exercise is safe and can help with fatigue. Avoid overexertion and listen to your body. Speak with your doctor about a suitable exercise plan.
Is it safe to drink alcohol while taking Chlorambucil?
Alcohol can increase nausea or liver strain while on Chlorambucil. It’s best to limit or avoid alcohol during treatment and discuss with your doctor.
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