Aripiprazole
Alteus Biogenics Pvt Ltd ,
Alteus Biogenics Pvt Ltd
Nulet 5 Tablet ,
نولیٹ 5 ٹیبلٹ
Schizophrenia ,
DRUG STATUS
Approvals
US. FDA / uk mhra / ema / pdma
Essential Medicine
WHO / India
Use in Pregnancy
Not Advised / Caution
Pharmaceutical Class
ama / pdma
Summary
Aripiprazole is used to treat conditions such as schizophrenia, bipolar disorder, major depressive disorder, and irritability associated with autism. It's also prescribed for Tourette's syndrome and in some cases, it may be used for other mental health conditions.
Aripiprazole works by balancing the levels of certain neurotransmitters in the brain, mainly dopamine and serotonin. It acts as a partial agonist at dopamine receptors, meaning it can both increase and decrease dopamine activity depending on the brain's needs. This helps stabilize mood and reduce symptoms.
For adults, the usual starting dose of Aripiprazole is 10-15 mg per day. The dose may be gradually increased, typically to 15-30 mg per day, depending on the condition being treated. It's usually taken once daily, with or without food.
Common side effects of Aripiprazole include nausea, headache, dizziness, anxiety, insomnia, and weight gain. Significant adverse effects can include movement disorders like tremors or restlessness, increased risk of suicidal thoughts, and metabolic changes such as high blood sugar or cholesterol.
Important warnings for Aripiprazole include an increased risk of suicidal thoughts, especially in young adults, and potential for movement disorders like tardive dyskinesia. It should be used cautiously in people with a history of heart disease, diabetes, or seizures. Aripiprazole is contraindicated in individuals with known hypersensitivity to the drug.
Indications and Purpose
How does Aripiprazole work?
Aripiprazole works by balancing the levels of certain neurotransmitters in the brain, mainly dopamine and serotonin. It acts as a partial agonist at dopamine receptors, meaning it can both increase and decrease dopamine activity depending on the brain’s needs. This helps stabilize mood and reduce symptoms of conditions like schizophrenia and bipolar disorder.
How does one know if Aripiprazole is working?
The benefit of Aripiprazole is evaluated through regular clinical assessments by doctors. These include monitoring symptom improvement, such as reduced hallucinations, improved mood stability, and better daily functioning. Doctors also track side effects, the patient’s response to treatment, and any changes in mental health over time. Regular follow-ups and adjustments to the dose help ensure its effectiveness.
Is Aripiprazole effective?
Evidence supporting Aripiprazole's effectiveness comes from clinical studies showing its ability to reduce symptoms of schizophrenia, bipolar disorder, and major depression. It has been shown to improve mood stability, reduce hallucinations, and prevent manic or depressive episodes. Multiple randomized controlled trials confirm its safety and efficacy, making it a widely prescribed medication for these conditions.
What is Aripiprazole used for?
Aripiprazole is commonly used to treat conditions like schizophrenia, bipolar disorder (mania and mixed episodes), and major depressive disorder (as an add-on treatment). It is also prescribed for irritability associated with autism and Tourette's syndrome. In some cases, it may be used off-label for other mental health conditions. Always follow your doctor’s guidance for its use.
Directions for Use
How do I take Aripiprazole?
Aripiprazole can be taken with or without food. There are no specific food restrictions, but it’s important to avoid alcohol, as it can increase side effects. Take the medicine exactly as prescribed, and don’t miss doses. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for the next dose.
How long does it take for Aripiprazole to start working?
Aripiprazole may start showing effects within 1 to 2 weeks, but it can take up to 4 to 6 weeks for the full benefits to be noticeable, especially for conditions like schizophrenia or bipolar disorder. It’s important to continue taking it as prescribed, even if you don’t feel immediate improvement. Always consult your doctor for progress updates.
How should I dispose of Aripiprazole?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of the medicines properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How should I store Aripiprazole?
Aripiprazole should be stored at room temperature, away from moisture, heat, and direct sunlight. Keep the medication in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom or expose it to extreme temperatures. Dispose of any unused or expired medication properly as per your doctor's instructions.
What are the consequences to stopping Aripiprazole?
Stopping Aripiprazole suddenly can lead to withdrawal symptoms like nausea, vomiting, dizziness, and return of the symptoms being treated, such as mood swings or psychosis. It's important to consult your doctor before discontinuing it, as they may gradually reduce the dose to avoid withdrawal effects. Never stop the medication without medical guidance.
What is Aripiprazole’s dose and duration?
For adults, the usual starting dose of Aripiprazole is 10-15 mg per day. The dose may be gradually increased, typically to 15-30 mg per day, depending on the condition being treated. It’s usually taken once daily, with or without food. Always follow the doctor's instructions and don't stop abruptly. Avoid alcohol and be cautious with other medications.
What should I do if I miss a dose of Aripiprazole?
"If you forget to take one or more doses: take your next dose at the normal time and in the normal amount. Do not take any more than your doctor prescribed.
Warnings and Precautions
Can Aripiprazole be taken safely while breastfeeding?
Aripiprazole is excreted in breast milk, and its safety during breastfeeding is not fully established. It may pose a risk to the infant, especially in newborns or preterm babies. If breastfeeding, it’s important to consult your doctor to evaluate the risks and benefits. The doctor may recommend monitoring the baby for any side effects or suggest alternative treatments.
Can Aripiprazole be taken safely while pregnant?
Aripiprazole is classified as a Category C medication for pregnancy, meaning its safety has not been established. Animal studies have shown potential risks, but there is insufficient human data. It may cause harm to the fetus, including withdrawal symptoms after birth. It should only be used during pregnancy if the benefits outweigh the risks. Always discuss with your doctor if you’re pregnant or planning to become pregnant.
Can Aripiprazole be taken safely while trying to conceive?
There is limited data on the effect of Aripiprazole on fertility. However, it is not known to have a direct impact on fertility in either men or women. Some side effects, like hormonal changes, may affect reproductive health, but these are rare. It’s important to consult a doctor if planning for pregnancy or experiencing any fertility concerns while taking the medication.
Can I take Aripiprazole with other prescription drugs?
Aripiprazole can interact with several prescription drugs. For example, strong CYP3A4 or CYP2D6 inhibitors (like fluoxetine or ketoconazole) can increase Aripiprazole levels, leading to more side effects. Conversely, drugs that induce these enzymes (such as carbamazepine) may reduce its effectiveness. Additionally, combining Aripiprazole with other central nervous system depressants (like benzodiazepines) may increase sedation. Always consult your doctor before taking any new medications.
Can I take Aripiprazole with vitamins or supplements?
Aripiprazole may interact with certain vitamins and supplements. For example, high doses of vitamin E might increase the risk of side effects, and supplements that affect serotonin levels, like St. John's Wort, could reduce Aripiprazole’s effectiveness. Always inform your doctor about any vitamins, herbs, or supplements you're taking to avoid harmful interactions.
What are Aripiprazole possible harms and risks?
Common side effects of Aripiprazole include nausea, headache, dizziness, anxiety, insomnia, and weight gain. Significant adverse effects can include movement disorders (like tremors or restlessness), increased risk of suicidal thoughts, and metabolic changes (such as high blood sugar or cholesterol). Rare but serious effects may involve heart problems or neuroleptic malignant syndrome. Always consult a doctor for any concerns.
Who should avoid taking Aripiprazole?
Important warnings for Aripiprazole include an increased risk of suicidal thoughts, especially in young adults, and potential for movement disorders like tardive dyskinesia. It should be used cautiously in people with a history of heart disease, diabetes, or seizures. Aripiprazole is contraindicated in individuals with known hypersensitivity to the drug. Always inform your doctor about any pre-existing conditions.
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